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Nanometer magnetic resonance contrast material, nanometer magnetic resonance contrast agent and preparation method of nanometer magnetic resonance contrast agent

A magnetic resonance contrast agent and magnetic resonance technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, emulsion delivery, drug delivery, etc., can solve problems such as weak method, increased dose of free Gd, increased toxicity, etc. Achieve the effect of not easy to decompose and ionize, low toxicity and stable performance

Inactive Publication Date: 2014-03-12
SUZHOU BIOMAGNOVATION
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Problems solved by technology

Li Yongxiu reported in the Chinese patent CN102397562A that a contrast agent is prepared by using Prussian blue to adsorb Gd ions, which physically adsorbs Gd by electrostatic attraction. 3+ The method is not firm, so that the dose of free Gd in the body increases, and the toxicity also increases

Method used

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  • Nanometer magnetic resonance contrast material, nanometer magnetic resonance contrast agent and preparation method of nanometer magnetic resonance contrast agent
  • Nanometer magnetic resonance contrast material, nanometer magnetic resonance contrast agent and preparation method of nanometer magnetic resonance contrast agent
  • Nanometer magnetic resonance contrast material, nanometer magnetic resonance contrast agent and preparation method of nanometer magnetic resonance contrast agent

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preparation example Construction

[0045] The nano-magnetic resonance imaging material can be prepared by the following preparation method, including the following steps:

[0046] Step 1. Prepare concentration 0.1mmol / L~2000mmol / L A 4 [Fe II (EN) 6 ] aqueous solution, a concentration of 0.1mmol / L~2000mmol / L soluble iron salt solution and a concentration of 0.1mmol / L~2000mmol / L soluble gadolinium salt solution, wherein A is Li + 、Na + 、K + or NH 4 + .

[0047] Wherein, the soluble iron salt can be the soluble iron salt commonly used in this field, or the insoluble iron salt is subjected to reactions such as acid-base oxidation to generate soluble iron salt, and the divalent iron salt is subjected to reactions such as acid-base oxidation to generate trivalent soluble iron salt, It is preferably at least one of anhydrous ferric chloride, ferric chloride hexahydrate, ferric nitrate, ferric sulfate, ferric acetate, ferric citrate and ferric gluconate.

[0048] The soluble gadolinium salt can be a soluble gad...

Embodiment 1

[0064] Weigh 4.224g of K 4 [Fe(CN) 6 ]·3H 2 O is dissolved in 1000mL of water to obtain 10mmol / L of K 4 [Fe(CN) 6 ] aqueous solution, and then 20g dextran was dissolved in potassium ferricyanide aqueous solution to obtain solution C;

[0065] 2.433g FeCl 3 ·6H 2 O was dissolved in 900mL water and stirred to obtain a 10mmol / L ferric chloride solution;

[0066] 0.372g GdCl 3 ·6H 2 O is dissolved in 100mL water, stirs, obtains the gadolinium chloride solution of 10mmol / L;

[0067] Mix the above-mentioned ferric chloride and gadolinium chloride solutions, and then slowly drop them into solution C, the stirring speed is 1000rpm, the reaction temperature is 15°C, and the reaction time is 60min. Dialyze the reacted solution, and then centrifuge at a speed of 10000 rpm for 10 minutes, discard the precipitate, remove excess dextran and impurities in the supernatant by ultrafiltration, and freeze-dry to obtain the nano-magnetic resonance imaging material. The nano magnetic res...

Embodiment 2

[0070] Weigh 2.112g of K 4 [Fe(CN) 6 ]·3H 2 O is dissolved in 1000mL of water to obtain 5mmol / L of K 4 [Fe(CN) 6 ] aqueous solution, then 12g polyvinylpyrrolidone (PVP) was dissolved in potassium ferricyanide aqueous solution, obtain solution C;

[0071] 1.217g FeCl 3 ·6H 2 O was dissolved in 900mL water and stirred to obtain a 5mmol / L ferric chloride solution;

[0072] 0.186g GdCl 3 ·6H 2 O is dissolved in 100mL water, stirs, obtains the gadolinium chloride solution of 5mmol / L;

[0073] Mix the above-mentioned ferric chloride and gadolinium chloride solutions, and then slowly drop them into solution C, the stirring speed is 800rpm, the reaction temperature is 25°C, and the reaction time is 30min. Dialyze the reacted solution, and then centrifuge at a speed of 12000 rpm for 15 minutes, discard the precipitate, go through dialysis, and then freeze-dry to obtain the nano-magnetic resonance imaging material. The nano magnetic resonance imaging material includes the chem...

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Abstract

The invention relates to a nanometer magnetic resonance contrast material, a nanometer magnetic resonance contrast agent and a preparation method of the nanometer magnetic resonance contrast agent. The nanometer magnetic resonance contrast material comprises a core having the chemical formula of A3x[GdyFeIII1-y](4-x)[FeII(CN)6]3.nH2O, and a casing which is composed of auxiliary materials and coats the core. In the chemical formula, A represents Li<+>, Na<+>, K<+> or NH4<+>, x is greater than 0 and less than or equal to 1, y is in a range of 0-1, and n is in a range of 1-16. The nanometer magnetic resonance contrast agent prepared from the nanometer magnetic resonance contrast material has stable properties, is decomposed and ionized difficultly, has low toxicity and is suitable for injection and oral administration.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a nano magnetic resonance imaging material, a contrast agent and a preparation method thereof. Background technique [0002] The purpose of medical diagnosis is to be able to clearly observe the organs and tissues of the human body. Magnetic resonance imaging is a non-invasive and radioactive medical diagnostic method. Under normal circumstances, there are only slight differences in the density of protons in different tissues, which makes the image contrast of each organ not high. Therefore, we usually use contrast agents to change the relaxation time of protons in tissues, thereby enhancing the contrast between normal tissues and lesion tissues, allowing doctors to diagnose diseases. [0003] Magnetic resonance contrast agents are divided into two categories: T 1 contrast agent and T 2 contrast agent. T 1 The contrast agent can shorten the longitudinal r...

Claims

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Application Information

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IPC IPC(8): A61K49/06A61K49/18
Inventor 陈国军黄颂平王磊
Owner SUZHOU BIOMAGNOVATION
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