Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A photosensitizer with high singlet oxygen yield and preparation method thereof

A singlet oxygen and photosensitizer technology, applied in the field of photosensitizers, can solve problems such as hindering the development of photodynamic therapy and low singlet oxygen yield, and achieve the effects of long triplet excited state lifetime, stable structure and stable fluorescence performance.

Active Publication Date: 2022-01-21
SHANDONG UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although these current strategies have improved the singlet oxygen yield of photosensitizer molecules to a certain extent, the yield of singlet oxygen is still relatively low, and it is necessary to increase the dose to achieve the purpose of treating tumors, which is extremely difficult. Large obstacles hinder the development of photodynamic therapy in the field of cancer treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A photosensitizer with high singlet oxygen yield and preparation method thereof
  • A photosensitizer with high singlet oxygen yield and preparation method thereof
  • A photosensitizer with high singlet oxygen yield and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention.

[0024] The invention provides a photosensitizer with high singlet oxygen production rate, its structural formula is as follows:

[0025]

[0026] The preparation method of above-mentioned photosensitizer is as follows:

[0027] In the vacuum reaction bottle, pass through N for about 15 minutes. 2 , to ensure an oxygen-free environment in the vacuum reaction bottle, in the presence of N 2 Add a mixed solution of 20mL toluene solution and 5mL water into the vacuum reaction bottle as the reaction solvent, and then pass through the long needle tube to pass in N for about 20 minutes. 2 to remove oxygen from the solvent.

[0028] Join K first 2 CO 3 (129.7mg, 0.868mmol) The solid powder provides an alkaline environment, and then 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-y...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a photosensitizer with a high yield rate of singlet oxygen and a preparation method thereof. The Suzuki coupling reaction is adopted to synthesize 4,8-dibromo-6-(2-ethylhexyl)-[1,2, 5] Thiadiazo[3,4-F]benzotriazole and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolin-2-yl)pyridine , under the catalysis of [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride, the photosensitizer is obtained through oxidative addition and reductive elimination. The photosensitizer disclosed by the invention has a strong absorption ability in visible light, has a stable structure under slightly acidic to weakly alkaline conditions, and has a high quantum yield and high singlet oxygen generation ability, and can be used as a new photosensitizer. Fluorescence imaging or photodynamic therapy of tumors.

Description

technical field [0001] The invention relates to a photosensitizer, in particular to a photosensitizer with high singlet oxygen yield and a preparation method thereof. Background technique [0002] Traditional cancer treatments such as chemotherapy, surgery, and radiotherapy have strong side effects, such as damage to normal cells and the nervous system, and are often accompanied by a high recurrence rate. Therefore, developing a safe and effective cancer treatment is an urgently needed research topic. In recent years, photodynamic therapy has attracted extensive attention due to its low toxicity, wide anti-tumor selectivity and minimal invasiveness. The main building block in photodynamic therapy is the photosensitizer molecule. Among them, the photosensitizer absorbs light from a specific wave source (visible light or near-infrared) and is excited from the ground state to the singlet excited state, and then undergoes an intersystem crossing process to transform into a tri...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D513/04C09K11/06A61K41/00A61P35/00
CPCC07D513/04C09K11/06A61K41/0057A61P35/00C09K2211/1081C09K2211/1029
Inventor 吕世博苗钰阳刘大鹏宋锋玲
Owner SHANDONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com