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Transdermal absorption preparation for treating diabetic peripheral neuropathic pain

A technology for transdermal absorption preparations and diabetes, which is applied in the direction of nervous system diseases, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of high price, high curative effect, and low side effects

Active Publication Date: 2018-10-26
李建会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two drugs have high curative effect and low side effects, and have broad clinical application prospects, but they are expensive and cannot be used as first-line routine drugs

Method used

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  • Transdermal absorption preparation for treating diabetic peripheral neuropathic pain
  • Transdermal absorption preparation for treating diabetic peripheral neuropathic pain
  • Transdermal absorption preparation for treating diabetic peripheral neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Antidiabetic Peripheral Neuralgia Gel and Its Preparation

[0030] Gel formulation: Pregabalin 70g, compound (IA) 10g, carbomer 940 21g, glycerin 78g, Tween 80 21g triethanolamine 32g, laurocaprolactone 7g and distilled water 1261g.

[0031] Preparation method: Take the prescribed amount of Carbomer 940 and add 1029g of distilled water, let stand overnight to fully swell; add the prescribed amount of glycerin to grind to moisten, and add the prescribed amount of triethanolamine to grind into a transparent gel matrix. Take the remaining amount of distilled water, prescription Tween 80, laurocaprazine, compound (IA), and pregabalin, stir, add to the gel base and stir at 90 rpm for 8 minutes, and divide into medicinal ointment tubes to obtain.

Embodiment 2

[0032] Example 2 Antidiabetic Peripheral Neuralgia Gel and Its Preparation

[0033] Gel formulation: gabapentin 90g, compound (IA) 10g, carbomer 940 21g, glycerin 78g, Tween 80 21g triethanolamine 32g, laurocaprolactone 7g and distilled water 1241g.

[0034] Preparation method: Take the prescribed amount of Carbomer 940 and add 1029g of distilled water, let stand overnight to fully swell; add the prescribed amount of glycerin to grind to moisten, and add the prescribed amount of triethanolamine to grind into a transparent gel matrix. Take the remaining amount of distilled water, prescription Tween 80, laurocaprazine, compound (IA), and gabapentin and stir, add to the gel base and stir at 60 rpm for 12 minutes, then put them into medicinal ointment tubes.

Embodiment 3

[0035] Example 3 Investigation of Drug Effects of Antidiabetic Peripheral Neuralgia Prescription

[0036]Healthy male SD rats, weighing 190-200 g, were raised in the SPF laboratory. Streptozotocin was dissolved in sodium citrate buffer solution and prepared immediately. After the rats were fasted for 24 hours, each rat was intraperitoneally injected with 12 mg of streptozotocin. On the 14th day after streptozotocin injection, the diabetic rats were taken to measure the reaction time of licking, screaming and jumping in the rats by the hot plate method, that is, the heat shrinkage latency period before administration, and the temperature of the hot plate was 51- 52°C. Each rat was repeatedly measured 3 times, with an interval of 15 minutes between the two measurements, and the mean value of the 3 measurement results represented the thermal paw withdrawal latency of the rat before administration.

[0037] On the 15th day after streptozotocin injection, the rats were randomly ...

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Abstract

The invention belongs to the field of chemical drugs and in particular relates to a transdermal absorption preparation for treating diabetic peripheral neuropathic pain. The transdermal absorption preparation is prepared from gamma-aminobutyric acid analogue-like analgesic and small-molecule tricarbonyl nitrogen-containing compounds, and pharmaceutical excipients of the preparation include Carbomer 940, glycerin, Tween-80, triethanolamine, laurocapram and distilled water. Due to topical drug delivery, the transdermal absorption preparation has an obvious effect of relieving the diabetic peripheral neuropathic pain. Moreover, the dose of the gamma-aminobutyric acid analogue-like analgesic can be reduced.

Description

technical field [0001] The invention belongs to the field of chemical medicines, in particular to a transdermal absorption preparation for treating diabetic peripheral neuralgia. Background technique [0002] Diabetes is a metabolic disease characterized by elevated blood sugar. The disease, cardiovascular and cerebrovascular diseases, and tumors are the three major chronic diseases that threaten human health at present. In recent years, with the improvement of living standards and the acceleration of the pace of life, the incidence of diabetes has also shown an obvious upward trend, and the current incidence has reached 12%; and the population of pre-diabetes is also increasing day by day. And blood sugar control requires long-term medication. [0003] Diabetic peripheral neuralgia is one of the main complications of diabetes, and its patients account for about 7.5-24% of the total number of diabetics. As early as the mid-19th century, European and American countries had...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/22A61K47/32A61K31/197A61K31/196A61K31/198A61K31/223A61P3/10A61P25/02
CPCA61K9/0014A61K9/06A61K31/196A61K31/197A61K31/198A61K31/223A61K47/22A61K47/32A61P3/10A61P25/02A61K2300/00
Inventor 李建会王玉玲张明慧
Owner 李建会
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