105 results about "1-Naphthol" patented technology

The invention provides for the first time an oral liquid composition of duloxetine or its pharmaceutically equivalent derivatives like salts, isomers, complexes, polymorphs, hydrates or esters thereof. The duloxetine or its pharmaceutically equivalent derivative is present from about 2 mg to approximately 200 mg; and a buffering agent was used to stabilize the acid sensitive duloxetine. The composition has duloxetine from about 0.1 meq to about 2.5 mEq per mg of duloxetine. The invention further discloses an oral liquid composition of duloxetine or its pharmaceutically equivalent derivative wherein the degradation product 1-Naphthol is less than 0.01%. Also provided is a method for treating of major depressive disorder and or diabetic peripheral neuropathic pain comprising administering to a mammal in need of such treatment a therapeutically effective amount of a composition.

A process for preparing the 1-naphthol and 2-naphthol simultaneously includes sulfonating naphthalene by concentrated sulfuric acid, filtering to obtain alpha-naphthalenesulfonic acid and acidic mother liquid, dripping the mother liquid in fused naphthalene, high-temp sulfonating, hydrolyzing, blowing naphthalene to obtain high-purity beta-naphthalenesulfonic acid solution, respectively neutralizing the alpha-naphthalenesulfonic acid and beta-nephthalenesulfonic acid solution, alkali fusing, acidifying to obtain said two products, and dissolving beta-naphthalenesulfonic acid in sulfuric acid. Its advantages are high output rate and low pollution.

The invention discloses a novel process for efficiently and continuously synthesizing 2-naphthol, which comprises the following steps of: (A) putting refined naphthol from a naphthol-melting tank (1) into a prime kettle of a sulfonation reaction kettle, respectively putting sulphuric acid into various levels of the sulfonation reaction kettle from a sulphuric acid-weighting tank (2) for a sulfonation reaction for 2-6h and reducing the pressure of the sulfonation reaction kettle so as to remove water generated by the reaction; (B) guiding a sulfonated product in the step (A) into a neutralizing tank (7), directly neutralizing with diluted alkali, keeping impurities in the sulfonation reaction, primarily evaporating to dewater and directly guiding into an alkali melting pot (9) for an alkali-melting reaction; (C) acidifying an alkali-melting reaction product in an acidifying tank (11) and extracting 2-naphthol and 1-naphthol from the alkali-melting reaction product in an extracting tower (13) with an extracting agent; and (D) rectifying an organic phase after extracting the naphthol in a rectification tower to recycle the extracting agent and rectifying and separating the 2-naphthol, the 1-naphthol and naphthol without participating the reaction. The invention adopts continuous reaction process design, has simple and convenient process, stable performance and high yield, overcomes the detects of intermittent operation, low synthesis effect, multiple steps for separating 2-naphthol from other impurities, low separation efficiency and much three-waste generation in a sulfonation alkali-melting 2-naphthol synthesis process of the prior art, realizes continuous process, greatly reduces three-waste emission, lessens wastewater by 20 percent than that of the traditional process, greatly improves the 2-naphthol synthesis efficiency and obtains the 1-naphthol as a byproduct.

The invention discloses a naphthalene sulfonating method for coproducing 1-naphthol and 2-naphthol. The naphthalene sulfonating method comprises the following steps: directly neutralizing after carrying out sulfonating reaction: adding a sodium sulfite solution of which the concentration is 12 percent into a neutralizing kettle, then adding a naphthalene sulfonic acid molten material, reacting byregulating PH (Potential of Hydrogen) to be 1 to 2, heating the solution to be 105 DEG C, keeping warm for 15 minutes, and regulating the PH of the neutralizing kettle to be 7 to 8 after completing reaction; after neutralizing, sequentially carrying out naphthalene blowing, cooling crystallization, filtering, alkaline fusion, diluting, acidifying, boiling and stratifying, dewatering and drying and distillation separation, thus generating 1-naphthol and 2-naphthol. According to the naphthalene sulfonating method disclosed by the invention, a 1-naphthalene sulfonic acid isomer in a sulfonatingproduct does not need to be removed, 1-naphthol and 2-naphthol are simultaneously obtained through co-production, and the yield and the purity of 1-naphthol and 2-naphthol are effectively increased through specific production steps; a hydrolysis step is omitted, generation of wastewater during production is reduced, a production technology is simplified, and the production cost is reduced.

