33results about How to "Retain pharmacological activity" patented technology

The invention relates toa an Apocynum extract and extracting method, which consists of, (1) determining the extract with hyperin as the representing composition, the content of flavones in the extract is 35-90%, (2) after the complete hydrolysis of the extract, the content of meletin compound is 30-80%, (3) the content of hyperin in the extract is 15-55%.

The invention relates to ganoderma lucidum refined polysaccharides with significant assistant antitumor activity and a preparation method and application of the ganoderma lucidum refined polysaccharides. The refined polysaccharides is heteropolysaccharide which is mainly prepared from mannose, glucosamine, glucuronic acid, glucose, galactose, xylose and fucose in a molar ratio of (3 to 4) to 1 to(1.3 to 1.7) to (56 to 65) to (4 to 6) to (1.3 to 1.8) to (2.5 to 3.5), the absolute purity is greater than 52%, the weight average molecular weight is 7500-8500D, and the molecular weight distribution index is 1.3 to 1.5. The preparation method comprises the following steps of dynamically extracting by hot water, coarsely filtering to remove residues, carrying out fine filtration and clarifying,deproteinizing and decoloring by in-series resin beds, concentrating and removing impurities by an ultrafiltration membrane, and carrying out spray-drying or alcohol precipitation air drying. The method is intelligent and energy-saving, can solve industrial difficult problems, and has significant large scale advantage and good product safety, effectiveness, controllability and stability. The polysaccharides have significant functional activity in assisting in antitumor and are useful for the development of drugs for prevention and treatment of tumors and the development of food and health products in related fields.

The invention relates to a waste treatment method, in particular to a method for simultaneously extracting polysaccharide and flavone from phellinus igniarius sporophore cultivation waste. The method includes the steps: drying the phellinus igniarius sporophore cultivation waste, crushing the dried phellinus igniarius sporophore cultivation waste to obtain dry phellinus igniarius sporophore cultivation waste powder, and mixing the day powder and alkaline ethanol solution; ultrasonically treating the mixed solution for 20-40 minutes, and filtering to obtain filter solution and residues; adding deionized water into the residues, uniformly mixing, adjusting a pH (potential of hydrogen) value to be 4-6 to obtain mixed solution, adding compound enzyme, performing enzymolysis at the temperature ranging from 45 DEG C to 55 DEG C, and centrifuging the enzymolysis solution to obtain supernatant solution and sediments; rotatably evaporating filter solution to remove ethyl alcohol, adding ethyl acetate, extracting, separating solution, and performing pressure reduction, concentration and drying for upper layer solution to obtain phellinus igniarius sporophore flavone; performing pressure reduction and concentration for the obtained supernatant solution by the aid of a rotary evaporator, and performing alcohol precipitation and centrifugation to obtain supernatant solution and sediments. The sediments are phellinus igniarius sporophore polysaccharide.

The invention discloses a biphenyl furocoumarin compound and a preparation method and an application thereof; the provided biphenyl furocoumarin compound is a new compound with vasodilating activity, which is obtained by modifying and optimizing the structure based on a natural product imperatorin, reserving the pharmacological activity, improving the physicochemical property and enhancing the druggability. The preparation method of the biphenyl furocoumarin compound provided by the invention has the advantages of easily-obtained material source, mild reaction conditions, simple operation in reaction process, and cheap and easily-obtained reagents. The prepared biphenyl furocoumarin compound is a ramification of the imperatorin and has the effect similar to the imperatorin; an in vitro vascular ring tension research shows that the biphenyl furocoumarin compound has a relaxant effect on the mesenteric microvessels of rats, so that the biphenyl furocoumarin compound can be applied to preparing antihypertensive drugs.

The invention aims to provide a preparation method and application of biologically-fermented Chinese angelica root oil. The preparation method comprises the following steps: performing superfine grinding on Chinese angelica root at a low temperature; performing wall breaking under increased pressure; adding a composite biological preparation for performing composite hydrolysis and fermentation; extracting fermented Chinese angelica root volatile oil A by means of water vapor distillation; performing suction filtration; adding filter residue into ethyl acetate, and heating and pressurizing to perform circular extraction of the Chinese angelica root oil; performing suction filtration and concentration, and removing a solvent to obtain Chinese angelica root oil B; compounding the Chinese angelica root oil A and the Chinese angelica root oil B to obtain the biologically-fermented Chinese angelica root oil. The biologically-fermented Chinese angelica root oil has the advantages of naturallycompounding natural smell such as the medicinal smell and of the Chinese angelica root and fresh fruit smell, lowering irritation and improving the fragrance quality, along with higher free radial scavenging capability and high oxidation resistance. When the biologically-fermented Chinese angelica root oil is applied to cigarettes, the biologically-fermented Chinese angelica root oil has abundantand natural fragrance, medicinal smell, fresh smell, fruit smell and fermentation smell, is coordinated with smoke, makes the smoke smell become clear, has the effects of resisting inflammation, relieving pain and asthma, improving laryngeal comfort degree, and overcomes the defects of over-strong medicinal smell, higher irritation and presence of offensive odor in the Chinese angelica root.

