41results about How to "High yield of singlet oxygen" patented technology

The invention provides nano particles compounded of up-conversion nano particles and gold nanorods and a preparation method and application of the nano particles, and belongs to the field of nano biomedicine. The method comprises the following steps: reacting up-conversion nuclear shell nano particles with a photosensitizer; and then, coupling with SiO2-coated gold nanorods to obtain the nano particles compounded of up-conversion nano particles and gold nanorods. The shell thickness of the SiO2-coated gold nanorods is 30-60nm. By means of the surface covalency or photosensitizer absorption of the up-conversion nano particles, the energy transfer efficiency is improved, so that the singlet oxygen yield is improved and the effect of photodynamics therapy is improved. Meanwhile, the acting distance betweeb the gold nanorods and the up-conversion nano particles is regulated to avoid the up-conversion fluorescence quenching phenomenon. According to the invention, upconversion and photodynamics therapy of the photosensitizer are combined with the photo-thermal effect of the SiO2-coated gold nanorods for preparing a synergic treatment nano platform. The purpose of two treatment ways are realized by one excitation light source is reached.

The invention discloses a phthalocyanine metal complex as well as a preparation method and an application of the phthalocyanine metal complex. 3-[2,4,6-tri(dimethylamino methyl)-phenoxyl] phthalonitrile is prepared by using 2-phthalonitrile nitryl and 2,4,6-tri(dimethylamino methyl)-phenol as reactants, and further, the phthalocyanine metal complex substituted with amido or amido alpha bit is prepared. The phthalocyanine metal complex has the characteristics of high photosensitive activity and high water solubility; the phthalocyanine metal complex exists in water in a monomer mode, so that the photodynamic activity is facilitated in the water; the phthalocyanine metal complex is subjected to absorption spectroscopic redshift and shifted to a near-infrared area where is beneficial for penetrating through human tissues. The phthalocyanine metal complex is specially high in photodynamic antifungal activity and can be used for preparing photosensitizers or photodynamic medicines or photosensitive medicaments.

The invention relates to methoxy polyethylene glycol-poly-N-isopropyl acrylamide-metal tetramino phthalocyanine and a preparation method therefor and belongs to the field of photodynamic therapy. Methoxy polyethylene glycol-poly-N-isopropyl acrylamide-metal tetramino phthalocyanine is used for solving the problem that the existing phthalocyanine photosensitizer is poor in water solubility and low in tumor targeting performance and the application in the photodynamic therapy is limited by unstable PI-PI accumulative action. Methoxy polyethylene glycol-poly-N-isopropyl acrylamide-metal tetramino phthalocyanine disclosed by the invention has the skeleton symbol of MPEG-PNIPAM-MTAPc, wherein MPEG means methoxy polyethylene glycol, PNIPAM means poly-N-isopropyl acrylamide, and MTAPc means metal tetramino phthalocyanine. The preparation method disclosed by the invention comprises the steps: firstly, preparing an ATRP (Atom Transfer Radical Polymerization) initiator MPEG-X from MPEG-OH and a halogenated substance; secondly, initiating an NIPAM (N-isopropyl acrylamide) monomer to subject to ATRP by the initiator, so as to obtain a temperature-sensitive diblock copolymer MPEG-PNIPAM-X; then, carrying out terminal group functionalization on the MPEG-PNIPAM-X with MA (Maleic Anhydride), so as to obtain MPEG-PNIPAM-MA-X; and finally, bonding MTAPc to the MPEG-PNIPAM-MA-X, thereby obtaining the MPEG-PNIPAM-MTAPc. The prepared photosensitizer is good in water solubility and high in tumor targeting performance, is not liable to aggregation in aqueous solutions and is a phthalocyanine photosensitizer with development potential.

The invention discloses a preparation method for a ZnPc-UCNP-PEG-G nano-compound. The preparation method comprises the following steps: synthesizing NaYF4:Yb<3+> through a micro-emulsion method; modifying Er<3+> up conversion nanoparticles with polyethylene glycol through a ligand oxidizing method to obtain water-soluble UCNP-PEG-OH; modifying a photosensitive agent and bi-carboxyl polyethylene glycol onto the surface through an EDC concentration method to a obtain ZnPc-UCNP-PEG nano-compound; lastly, loading targeted molecular gefitinib (G) modified by the polyethylene glycol onto the surface to obtain the ZnPc-UCNP-PEG-G nano-compound. The ZnPc-UCNP-PEG-G prepared by the preparation method has uniform particle distribution, high crystallization performance and high photoactivity, and can be hopefully developed into an efficient and low-toxicity novel drug loading system; the PDT therapy depth of zinc phthalocyanine and targeting ability for tumor cells can be improved.

