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Multifunctional probe and preparation method and application thereof

A multi-functional probe and probe technology, applied in the field of multi-functional probe and its preparation, nano-gold rod diagnosis and treatment probe, can solve the problems of low yield and cumbersome preparation process, and achieve simple preparation, easy metabolism, The effect of excellent biocompatibility

Inactive Publication Date: 2016-03-16
SHANGHAI JIAO TONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its preparation process is cumbersome and the yield is not high.

Method used

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  • Multifunctional probe and preparation method and application thereof
  • Multifunctional probe and preparation method and application thereof
  • Multifunctional probe and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] a. Add 10 parts of cetyltrimethylammonium bromide to 150 parts of deionized water, stir at 50°C for 1 hour, after the surfactant is completely dissolved, add 10 parts of chloroauric acid solution with a mole fraction of 10 μM After a little stirring, 0.15 parts of a silver nitrate solution with a mole fraction of 0.25 mM was added. After stirring evenly, 0.1 part of sodium borohydride was added and then a sol mixture was generated, followed by incubating at 37° C. for 10 hours, and centrifuging and washing with deionized water at 9000 rpm to obtain a concentrated solution of gold nanorods from which the surfactant was removed.

[0069] b. Add 200 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide sodium hydrochloride to 10 parts of deionized water. After the cross-linking agent is dissolved, add 400 parts of sodium hyaluronate powder Add and stir for 3 hours to obtain a sodium hyaluronate solution with activated carboxyl groups.

[0070] c. Disperse 5 parts of the ...

Embodiment 2

[0075] a. Add 20 parts of cetyltrimethylammonium bromide to 200 parts of deionized water, stir at 60°C for 1 hour, after the surfactant is completely dissolved, add 15 parts of chloroauric acid solution with a mole fraction of 10 μM After a little stirring, 0.3 parts of a silver nitrate solution with a mole fraction of 0.25 mM was added. After stirring evenly, 0.1 part of sodium borohydride was added to generate a sol mixture, followed by incubating at 37°C for 12 hours, and centrifuging and washing with deionized water at 9000 rpm to obtain a concentrated solution of gold nanorods from which the surfactant was removed.

[0076] b. Add 200 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide potassium hydrochloride to 10 parts of deionized water. After the cross-linking agent is dissolved, add 300 parts of sodium hyaluronate powder Add and stir for 3 hours to obtain a sodium hyaluronate solution with activated carboxyl groups.

[0077] c. Disperse 10 parts of gold nanorod c...

Embodiment 3

[0082] a. Add 30 parts of cetyltrimethylammonium bromide to 200 parts of deionized water, stir for 1 hour above 80 ° C, and after the surfactant is completely dissolved, add 15 parts of chloroauric acid with a mole fraction of 10 μM After the solution was stirred for a while, 0.2 parts of silver nitrate solution with a mole fraction of 0.25 mM was added. After stirring evenly, 0.2 parts of sodium borohydride was added to form a sol mixture, followed by incubating at 40°C for 14 hours, and centrifuging and washing with deionized water at 9500 rpm to obtain a concentrated solution of gold nanorods from which the surfactant was removed.

[0083] b. Add 100 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide potassium hydrochloride to 10 parts of deionized water. After the cross-linking agent is dissolved, add 500 parts of sodium hyaluronate powder Add and stir for 3 hours to obtain a sodium hyaluronate solution with activated carboxyl groups.

[0084] c. Disperse 10 parts of ...

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Abstract

The invention discloses a multifunctional probe and a preparation method and application thereof. The nano diagnosis and treatment probe with the two functions of magnetic resonance imaging and thermal therapy is formed in the mode that nano gold bars are formed by adding surfactant, chloroauric acid, a reduction agent and silver nitrate, target macromolecules are inoculated, and gadolinium ions are adsorbed. The preparation method is simple, the probe is good in dispersity in an aqueous solution, good in stability and capable of meeting requirements of clinical application and combining radiography and thermal therapy, and the dual functions of lymphoma diagnosis and treatment are achieved.

Description

technical field [0001] The present invention relates to the field of preparation of nanomaterials, in particular to a multifunctional probe and its preparation method and application, in particular to a nano gold rod diagnosis and treatment probe with lymphatic targeting and magnetic resonance imaging and thermotherapy functions Preparation. Background technique [0002] In the treatment and diagnosis of tumors, it is very meaningful to be able to combine treatment and diagnosis to realize the integration of diagnosis and treatment. With the development of medical engineering and computer technology, molecular imaging provides a faster and more intuitive basis for clinical diagnosis of tumors. Among them, magnetic resonance imaging has been widely used clinically due to its advantages of high soft tissue resolution, multiple imaging parameters, large amount of image information and no ionization damage. Hyperthermia, as a new treatment for tumors, has undoubted efficacy in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/12A61P35/00B22F9/24
CPCA61K41/0052A61K49/12B22F9/24
Inventor 何丹农乔宇易帆姬豫朱君金彩虹
Owner SHANGHAI JIAO TONG UNIV
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