41results about How to "High yield of singlet oxygen" patented technology

The invention provides nano particles compounded of up-conversion nano particles and gold nanorods and a preparation method and application of the nano particles, and belongs to the field of nano biomedicine. The method comprises the following steps: reacting up-conversion nuclear shell nano particles with a photosensitizer; and then, coupling with SiO2-coated gold nanorods to obtain the nano particles compounded of up-conversion nano particles and gold nanorods. The shell thickness of the SiO2-coated gold nanorods is 30-60nm. By means of the surface covalency or photosensitizer absorption of the up-conversion nano particles, the energy transfer efficiency is improved, so that the singlet oxygen yield is improved and the effect of photodynamics therapy is improved. Meanwhile, the acting distance betweeb the gold nanorods and the up-conversion nano particles is regulated to avoid the up-conversion fluorescence quenching phenomenon. According to the invention, upconversion and photodynamics therapy of the photosensitizer are combined with the photo-thermal effect of the SiO2-coated gold nanorods for preparing a synergic treatment nano platform. The purpose of two treatment ways are realized by one excitation light source is reached.

The invention relates to methoxy polyethylene glycol-poly-N-isopropyl acrylamide-metal tetramino phthalocyanine and a preparation method therefor and belongs to the field of photodynamic therapy. Methoxy polyethylene glycol-poly-N-isopropyl acrylamide-metal tetramino phthalocyanine is used for solving the problem that the existing phthalocyanine photosensitizer is poor in water solubility and low in tumor targeting performance and the application in the photodynamic therapy is limited by unstable PI-PI accumulative action. Methoxy polyethylene glycol-poly-N-isopropyl acrylamide-metal tetramino phthalocyanine disclosed by the invention has the skeleton symbol of MPEG-PNIPAM-MTAPc, wherein MPEG means methoxy polyethylene glycol, PNIPAM means poly-N-isopropyl acrylamide, and MTAPc means metal tetramino phthalocyanine. The preparation method disclosed by the invention comprises the steps: firstly, preparing an ATRP (Atom Transfer Radical Polymerization) initiator MPEG-X from MPEG-OH and a halogenated substance; secondly, initiating an NIPAM (N-isopropyl acrylamide) monomer to subject to ATRP by the initiator, so as to obtain a temperature-sensitive diblock copolymer MPEG-PNIPAM-X; then, carrying out terminal group functionalization on the MPEG-PNIPAM-X with MA (Maleic Anhydride), so as to obtain MPEG-PNIPAM-MA-X; and finally, bonding MTAPc to the MPEG-PNIPAM-MA-X, thereby obtaining the MPEG-PNIPAM-MTAPc. The prepared photosensitizer is good in water solubility and high in tumor targeting performance, is not liable to aggregation in aqueous solutions and is a phthalocyanine photosensitizer with development potential.

The invention discloses a preparation method for a ZnPc-UCNP-PEG-G nano-compound. The preparation method comprises the following steps: synthesizing NaYF4:Yb<3+> through a micro-emulsion method; modifying Er<3+> up conversion nanoparticles with polyethylene glycol through a ligand oxidizing method to obtain water-soluble UCNP-PEG-OH; modifying a photosensitive agent and bi-carboxyl polyethylene glycol onto the surface through an EDC concentration method to a obtain ZnPc-UCNP-PEG nano-compound; lastly, loading targeted molecular gefitinib (G) modified by the polyethylene glycol onto the surface to obtain the ZnPc-UCNP-PEG-G nano-compound. The ZnPc-UCNP-PEG-G prepared by the preparation method has uniform particle distribution, high crystallization performance and high photoactivity, and can be hopefully developed into an efficient and low-toxicity novel drug loading system; the PDT therapy depth of zinc phthalocyanine and targeting ability for tumor cells can be improved.

The invention relates to a near-infrared nano photosensitizer as well as a preparation method and application thereof, and relates to the technical field of photosensitizers. According to the near-infrared nano photosensitizer disclosed by the invention, the absorption and emission spectrum of the near-infrared nano photosensitizer is close to a near-infrared light region by performing conjugate extension modification on a BODIPY parent nucleus; introducing a polyfluoroalkane group and a polyethylene glycol group into the BODIPY structure to obtain the amphiphilic photosensitizer; the nano photosensitive micelle with an ultralow CMC (Carboxymethyl Cellulose) value is finally constructed by utilizing the strong fluorine-fluorine action between the polyfluoroalkane groups and the hydrophilic action of the polyethylene glycol groups; j-aggregation of the BODIPY is induced by utilizing a fluorine-fluorine effect, so that the maximum absorption peak of the BODIPY is red-shifted to a near-infrared region, and deep phototherapy of tumors is facilitated.

The invention discloses temperature sensitive type water-soluble polymers based on a D-pi-A structure as well as a preparation method and an application of the water-soluble polymers. The structural formula of the polymers is shown in the description. The temperature sensitive type polymers are prepared through polymerization of molecules of the simple D-pi-A structure with water-soluble molecules. Phase-transition temperature of the polymers is 25-45 DEG C in which human physiological temperature of 37 DEG C is included, the polymers have better nano-size, good water solubility and higher singlet oxygen yield and can be applied to bioimaging and time-resolved optics, and photodynamic therapy can be realized.

