The invention discloses a Chinese and western medicine compound orificium fistulae nursing agent and a preparation method thereof, and belongs to the technical field of a medicine. The nursing agent consists of the following medicinal raw materials: pyramydal billbergia leaves, cragana jubata poir, henry Urophysa, rhizomys sinensis gray oil, sagittaria trifolia, kopsia officinalis Tsiang et P.T., filiformis var.glandulosa kryl, eurya distichophylla hemsl., henry saruma root and rhizome, neopallasia pectinata, schoepfia jasminodora sieb. et zucc., Yunnan machilus leaves, leaves of lalang grass, masson pine bark, lungwortlike lobaria herb, benzyl alcohol, chitin, allantoin, limonin, sodium chloride, dipotassium glycyrrhizinate, zinc carbonate and a surfactant. The Chinese and western medicine compound orificium fistulae nursing agent disclosed by the invention has functions of sterilizing and detoxifying, diminishing inflammation and relieving pain, expelling pus and relieving itching, eliminating foreign smell, promoting circulation of blood and stopping bleeding, and the nursing agent is capable of controlling infection, improving blood circulation, protecting skin around external orificium fistulae and promoting the recovery of inflammation in the orificium fistulae; and moreover, the nursing agent is convenient to use, free from any toxic and side effects and is capable of greatly improving life quality of patients, and the nursing agent is suitable for popularization and application.