32results about How to "Chiral" patented technology

This invention relates to a Phe-1-methyl-3-butyl imidazole amino acid ionic liquid and its preparation method including: chloro normal butane and N-methyl imidazole are heated and flown back to be synthesized to BMIC, acetic acid, ethyl and acetonit rile solution are heated and flown back to filter the BMIC, ions in anion exchange resin are exchanged to synthesize BMIOH, titration is done to BMIOH with HCl to take the BMIOH solution and add it into D-Phe solution to be mixed for 24h in icy water to eliminate the water and dry it for 48h under 80deg.C to be cooled and added with absolute methyl alcohol and acetonit rile solution to be sealed and beated up for 12h acutely, then placed at 0-10deg.C to pick up the un-reacted D-Phe and depress and filter them, rotate and evaporate to eliminate methyl alcohol and acetonit rile and get the product, which is dried under 80deg.C.

The invention relates to a thiazole amino acid salt type ionic liquid and a preparation method thereof. The ionic liquid has the structural general formula of A<+>B<->, wherein A<+> has a structural general formula containing R1, R2 and R3, and R1, R2 and R3 in the general formula comply to the following rules: (a) at least containing one carbon atom; and (b) at most containing 20 carbon atoms; and B<-> is one of amino acid anions. The preparation method comprises the following steps of: preparing a thiazole non-amino-acid-salt-type ionic liquid; converting the thiazole non-amino-acid-salt-type ionic liquid into a thiazole hydroxide type ionic liquid through anion exchange reaction; and performing neutralization reaction between amino acid and the thiazole hydroxide type ionic liquid to prepare the thiazole amino acid salt type ionic liquid. The thiazole amino acid salt type ionic liquid which has the advantages of environmental friendliness, diversity, strong dissolvability, biocompatibility and the like is a new generation of ionic liquid which is more environmentally friendly and greener and has wide application prospects in pharmaceutical chemistry, organic chemistry and industrial chemistry.

The invention discloses a making method chiral amine protonic acid salt with general formula as III and IV, which comprises the following steps: dissolving chiral amine with imidazole sulfide structure as general formula I or II in the organic solvent; adding the solution of protonic acid HY into chiral amine solution; stirring to react completely; removing solvent; obtaining the product as chiral agent, catalyst and chiral material or ionic liquid.

The invention discloses a making method chiral amine protonic acid salt with general formula as I and II, which comprises the following steps: dissolving halogenated aliphatic amine haloid acid salt of chiral amino acid derivant as formula III or IV and mercapto imidazole substituted by N-R3 as formula V into organic solvent to do substituted reaction; neutralizing the reacting liquid; obtaining the product as chiral agent, catalyst and chiral material.

The invention discloses a preparation method and application of a glycosyl porous coordination coordination polymer. The preparation method comprises the following steps: performing ball milling on anorganic compound with chiral carbon atoms such as monosaccharide, disaccharide or polysaccharide having a skeleton containing or partially containing a hydroxyl group, an aldehyde group or a ketone group and salts containing various metal ions for a polymerization reaction to form the porous coordination polymer, performing heating to 400-1200 DEG C, and performing carbonization to obtain a porous carbon material based on the porous coordination polymer. The porous carbon material based on the chiral porous coordination polymer provided by the invention has the advantages of a multi-stage pore structure, an adjustable pore size, low costs, a simple preparation process, good stability and good safety, is easy to use, and can be recycled and be used in the fields of gas adsorption, chiral separation, catalysis and gas storage.

The invention discloses a making method chiral amine protonic acid salt with general formula as I and II, which comprises the following steps: dissolving halogenated aliphatic amine haloid acid saltof chiral amino acid derivant as formula III or IV and mercapto imidazole substituted by N-R3 as formula V into organic solvent to do substituted reaction; neutralizing the reacting liquid; obtainingthe product as chiral agent, catalyst and chiral material.

The invention discloses a making method chiral amine protonic acid salt with general formula as III and IV, which comprises the following steps: dissolving chiral amine with imidazole sulfide structure as general formula I or II in the organic solvent; adding the solution of protonic acid HY into chiral amine solution; stirring to react completely; removing solvent; obtaining the product as chiral agent, catalyst and chiral material or ionic liquid.