The invention relates to the field of aquatic product processing and storage, and discloses a halogenated curcumin derivative, a preparation method thereof and an application of the halogenated curcumin derivative in aquatic product preservation in order to solve the problems that in the prior art, active oxygen generated by a photosensitizer in photodynamic sterilization is less, and the aquatic product preservation effect needs to be improved. The halogenated curcumin derivative is shown as a structural general formula I, and in the structural general formula I, R1 is one of F, Cl, Br and I; and R2 is one of F, Cl, Br, I and OH. The halogenated curcumin derivative can be prepared by a one-step method and can be used for photodynamic sterilization of aquatic products. The preparation steps are simple, the reaction conditions are mild, the singlet oxygen yield of the prepared halogenated curcumin derivative under blue light irradiation is high, the sterilization and preservation effects on aquatic products are good, the shelf life of fresh shrimps can be effectively prolonged, and the influence on food sense is small.

The invention discloses application of a nano sound sensitizer to preparing optoacoustic guidance-based acoustodynamic tumor treatment drugs. The nano sound sensitizer is water-soluble nanoparticles with hydrophobic alpha-substituted iridium octabutoxy-phthalocyanine as the core and bovine serum albumin as the shell, the hydrate dynamic diameter of the nano sound sensitizer is 134.5 nm, and the Zeta surface potential of the nano sound sensitizer is -28.4 mV; the nano sound sensitizer can catalyze hydrogen peroxide to produce oxygen and convert the oxygen under ultrasonic conditions into singlet oxygen to achieve enhancement of optoacoustic guidance-based acoustodynamic treatment. When applied to preparing the optoacoustic guidance-based acoustodynamic tumor treatment drugs, the nano soundsensitizer can save external oxygen sources and achieve good effects.

The invention belongs to the field of functional materials, and particularly relates to a fluorine-containing near-infrared absorption conjugated polymer and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing a 3, 6-bis (5-bromothiophene-2-yl)-2, 5-bis (alkyl) pyrrolo [3, 4-c] pyrrole-1, 4-diketone monomer, then preparing dibromo fluorine-containing fluorene, and finally, reacting the 3, 6-bis (5-bromothiophene-2-yl)-2, 5-bis (alkyl) pyrrolo [3, 4-c] pyrrole-1, 4-diketone monomer with the dibromo fluorine-containing fluorene to prepare the fluorine-containing fluorene dibromo fluorine-containing fluorene. The preparation method comprises the following steps: dissolving a 1, 4-diketone monomer, dibromo fluorine-containing fluorene, a bis (trimethyltin) compound, tris (dibenzylideneacetone) dipalladium and tris (o-tolyl) phosphine in toluene, and reacting at 110 DEG C for 48 hours in an inert gas atmosphere to obtain the fluorine-containing fluorene and diketopyrrolopyrrole copolymer. The fluorine-containing fluorene and diketopyrrolopyrrole copolymer disclosed by the invention has strong absorption in a near-infrared region, and contains a perfluoro side chain, so that the efficiency of generated singlet oxygen is higher, and the photodynamic therapy efficiency can be improved.

The invention relates to an amino silicon phthalocyanine nano-sphere, a method for preparing the same and application of the amino silicon phthalocyanine nano-sphere. Amino silicon phthalocyanine is dissolved in N,N-dimethylformamide to prepare mother liquor with certain concentration, then the mother liquor is injected into deionized water, and self-assembly is carried out to form the amino silicon phthalocyanine nano-sphere. The amino silicon phthalocyanine nano-sphere, the method and the application have the advantages that red shift is carried out on absorption spectra of the amino siliconphthalocyanine nano-sphere under agglomeration effects, and accordingly the therapy depths can be increased; phthalocyanine nano-spheres have certain photo-thermal conversion capacity, photo-thermaltherapy and photodynamic therapy can be carried out in red-light and near-infrared bands, and accordingly cancer therapeutic effects can be enhanced; excellent photodynamic therapy and photo-thermal therapy synergistic effects are realized in in-vitro cell experiments, the cancer cell fatality rate can be increased, and the cancer cell therapeutic efficiency can be improved; the method for preparing the amino silicon phthalocyanine nano-sphere includes simple processes and is wide in application range.

The invention provides a photoactivated porphyrin prodrug ternary assembly, which is obtained by interaction of a subject and an object, the subject is fully methylated beta-cyclodextrin modified hyaluronic acid, the object is a porphyrin prodrug, and the subject is a photoactivated porphyrin prodrug. The porphyrin prodrug is obtained by covalent linkage of monocarboxyl phenyl porphyrin and anti-tumor drug molecules modified by photooxidation active functional groups. The invention further provides a preparation method and application of the photoactivated porphyrin prodrug ternary assembly. The porphyrin prodrug ternary assembly provided by the invention can be used for conveniently and effectively carrying out fluorescence imaging and tracing a tumor treatment process; the supramolecular assembly has a good treatment effect, can greatly reduce systemic toxicity caused by chemotherapeutic drugs, has remote operability and non-invasiveness, has efficient and sensitive imaging capability, and has potential application value in the fields of cancer and tumor treatment and imaging.