The invention relates to a near-infrared nano photosensitizer as well as a preparation method and application thereof, and relates to the technical field of photosensitizers. According to the near-infrared nano photosensitizer disclosed by the invention, the absorption and emission spectrum of the near-infrared nano photosensitizer is close to a near-infrared light region by performing conjugate extension modification on a BODIPY parent nucleus; introducing a polyfluoroalkane group and a polyethylene glycol group into the BODIPY structure to obtain the amphiphilic photosensitizer; the nano photosensitive micelle with an ultralow CMC (Carboxymethyl Cellulose) value is finally constructed by utilizing the strong fluorine-fluorine action between the polyfluoroalkane groups and the hydrophilic action of the polyethylene glycol groups; j-aggregation of the BODIPY is induced by utilizing a fluorine-fluorine effect, so that the maximum absorption peak of the BODIPY is red-shifted to a near-infrared region, and deep phototherapy of tumors is facilitated.

The invention discloses a heterogeneous photosensitizer based on a metal organic framework material as a carrier as well as a preparation method and application of the heterogeneous photosensitizer, and belongs to the technical field of preparation of environment-friendly functional composite materials. The heterogeneous photosensitizer disclosed by the invention is an iodo-BODIPY-coated ZIF-8 composite material prepared by loading iodo-BODIPY which has strong absorption in a visible light region and can efficiently generate singlet oxygen (1O2) into a ZIF-8 metal organic framework material pore passage through a simple one-pot boiling self-assembly method. The prepared heterogeneous photosensitizer is used for catalytically oxidizing diphenyl sulfide, and then the catalyst can be recovered through simple centrifugation, washing and drying, and can be recycled for catalytic oxidation of diphenyl sulfide. The preparation method is simple, easy to operate, environmentally friendly, cheap, good in repeatability and short in consumed time; and the heterogeneous photosensitizer has strong absorption in a visible light region, can efficiently generate 1O2, can selectively oxidize thioether compounds into sulfoxide under the condition of stirring at room temperature, and has high conversion rate and good reusability.

The invention discloses a two-dimensional metal-organic framework structure nano-sheet, a preparation method and applications thereof. The preparation method comprises the following steps: providing amixed solution containing tetraphenylporphyrin, gadolinium metal ions, an organic solvent and water, adjusting the ratio of the organic solvent to the water in the mixed solution, and carrying out asolvothermal reaction to obtain a two-dimensional metal-organic framework structure nano-sheet with uniform size distribution; and carrying out hydrogen protonation treatment on the nano-sheet to obtain the protonated nano-sheet with the two-dimensional metal-organic framework structure. According to the invention, the obtained two-dimensional metal-organic framework structure nano-sheet can be used for magnetic resonance imaging analysis or photodynamic therapy of tumors; and the nano-sheet with uniform size distribution is obtained by adjusting the proportion of the mixed solution and carrying out solvothermal treatment, and the ultraviolet and visible absorption intensity and the ultraviolet and visible absorption intensity range of the nano-sheet are improved through hydrogen protonation treatment, so that the nano-sheet generates sensitive magnetic resonance imaging and photodynamic treatment effects on tumors.

The invention discloses a preparation method of a ZnPc-UCNP@SiO2-PEG-G nano composite. The preparation method comprises the following steps: synthesizing UCNPs (upconversion nano particles) through a micro-emulsion method, coating the surfaces of the UCNPs with SiO2, carrying out surface amination on the SiO2 to obtain UCNP@SiO2-NH2, modifying the surface of the UCNP@SiO2-NH2 to obtain ZnPc-UCNP@SiO2-PEG-COOH nano composite, loading targeting molecules gefitinib (G) to the surface of the ZnPc-UCNP@SiO2-PEG-COOH nano composites to obtain the ZnPc-UCNP@SiO2-PEG-G nano composite. The nano composite has the advantages that the particle distribution is uniform, the crystallinity is good, the photodynamic activity is good, and the ZnPc-UCNP@SiO2-PEG-G nano composite is hopefully developed into a high-efficiency and low-toxicity novel drug-loading system.

