282 results about "2-Naphthol" patented technology

The invention discloses a preparation method of one of components of a novel antihypertensive drug LCZ696, namely, sacubitril (sacubitril, AHU-377, I). The method comprises the following preparation steps: carrying out cyclization, addition, debenzylation, ring opening, esterification, amidation and the like on a chiral induciton reagent (S)-1-(alpha-aminobenzyl)-2-naphthol (S-betti Base) and 2R-methyl-4-oxo-butyric acid to prepare the sacubitril (I). The preparation method is available in raw materials, concise in process, economic and environmentally friendly, and is suitable for industrial production.

The invention relates to a process for preparing amino G acid, which belongs to the technical field of amino K acid production process. The process comprises the steps of sulfonating, salting out by ammoniacal liquor, treating G salt mother liquor, ammoniating G salt ammonium base sulfite, treating dehydrated liquid and the like, ammonium base sulfite is employed as a catalyst for replacing ammonium bisulfite, so that the pressure generated during ammonification process can be effectively reduced, the reaction time can be shortened, and the product yield and content can be increased. The method is characterized in that two streams of waste water are respectively treated, 2-naphthol is hydrolyzed and recovered by G salt mother liquor, neutralized for reaching the standard, and then exhausted; ammonium sulfate-rich effluent is used for producing fertilizer, and the zero discharge is realized. The unit consumption of the raw material 2-naphthol is decreased from 0.75 ton/ton in a traditional process to less than 0.64 ton/ton when the problem of waste water treatment is solved, so that the production cost is reduced, the production safety coefficient is high and no harmful gas is discharged. The process of the invention solves the problems that two streams of waste water are generated during the present production process, the difficulty of waste water treatment is large, the production cost is high and the large harm on environment is caused.

The invention relates to an environment-friendly production process of 2-naphthol. The environment-friendly production process of the 2-naphthol comprises the following steps: adding refined naphthalene into a sulfonation kettle, adding concentrated sulfuric acid, heating and performing sulfonation reaction, neutralizing a mixture by using alkali after the reaction is finished, crystallizing, filtering, drying, performing alkali fusion and diluting; neutralizing the diluted alkali fused sulfonation liquid by using sulfuric acid at 70 to 80 DEG C, controlling the pH to be 4 to 7, standing and layering, and separating out crude 2-naphthol; washing, dehydrating and rectifying the separated crude 2-naphthol to obtain refined 2-naphthol; and removing alkali from the separated waste liquid, neutralizing to serve as alkaline liquid, absorbing sulfur dioxide generated by neutralization by using a sodium carbonate aqueous solution to produce sodium sulfite, adjusting the pH value of the waste liquid after 2-sodium naphthalene sulfonate is separated to be 2+/-1, performing three-stage extraction by using an extracting agent, performing reverse extraction on the extracting liquid by using dilute alkali, diluting sulfonated liquid by using the reverse extraction liquid, oxidizing the water phase by using a Fenton reagent or KMnO4, decoloring by using active carbon, and recovering sodium sulfate by a mechanical vapor recompression (MVR) concentration technology. By the process provided by the invention, no waste water is discharged basically and the production cost is reduced.

The invention relates to a method for preparing acid black 172. The method comprises the following steps that: (1) 6-nitro-1 and 2-diazoxynaphthalene-4-sulfonic acid are put into a dissolution tank, added with water for dissolution, added with a sodium hydroxide solution and stirred. (2) 2-naphthol is put into the dissolution tank, added with water for dissolution, added with the sodium hydroxide solution, stirred, heated, added with a dispersant and aliphatic diol or ether and stirred again; (3) a prepared 2-naphthol solution is rapidly put into and coupled with a solution with 6-nitro-1 and 2-diazoxynaphthalene-4-sulfonic acid so as to obtain coupled liquid; and (4) the coupled liquid is added with formic acid, ammonium bicarbonate or sodium bicarbonate and basic chromium sulfate, heated to be between 100 and 102 DEG C, thermally insulated and stirred so as to obtain an acid black 172 serous finished product. The method for preparing acid black 172 has the advantages of simple production process, scientific reasonable control on reaction conditions, short production cycle of produces, high yield, good quality, friction resistance, obviously raised fastness of resisting rinse and sunshine, obviously reduced side reaction and impurities, low production cost, high production efficiency and better environment-friendly property.

