13 results about "Diethyldithiocarbamic Acid" patented technology

The invention provides room-temperature vulcanized rubber cement for a static balance patch of an aircraft tire and a preparation method of the room-temperature vulcanized rubber cement, and the room-temperature vulcanized rubber cement is prepared by taking natural rubber as a main material and C5 petroleum resin, an anti-aging agent BLE-W, an anti-aging agent RD, an anti-aging agent 4020, an anti-reversion agent HVA-2, precipitated white carbon black, a silane coupling agent, high-wear-resistance carbon black, a diethyl dithiocarbamic acid accelerant and insoluble sulfur as auxiliary materials. One part is mixed through an open mill or an internal mixer to prepare masterbatch containing insoluble sulfur, then the masterbatch is dissolved in n-heptane to obtain first masterbatch cement, the other part is directly dissolved in n-heptane to obtain second masterbatch cement containing the accelerant SDC, and the two kinds of rubber cement are mixed according to the mass ratio of 1: 1 during use. The rubber cement is moderate in hardness and can perfectly accord with a natural rubber inner liner of an existing aircraft tire, the bonding strength between a static balance sheet using the rubber cement and a tire lining of the tire is high, and the rubber cement has the advantages of relatively high tensile strength and tearing strength, good heat aging resistance and room-temperature vulcanization capacity.

The invention provides a pesticide synergist and a pesticide synergistic method adopting the same. The pesticide synergist is prepared from the following raw materials: diethyldithiocarbamic acid (DIECA) or a pesticide acceptable salt of the diethyldithiocarbamic acid, and alpha-ketoglutaric acid or a pesticide acceptable salt of the alpha-ketoglutaric acid. According to the invention, the intervention effect of low-dose DICEA and alpha-ketoglutaric acid on plant signals is utilized to improve the exchange efficiency of plants and environmental substances, so that the absorption and utilization of pesticides by the plants are promoted, and the purposes of improving the use efficiency of the pesticides and promoting the application reduction and synergism of the pesticides are achieved.

This invention discloses a semi-sandwich structured ruthenium triphenylphosphine dithiocarboxylic acid complex with a simple preparation process and its applications. The complex has the structure shown in Figure (I), with the central ruthenium and... η 5 - Coordination with cyclopentadiene, triphenylphosphine, and dithiocarboxylic acid derivatives, wherein the dithiocarboxylic acid ligands are selected from ethyl xanthic acid, isopropyl xanthic acid, ... N,N Diethyldithiocarbamic acid, morpholine dithiocarbamic acid, and carbazole dithiocarbamic acid. This invention employs a simple one-step method of room temperature preparation and recrystallization purification using a ruthenium precursor and dithiocarbamic acid ligand. This method offers advantages such as readily available raw materials, mild reaction conditions, simple post-processing, and high yield. In vitro tests show that the complexes exhibit excellent anti-proliferative activity against non-small cell lung cancer A549 cells, significantly superior to cisplatin. The complexes demonstrate activity by reducing mitochondrial membrane potential, inducing intracellular reactive oxygen species accumulation, and arresting the cell cycle (G1 phase), leading to late apoptosis in A549 cells.

The invention discloses a nano-drug for promoting cupric death of tumor cells and a preparation method of the nano-drug. The nano-drug comprises hyaluronic acid; a dopamine; copper ions; a diethyldithiocarbamic acid-copper conjugate; and a method for preparing the same. A peptide fragment with a targeting function; modifying a thiol ligand; the preparation method comprises the following steps: preparing a diethyl dithiocarbamic acid-copper conjugate, forming a nano-structure inner core, wrapping the conjugate, forming a copper ion protection layer, and purifying and carrying out targeted modification on a nano-drug. The preparation method comprises the following steps of: preparing the diethyl dithiocarbamic acid-copper conjugate, forming a nano-structure inner core, wrapping the conjugate, forming a copper ion protection layer, and carrying out targeted modification on the nano-drug. The copper ions are further fixed through the coordination effect of dopamine and the copper ions, wrapping of the diethyl dithiocarbamic acid-copper conjugate and the thiol-copper coordination effect of the modified thiol ligands, so that a double-coordination mechanism is formed, the loading capacity of the copper ions in the nano-drug is remarkably improved, and the stability of the nano-drug is improved. The copper death of tumor cells can be more effectively triggered, the copper ion loading capacity can be improved, and a material basis is provided for the efficient copper death effect.

