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MRI contrast agent and preparation method and application thereof

A contrast agent and nanoparticle technology, applied in the field of medical clinical magnetic resonance imaging, can solve the problems of poor targeting performance, limited improvement of relaxation performance, poor biocompatibility, etc., and achieve good biocompatibility and good hydrophilicity. The effect of the simple method of preparation and

Active Publication Date: 2019-12-03
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Problems solved by technology

Recently, some researchers have proposed a simple method to improve the relaxation performance, specifically by confining the imaging material to the nanopores and then restricting the rotation of the imaging material and the diffusion of water molecules, but this scheme is not conducive to the improvement of the relaxation performance. However, in application, the above-mentioned contrast agents still have disadvantages such as poor biocompatibility and poor targeting performance

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  • MRI contrast agent and preparation method and application thereof
  • MRI contrast agent and preparation method and application thereof
  • MRI contrast agent and preparation method and application thereof

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preparation example Construction

[0042] A method for preparing an MRI contrast agent provided by an embodiment of the present invention includes the following steps:

[0043] 1) providing gadolinium oxide nanoparticles and mesoporous carbon nanoparticles, the particle diameter of the gadolinium oxide nanoparticles is smaller than the aperture diameter of at least part of the pores contained in the mesoporous carbon nanoparticles;

[0044] 2) loading the gadolinium oxide nanoparticles in at least part of the pores of the mesoporous carbon nanoparticles;

[0045] 3) Modification of biocompatible substances at least on the surface of the mesoporous carbon nanoparticles loaded with gadolinium oxide nanoparticles.

[0046] In some embodiments, the particle size of the gadolinium oxide nanoparticles is 2.3-2.6 nm.

[0047] In some embodiments, the pores contained in the mesoporous carbon nanoparticles have a pore diameter of 2.8-3.2 nm and a pore volume of 1.41-1.52 cm 3 g -1 .

[0048] In some embodiments, the...

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Abstract

The invention discloses an MRI contrast agent, which is prepared from gadolinium oxide nanoparticles and mesoporous carbon nanoparticles. The gadolinium oxide nanoparticles are loaded into holes of the mesoporous carbon nanoparticles, and the surfaces of the mesoporous carbon nanoparticles are modified with biological affinity substances such as PEG. The invention further discloses a preparation method and application of the MRI contrast agent. Compared with the prior art, the MRI contrast agent is simple in preparation method, has the high relaxation rate, and good hydrophilicity and biocompatibility, and has the longer blood circulation time and excellent tumor target performance.

Description

technical field [0001] The invention relates to medical clinical magnetic resonance imaging technology, in particular to a high-relaxation MRI contrast agent for magnetic resonance imaging contrast based on the confinement effect and a preparation method thereof. Background technique [0002] Contrast agent is an imaging-enhanced contrast agent used to shorten imaging time and improve imaging contrast and clarity in medical clinical MRI. Imaging contrast, thus revealing the functional status of internal organs. In diagnostic magnetic resonance imaging, nearly 50% of examinations use MRI contrast agents. Contrast agents are mainly divided into two categories: paramagnetic agents, namely T1 category; ferromagnetic or superparamagnetic contrast agents, namely T2 category. Among them, the small-molecule non-targeting Gd-based contrast agents that are widely used in clinical practice belong to the T1 category. These small-molecule contrast agents still have some disadvantages w...

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Application Information

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IPC IPC(8): A61K49/06A61K49/18B82Y5/00B82Y40/00
CPCA61K49/06A61K49/1818A61K49/186A61K49/1869B82Y5/00B82Y40/00
Inventor 裴仁军况烨
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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