A preparation method for S-(+)-1-(alpha-aminobenzyl)-2-naphthol or R-(-)-1-(alpha-aminobenzyl)-2-naphthol mainly includes the following steps: A. under room temp., racemized (minus or plus)-1-(alpha-aminobenzyl)-2-naphthol is added with acetone and mixed, L-(+)-tartaric acid is added, mixing is continued until white solid is completely deposited, and then it is filtered to obtain S-(+)-1-(alpha-aminobenzyl)-2-naphthol and complex substance S-L-2 solid of L-(+)-tartaric acid; B. the obtained two components in step A are mixed and analyzed in sodium carbonate solution, and extracted with ethyl ether. The merged liquid extracts after being concentrated have the residual liquid obtained and stood still under low-temp., and the high-optical purity crystal of S-(+)-1-(alpha-aminobenzyl)-2-naphthol (S-1) is precipitated.

The invention relates to a preparation method for synthetizing a high efficiency water reducing agent by 2-naphthol waste water. The invention belongs to the technical field of concrete water reducing agents. According to the preparation method for synthetizing the high efficiency water reducing agent by the 2-naphthol waste water, the proportion of crude naphthalene to concentrated sulfuric acid to naphthol waste water to formaldehyde is (1:0.8)-(1.0:0.1)-(0.9:0.5)-0.8. The preparation method for synthetizing the high efficiency water reducing agent by the 2-naphthol waste water comprises the following process flows of: 1-, sulfonating: heating to melt crude naphthalene, adding the concentrated sulfuric acid when the temperature rises to 130-160 DEG C, and reacting for 2-2.5 hours at the temperature of 160-165 DEG C; 2-, hydrolyzing: cooling reactants to 90-110 DEG C, adding naphthol waste liquor and hydrolyzing for 0.5-1 hour; 3-, condensation: dropwise adding the formaldehyde at the temperature of 95-115 DEG C and reacting for 3-6 hours; and (4) neutralizing: adding liquid caustic soda to neutralize a condensation compound to regulate a pH value to be 7-9 to obtain a water reducing agent product. The preparation method for synthetizing the high efficiency water reducing agent by the 2-naphthol waste water has the advantages that the production process is simple, the operation is convenient, the process control is easy, waste is turned into wealth, and thereby, secondary emission cannot be generated, and the economic value and the social benefit are high and the like.

The invention discloses a method for preparing electronic 2,2'-binaphthol. The method comprises the following steps: under the action of a phase transfer catalyst and/or a surfactant, enabling 2-naphthol to react with a ferric trichloride solution and hydrogen peroxide, and finally performing reaction treatment with a water insoluble organic solvent, thereby obtaining an electron-grade product, namely 2,2'-binaphthol. Compared with the prior art, the method has the advantages that (1) the method has the advantages of a small amount of wastes of a solid-phase method and reaction balance, easiness in operation and low equipment requirements of a liquid-phase method; (2) the reaction efficiency is high, and a small amount of ferric chloride is used; (3) a product yield is high, and the highest product yield is up to 95%; (4) the product purity is improved, and electron-grade high requirements of electronic chemicals on raw materials are met; (5) a good production environment can be made,the working intensity is low, a small amount of wastewater is generated, and wastewater with ferrous ions can be oxidized and recycled.