The invention belongs to the field of rubber materials, and particularly relates to a durable high-resilience rubber composite material and a preparation method thereof. The rubber composite material provided by the invention is prepared from the following raw materials: natural rubber, high trans-1, 4-butadiene-isoprene copolymer rubber, high butadiene rubber, epoxy natural rubber grafted lignosulfonate, tetrapod-like zinc oxide whiskers, nano spherical zinc oxide, stearic acid, an anti-aging agent, a flame retardant, a vulcanizing agent, a first accelerant and a second accelerant. The first accelerant is selected from sulfoxide diethyldithiocarbamate, sulfoxide dibenzyl dithiocarbamate, sulfone dithiocarbamate and sulfone dibenzyl dithiocarbamate, and the second accelerant is selected from sulfoxide diethyldithiocarbamate, sulfoxide dibenzyl dithiocarbamate, sulfone dithiocarbamate and sulfone dibenzyl dithiocarbamate; the second accelerant is 4, 4 '-dithio-dimorpholine, 2-morpholinyl dithio-benzothiazole, N-oxydiethylene-2-benzothiazole sulfenamide, and dibenzoyl morpholine. The invention further discloses a preparation method of the flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame-retardant flame retardant. The rubber composite material provided by the invention has excellent high resilience and use durability.

The invention discloses a method for measuring the concentration of inorganic copper through liquid chromatography-tandem mass spectrometry, and relates to the technical field of detection. The method comprises the following steps: extracting inorganic copper in a sample by adopting acetic acid to obtain an extracting solution; adding a DDDC-Na solution into the extracting solution, mixing, standing, and deriving inorganic copper in the sample into copper diethyl dithiocarbamate to obtain a derived solution; and purifying the derivatized liquid through liquid-liquid extraction and / or solid-phase extraction, and injecting the purified liquid into a liquid chromatography tandem mass spectrometer for detection. Interference of other ions can be reduced, and complex samples can be analyzed. Strong acid, strong alkali and toxic compounds are not used in the pretreatment process, the steps are simple, and operation is easy. The method is high in sensitivity and analysis speed, the detection lower limit LOD is 0.00001 mg / L, and the quantification lower limit LOQ is 0.0005 mg / L. And the analysis speed can reach 2-3 minutes for each sample.

The invention belongs to the technical field of biological medicine and tumor diagnosis and treatment, and particularly relates to manganese diethyldithiocarbamate loaded nanoparticles and a pharmaceutical composition. The nanoparticles loaded with the manganese diethyldithiocarbamate are prepared from an amphiphilic polymer and diethyldithiocarbamate according to the mass ratio of (0.25 to 4) to 1; the manganese diethyldithiocarbamate accounts for more than 50% of the molar mass of the diethyldithiocarbamate; the amphiphilic polymer is one or more of DSPE (Distearoyl Polyethylene)-PEG (Polyethylene Glycol), DSPE-PEG-folic acid, DSPE-PEG-phenylboronic acid and DSPE-PEG-arginyl glycyl aspartic peptide. According to the application, the amphiphilic polymer of the DSPE-PEG and the derivative of the DSPE-PEG and the ethyl dithiocarbamate are adopted to form the nano-particles, and hydrophobic manganese ethyl dithiocarbamate can be wrapped in a hydrophobic micro-area.

The invention discloses a method for measuring the concentration of inorganic copper through liquid chromatography-tandem mass spectrometry, and relates to the technical field of detection. The method comprises the following steps: extracting inorganic copper in a sample by adopting acetic acid to obtain an extracting solution; adding a DDDC-Na solution into the extracting solution, mixing, standing, and deriving inorganic copper in the sample into copper diethyl dithiocarbamate to obtain a derived solution; and purifying the derivatized liquid through liquid-liquid extraction and / or solid-phase extraction, and injecting the purified liquid into a liquid chromatography tandem mass spectrometer for detection. Interference of other ions can be reduced, and complex samples can be analyzed. Strong acid, strong alkali and toxic compounds are not used in the pretreatment process, the steps are simple, and operation is easy. The method is high in sensitivity and analysis speed, the detection lower limit LOD is 0.00001 mg / L, and the quantification lower limit LOQ is 0.0005 mg / L. And the analysis speed can reach 2-3 minutes for each sample.

