52 results about "Peripheral neuropathic pain" patented technology

This invention describes a topical delivery mechanism that contains a mixture of cetylated fatty esters that act as transdermal carriers of desired therapeutic molecules. The proposed cetyl fatty ester penetrant-complex (Base CFEP-complex) contains specific cetyl fatty esters, polar solvents, a carrier base (gel, cream, lotion, patch or stick gel), antioxidants and the desired pharmaceutical, cosmetic or antigenic response eliciting molecules that are efficaciously delivered by selectively varying component ratios in the complex. The invention proposes the use of transdermal delivery of medications such as those used in treatment of urinary incontinence, testosterone deficiency, arthritic and joint pain and other pains such as pain in the neck, lower back, back, knees, headaches, and other types of inflammatory pains, peripheral neuropathic pain, pain associated with repetitive strain injuries such as myofacial pain, rapid treatment of epileptic seizures, soluble antigens in the immuno-therapeutic treatment of allergies, actives in the treatment of foot cracks and elbow cracks, actives in the treatment of facial and other wrinkles in the form of anti-aging creams and gels and other topically delivered therapies.

The invention provides for the first time an oral liquid composition of duloxetine or its pharmaceutically equivalent derivatives like salts, isomers, complexes, polymorphs, hydrates or esters thereof. The duloxetine or its pharmaceutically equivalent derivative is present from about 2 mg to approximately 200 mg; and a buffering agent was used to stabilize the acid sensitive duloxetine. The composition has duloxetine from about 0.1 meq to about 2.5 mEq per mg of duloxetine. The invention further discloses an oral liquid composition of duloxetine or its pharmaceutically equivalent derivative wherein the degradation product 1-Naphthol is less than 0.01%. Also provided is a method for treating of major depressive disorder and or diabetic peripheral neuropathic pain comprising administering to a mammal in need of such treatment a therapeutically effective amount of a composition.

Use of 1-phenyl-3-dimethylaminopropane compounds for the production of medicaments for treating neuropathic pain, preferably polyneuropathic pain, also preferably diabetic neuropathic pain, more preferably diabetic peripheral neuropathic pain, and furthermore preferably for treating diabetic peripheral neuropathy.

The invention provides a method of treating spinal cord injury pain or peripheral neuropathic pain in a mammal comprising administering to a mammal a vector comprising a nucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein in an amount effective to treat spinal cord injury pain or peripheral neuropathic pain.

A plasma radiofrequency ablation and puncture trocar combination device. The invention relates to the field of medical devices. It includes an external puncture trocar and a built-in radio frequency puncture needle. The external puncture trocar is composed of a needle point, a needle body and a needle wing. The needle point and the needle body are coated with Teflon. The built-in radio frequency puncture needle Consists of a needle tip, a needle body, a needle seat and a needle core. There is no Teflon coating on the outside of the needle tip, and the length is 2mm. The outside of the needle body has a Teflon coating. The tip of the needle tip is 5 mm, and the inner diameter of the external puncture trocar corresponds to the outer diameter of the built-in radio frequency puncture needle, and the external puncture trocar and the built-in radio frequency puncture needle are detachable structures. The invention has the advantages of simple structure, low cost and convenient use, and provides technical convenience for patients with peripheral neuralgia to implement low-temperature plasma radiofrequency ablation to establish a working channel.

The invention belongs to the field of chemical drugs and in particular relates to a transdermal absorption preparation for treating diabetic peripheral neuropathic pain. The transdermal absorption preparation is prepared from gamma-aminobutyric acid analogue-like analgesic and small-molecule tricarbonyl nitrogen-containing compounds, and pharmaceutical excipients of the preparation include Carbomer 940, glycerin, Tween-80, triethanolamine, laurocapram and distilled water. Due to topical drug delivery, the transdermal absorption preparation has an obvious effect of relieving the diabetic peripheral neuropathic pain. Moreover, the dose of the gamma-aminobutyric acid analogue-like analgesic can be reduced.

The present invention provides method and compositions for the treatment of peripheral neuropathic pain by administering to a patient a therapeutically effective amount of a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, and wherein the spacer is bonded to the two opioid molecules via an ether bond. Preferably, the active agent is provided in the form of an injectable depot.

The invention refers to the use of a sigma ligand, particularly a sigma ligand of formulae (I), (II) or (III) to prevent and / or treat acute and chronic pain developed as a consequence of surgery, especially superficial and / or deep pain secondary to surgical tissue injury, and peripheral neuropathic pain, neuralgia, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathia, neuritis or neuropathy secondary to surgical procedure.