The invention discloses a green preparation method for 14-aryl group-14 H-dibenzo [a, j] xanthene type derivative and belongs to the technical field of chemical material preparation. According to the preparation method, in preparation reaction, the molar ratio of aromatic aldehyde to 2-naphthol is 1 to 2; the molar weight of the catalyst is 3-5 % of aromatic aldehyde; the reaction temperature is 110 DEG C; the reaction time is 10-30 min; the preparation method comprises the following steps: after reaction, water is added for cooling; a great amount of solid materials are precipitated; the solid materials are grinded and stand still and then are subjected to suction filtration; the obtained filter residues are water-washed and dried and then an aqueous solution with 95% of ethyl alcohol is adopted for recrystallization; the pure 14-aryl group-14 H-dibenzo [a, j] xanthene type derivative is obtained after vacuum drying. Compared with other preparation methods using acidic ionic liquid as the catalyst, the preparation method has the advantages that the catalyst activity is good, the losses in recycling are less, the biological degradation is easy to realize, the whole preparation process is simple, convenient and economic and the industrialized mass production is facilitated.

The invention discloses a method for quickly and conveniently preparing a dual-emitting carbon spot. The method comprises the following steps: step (1) weighing 1-(2-pyridine azo)-2-naphthol and copper chloride dihydrate in the mole ratio of 1:(1-3), adding absolute ethyl alcohol and water in the volume ratio of (10-0):(0-10) and ultrasonically dissolving, thereby acquiring a mixed solution; step(2) transferring the mixed solution into an airtight reactor for heating and reacting, wherein the reaction temperature is 170 DEG C-190 DEG C and the reaction time is 3-5h; and step (3) naturally cooling the reaction system to room temperature, performing silicagel column chromatography, removing a solvent and performing vacuum drying, thereby acquiring the carbon spot. The carbon spot prepared by the method has fluorescence emission at 426nm and 488nm wavelength under the excitation of 350nm light; the carbon spot is capable of detecting Fe<3+> according to specific dual signals of fluorescence peaks at the two wavelengths; the method is wide in linear range and low in limit of detection.

The invention discloses a method for treating wastewater generated in the production of 2-naphthol. The method comprises the following steps: (1) adding an extracting agent into acidified wastewater generated in production of 2-naphthol, uniformly stirring, extracting, after the extraction is completed, standing for layering to obtain an oil-phase extract and a water-phase raffinate; and (2) adding activated carbon to the raffinate for adsorption, after the adsorption is completed, separating to remove activated carbon to obtain purified wastewater. By combining extraction and activated carbon adsorption, the method has the advantages of high treatment efficiency, mild condition and the like and is simple to operate and easy to control, and furthermore, the extracting agent and activated carbon can be repeatedly used so that the cost is reduced and the naphthalene sulfonate in the wastewater can also be used as a resource for recycling.

Disclosed is a method for producing a high purity 2-hydroxy-3-naphthoic acid. The method includes a 2-naphthol measuring tank, a caustic soda liquid storage tank, a caustic soda liquid measuring tank, a salt forming reaction vessel, carbon dioxide, a carbonization kettle, a resin separation, a resin solid waste, a dilute sulfuric acid, a neutralization, a filter pressing, a filter cake distillation, a 8% sodium hydroxide, a resin adsorption, an acid eduction, a sewage treatment workshop, a centrifugal dewatering, a pneumatic drying and finishing of a high purity 2-hydroxy-3-naphthoic acid product. The caustic soda liquid storage tank is downwards connected to the caustic soda liquid measuring tank, the caustic soda liquid measuring tank is connected to the salt forming reaction vessel, the salt forming reaction vessel is downwards connected to the carbonization kettle, simultaneously the carbon dioxide is connected to the carbonization kettle, 2-naphthol generated by reaction in the carbonization kettle and 2-naphthol obtained by the filter cake distillation are connected to the 2-naphthol measuring tank, the carbonization kettle is downwards connected to the resin separation, and simultaneously the resin separation is upwards connected to an ethyl naphthol feed liquid and the dilute sulfuric acid and downwards connected to the neutralization and the resin solid waste. According to the method, the whole process is simple, the operation and the usage are convenient, the stability is good, and the reliability is high.

