PEG modifying PHPMA material and preparation method thereof

A modified and hydroxyl technology, applied in the field of PEG modified PHPMA material and its preparation, can solve the problems of wide molecular weight distribution, no prevention, uncontrollable molecular weight of the carrier, etc., to achieve high targeting, good biocompatibility, The effect of preventing non-specific adsorption of proteins
CN101265331AInactive Publication Date: 2008-09-17INST OF CHEM CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF CHEM CHINESE ACAD OF SCI
Publication Date
2008-09-17
Estimated Expiration
Not applicable · inactive patent
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Abstract

The invention discloses a PEG modified PHPMA material and a preparation method thereof. The PEG modified PHPMA material which is provided by the invention is N-(2'-hydroxyl) propyl methyl acrylamide (HPMA) and / or a copolymer of the derivative of the N-(2'-hydroxyl) propyl methyl acrylamide and polyethylene glycol (PEG). The PEG modified PHPMA material of the invention is a polymer which is formed by the copolymerization of the polyethylene glycol (PEG), poly-N-(2'-hydroxyl) propyl methyl acrylamide (PHPMA) and the derivative of the PHPMA, the copolymer can be obtained by adopting the reversible addition-fragmentation chain transfer (RAFT), the composition and the molecular weight are controllable, and the molecular weight distribution is narrow (the molecular weight distribution d is less than 1, 4). Such polymers can be applied in the targeting drug delivery, which can not only have high targeting property and good biocompatibility, but can also have the function of preventing the protein non-specific absorption after the PEG modification, so the PEG modified PHPMA material is a good drug targeting carrier with the good performance, in particular to the drug targeting carrier of an anti-tumor drug.
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Description

technical field

[0001] The invention relates to a modified polymer material, in particular to a PEG modified PHPMA material and a preparation method thereof. Background technique

[0002] Tumor is the second largest disease that threatens human health at present, with high mortality rate, low cure rate and poor prognosis. At present, there are three main types of treatment methods for tumors: surgery, chemotherapy and radiotherapy. Generally speaking, chemotherapy and radiotherapy are combined with surgery to kill residual and metastatic tumor cells after surgery.

[0003] Although chemotherapy and radiotherapy have significant curative effects in tumor treatment, there are still many problems. For chemotherapy, while the drugs kill tumor cells, they also non-selectively kill normal cells, causing considerable systemic side effects in patients, seriously affecting the recovery of the patient's body and the enthusiasm of the patient to cooperate with the treatment. For rad...

Claims

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