Nasopharyngeal carcinoma targeted magnetic resonance contrast agent and preparation method thereof

A technology of magnetic resonance contrast agent and nasopharyngeal carcinoma, which is applied in the field of medical biomaterials, can solve the problems of weak tumor active targeting aggregation function and short half-life, and achieve high relaxation performance and good safety effects
CN102552944BActive Publication Date: 2013-03-27CENT SOUTH UNIV
3 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CENT SOUTH UNIV
Publication Date
2013-03-27

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a nasopharyngeal carcinoma targeted magnetic resonance contrast agent and a preparation method thereof. The method comprises the following steps: synthesizing superparamagnetic Fe3O4 with grain diameter of between 10 and 15nm by adopting a chemical coprecipitation method, coating with APTES ((3-aminopropyl)triethoxysilane) or connecting superparamagnetic Fe3O4 to 10-15nm Fe3O4 to carry out surface amination on Fe3O4 to obtain Fe3O4-APTES surface-modified micro-particles; and connecting Fe3O4-APTES and EB (Epstein-Barr) virus latent membrane protein 1 monoclonal antibody (LMP1, Clone CS.1-4) with polyethylene glycol (PEG) as a connecting arm to obtain Fe3O4-APTES-PEG-LMP1, Clone CS.1-4 colloidal solution with stable dispersion. Compared with a conventional contrast agent, the contrast agent has the advantages of low toxicity, high stability, good biocompatibility, high sensitivity and good specific targeting property to LMP1<+>-nasopharyngeal carcinoma, and can be used for nasopharyngeal carcinoma screening and specific magnetic resonance diagnosis.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of medical biomaterials, especially a kind of LMP1 + - Nasopharyngeal carcinoma targeting magnetic resonance contrast agent and preparation method thereof. Background technique

[0002] Tumor is one of the major diseases affecting human health today. A report by the World Health Organization shows that with the changes in the global human living environment, the incidence of global malignant tumors will increase from the current 10 million people / year to 15 million people / year. has become the number one killer threatening human health. In my country (especially South China), the incidence of nasopharyngeal carcinoma has been on the rise in recent years, and 80% of nasopharyngeal carcinoma cases in the world occur in China.

[0003] The pathological type of nasopharyngeal carcinoma is mainly non-keratinizing undifferentiated carcinoma, which is prone to cervical lymph nodes and distant metastasis; in the first course...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More