Use of aconine in medicine manufacture

A kind of technology of aconitine and analgesic, which is applied in the field of aconitine hydrolyzed product aconitine, which can solve the problems of aconitine’s strong toxicity, hidden dangers, and safety, and achieve good medicinal prospects and strong drug effects Effect

Inactive Publication Date: 2008-12-17
成都明昌节能环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem that aconitine is highly toxic and has potential safety hazards in pharmacy, and provides a hydrolyzed product of aconitine, aconitine, and the use of aconitine in pharmacy

Method used

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  • Use of aconine in medicine manufacture
  • Use of aconine in medicine manufacture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Toxicity determination test of aconitine before and after hydrolysis

[0028]

[0029] It can be seen that the total alkaloids, highly toxic diester alkaloids and toxicity of aconitine are greatly reduced after hydrolysis.

Embodiment 2

[0030] Embodiment 2 mouse acute toxicity test

[0031] A. Test drug

[0032] Aconitamine extract (1 gram is equivalent to 60 grams of the original drug), its concentration is prepared to 20mg / 100ml for human use, 0.75ml / time, 3-6 times / day, calculated as 0.000015g / Kg based on person kilogram body weight day. The maximum concentration of the prepared aconitamine extract was 0.3g / ml, which was used for intragastric administration of mice during the experiment.

[0033] B. Test animals

[0034] Kunming mice were provided by the Experimental Animal Center of Sichuan Academy of Sciences, and were given full-price pelleted feed. After weighing, they were divided into boxes according to gender and fed, with 5 birds in each box. The laboratory temperature is controlled at 18-22°C, and the humidity is controlled at 50-60%.

[0035] C. Test method

[0036] The administration method adopts gastrointestinal administration, and a preliminary test is carried out before the formal expe...

Embodiment 3

[0042] Embodiment 3 hot plate analgesic test

[0043] Select 21 female mice and divide them into 3 groups on average, 7 in each group. Different liquid medicines are applied on the soles of the mice respectively. Heat the three iron plates to 50°C, let the three groups of mice move on the hot plate respectively, and measure the pain threshold (that is, the time to start licking the limbs and twisting the body) and the number of writhing times of the mice. The results are as follows :

[0044] Average Pain Threshold Number of Writhings

[0045] Test group 28 seconds 18 times

[0046] Control group 23 seconds 26 times

[0047] Blank group 12 seconds 34 times

[0048] From the above results, it can be seen that not only there is a very obvious significant difference P<0.005 between the test group and the blank group, but also a significant difference P<0.05 between the test group and the control group, indicating that aconitamine has obvious analgesic effect , ...

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Abstract

The present invention discloses the pharmaceutical use of aconine. Aconine has obvious effects of relieving pain, raising blood pressure, stimulating heart, strengthening cardiac contractility, diminishing inflammation, etc. and is used in preparing analgesic, anesthetic, drug addiction eliminating medicine and fatigue eliminating medicine. Aconine has the same pharmaceutical activity of aconitine but 2000 times lower toxicity and is pharmaceutically safe and reliable. Various aconine preparations has high curative effect, high safety, no dependence and excellent application foreground.

Description

technical field [0001] The invention relates to aconitine hydrolysis product aconitine, in particular to the use of aconitine in pharmacy. Background technique [0002] Aconitine raw products contain a variety of diester alkaloids, such as Aconitine, Mesaconitine, Hypaconitine, etc. The active ingredient is aconitine. Various pharmacological tests have shown that: aconitine alkaloids are effective in analgesia, transient blood pressure reduction, transient blood pressure increase, slowing heart rate, strengthening heart, increasing myocardial contractility, anti-inflammation, improving immunity, local anesthesia and anti-cold have obvious effects. It is also known that the trace active ingredient racemized higenamine dl-Demethylcoclaurine isolated from Japanese aconitum also has a cardiotonic effect, and this alkali has a strong effect, so it is diluted to 10 -9 Still showing cardiotonic activity, the structural formula of the compound hydrochloride is as follows: [0003...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/439A61K31/485A61K9/00A61P25/04A61P23/00A61P43/00
Inventor 张树铭
Owner 成都明昌节能环保科技有限公司
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