The invention relates to the field of preparation of a chiral metal micro-nano structure, and particularly relates to a preparation method of a chiral metal micro-nano-spiral structure, wherein the metal micro-nano-spiral structure takes polystyrene spheres as a substrate, an inclined evaporation insulating material is rotated clockwise or counterclockwise on the substrate to form a spiral structure, and then a metal material is perpendicularly evaporated on the spiral structure to finally form a metal spiral structure. The preparation method is simple and easy to operate, has low requirementsfor experimental equipment, and the prepared chiral metal micro-nano-spiral structure is strong in circular dichroism signal.

The invention provides an asymmetric synthesis method of a chiral bicyclo-caprolactam compound as shown in a formula (I). The asymmetric synthesis method comprises the following steps of: mixing a chiral secondary amine catalyst, an alkaline substance and an organic solvent; adding alpha,beta-unsaturated carbonyl compound as shown in a formula (II) and an alpha-carbonyl amide ramification as shown in a formula (III) under the condition of stirring, and reacting at -20 DEG C -60 DEG C for 12-84 hours; and after the reaction is finished, carrying out post treatment on reaction liquid to obtain the chiral bicyclo-caprolactam compound as shown in a formula (I). The chiral bicyclo-caprolactam compound has chirality; the asymmetric synthesis method provided by the invention omits the purifying step through adoption of a one-pot method, enhances the product yield, is especially suitable for industrial production and can be applied to the fields of organic synthesis, materials and the like.

The present invention relates to the field of micro-nano optics technology, in particular to an optical micro-nano structure, comprising a first metal strip, a second metal strip, a third metal strip and a fourth metal strip, one end of the second metal strip is vertically connected to the first metal strip One end of the strip, the third metal strip is vertically connected to the non-end position of the other end of the first metal strip, the second metal strip and the third metal strip are located on the same side direction of the first metal strip, and one end of the fourth metal strip is vertically connected to the first metal strip The other end of the three metal strips and the other end of the second metal strip are vertically connected to the non-end position of the other end of the fourth metal strip. The micro-nano optical structure of the present invention has chirality and can produce large circular dichroism. Under the excitation of incident light, the surface generates an exciting electric field, which produces different absorption for left-handed polarized light and right-handed polarized light, forming a magnetic dipole Muons and electric dipoles produce different phases, thereby generating circular dichroism signals, which can be combined with natural molecules to enhance their chirality and facilitate detection.

The invention provides a synthesis method of an ester compound represented by the formula (1), the formula (2) or the formula (3), wherein the method comprises the steps: dissolving an aldehyde compound, sodium azide, tetrabutylammonium iodide and a halogenated compound in a solvent, or directly dissolving an aldehyde compound, sodium azide and tetrabutylammonium iodide in a halogenated compound, carrying out a reaction for 1-12 h at the temperature of 90-100 DEG C, and after the reaction is finished, postprocessing the reaction liquid to obtain the compound represented by the formula (1). The synthesis method has the advantages of mild reaction conditions, no participation of strong acids, strong alkalis or metals, simpliness, high efficiency, high yield, wide application range of substrates, amplified production potential, and relatively large potential economic value.

The present invention discloses azo chiral metal coordination compounds, a synthesis method and applications thereof, and relates to a variety of azobenzene group-containing chiral Schiff base metal coordination compounds substituted with different substituents. According to the present invention, the obtained metal coordination compounds have characteristics of reversible photochromism property of the azobenzene function group, light-emitting property of the Schiff base metal coordination compound, and the chiral characteristic of the molecule, and have good application potential in the photochromism field, and the preparation method has characteristics of simple preparation conditions, easy operation, mild reaction conditions and easily available raw materials, and is suitable for popularization and application.

The invention provides an asymmetric synthesis method of a chiral benzofuran spiro indole compound represented by formula (I), and the synthesis method is carried out according to the following steps: The nitroalkene compound is mixed with the oxidized indole compound represented by the formula (III), a chiral hydrogen bond catalyst, and an organic solvent, and the reaction is carried out at ‑40~60° C. for 1~240h to obtain the compound represented by the formula (IV), Add iodine source additive and oxidant to the compound represented by formula (IV), react at -40~60°C for 1~48h, the reaction solution is post-treated to obtain the chiral benzofuran spiro indole represented by formula (I) compound; the reaction conditions of the present invention are mild, the product yield is high, and the selectivity is excellent.