The invention discloses an ultra-fast and macro-scale preparation method of an ultra-fine and ultra-long Au nanowire. The method comprises the following steps: taking ethanol and water as a mixed solvent; taking Au salt as a precursor; taking 1-naphthol as a surfactant, a reducing agent and a morphology guiding agent; and after mixing the Au salt and the 1-naphthol with the mixed solvent, carrying out water bath for heat preservation, and obtaining the ultra-fine and ultra-long Au nanowire with a length exceeding 1 micron and a particle size of about 4.5nm. Compared with a traditional preparation method, the method is simple and rapid to operate, the prepared ultra-fine and ultra-long Au nanowire is single in morphology and high in purity, and large-scale production can be realized; and the ultra-fine and ultra-long Au nanowire prepared through the method has the advantages of a large specific surface area, multiple active sites, good flexibility and the like, and has excellent electrocatalytic activity for oxygen reduction.

The invention provides preparation of a block copolymer micelle with quadruple responsiveness and application thereof. The preparation specifically comprises the following steps: preparing a polyethylene glycol-block-polymethylacrylic acid dimethylamino ethyl ester (PEG-b-PDMAEMA) block copolymer with a macroinitiator (mPEG-Br) and a methylacrylic acid dimethylamino ethyl ester monomer by atom transfer radical polymerization; grafting 2-diazo-1-naphthol-5-sulfonyl chloride on the polyethylene glycol-block-polymethylacrylic acid dimethylamino ethyl ester (PEG-b-PDMAEMA) block copolymer by a quaternization reaction, so as to obtain the amphiphilic block copolymer with quadruple responsiveness of near-infrared light, ultraviolet light, pH and temperature. The polymer can be self-assembled in water to form nano-particles capable of wrapping hydrophobic micromolecules such as coumarin 102; due to single or synergistic stimulation of near-infrared light 808nm, ultraviolet light 365nm, pH and temperature, the appearance of the micelle is changed, so that loaded micromolecules are released. The micelle provided by the invention has quadruple responsiveness of near-infrared light, ultraviolet light, pH and temperature and has wide application prospect in the aspect of controlling drug release.

The invention discloses a method for synthesis of monosodium 8-amino-1-naphthol-3,6-disulfonate through hydrogenation catalysis and a catalyst. The catalyst is an active-carbon-loaded nickel molybdenum iron three-way catalyst. The method is as follows: a nitro T ammonium salt reaction liquid is employed as a reaction raw material, pH value adjustment pretreatment of the reaction raw material is carried out, then hydrogenation reduction is carried out by the active-carbon-loaded nickel molybdenum iron three-way catalyst, then alkali fusion and acidification are carried out, and monosodium 8-amino-1-naphthol-3,6-disulfonate is prepared. Preparation for the catalyst is simple, he nitro T ammonium salts can be reduced to amino T ammonium salts effectively, and the problems of catalyst poisoning, rapid inactivation and low recovery frequency and the like in the hydrogenation reduction process can be solved. The synthetic method raises the yield and the product purity of the hydrogenation catalysis technology greatly, generation of waste water and environment pollution are reduced, the technology steps are simple and safe, and the reaction is stable and easy to control.

The invention discloses a method for preparing a 1-naphthol phosphine oxide ligand. The method comprises the following steps: uniformly mixing a sulfur ylide compound, a phenylethyny phosphine oxide derivative, a catalyst, a Lewis acid and an organic solvent, and reacting in nitrogen at a temperature of 60-100 DEG C for 6-16 hours, thereby obtaining the finished 1-naphthol phosphine oxide ligand of a structural formula as shown in the specification. According to the method disclosed by the invention, the 1-naphthol phosphine oxide ligand that is difficultly prepared in the conventional synthetic method can be obtained, the step of the method is simple, and the 1-naphthol phosphine oxide ligand can be constructed by one step only. Moreover, the method is mild in reaction condition, excellent in substrate adaptability and high in yield, and can synthesize the 1-naphthol phosphine oxide ligand of multiple different substituent groups.

A scale adhesion preventing agent for use in a polymerization reactor, consisting essentially of a condensate of a phenol represented by the following formula (1), a 1-naphthol and an aldehyde, which is soluble in an alkaline aqueous solution: wherein R1 and R2 are the same or different and each a hydroxyl group, alkyl group having 1 to 8 carbon atoms, halogen atom, hydrogen atom, alkoxycarbonyl group whose alkyl moiety has 1 to 8 carbon atoms or phenyl group, with the proviso that a hydrogen atom is existent at at least two of ortho-positions and para-positions with respect to the hydroxyl group.When a vinyl-based monomer is to be polymerized using a polymerization reactor having a film of this scale adhesion preventing agent on the inner wall, the vinyl-based polymer can be produced by preventing the adhesion of a scale.