Two-dimensional metal-organic framework structure nano-sheet, preparation method and applications thereof

A technology of organic framework and nanosheets, applied in the field of two-dimensional metal-organic framework nanosheets and its preparation and application, to achieve the effects of increased relaxation properties, sensitive magnetic resonance imaging and photodynamic therapy effects, and improved performance

Active Publication Date: 2020-03-03
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Problems solved by technology

Although metal-organic framework materials have been prepared and studied in large quantities, it is still challenging to directly construct metal-organic frameworks into two-dimensional nanosheets. Therefore, the development of simple and effective methods for the synthesis of two-dimensional metal-organic framework nanomaterials has Significance

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  • Two-dimensional metal-organic framework structure nano-sheet, preparation method and applications thereof
  • Two-dimensional metal-organic framework structure nano-sheet, preparation method and applications thereof
  • Two-dimensional metal-organic framework structure nano-sheet, preparation method and applications thereof

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preparation example Construction

[0028] As an aspect of the technical solution of the present invention, it relates to a method for preparing a two-dimensional metal-organic framework nanosheet, which includes:

[0029] Provide a mixed solution containing tetraphenylporphyrin, gadolinium metal ions, organic solvent and water;

[0030] subjecting the mixed solution to a solvothermal reaction to obtain two-dimensional metal-organic framework nanosheets with uniform size distribution; and,

[0031] The nano sheet is subjected to hydrogen protonation treatment to obtain a protonated two-dimensional metal-organic framework structure nano sheet.

[0032] Wherein, the size of the two-dimensional metal-organic framework nanosheet is 120-180 nm, and the thickness is 15-25 nm.

[0033] In some embodiments, the preparation method includes: uniformly mixing a tetraphenylporphyrin solution, an aqueous solution of gadolinium metal ions, and an organic solvent to form the mixed solution (also called a precursor solution). ...

Embodiment 1

[0060] Meso-tetrakis(4-carboxyphenyl)porphine used in this example was purchased from Aladdin Reagent Company; gadolinium chloride was purchased from Sigma-Aldrich Reagent Company; N,N-dimethylformamide was purchased from Sinopharm Group. Prepare a 5.0mmol / L meso-tetrakis(4-carboxyphenyl)porphin solution with N,N-dimethylformamide as a solvent, and then prepare a 5.0mmol / L gadolinium chloride solution with water as a solvent. Add 2 mL of mes-tetrakis(4-carboxyphenyl) porphine solution and 1 mL of gadolinium chloride solution into a round-bottom flask, then add 20 mL of N,N-dimethylformamide, and stir evenly to form a precursor solution. The homogeneously mixed precursor solution was heated and reacted under stirring, the temperature was 50°C, and the reaction time was 4 hours. After the reaction was completed, the product was cooled and washed with N,N-dimethylformamide and ethanol several times to obtain gadolinium and Porphyrin-bound two-dimensional metal-organic framework n...

Embodiment 2

[0063] In this example, a 5.0 mmol / L meso-tetrakis(4-carboxyphenyl)porphine solution was prepared with N,N-dimethylformamide as a solvent, and a 5.0 mmol / L gadolinium sulfate solution was prepared with water as a solvent. Add 2mL of tetrakis(4-carboxyphenyl)porphine solution and 1mL of gadolinium sulfate solution into a round bottom flask, then add 15mL of N,N-dimethylformamide, add 5mL of ethanol, stir well to form a precursor solution . The homogeneously mixed precursor solution was heated and reacted under stirring, the temperature was 100°C, and the reaction time was 5 hours. After the reaction was completed, the product was cooled and washed with N,N-dimethylformamide and ethanol several times to obtain gadolinium and Porphyrin-bound two-dimensional metal-organic framework nanosheets. Centrifuge 2 mL of the nanosheet dispersion, add 2 mL of sulfuric acid solution with a concentration of 0.005 mol / L and a pH value of about 2.0, and stir at room temperature for 20 min to o...

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Abstract

The invention discloses a two-dimensional metal-organic framework structure nano-sheet, a preparation method and applications thereof. The preparation method comprises the following steps: providing amixed solution containing tetraphenylporphyrin, gadolinium metal ions, an organic solvent and water, adjusting the ratio of the organic solvent to the water in the mixed solution, and carrying out asolvothermal reaction to obtain a two-dimensional metal-organic framework structure nano-sheet with uniform size distribution; and carrying out hydrogen protonation treatment on the nano-sheet to obtain the protonated nano-sheet with the two-dimensional metal-organic framework structure. According to the invention, the obtained two-dimensional metal-organic framework structure nano-sheet can be used for magnetic resonance imaging analysis or photodynamic therapy of tumors; and the nano-sheet with uniform size distribution is obtained by adjusting the proportion of the mixed solution and carrying out solvothermal treatment, and the ultraviolet and visible absorption intensity and the ultraviolet and visible absorption intensity range of the nano-sheet are improved through hydrogen protonation treatment, so that the nano-sheet generates sensitive magnetic resonance imaging and photodynamic treatment effects on tumors.

Description

technical field [0001] The present invention relates to a method for preparing metal-organic framework nanomaterials with uniform size, in particular to a method for preparing two-dimensional metal-organic framework nanosheets by solvothermal technology based on the coordination characteristics of gadolinium metal ions and porphyrin, As well as its application in magnetic resonance imaging analysis and photodynamic therapy of tumors, it belongs to the technical field of metal-organic framework nanomaterials. Background technique [0002] Metal-organic frameworks have the characteristics of good crystallinity, structural tunability, high specific surface area and ordered pore structure, which endow them with great potential in gas storage and separation, fuel cell performance conversion, biomedical imaging and cancer treatment, etc. Various applications. Although metal-organic framework materials have been prepared and studied in large quantities, it is still challenging to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K41/00A61K49/10A61K49/18A61P35/00
CPCA61K41/0071A61K49/106A61K49/18A61P35/00C08G83/008
Inventor 裴仁军赵岳五王金娥
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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