The invention provides photochromic compounds. The structure of the photochromic compounds is shown as general formula I-I or general formula I-II in the description, wherein R1 is H or an alkyl groupwith 1-10 carbon atoms; R2 is an alkyl group with 1-10 carbon atoms, an alkoxy group with 1-10 carbon atoms, halogen or nitro group; R3, R4, R5 and R6 are independently selected from hydrogen, alkylgroups, alkoxy groups, cyano groups,-B(OH)2, groups shown in the description, halogen or other chromophores. The invention further provides a preparation method of the photochromic compounds and an application of the photochromic compounds to photochromic products.

The invention relates to an ion type compound containing a chiral amine-thiourea (urea) structure, the general formula is <plus> <minus>, wherein, the structure of <plus> is shown as the formular (I), and the structure of <minus> is shown as the formular (V). In a preparation method, the bromine salt of <plus>and the sodium salt of <minus> are resolved in organic solvent, under the room temperature, stiring continues untile the reaction is sufficient, and therefore the ion type compound containing a chiral amine-thiourea (urea) structure is produced. The substance ofthe invention can be used as not only a catalyst in an organic asymmetric reaction but also a chiral shift reagent in the chiral identification. The substance of the invention has a good chiral inducement property and can be used as a chiral reagent, a catalyst and a chiral material in the fields of organic synthesis, materials, etc.

The invention provides a tandem catalytic preparation method of chiral pyrazole spirofuran compounds shown in formula (I), the synthesis method is carried out as follows: the o-hydroxyl nitroalkene shown in formula (II) Compounds and pyrazolone compounds shown in formula (III), chiral squaraine catalysts, and organic solvents are mixed, and reacted at -20 to 60°C for 1 to 48 hours to obtain compounds shown in formula (IV). Add an iodine source additive and an oxidizing agent to the compound shown in (IV), react at -20 to 60°C for 1 to 48 hours, and the reaction solution is post-treated to obtain the chiral pyrazole spirofuran compound shown in the formula (I); the present invention The reaction conditions are mild, the product yield is high, and the selectivity is excellent; the prepared chiral pyrazole spirofuran compound has chirality, and the core skeleton structure is novel.

The invention provides an iodine-mediated preparation method of chiral pyrazole spirofuran compounds shown in formula (I), the synthesis method is carried out as follows: the o-hydroxyl nitroalkene shown in formula (II) Compounds and pyrazolone compounds shown in formula (III), chiral squaraine catalysts, and organic solvents are mixed, and reacted at -60 to 60°C for 1 to 48 hours to obtain compounds shown in formula (IV). Add an iodine source additive and an alkali to the compound shown in (IV), react at -60 to 60°C for 1 to 48 hours, and the reaction solution is post-treated to obtain the chiral pyrazole spirofuran compound shown in the formula (I); the present invention The reaction conditions are mild, the product yield is high, and the selectivity is excellent.

The invention discloses a class of chiral dark blue fluorescent materials and a preparation method thereof. In the structural general formula of the fluorescent material, R1 represents methyl methyl ether or C1-C3 alkyl, and R2 represents any one of H, phenyl, C1-C2 alkoxy substituted phenyl, C1-C3 alkyl substituted phenyl and triphenylamino. According to the preparation method, hydroxyl-protected3,3'-iodo-o-dinaphthol and triphenylamine-4-boric acid are utilized to synthesize an o-dinaphthol intermediate, and then a Suzuki coupling reaction is utilized to synthesize the final fluorescent material. The fluorescent material provided by the invention realizes dark blue fluorescence luminescence characteristics and chirality in one molecular skeleton at the same time, can be used for preparing organic light emitting devices and chiral light emitting devices, has strong fluorescence intensity in an organic solvent and water, has high solid-state luminous efficiency, and can realize imaging of cells, tissues and bacteria, glycosylation analysis of proteins, detection of ions and the like.