The invention discloses a furocoumarin compound with a hypertension activity reducing function and preparation method thereof; the furocoumarin compound has similar nature to imperatorin, shows the activity of dilating blood vessels in isolated vascular ring tension research, and can be applied to the preparation of antihypertensive drugs. The preparation method of the furocoumarin compound has the advantages of easily available raw material sources, mild reaction conditions, simple reaction process operation, and inexpensive and easily available reagent.

The present invention provides a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, wherein the spacer is bonded to the two opioid molecules via an ether bond. Pharmaceutical compositions comprising such a buprenorphine dimer drug are also disclosed, and the use of such compounds in the treatment of gastrointestinal hyperalgesia generally and in particular diarrhea-predominant irritable bowel syndrome.

The invention relates to a mithramycin nano-particle suspension and a preparation method thereof. The preparation method comprises the following steps: preparation of a diblock copolymer solution; preparation of an organic phase of mithramycin; preparation of an emulsifier solution; mixing and aftertreatment; etc. A mithramycin nano-particle prepared in the invention can retain the pharmacological activity of mithramycin; materials used in the invention are biocompatible materials, so the mithramycin nano-particle has the characteristic of application security and has good application prospect; meanwhile, the mithramycin nano-particle can be effectively enriched in the part of a transplanted tumor of a naked mouse and presents substantial treatment effect on transplanted tumors of human pancreatic cancer cells BxPC-3 in naked mice.

The invention provides a traditional Chinese medicine bacteriostatic spray, and belongs to the technical field of disinfectants and bactericides. The traditional Chinese medicine bacteriostatic sprayconsists of the following raw materials in parts by weight: 1-5 parts of a cyrtomium rhizome extract, 1-6 parts of a radix isatidis extract, 0.1-0.5 part of a folium artemisiae argyi extract, 0.5-5 parts of a borneol cinnamomum camphora extract, 0.5-5 parts of a honeysuckle flower extract, 1.5-5 parts of abaical skullcap root extract, 0.5-5 parts of weeping forsythia capsule extract, 0.5-5 parts of a dyers woad leaf extract, 0.1-1.5 parts of a eucalyptus leaf extract, 0.5-3 parts of a solubilizer, and water for supplementing the raw mateirals to 100 parts. The disinfection spray fully retainspharmacological activity of effective components of the traditional Chinese herbal medicines, exerts natural activity of the natural raw materials, has no chemical addition, and has the effect of preventing infection of bacteria and viruses.

The invention belongs to the technical field of organic pharmaceutical co-crystals and particularly relates to a novel edaravone pharmaceutical co-crystal and a preparation method thereof. The edaravone pharmaceutical co-crystal takes edaravone as an active ingredient of the medicine and beta-cyclodextrin as a co-crystal formation; a basic structure unit of the edaravone pharmaceutical co-crystal consists of an edaravone molecule, a beta-cyclodextrin molecule and 10.5 water molecules, wherein a carbonyl oxygen atom and an amido nitrogen atom in the edaravone molecule are taken as a hydrogen bonding acceptor and hydroxyl in the beta-cyclodextrin molecule is taken as a hydrogen bonding donor to form two different intermolecular hydrogen bonds, and the antioxygenation of the edaravone is mainly exerted through clearing free radicals and inhibiting lipid peroxidation so as to inhibit the oxidative damage of brain cells, vascular endothelial cells and nerve cells. The co-crystal prepared by the invention keeps the pharmacological activity of the edaravone, and the solubility, the stability and the bioavailability are all remarkably improved. The result of the solubility test shows that the solubility of the pharmaceutical co-crystal is 6 times that of the edaravone.

