A multilayer film having two or more separable adjacent layers. The multilayer film includes adjacent layers formed of compositions of dissimilar primary materials. Optionally, at least one of the layers contains a slip additive to change the release tension between adjacent layers. The multilayer film may include an adhesive layer between layers, with the adhesive layer more adhesion compatible with one of the layers than the other. The multilayer film may be a relatively inexpensive means to produce labels, films, sheets, containers, etc., requiring protection or isolation of one surface without the additional processes of gluing together individual dissimilar layers. Applications include, but are not limited to, the multilayer film being used as a seal to secure containers, including envelopes, and being imprinted and used as a multilayer labeling system. In one preferred embodiment, at least one layer of the multilayer film undergoes a visibly observable change when the at least one layer is released from at least one other layer; the visibly observable change is useful for many purposes, including, but not limited to, serving as a security mechanism within a container seal which, when the seal is broken, provides evidence that the container was opened.