41results about How to "High yield of singlet oxygen" patented technology

The invention discloses a photosensitizer with a high yield rate of singlet oxygen and a preparation method thereof. The Suzuki coupling reaction is adopted to synthesize 4,8-dibromo-6-(2-ethylhexyl)-[1,2, 5] Thiadiazo[3,4-F]benzotriazole and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolin-2-yl)pyridine , under the catalysis of [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride, the photosensitizer is obtained through oxidative addition and reductive elimination. The photosensitizer disclosed by the invention has a strong absorption ability in visible light, has a stable structure under slightly acidic to weakly alkaline conditions, and has a high quantum yield and high singlet oxygen generation ability, and can be used as a new photosensitizer. Fluorescence imaging or photodynamic therapy of tumors.

The invention belongs to the field of organic synthesis and drugs, and more specifically relates to a porphyrin compound which is high in water solubility and is capable of absorbing near infrared ray, and a preparation method and applications thereof. According to the preparation method, the water solubility of the porphyrin compound is improved via introducing PEG chains and adjusting PEG chain length, and the absorption wavelength of porphyrin photosensitizer molecules is adjusted via introducing acetylene bonds or other conjugate groups. The porphyrin compound possesses relatively high singlet oxygen productive rate, low phototoxicity, and low dark toxicity, and is promising to be applied in photodynamic therapy.

The invention provides nano particles compounded of up-conversion nano particles and gold nanorods and a preparation method and application of the nano particles, and belongs to the field of nano biomedicine. The method comprises the following steps: reacting up-conversion nuclear shell nano particles with a photosensitizer; and then, coupling with SiO2-coated gold nanorods to obtain the nano particles compounded of up-conversion nano particles and gold nanorods. The shell thickness of the SiO2-coated gold nanorods is 30-60nm. By means of the surface covalency or photosensitizer absorption of the up-conversion nano particles, the energy transfer efficiency is improved, so that the singlet oxygen yield is improved and the effect of photodynamics therapy is improved. Meanwhile, the acting distance betweeb the gold nanorods and the up-conversion nano particles is regulated to avoid the up-conversion fluorescence quenching phenomenon. According to the invention, upconversion and photodynamics therapy of the photosensitizer are combined with the photo-thermal effect of the SiO2-coated gold nanorods for preparing a synergic treatment nano platform. The purpose of two treatment ways are realized by one excitation light source is reached.

The invention relates to a water-soluble naphthalocyanine base compound, a preparation method and an application of the compound as a photosensitizer. A structural formula of the compound is as Formula (I) as shown in the specification. The compound is a carboxylic acid base modified water-soluble naphthalocyanine metal complex, has a good singlet oxygen occurrence rate, low cell photophobic toxicity, and excellent phototoxicity under irradiation, and can serve as a near-infrared PDT (Photodynamic Therapy) photosensitizer. The invention also provides a preparation method of the compound. The preparation method is simple in technology and wide in application scope.