The invention discloses a synthetic method of 6-hydroxy-2-naphthaldehyde, which comprises the following steps: A. beta-naphthol and bromine are reacted for generating 1, 6-dibromo-2-naphthol; then 1, 6-dibromo-2-naphthol and a reducing agent are reacted for obtaining 6-bromine-2-naphthol; B. 6-bromine-2-naphthol and a methyl esterification reagent are reacted for obtaining 6-bromine-2-naphthyl methyl ether; C. 6-bromine-2-naphthyl methyl ether and magnesium are reacted in a Grignard reaction solvent for generating a Grignard reagent; and then the Grignard reagent and N,N-dimethyl formamide are reacted for obtaining 6-methoxy-2-naphthaldehyde; D. 6-methoxy-2-naphthaldehyde and a demethylating reagent lithium chloride are dissolved in a high boiling point aprotic polar solvent for reaction, thereby obtaining a 6-hydroxy-2-naphthaldehyde. Cheap and easily obtained beta-naphthol is used as raw material according to the invention, and after bromination, reduction, methylation, Grignard, demethylating and other reactions, 6-hydroxy-2-naphthaldehyde is obtained; the invention has good advantages of industrial amplification maturation, simple reaction condition and low cost, and the demethylating yield reaches up to 91% and the overall yield reaches up to 62.8%.

The invention discloses a method for cooperatively producing 1-naphthol and 2-naphthol from a naphthalene sulfonation product by virtue of direct alkali fusion. The method comprises the following steps: performing multiple sulfonation reactions on naphthalene and concentrated sulfuric acid, directly performing an alkali fusion reaction on the obtained liquid sulfonation product and sodium hydroxide in a molten state, and then diluting, acidifying, boiling for layering, dehydrating and drying, rectifying and separating, thereby obtaining high-purity 1-naphthol and 2-naphthol simultaneously. The steps of hydrolyzing, naphthalene blowing, neutralization, cooling and crystallization and filtration of sulfonation products, and feeding for performing alkali fusion on a water-containing filter cake at a normal temperature in the existing process are avoided; no filtration wastewater difficult to treat is not generated anymore, the energy source and the resources are saved, the yield is increased and the operating environment is improved; as a result, the problems of three-waste treatment during naphthol production are thoroughly solved from the production process.

The invention relates to a sulfonation and alkali fusion optimized production process for 2-naphthol, and belongs to the field of organic chemical industry. By taking refined naphthalene as a material, 2-naphthol is prepared through processes such as sulfonating by 98% sulfuric acid, salting-out, alkali-fusing, acidifying, distilling, and the like. Defects of sulfonating, hydrolyzing and naphthalene-blowing, neutralizing, cold-separating, drying, alkali-fusing, acidifying and distilling in the convention process are overcome, the process is optimized, process flow is shortened, production cost is lowered, and no wastewater is produced; besides, the sulfonation and alkali fusion optimized production process for 2-naphthol has positive meaning for environment protection, and is especially applicable to production and usage of 2-naphthol.

The invention discloses a combination treatment method of 2-naphthol production wastewater, belonging to the technical field of wastewater treatment. The method comprises the steps of: respectively treating the 2-naphthol production wastewater through complexing extraction and liquid membrane separation technologies to ensure that the wastewater is easily subjected to biochemical treatment; and respectively carrying out alkali washing and demulsification on a load extraction agent and a load emulsion to ensure that the extraction agent and a liquid membrane oil phase are regenerated, wherein a concentrated solution contains high-concentration sodium phenolate and sodium naphthalene sulphonic and can be reused in production sections. The treatment method of the 2-naphthol production wastewater has the advantages that the COD (Chemical Oxygen Demand) in the wastewater is reduced from about 100000mg/L to about 3000mg/L; nonbiodegradable organic pollutants in the wastewater are greatly decreased; the biodegradability of the wastewater is increased; reduction and resource utilization of the pollutants in the 2-naphthol production wastewater can be realized at the same time; and a certain economic benefit is provided.