The invention provides a preparation method of a metal ruthenium nano material. The preparation method comprises the following steps that 1, a metal ruthenium complex is dissolved in a polycarboxyliccompound aqueous solution, and ultrasonic dispersion is carried out to obtain a mixed solution A, wherein the metal ruthenium complex is formed by coordination of a polypyridine ligand containing amino and ruthenium trichloride; 2, water bath heating is carried out on the mixed solution A to obtain a reaction solution B; 3, the pH value of the reaction solution B is adjusted by using an alkaline reagent, then supernate of the reaction solution B is dialyzed, an aqueous solution obtained through dialysis is collected and freeze-dried, and the metal ruthenium nano material is obtained. Accordingto the preparation method of the metal ruthenium nano material, protonation of amino and a hydrothermal method are used, the metal ruthenium complex difficult to dissolve in water is wrapped with thewater-soluble polycarboxylic compound, so that the prepared metal ruthenium nano material is good in water solubility, high in light stability, relatively high in fluorescence quantum yield, high intumor photodynamic therapy, good in biocompatibility and high in singlet oxygen yield.

The invention discloses preparation and application of a heterogeneous binuclear metallic complex. The heteronuclear complex consists of an iridium complex and a manganese porphyrin complex; the structure formula of the heteronuclear complex is shown as follows. The complex is high in relaxivity and is capable of realizing magnetic resonance imaging application; and meanwhile, the complex is highin singlet oxygen quantum yield; ROS can be produced in cells, and the good photodynamic treatment can be confirmed by observing the change of the cellular morphology before and after the operation. The complex has a good application prospect in the magnetic resonance imaging and the photodynamics therapy.

The invention aims to provide a biological photosensitizer, namely a novel biological photosensitizer high in penetratability and targeting. Nanoparticles are modified with titanium phthalocyanine dichloride and hyaluronic acid in a suitable loading sequence and in an efficient combination manner, the modified up-converted nanoparticles are high in singlet oxygen yield and have a high targeting function of specific recognition for cells of over-expressed CD44 protein.

The invention belongs to the technical field of high polymer materials, biomedical materials and photodynamic and sonodynamic therapy, and provides a preparation method of a water-soluble polyporphyrin carrier-free nano-drug. The number-average molecular weight of the water-soluble polyporphyrin carrier-free nano-drug prepared by the preparation method disclosed by the invention ranges from 5000g / mol to 30000g / mol, the solubility of the water-soluble polyporphyrin carrier-free nano-drug in water can reach 50mg / mL, and the singlet oxygen yield of the water-soluble polyporphyrin carrier-free nano-drug is 1.5-3 times that of tetracarboxyphenyl porphyrin. The polymer can be directly dissolved in water, and can spontaneously form stable nanoparticles in a carrier-free form within the concentration range of 0.01 mg / mL to 10 mg / mL, and the particle size range is 100 nm to 200 nm. Compared with common polyporphyrin, the polyporphyrin has the advantages that water solubility is realized, and the biocompatibility is improved. The polyporphyrin can be self-assembled into nano-particles in water, other carriers are not needed, and a potential in-vivo delivery effect is achieved.

The invention discloses an organic-inorganic hybrid photosensitizer and a preparation method for a hybrid nanometer diagnosis and treatment reagent. According to the invention, polysilsesquioxane witha three-dimensional cage structure and a dodecyl chain are introduced into a porphyrin photosensitizer, and the photosensitizer is doped into organic semiconductor nanoparticles by a coprecipitationmethod; by utilization of the characteristic of high extinction coefficient of an organic semiconductor, the organic semiconductor is used as a light energy donor; the three-dimensional cage structureof the polysilsesquioxane can effectively inhibit aggregation of the porphyrin photosensitizer and reduce fluorescence quenching caused by aggregation of the organic semiconductor; meanwhile, the dodecyl chain on the polysilsesquioxane has the effect of enhancing the stability of nanometer particles; and thus, the obtained organic-inorganic hybrid nanometer diagnosis and treatment reagent is usedfor cancer photodynamic treatment under the guidance of high-performance fluorescence imaging.

The invention discloses temperature sensitive type water-soluble polymers based on a D-pi-A structure as well as a preparation method and an application of the water-soluble polymers. The structural formula of the polymers is shown in the description. The temperature sensitive type polymers are prepared through polymerization of molecules of the simple D-pi-A structure with water-soluble molecules. Phase-transition temperature of the polymers is 25-45 DEG C in which human physiological temperature of 37 DEG C is included, the polymers have better nano-size, good water solubility and higher singlet oxygen yield and can be applied to bioimaging and time-resolved optics, and photodynamic therapy can be realized.

