44 results about "Oxidative addition" patented technology

Reactor membranes for used in oxidation reactions of hydrocarbons involving oxygen comprising a selective oxidation catalyst on a mixed conducting, oxide ion selective ceramic membrane of the composition (Sr1-xCax)1-yAyMn1-zBzO3-delta, whereA is Ba, Pb, Na, K, Y, an element of the lanthanide group or a combination thereof,B is Mg, Al, Ga, In, Sn, an element of the 3d or 4d period or a combination thereof,x is from 0.2 to 0.8,y is from 0 to 0.4,z is from 0 to 0.6, anddelta is a number, dependent on x, y and z, that renders the composition charge neutral.

The invention discloses a preparation method for preparing sofosbuvir (Sofosbuvir,I) with uridine as a raw material and through etherification, oxidation, addition, condensation and other steps; the preparation method has the advantages of easily obtained raw materials, concise process, economy, and environmental protection, and is suitable for industrialized production.

The invention provides a synthetic method of high-purity tulathromycin. The method includes subjecting demethylated azithromycin adopted as a raw material to substitution, oxidation, addition, reduction, condensation, and the like, so as to obtain a target compound. According to the synthetic method, the cheaper raw material is adopted, and a traditional process employing low-temperature reaction is changed. The method has the advantages of short process route, easy-to-control reaction, high yield, and the like. The method is suitable for large-scale industrialized production.

The invention relates to a preparation method of a high-yield and low-cost peptizer DBD. The method comprises steps as follows: (1) desulfurizing 2-mercaptobenzothiazole to obtain benzothiazole; (2) performing alkaline hydrolysis and decarbonization on the benzothiazole to obtain 2-aminothiophnol; (3) oxidizing the 2-aminothiophnol to produce diphenyl amino disulfide; (4) performing acylation on the diphenyl amino disulfide and benzoyl chloride to produce the DBD. According to the method, the 2-mercaptobenzothiazole is used as a raw material, so that the production cost is greatly reduced; the path for synthesizing the 2-aminothiophnol is simple and convenient, workshop operation is easy, and the yield is high.

A process for preparing biphenyl polyimide includes such steps as dissolving bichlorodiphthalimide monomer, triphenylphosphino nickel as catalyst and zinc powder as reducer in non-proton solvent, reaction at 60-120 deg.C to generate Ni mating substance, oxydizing addition reaction on bichlorodiphthalimide to generate intermediate, and dereducing reaction to generate its condensate and zinc chloride while reducing Ni to react on chloroimide to generate polyimide. Its advantages are simple process and low cost.

The invention provides a palladium complex of general formula (I) or general formula (II), wherein, X represents halogen, L represents phosphorus ligand or nitrogenous ligand, G represents a sulfonic group, a carboxylic group, a phosphonate group, a hydroxy group or a polyether chain, G is positioned at para-position or meta-position of L, n represents a positive integer, and m represents 2, 3 or 4. The invention further provides a preparation method of the palladium complex, and a method for preparing a conjugated aromatic polymer by using a palladium complex catalyst. According to the invention, because a neutral hydrophilic substituent group is introduced to the palladium complex catalyst ligand, the palladium complex catalyst is amphiphilic and can simultaneously dissolved in water phase and organic phase; the catalyst undergoes oxidative addition with a polymer monomer easily, and can promote the transmetallation step to let the coupling polymerization reaction carry out continuously and rapidly, thus the conjugated aromatic polymer having high molecular weight is obtained. The conjugated aromatic polymer is represented as PdX2(L-Gn)2 (I) or Pd(L-Gn)m (II).

The invention discloses a water treatment method for oxidative degradation of organic pollutants by catalyzing monopersulfate through manganese sand, and relates to a water treatment method which solves the problems that an existing pre-oxidizing agent is poor in oxidizing ability, poisonous and harmful byproducts are liable to generate, the existing pre-oxidizing agent is inconvenient to use andoperate, and operation investment cost is high. The water treatment method comprises the following steps: adding the monopersulfate into to-be-treated water, introducing water into a filter bed with manganese sand to filter, catalyzing the monopersulfate by manganese sand to generate a sulfate radical free group to oxidize and degrade organic pollutants in water, thereby completing oxidative removal on organic substances. The monopersulfate is stable in chemical property, is convenient to transport and store, and is normally listed as a drinking water disinfector product summary in China; andthe water treatment method is simple to operate, does not need to additionally arrange equipment, does not change the original treatment process of the water feeding plant, can be applied on a large scale; and the monopersulfate is catalyzed by the manganese sand, so that the organic substance removal efficiency is high; and moreover, residual monopersulfate further can be used for sterilizing filtered water as a disinfector, so that poisonous and harmful byproducts are not generated.

