The invention relates to the technical field of medicines, in particular to a pharmaceutical composition of a
paclitaxel conjugate, which comprises
paclitaxel, a
paclitaxel analogue or a conjugate thereof, an
organic solvent; a solubilizer; and, a pH
regulator. The conjugate is ANG1005, the solubilizer comprises mPEG-DSPE, in the mPEG-DSPE, the molecular weight of PEG is 500-10000, the molecular weight of PEG is 500-10000, and in the mPEG-DSPE, the molecular weight of PEG is 500-1000. The weight ratio of the mPEG-DSPE to the ANG1005 is (3 to 15): 1. According to the preparation method, the active substance solution and the solubilizer solution are prepared respectively, and then the two solutions are mixed together, so that the prepared solution is good in
physical stability. When the ANG1005 freeze-
drying agent prepared by the invention is redissolved, only normal
saline is needed as a redissolving agent, the clarification of the redissolving solution can be realized within 5 minutes, and the clinical use is more convenient; the
osmotic pressure of the freeze-
drying agent after redissolution is lower than that of an ANG1005 freeze-
drying agent in the prior art; meanwhile, in the in-vivo
metabolism process of the freeze-drying agent (redissolving solution), ANG1005 is higher in
chemical stability and not prone to
hydrolysis, paclitaxel released in blood is less, and side effects on the
human body are smaller.