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Magnetic resonance imaging (MRI)-oriented high intensity focused ultrasound (HIFU) synergist and preparation method thereof

A synergist and oriented technology, applied in the field of nanomaterials, can solve the problems of poor imaging performance of manganese-based contrast agents, achieve uniform and adjustable pore size distribution, good biocompatibility, and improve therapeutic effects

Inactive Publication Date: 2012-02-22
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the problem of poor imaging performance of manganese-based contrast agents in the above-mentioned prior art

Method used

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  • Magnetic resonance imaging (MRI)-oriented high intensity focused ultrasound (HIFU) synergist and preparation method thereof
  • Magnetic resonance imaging (MRI)-oriented high intensity focused ultrasound (HIFU) synergist and preparation method thereof
  • Magnetic resonance imaging (MRI)-oriented high intensity focused ultrasound (HIFU) synergist and preparation method thereof

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Experimental program
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preparation example Construction

[0038] Mesoporous SiO 2 Preparation of hollow nanoparticles.

[0039] First, monodisperse SiO with controllable particle size was prepared by the traditional Stäber method 2 nanoparticles. In this step, ethanol and water (preferably deionized water) are used as co-solvents, ammonia water is used as an alkali catalyst, and ethyl orthosilicate is used as a silicon source, and the target product is obtained after reaction at room temperature to 40°C. After the product was collected by centrifugation, the product was washed with a large amount of ethanol and dried in vacuum.

[0040] Then a certain amount of the above SiO 2 The nanoparticles are dispersed into the alcohol / water solution, and a mesoporous structure-directing agent (surfactant, where the surfactant is selected from a reducing organic molecule, such as cetyltrimethylammonium bromide), with ammonia as Catalyst, tetraethyl orthosilicate as silicon source, in solid SiO 2 The surface is coated with a layer of mesopo...

Embodiment 1

[0062] Preparation of mesoporous SiO 2 Hollow nanoparticles: 71.4 mL of ethanol, 10 mL of deionized water and 3.14 mL of ammonia water were evenly mixed and placed under magnetic stirring at 30°C. Subsequently, 6 mL of ethyl orthosilicate was rapidly added dropwise under stirring conditions. After stirring for 1 h, the product was collected by centrifugation, and the sample was washed with a large amount of absolute ethanol. Dry in vacuum at room temperature for use. Then on the pre-prepared solid SiO 2 The surface is coated with a layer of mesoporous SiO with cetyltrimethylammonium bromide (CTAB) as the structure directing agent. 2 Floor. Weigh out 100 mg of solid SiO 2 Nanoparticles were uniformly ultrasonically dispersed in 20 mL of deionized water. Dissolve 150 mg of CTAB in a mixture of 30 mL of deionized water, 30 mL of ethanol and 0.55 mL of ammonia water, and magnetically stir at 30 °C. Solid SiO 2 After adding the aqueous solution of nanoparticles into the mix...

Embodiment 2

[0064] Preparation of Mn-containing mesoporous SiO 2 Hollow nanoparticles: weigh 50 mg of prepared mesoporous SiO 2 Hollow nanoparticles were uniformly dispersed in 10 mL of deionized water. Then the mesoporous SiO 2 The aqueous solution of hollow nanoparticles was added to 10 mL of 0.1 M KMnO 4 In the aqueous solution, it was stirred at 40 °C for 4 h under the condition of protecting from light. After the product was collected by centrifugation, the unreacted KMnO in the sample was washed with a large amount of deionized water 4 Molecules were then freeze-dried. KMnO 4 Treated mesoporous SiO 2 Hollow nanoparticles were calcined at 550 °C for 6 h to remove residual surfactant.

[0065] Example 2

[0066] Take 50 mg mesoporous SiO 2 hollow nanoparticles and 10 mL of 0.2 M KMnO 4 The aqueous solution repeats the method of embodiment 1 to prepare the mesoporous SiO containing Mn 2 hollow nanoparticles.

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Abstract

The invention relates to a magnetic resonance imaging (MRI)-oriented high intensity focused ultrasound (HIFU) synergist and a preparation method thereof. The MRI-oriented HIFU synergist comprises mesoporous nano particles, manganese oxide nano particles dispersed in the mesoporous nano particles, and guest molecules which are loaded in the mesoporous nano particles and are used for HIFU synergism. Manganese oxides and mesoporous hollow nano materials are combined, so that tumor parts are accurately positioned by manganese-based MRI and by using an imaging function of the materials, and high biocompatibility is achieved. Moreover, a large-cavity structure of the mesoporous material can be loaded on HIFU synergistic perfluorohexane, so that the treatment effect if HIFU can be improved.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to the technical field of medical nanobiological materials, in particular to a mesoporous silica hollow nanomaterial used as an MRI-guided HIFU synergist and a preparation method thereof. Background technique [0002] At present, the concept of non-invasive treatment has become a new direction of future medical development. Ultrasound therapy is a minimally invasive or non-invasive method of depositing sound energy into tissue. High Intensity Focused Ultrasound (HIFU), as the most representative non-invasive and non-radioactive new treatment mode, has achieved great success in clinical treatment of certain diseases (such as uterine fibroids). [0003] However, HIFU has not been widely used in the surgical treatment of tumors, especially malignant tumors (cancer). To solve this problem, two key points must be effectively resolved: one is how to use imaging systems widely used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/08A61K49/22A61K9/14A61K47/04A61P35/00
Inventor 陈雨陈航榕施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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