The invention discloses a methodfor predicting oxidative degradation for removing dicamba in organic wastewaterofozone/hydrogen peroxide.The method includes the following steps that step 1, adynamical modelfor oxidative degradation is established, and the dynamical model is established according to free radicalchain reaction mechanism of ozone and hydrogen peroxide and dicamba containing organic wastewater; step 2, the efficiency of degrading the dicamba in the organic wastewater of the ozone/hydrogen peroxide is predicted according to the model in the step 1; step 3, degradation is executed according to results in the steps 1 and 2, and the degradation is achieved by mixing the ozone and hydrogen peroxide and the dicamba containing organic wastewater and performing degradation reaction at room temperature, wherein the ozone concentration in the mixed liquid is 0.001-1 mM, and the hydrogen peroxide concentration is 0.001-1 mM. The method can simulate the dicamba removal situation by establishing the model, and the cost is saved.

The invention relates to the field of organic chemistry, and discloses a preparation method of a deuterated benzene compound, in the method, active carbon supported noble metal is mainly used as a catalyst, deuterium water is used as a deuterium source, and the deuterated benzene compound is prepared from a benzene compound. Wherein in a reaction system, isopropanol is activated on the surface of a catalyst, trace active hydrogen is generated in situ, oxidative addition and reduction elimination reactions are carried out, and finally deuterium atoms in deuterium water and hydrogen atoms in a benzene ring compound are exchanged to generate the deuterated benzene compound. Compared with a traditional deuteration reaction, the method has the following advantages that conditions are mild, reaction raw materials are easy to obtain, and the deuteration reaction of benzene substances can be completed under the hydrogen-free condition; and in the reaction process, deuterium gas is prevented from being used as a deuterium source, so that the occurrence of excessive deuterium addition reaction and the safety problem are avoided, and the producing cost is reduced. And the reaction product is clean and has high yield.

The invention discloses a method for synthesizing amidine compounds through oxidative amidation of aryl methyl ketone under the catalysis of copper (II). The method comprises the following steps: in an oxygen-containing atmosphere and in an organic carboxylate/DMSO mixed system, performing a reaction on the aryl methyl ketone and aryl primary amine under the catalysis of divalent copper salt, or performing a reaction on the aryl methyl ketone and the aryl primary amine and secondary amine under the catalysis of the divalent copper salt to obtain the amidine compounds. By the method, the aryl methyl ketone and amine compounds are used as raw materials for producing the amidine compounds through the one-step reaction; the method has the characteristics of a simple step, low cost and the like, and is conducive to industrial production.

The invention belongs to the technical field of organic chemical synthesis and particularly relates to a preparation method of oxalyl sulfonyl hydrazide and application of the oxalyl sulfonyl hydrazide in olefin sulfonation reaction. The preparation method allows aryl sulfonyl hydrazide to have reaction with oxalyl chloride in the presence of alkali to prepare the oxalyl sulfonyl hydrazide. The invention further provides a novel method using the oxalyl sulfonyl hydrazide to have reaction with substituted olefin to prepare beta-keto-sulfone or beta-hydroxyl sulfone. The novel method uses the substituted olefin and the oxalyl sulfonyl hydrazide as the raw materials and oxygen in air as the oxidizing agent to perform oxidative addition reaction in the presence of a catalyst to generate the beta-keto-sulfone or beta-hydroxyl sulfone.

The invention which relates to alcohol compounds provides o-aminoalcohol compounds, a preparation method thereof and an application thereof. Eight natural products of o-aminoalcohols having important physiological activities and derivatives thereof are prepared through carrying out a single stereoselective synthesis and a four-step process on an amino acid which is cheap and easily available and is treated as a raw material. A one-bottle/two-step process which is adopted in oxidative addition allows a target of single stereoselectivity to be realized and C-2 racemization not to be generated in asymmetric synthesis. The activity of the compounds as an FAAH enzyme inhibitor is analyzed through active experiments, so results provide reliable and valuable basis for medicinal development. The synthetic process which has the advantages of generality, concision, high efficiency, single selectivity, cheap and easily available raw materials, and simplicity of operation and separation of each step is suitable for industrial large-scale production.