A disclosed 2-naphthol wastewater processing technology comprises adjusting the pH value of wastewater to be neutral, then enabling wastewater to enter MVR water processing operation and performing evaporation concentration, and returning clear water obtained after evaporation condensation to a workshop for reutilization; cooling wastewater subjected to concentration, crystallizing to precipitate sodium 2-naphthalenesulfonate, then performing separation, enabling the obtained filtrate to enter refrigeration desalting operation and performing cooling reprocessing, crystallizing to precipitate inorganic salts, performing separation on the crystal-containing concentrate to obtain the inorganic salts, and drying; and enabling the clear liquid subjected to refrigeration desalting to enter the MVR water processing operation and performing cyclic concentration. The processing technology performs cooling crystallization separation on wastewater at different temperature by utilizing the principle that the solubility difference of organic salts and inorganic salts is large in wastewater at different temperature, thereby effectively removing sodium 2-naphthalenesulfonate, sodium sulfite and sodium sulfate in wastewater. The processing technology is simple, employed equipment is less, energy consumption is less, cost is low and processing efficiency is improved.

The invention discloses a method of improving content of 2-hydroxy-3-naphthoic acid produced in a gas-solid phase method; the method comprises the steps: performing a salt forming reaction to concentrated alkaline and 2-naphthol, performing a carboxylation reaction with carbon dioxide and then obtaining the finished 2-hydroxy-3-naphthoic acid after a series of steps of resin separation, neutralization reaction, cooling and filter pressing, resin absorption, acidification reaction and centrifugal drying. A resin absorption procedure is added between the filter pressing procedure and the acidification procedure, so that the residual 2-naphthol in the filtrate after the filter pressing can be removed and the content of 2-hydroxy-3-naphthoic acid is greatly increased; meanwhile, the concentrated solution produced after the desorption of absorbed saturated resin is recovered, the 2-naphthol and the 2-hydroxy-3-naphthoic acid are obtained and the recovery of the 2-naphthol is realized; meanwhile, the source consumption is reduced. The method is simple, is simple and convenient in operation, good in stability and high reliability.

The invention discloses an improved K acid synthesis technology. Through primary sulfonation, salting-out, ammonification, acidification and secondary sulfonation, a K acid product and K acid waste water are prepared from 2-naphthol. The K acid waste water treatment process comprises 1, pre-treatment: pre-treating K acid waste water to remove organic impurities of the waste water and to obtain a filtrate, 2, electroosmosis concentration: carrying out common electroosmosis concentration on the pretreated filtrate to obtain concentrated water and fresh water, 3, bipolar membrane desalination: carrying out bipolar membrane electroosmosis on the concentrated water obtained by the step 2 to obtain a sulfuric acid solution, a potassium hydroxide solution and dilute brine, recycling the sulfuric acid solution and the potassium hydroxide solution in the K acid synthesis process and/or the step 1, returning the dilute brine into an electroosmosis device and carrying out re-condensation. The improved K acid synthesis technology realizes standard discharge of waste water produced by the K acid synthesis technology, utilizes an effective resource in waste water by the bipolar membrane electroosmosis technology, realizes use in the technology and reduces a K acid synthesis cost.

The invention relates to textile a sizing agent and a preparation method thereof. The textile sizing agent comprises, by mass percentage, 82-88% of main materials and 12-18% of auxiliaries. The main materials comprise nano silicon dioxide modified starch, pea starch, phosphate starch, acrylic acid, butyl acrylate, acrylamide, sodium sulfamate, diphenylmethane and protein amino acid. The auxiliaries comprise methyl alcohol, 2-naphthol, monochloroacetic acid and NaOH. The preparation method of the textile sizing includes the steps that firstly, the main materials are prepared; secondly, the main materials and the auxiliaries are evenly mixed to obtain the textile sizing agent. When the textile sizing agent is used for sizing, textiles can be subjected to sizing in the temperature range of 25-28 DEG C; after sizing, yarn is stable in performance, and strength and wear resistance are enhanced.