The invention provides a photosensitizer coupled rare earth-doped LiAF4 nanocomposite material, its preparation method, and its application in the photodynamic therapy. The above photosensitizer coupled nanomaterial emits strong visible light under the irradiation of 980nm laser, and can sensitize the photosensitizer to generate singlet oxygen, so the nanomaterial can be used in the up-conversion photodynamic therapy. The method has the advantages of simplicity and high yield, the prepared nanomaterial has the advantages of good water solubility, excellent luminescence performance and high singlet oxygen yield, and the singlet oxygen can well kill cancer cells, so the nanomaterial can be applied in the diagnosis and treatment field of tumor diseases.

The invention relates to a phthalocyanine-RGD polypeptide-graphene oxide composite nano material and a preparation method and application thereof. The phthalocyanine-RGD polypeptide-graphene oxide composite nano material is a compound formed by bonding phthalocyanine and RGD polypeptide to graphene oxide through covalent bonds. Due to existence of the RGD polypeptide, the composite nano material has a special targeting effect on specific cancer cells and can be specifically gathered at the cancer cells; moreover, the graphene oxide exists in the composite nano material, so that the material has very high photothermal conversion efficiency and shows a good photodynamic therapy and photothermal therapy synergistic effect in a near-infrared band; and meanwhile, an in-vitro cell experiment shows that the composite nano material can be used for remarkably improving the fatality rate and the treatment efficiency of the cancer cells. The invention further provides the preparation method of the phthalocyanine-RGD polypeptide-graphene oxide composite nano material; and the preparation method is simple in process and wide in applicable range.

The invention relates to the field of aquatic product processing and storage, and discloses a halogenated curcumin derivative, a preparation method thereof and an application of the halogenated curcumin derivative in aquatic product preservation in order to solve the problems that in the prior art, active oxygen generated by a photosensitizer in photodynamic sterilization is less, and the aquatic product preservation effect needs to be improved. The halogenated curcumin derivative is shown as a structural general formula I, and in the structural general formula I, R1 is one of F, Cl, Br and I; and R2 is one of F, Cl, Br, I and OH. The halogenated curcumin derivative can be prepared by a one-step method and can be used for photodynamic sterilization of aquatic products. The preparation steps are simple, the reaction conditions are mild, the singlet oxygen yield of the prepared halogenated curcumin derivative under blue light irradiation is high, the sterilization and preservation effects on aquatic products are good, the shelf life of fresh shrimps can be effectively prolonged, and the influence on food sense is small.

The invention relates to an aminophthalocyaninosilicon-graphene oxide composite nano-material, and a preparation method and an application thereof. The aminophthalocyaninosilicon-graphene oxide composite nano-material is a compound formed through bonding aminophthalocyaninosilicon to graphene oxide through a covalent bond; and the composite nano-material has good photodynamic therapy and photothermal therapy synergism in in-vitro cell experiments and mouse in-vivo experiments, and improves the fatality and the therapy efficiency of cancer cells. The invention also provides the preparation method of the aminophthalocyaninosilicon-graphene oxide composite nano-material. The method has the advantages of simple process and wide application range.

The invention discloses application of a nano sound sensitizer to preparing optoacoustic guidance-based acoustodynamic tumor treatment drugs. The nano sound sensitizer is water-soluble nanoparticles with hydrophobic alpha-substituted iridium octabutoxy-phthalocyanine as the core and bovine serum albumin as the shell, the hydrate dynamic diameter of the nano sound sensitizer is 134.5 nm, and the Zeta surface potential of the nano sound sensitizer is -28.4 mV; the nano sound sensitizer can catalyze hydrogen peroxide to produce oxygen and convert the oxygen under ultrasonic conditions into singlet oxygen to achieve enhancement of optoacoustic guidance-based acoustodynamic treatment. When applied to preparing the optoacoustic guidance-based acoustodynamic tumor treatment drugs, the nano soundsensitizer can save external oxygen sources and achieve good effects.

