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Method of preparing ultrasonic contrast agent using mechanical oscillation

A technology of ultrasonic contrast agent and mechanical oscillation, applied in the direction of MRI/MRI contrast agent, etc., can solve the problems of increased preparation process, difficulty in aseptic operation, metal contamination, etc.

Inactive Publication Date: 2006-06-14
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, in the further development process, we found that the vibroacoustic method has certain limitations, which are prominently manifested in: ① The process parameters of the probe-type vibro-acoustic instrument, including power, position of the probe on the liquid surface, depth, etc., are not easy to control, The reproducibility of the process is affected to a certain extent; ②It is difficult to achieve aseptic operation during the acoustic vibration process, and there is a possibility of metal contamination, which adds a certain degree of difficulty to the quality control and preparation process of the contrast agent; ③The acoustic vibration process produces more The heat, the activity of lipids, especially when preparing contrast agents carrying certain ligands, drugs or genes, has a great impact on the activity of ligands, drugs or genes that are simultaneously vibrated

Method used

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  • Method of preparing ultrasonic contrast agent using mechanical oscillation
  • Method of preparing ultrasonic contrast agent using mechanical oscillation
  • Method of preparing ultrasonic contrast agent using mechanical oscillation

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Embodiment Construction

[0050] Weigh 30mg of dipalmitoylphosphatidylglycerol (DPPG), 30mg of DSPC, 1940mg of PEG4000 in a 100ml Erlenmeyer flask, add 40ml of deionized water preheated in a 60°C constant temperature water bath, put the Erlenmeyer flask into a 60°C constant temperature water bath Shaker, adjust the speed of the shaker to about 200rpm, shake for 10-20min, until the lipid is completely dispersed. Use a pipette to divide the lipid suspension in the Erlenmeyer flask into 40 bottles of 1ml vials (the actual volume of the vials is about 3.5ml, which is suitable as a shaker vial), and freeze-dry to become a lyophilized powder. A mixture of hypertonic sugar / glycerin / propylene glycol (volume ratio of 8:1:1) was used as the hydration solution, wherein the hypertonic sugar was 20% glucose, and 1.2 ml of each bottle was added to the hydration solution, and mixed gently by hand. Put the vial upright, inject about 2.5ml of perfluoropropane directly into the vibrating bottle, and replace the air with...

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Abstract

A process for preparing the ultrasonic contrast medium by mechanical oscillation is disclosed. Said ultrasonic contrast medium may be conventional one, target one, nano-foam one, and therapeutic one. A process for preparing aliphatic ultrasonic contrast medium is also disclosed.

Description

1. Technical field [0001] The present invention relates to an ultrasound contrast agent, in particular to a method for preparing an ultrasound contrast agent by utilizing mechanical vibrations. The method is suitable for preparing a variety of ultrasound contrast agents, including conventional ultrasound contrast agents (lipids, albumins, Polymers, surfactants, etc.), targeted ultrasound contrast agents, nanoscale microbubble ultrasound contrast agents, and therapeutic ultrasound contrast agents that are also drug or gene targeting carriers; the present invention also specifically relates to a A method for preparing a lipid ultrasound contrast agent. 2. Background technology [0002] Conventional ultrasound contrast agent is a suspension containing a high concentration of microbubbles. The average diameter of the microbubbles is about 2 to 4 microns, smaller than red blood cells, and can freely pass through the pulmonary circulation, but not through blood vessels. It is a bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06
Inventor 谭开彬高云华刘政刘平夏红梅
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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