The invention discloses an acenaphtho-imidazolyl nitrogen heterocyclic carbene metal palladium complex catalyst, which is prepared by the following steps: 3-chloropyridine or pyridine is taken as an axial ligand, acenaphtho-imidazole salt is taken as a framework, and coordination is carried out on the 3-chloropyridine or pyridine and a metal ligand PdCl2 in the presence of potassium carbonate under the protection of nitrogen so as to obtain the acenaphtho-imidazole nitrogen heterocyclic carbene metal palladium complex catalyst. According to the acenaphtho-imidazole nitrogen heterocyclic carbene metal palladium complex, due to the introduction of the anthraquinone skeleton, the coordination of carbon 2 as atoms and metals is affected, the charge density of the metal center is increased, thesigma electron-donating capacity is enhanced, the oxidation addition reaction is facilitated, and the catalytic circulation is further promoted. The experimental results show that the selectivity ofthe carbonylation cyclization reaction is high (the selectivity is more than 99%) and the conversion rate is high (more than 85%) by using the acenaphtho-imidazole nitrogen heterocyclic carbene metalpalladium complex catalyst. In addition, the dosage of the catalyst is small, the reaction conditions are mild, the use of toxic phosphine ligands is avoided, and the method is safe and environment-friendly.

The invention relates to the field of unsaturated carbonic ester preparation, and discloses a catalyst and a preparation method and application thereof, and a method for preparing unsaturated carbonic ester. The catalyst comprises manganese oxide and a zinc metal organic framework compound, wherein a molar ratio of manganese element to zinc element in the catalyst is 0.3-2. The preparation method of the catalyst comprises the following steps: (1) mixing a manganese precursor with an activating agent and a first solvent, then sequentially carrying out separating, optional washing and optional drying, and then conducting roasting; and (2) mixing the obtained manganese oxide with a zinc precursor, 2-methylimidazole and a second solvent for a solvothermal reaction, and then carrying out separating, wherein a molar ratio of the usage amount of the manganese oxide in terms of elemental manganese to the usage amount of the zinc precursor in terms of elemental zinc is 0.3-2. According to the catalyst, unsaturated carbonic ester can be prepared only through one-step oxidation addition, a process is simple, and the comprehensive effect of excellent conversion rate and unsaturated carbonic ester selectivity can be obtained.

The invention provides oral liquid capable of lowering blood pressure and resisting thrombus and belongs to the technical field of biological preparations. A preparation method of the oral liquid includes: extracting laminarin; separating and purifying fucoidan; using free radicals to degrade the fucoidan in an oxidative manner, wherein choline chloride is added during the oxidative degradation of the fucoidan; dissolving; performing rough filtration; flavoring; sterilizing; filling; sealing. The oral liquid is small in molecular weight, easy to absorb, high in sulfate radical content, high in biological activity and capable of further increasing the anti-thrombus effect of the fucoidin by improving hemorheology.

The invention discloses a preparation method of isotope labeled N-(1, 3-dimethylbutyl)-N'-phenyl p-benzoquinone. The method comprises the following steps: reacting p-benzoquinone with aniline with all deuterated benzene ring hydrogen protons to obtain deuterated p-benzoquinone-2-aniline; and enabling reaction between the deuterated p-benzoquinone-2-aniline and 1, 3-dimethyl butylamine to obtain the N-(1, 3-dimethyl butyl)-N'-phenyl p-benzoquinone labeled by the isotope D. According to the invention, the continuous oxidative addition reaction of p-benzoquinone, aniline with all deuterated benzene ring hydrogen protons and 1, 3-dimethyl butylamine is adopted, so that the isotope D-labeled 6ppd-quinone can be simply and efficiently prepared under relatively mild conditions. The isotope D labeled 6ppd-quinone prepared by the method can be widely applied to content detection of environmental samples, cell and animal toxicological experiments and other related researches as a standard substance.

The invention discloses a photosensitizer with high singlet oxygen yield and a preparation method thereof. 4, 8-dibromo-6-(2-ethylhexyl)-[1, 2, 5] thiadiazole [3, 4-F] benzotriazole and 4- (4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborane-2-yl) pyridine are subjected to a Suzuki coupling reaction under the catalysis of a [1, 1'-bis (diphenylphosphino) ferrocene] palladium dichloride, and oxidation addition and reduction elimination are performed to obtain the photosensitizer. The photosensitizer disclosed by the invention has relatively strong absorption capability in visible light, is stable in structure under the condition of slight acid to weak base, has very high quantum yield and high singlet oxygen generation capability, and can be applied to fluorescence imaging or photodynamic therapy oftumors as a novel photosensitizer.