The invention belongs to the field of functional materials, and particularly relates to a fluorine-containing near-infrared absorption conjugated polymer and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing a 3, 6-bis (5-bromothiophene-2-yl)-2, 5-bis (alkyl) pyrrolo [3, 4-c] pyrrole-1, 4-diketone monomer, then preparing dibromo fluorine-containing fluorene, and finally, reacting the 3, 6-bis (5-bromothiophene-2-yl)-2, 5-bis (alkyl) pyrrolo [3, 4-c] pyrrole-1, 4-diketone monomer with the dibromo fluorine-containing fluorene to prepare the fluorine-containing fluorene dibromo fluorine-containing fluorene. The preparation method comprises the following steps: dissolving a 1, 4-diketone monomer, dibromo fluorine-containing fluorene, a bis (trimethyltin) compound, tris (dibenzylideneacetone) dipalladium and tris (o-tolyl) phosphine in toluene, and reacting at 110 DEG C for 48 hours in an inert gas atmosphere to obtain the fluorine-containing fluorene and diketopyrrolopyrrole copolymer. The fluorine-containing fluorene and diketopyrrolopyrrole copolymer disclosed by the invention has strong absorption in a near-infrared region, and contains a perfluoro side chain, so that the efficiency of generated singlet oxygen is higher, and the photodynamic therapy efficiency can be improved.

The invention relates to an amino silicon phthalocyanine nano-sphere, a method for preparing the same and application of the amino silicon phthalocyanine nano-sphere. Amino silicon phthalocyanine is dissolved in N,N-dimethylformamide to prepare mother liquor with certain concentration, then the mother liquor is injected into deionized water, and self-assembly is carried out to form the amino silicon phthalocyanine nano-sphere. The amino silicon phthalocyanine nano-sphere, the method and the application have the advantages that red shift is carried out on absorption spectra of the amino siliconphthalocyanine nano-sphere under agglomeration effects, and accordingly the therapy depths can be increased; phthalocyanine nano-spheres have certain photo-thermal conversion capacity, photo-thermaltherapy and photodynamic therapy can be carried out in red-light and near-infrared bands, and accordingly cancer therapeutic effects can be enhanced; excellent photodynamic therapy and photo-thermal therapy synergistic effects are realized in in-vitro cell experiments, the cancer cell fatality rate can be increased, and the cancer cell therapeutic efficiency can be improved; the method for preparing the amino silicon phthalocyanine nano-sphere includes simple processes and is wide in application range.

The invention discloses a red fluorescent protein-based two-photon photosensitizing dye RFP-Ac and a preparation method and application thereof. The red fluorescent protein-based two-photon photosensitizing dye RFP-Ac comprises phenothiazine, vinylbenzene and fluorescent protein methylene The conjugated structure of the base imidazolidinone, and the aryl acrylate was introduced at the end group of the fluorescent chromophore as an active thiol recognition site and a photosensitizer targeting group. The red fluorescent protein-based photosensitizing dye molecule RFP-Ac of the present invention has two-photon absorption characteristics, a Stokes shift of more than 200 nm, strong anti-interference ability, high sensitivity, low cytotoxicity, good biocompatibility, and singlet oxygen production. It can be used as two-photon photosensitizing dyes and fluorescent probes with high performance in near-infrared wavelengths for fluorescence sensing, endogenous or exogenous bioactive thiol detection, two-photon fluorescence imaging, fluorescent labeling, two-photon light Dynamic therapy has a wide range of applications.

The invention discloses a photosensitizer with a high yield rate of singlet oxygen and a preparation method thereof. The Suzuki coupling reaction is adopted to synthesize 4,8-dibromo-6-(2-ethylhexyl)-[1,2, 5] Thiadiazo[3,4-F]benzotriazole and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolin-2-yl)pyridine , under the catalysis of [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride, the photosensitizer is obtained through oxidative addition and reductive elimination. The photosensitizer disclosed by the invention has a strong absorption ability in visible light, has a stable structure under slightly acidic to weakly alkaline conditions, and has a high quantum yield and high singlet oxygen generation ability, and can be used as a new photosensitizer. Fluorescence imaging or photodynamic therapy of tumors.

The invention discloses a polyiodine-modified fluoroboridipyrrole derivative. The fluoroboridipyrrole derivative uses fluoroboridipyrrole as a mother nucleus, prolongs the conjugated system of fluoroboridipyrrole through condensation reaction, and It is obtained by introducing a hydrophilic ethylene glycol chain at the end, and then introducing different numbers of iodine atoms through an electrophilic substitution reaction. The invention also discloses the preparation method and application of the fluoroboron dipyrrole derivatives. The polyiodine-modified fluoroborate dipyrrole derivatives of the present invention have both photodynamic and photothermal therapeutic effects, and correspondingly avoid the shortcomings of single therapeutic effect and poor targeting of clinical photosensitizers.

