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Amino silicon phthalocyanine nano-sphere, method for preparing same and application of amino silicon phthalocyanine nano-sphere

A technology of nanospheres and silicon phthalocyanines, applied in nanotechnology, nano-optics, nanotechnology, etc., can solve problems such as single-component silicon phthalocyanine nanosphere drugs, and achieve good application prospects and good tumor suppression Function, beneficial to the effect of tissue penetration ability

Inactive Publication Date: 2019-05-24
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on a single-component silicon phthalocyanine nanosphere drug that can be used for the synergistic effect of photodynamic therapy and photothermal therapy

Method used

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  • Amino silicon phthalocyanine nano-sphere, method for preparing same and application of amino silicon phthalocyanine nano-sphere
  • Amino silicon phthalocyanine nano-sphere, method for preparing same and application of amino silicon phthalocyanine nano-sphere
  • Amino silicon phthalocyanine nano-sphere, method for preparing same and application of amino silicon phthalocyanine nano-sphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1. Preparation of amino silicon phthalocyanine (n=1) nanoparticles

[0046] Dissolve amino silicon phthalocyanine (n = 1) with N,N-dimethylformamide into a 2mmol / L solution, take 3ml of mother liquor, and when the stirring speed is 100rpm, the mother liquor is injected at a rate of 0.6mL / min It was injected into 297 ml of deionized water to obtain 10 μmol / L amino silicon phthalocyanine nanosphere aqueous solution.

[0047] Experimental test of amino silicon phthalocyanine nanospheres obtained in Example 1:

[0048] 1. Singlet oxygen test

[0049] 1,3-Diphenylisobenzofuran was used as a quencher to test the ability of the sample to generate singlet oxygen. The light source is equipped with a 610nm cut-off filter (λ> 610nm) and 750nm filter (λ=750nm±10nm) 150W halogen lamp. Firstly, DPBF was prepared into an aqueous solution with a concentration of 40μM, and then 3mL of this solution was transferred to a quartz cuvette, and then the sample mother solution prepared with ...

Embodiment 2

[0057] Example 2: Taking amino silicon phthalocyanine n=2 as an example

[0058] As described in Example 1, the difference is that the amino silicon phthalocyanine (n = 1) in step (2) is replaced with an equimolar amount of n=2 amino silicon phthalocyanine, and the resulting product amino silicon phthalocyanine The cyanine nanospheres have a higher singlet oxygen production rate in deionized water after the singlet oxygen test. And it has a very good hyperthermia effect, rising to about 25°C within 5 minutes.

Embodiment 3

[0059] Example 3. Take amino silicon phthalocyanine n=3 as an example

[0060] As described in Example 1, the difference is that the aminosilicon phthalocyanine (n=1) in step (2) is replaced with an equimolar amount of n=3 aminosilicon phthalocyanine, and the resulting product aminosilicon phthalocyanine The cyanine nanospheres have a higher singlet oxygen production rate in deionized water after the singlet oxygen test. And it has a good hyperthermia effect, rising to about 23°C in 5 minutes.

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Abstract

The invention relates to an amino silicon phthalocyanine nano-sphere, a method for preparing the same and application of the amino silicon phthalocyanine nano-sphere. Amino silicon phthalocyanine is dissolved in N,N-dimethylformamide to prepare mother liquor with certain concentration, then the mother liquor is injected into deionized water, and self-assembly is carried out to form the amino silicon phthalocyanine nano-sphere. The amino silicon phthalocyanine nano-sphere, the method and the application have the advantages that red shift is carried out on absorption spectra of the amino siliconphthalocyanine nano-sphere under agglomeration effects, and accordingly the therapy depths can be increased; phthalocyanine nano-spheres have certain photo-thermal conversion capacity, photo-thermaltherapy and photodynamic therapy can be carried out in red-light and near-infrared bands, and accordingly cancer therapeutic effects can be enhanced; excellent photodynamic therapy and photo-thermal therapy synergistic effects are realized in in-vitro cell experiments, the cancer cell fatality rate can be increased, and the cancer cell therapeutic efficiency can be improved; the method for preparing the amino silicon phthalocyanine nano-sphere includes simple processes and is wide in application range.

Description

Technical field [0001] The invention relates to an amino silicon phthalocyanine nanosphere, its preparation method and its application as an anticancer drug with synergistic effects of photodynamic therapy and photothermal therapy, belonging to the field of functional materials. Background technique [0002] Cancer cells are hypoxic, which inhibits the photodynamic therapy effect of photosensitizers to a certain extent. Therefore, if a drug can perform multiple treatments at the same time, the treatment efficiency can be improved while reducing the process difficulty. Recently, the combination of photodynamic therapy and photothermal therapy to improve treatment efficiency has become a research hotspot and urgent need. [0003] Different wavelengths of light have different penetration capabilities to tissues. As the wavelength increases, the penetration depth of light into tissues gradually increases. 600-1200nm is called the "optical window" of human tissue. Light in this range ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00B82Y5/00B82Y20/00
Inventor 刘伟潘佳宝欧阳安成刘久荣
Owner SHANDONG UNIV
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