The invention discloses a GLP-1R/GCGR/GIPR triple receptor agonist and application of the GLP-1R/GCGR/GIPR triple receptor agonist. The polypeptide compound provided by the invention has a parent peptide represented by the following amino acid sequence: H < X > a < 1 > < X > a < 2 > < Glu3-Gly4 < X > a < 5 >-Phe6 < X > a < 7 > < X > a < 8 >-Asp9 < Val < 10 > < X > a < 11 >-Ser12 < X > a < 13 > Leu14 < Glu15 < Gly16 < Gln < 17 >-X < aa < 18 >-Ala19 < X > a < 20 >-Glu21 < 1 >-Phe22 < Val < 27 >-X < aa < 18 >-Ala24 < Trp < 25 >-Leu26 < Val < 27 >-X < aa < 28 >-Gly29 < Arg < 30 >-Gly31 The polypeptide compound has the functions of reducing blood sugar, promoting insulin secretion, controlling appetite, regulating metabolic disorder, controlling lipolysis, improving heat consumption and the like, has the characteristics of good stability, high biological activity and the like, can be used as a GLP-1R/GCGR/GIPR triple receptor agonist, is expected to be used as a new-generation medicine for preventing or treating diabetes and obesity, and has wide application prospects. The traditional Chinese medicine composition can be used for preventing or treating diseases such as non-alcoholic fatty liver diseases, hyperlipidemia, arteriosclerosis and the like.

The invention discloses a method for simultaneously extracting polysaccharide and flavone from stems and leaves of Tetrastigma hemsleyanum. The method comprises the following steps: drying and crushing the stems and leaves of the Tetrastigma hemsleyanum to obtain dry powder of the stems and leaves of the Tetrastigma hemsleyanum; mixing the Tetrastigma hemsleyanum stem and leaf dry powder with an acidic ethanol solution to obtain a mixed solution; carrying out water bath treatment on the mixed solution, and performing centrifuging to obtain a first supernatant and a first residue; uniformly mixing the first residue with deionized water, carrying out microwave extraction, and centrifuging the extract to obtain a second supernatant and a second residue; combining and mixing the first supernatant and the second supernatant, performing rotary evaporation to remove ethanol, adding NaCl to be a saturation state, adding an ethyl acetate solution for extraction, and performing liquid separation; concentrating the supernatant under reduced pressure and performing drying to obtain tetrastigma hemsleyanum flavone, and performing dialyzing, reduced-pressure concentrating and precipitating on the subnatant to obtain tetrastigma hemsleyanum polysaccharide. According to the method, the production process is simplified, safety and reliability are achieved, the yield is high, the biological activity of polysaccharide and flavone in the Tetrastigma hemsleyanum stems and leaves is well reserved, and the economic value is high.

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine spray for helping sleep and a preparation method and application thereof. The traditional Chinese medicine spray is prepared from the following raw materials in parts by weight: 1 to 5 parts of semen ziziphi spinosae extract, 1 to 6 parts of caulis polygoni multiflori extract, 0.1 to 2 parts of poria cocos extract, 3 to 6 parts of lily bulb extract, 0.1 to 5 parts of ganoderma extract, 0.3 to 0.8 part of lavender extract, and 60 to 80 parts of water. The traditional Chinese medicine spray has the advantages that the semen ziziphi spinosae extract, the caulis polygoni multiflori extract, the poria cocos extract, the radix polygalae extract, the longan extract, the poria cocos extract, the ganoderma extract and the like are prepared into the traditional Chinese medicine spray according to the specific proportional ratio, the different pharmacological activities of the traditional Chinese medicine extracts are fully utilized, the traditional Chinese medicine extracts are mutually dependent and promoted, and the excellent technical effect of promoting sleep is realized; and the traditional Chinese medicine extracts are prepared into the external spray, and are sprayed to the Baihui acupoint at the top of head, so that the effective components inthe traditional Chinese medicine extracts can be absorbed in a transdermal way, and the problems of bad odor, bitter taste and difficulty in drinking of the traditional Chinese medicine are solved.

The invention relates to a novel secretin analogue and a preparation method of the novel secretin analogue. Compared with natural secretin, the compound has improved chemical stability and maintains the pharmacological activity of the natural secretin.

The invention provides selenium-rich hot-dried noodles, and relates to the technical field of food processing. The selenium-rich hot-dried noodles are prepared from selenium-rich wheat flour, konjac flour, malic acid, dietary alkali and selenium-rich water. The konjac flour subjected to acidification and puffing treatment by the malic acid is used as a raw material for preparing the hot-dried noodles, so that the boiling fastness of the noodles is improved, the adhesion problem of the hot-dried noodles is solved, meanwhile, the selenium loss in the preparation process is reduced, and the absorption of a human body to selenium is enhanced. The invention also provides a preparation method of the selenium-rich hot-dried noodles. The method is simple in process and low in cost, has no higher requirements on equipment, and has good large-scale industrial production prospects and great economic value.