The invention provides a photoactivated porphyrin prodrug ternary assembly, which is obtained by interaction of a subject and an object, the subject is fully methylated beta-cyclodextrin modified hyaluronic acid, the object is a porphyrin prodrug, and the subject is a photoactivated porphyrin prodrug. The porphyrin prodrug is obtained by covalent linkage of monocarboxyl phenyl porphyrin and anti-tumor drug molecules modified by photooxidation active functional groups. The invention further provides a preparation method and application of the photoactivated porphyrin prodrug ternary assembly. The porphyrin prodrug ternary assembly provided by the invention can be used for conveniently and effectively carrying out fluorescence imaging and tracing a tumor treatment process; the supramolecular assembly has a good treatment effect, can greatly reduce systemic toxicity caused by chemotherapeutic drugs, has remote operability and non-invasiveness, has efficient and sensitive imaging capability, and has potential application value in the fields of cancer and tumor treatment and imaging.

The invention belongs to the technical field of high polymer materials, biomedical materials and photodynamic therapy, provides a preparation method and application of water-soluble cationic polyporphyrin, and relates to a preparation method of water-soluble cationic polyporphyrin and application of water-soluble cationic polyporphyrin in photodynamic therapy of tumors. The invention provides the preparation method of water-soluble cationic polyporphyrin, and provides a technical reference for synthesizing a high-molecular-weight porphyrin polymer. Compared with monomer micromolecule porphyrin, the singlet oxygen yield of polyporphyrin can be increased to 1.5 times or above. Compared with monomer porphyrin, polyporphyrin has a potential photodynamic therapy effect. Compared with common polyporphyrin, the polyporphyrin has water solubility, and the biocompatibility of the polyporphyrin is improved.

The invention belongs to the field of organic synthesis and drugs, and more specifically relates to a porphyrin compound which is high in water solubility and is capable of absorbing near infrared ray, and a preparation method and applications thereof. According to the preparation method, the water solubility of the porphyrin compound is improved via introducing PEG chains and adjusting PEG chain length, and the absorption wavelength of porphyrin photosensitizer molecules is adjusted via introducing acetylene bonds or other conjugate groups. The porphyrin compound possesses relatively high singlet oxygen productive rate, low phototoxicity, and low dark toxicity, and is promising to be applied in photodynamic therapy.

The invention discloses preparation and application of a heterogeneous binuclear metallic complex. The heteronuclear complex consists of an iridium complex and a manganese porphyrin complex; the structure formula of the heteronuclear complex is shown as follows. The complex is high in relaxivity and is capable of realizing magnetic resonance imaging application; and meanwhile, the complex is highin singlet oxygen quantum yield; ROS can be produced in cells, and the good photodynamic treatment can be confirmed by observing the change of the cellular morphology before and after the operation. The complex has a good application prospect in the magnetic resonance imaging and the photodynamics therapy.

The invention provides nano particles compounded of up-conversion nano particles and gold nanorods and a preparation method and application of the nano particles, and belongs to the field of nano biomedicine. The method comprises the following steps: reacting up-conversion nuclear shell nano particles with a photosensitizer; and then, coupling with SiO2-coated gold nanorods to obtain the nano particles compounded of up-conversion nano particles and gold nanorods. The shell thickness of the SiO2-coated gold nanorods is 30-60nm. By means of the surface covalency or photosensitizer absorption of the up-conversion nano particles, the energy transfer efficiency is improved, so that the singlet oxygen yield is improved and the effect of photodynamics therapy is improved. Meanwhile, the acting distance betweeb the gold nanorods and the up-conversion nano particles is regulated to avoid the up-conversion fluorescence quenching phenomenon. According to the invention, upconversion and photodynamics therapy of the photosensitizer are combined with the photo-thermal effect of the SiO2-coated gold nanorods for preparing a synergic treatment nano platform. The purpose of two treatment ways are realized by one excitation light source is reached.

The invention relates to a water-soluble naphthalocyanine base compound, a preparation method and an application of the compound as a photosensitizer. A structural formula of the compound is as Formula (I) as shown in the specification. The compound is a carboxylic acid base modified water-soluble naphthalocyanine metal complex, has a good singlet oxygen occurrence rate, low cell photophobic toxicity, and excellent phototoxicity under irradiation, and can serve as a near-infrared PDT (Photodynamic Therapy) photosensitizer. The invention also provides a preparation method of the compound. The preparation method is simple in technology and wide in application scope.