The present invention provides a Ni9S8@Au core-shell nanocrystal and a preparation method thereof. The Ni9S8@Au core-shell nanocrystal includes a core and a shell wrapped around the core, wherein the core is Ni9S8 and the shell is Au. The preparation method comprises the following steps: mixing nickel diethyldithiocarbamate with oleylamine, 1-octadecene, and 1-dodecylmercaptan to form a uniform solution; heating the uniform solution to a reaction temperature under a protective atmosphere, reacting to obtain a reaction solution; adding a tri-n-octylphosphine solution of chloroauric acid to the reaction solution, and reacting at the reaction temperature; cooling the obtained reaction solution to room temperature, adding a mixture of a polar solvent and a non-polar solvent, separating a solid product, and drying to obtain the Ni9S8@Au core-shell nanocrystal. Due to the unique structure and potential properties of the Ni9S8@Au core-shell nanocrystal, it has a wide range of application potentials in the fields of catalysis, energy storage, and sensing.

The application belongs to the technical field of transition metal catalysts, and discloses an iron-based sulfide with a hierarchical structure and a preparation method and application thereof. The preparation method comprises the following steps: reacting an iron source and diethyl dithiocarbamate in an aqueous solution, collecting and drying the precipitate to obtain iron diethyl dithiocarbamate; dispersing the iron diethyl dithiocarbamate in anhydrous ethylenediamine for a solvothermal reaction, collecting and drying the precipitate to obtain a precursor; dispersing the precursor in water, adding an organic exchanger for ion exchange, collecting and drying the precipitate, and the iron-based sulfide with a hierarchical structure is obtained. The specific surface area of the iron-based sulfide with a hierarchical structure is significantly increased, the exposed active sites are greatly increased, and the catalytic efficiency and selectivity of hydrazine hydrate in reducing nitroaromatic hydrocarbons are improved. The catalytic conversion rate of different nitroaromatic hydrocarbons is greater than 91%, and the highest can reach 100%, and the selectivity is greater than 99%.

The invention discloses a positive electrode electrolyte suitable for a lithium-selenium battery, application of the positive electrode electrolyte and the lithium-selenium battery, and belongs to the field of lithium-selenium batteries. The positive electrode electrolyte comprises a basic electrolyte and organic molecules, wherein the organic molecules are 2-benzothiazole diethyldithiocarbamate, and the concentration of the organic molecules is 0.1 mol / L to 3 mol / L. According to the preparation method disclosed by the invention, organized molecules and Li2Sen generated in a selenium positive electrode discharging process are subjected to nucleophilic reaction, so that selenium is grafted to an organic framework to realize organification, and a shuttle effect of Li2Sen is avoided from the source; meanwhile, an organized product is a good lithium ion conductor, lithium ions can be quickly transferred, and stable circulation of the battery at higher magnification is realized; besides, the organized product has higher discharge voltage, the energy density of the battery is also improved, and the lithium-selenium battery which has high energy density, can be quickly charged and discharged and has excellent cycling stability is finally realized, so that the lithium-selenium battery has a wide application prospect.

The application provides an alpha-ketone amide peroxide responsive drug precursor compound and a preparation method and application thereof, relates to the field of chemical biotechnology, and the alpha-ketone amide peroxide responsive drug precursor compound in the application is broken under the action of hydrogen peroxide, releases diethyl dithiocarbamate after chemical structure is changed and a benzyl group is eliminated, the released product is combined with copper ions to generate the metal drug copper diethyl dithiocarbamate CuET, and has a remarkable inhibiting growth effect on malignant tumor cells. The prepared drug precursor compound has a simple and easy-to-operate synthesis method, is strong in controllability, and has a wide application prospect in the field of malignant tumor treatment using the responsive drug precursor compound.

The invention discloses a method for constructing a dissolvable microneedle loaded with an MOFs (Metal Organic Frameworks) nano-drug, which comprises the following steps of: preparing a metal organic nano-drug diethyl dithiocarbamate modified copper-trimesic acid complex from a copper-trimesic acid complex and sodium diethyldithiocarbamate; the preparation method comprises the following steps: preparing a copper-trimesic acid complex modified by diethyldithiocarbamate, forming composite hydrogel by utilizing the interaction of polyvinylpyrrolidone and the diethyldithiocarbamate modified copper-trimesic acid complex, putting the composite hydrogel into a microneedle mold, preparing a soluble microneedle by adopting a vacuumizing method, and drying in a constant-temperature drying box for 24 hours, so as to obtain the soluble microneedle. And demolding to obtain the prepared soluble microneedle loaded with the MOFs nano-drug. According to the soluble microneedle manufactured by the method, the controllable release of the nano-drug loaded on the microneedle can be realized while the good mechanical property is ensured; the invention further provides a dissolvable microneedle loaded with the MOFs nano-drug. The invention belongs to a preparation technology of a dissolvable microneedle, and is applied to transdermal drug delivery.