5 results about "Sulfohydrazide" patented technology

The application relates to the technical field of pharmaceutical chemistry, and discloses a sulfuryl hydrazone compound, a preparation method thereof and anti-tumor application. The compound is synthesized from isatin derivatives and sulfuryl hydrazine through two-step nucleophilic substitution-elimination reaction, has a chemical structure as shown in formula (I), and is characterized by 1H NMR, 13C NMR and HRMS. The sulfuryl hydrazone compound has significant inhibitory activity on A549 (lung cancer), HepG2 (liver cancer) and Hela (cervical cancer) three human cancer cell strains, the value of some compounds is as low as 0.03 micromole / L, the compound can induce cell apoptosis by mediating ROS generation in tumor cells, inhibiting the NF-kappa B signal pathway and activating Caspase-3 activity, and can effectively inhibit cancer cell migration and colony formation. The compound has a mild synthesis process, simple operation and wide substrate applicability, can be used as a potential anti-tumor active ingredient, can be used for preparing drugs for resisting lung cancer, liver cancer, cervical cancer and other tumors, and can provide new candidate compounds and technical support for cancer treatment.

The application provides a self-repairing stretch silver paste, a preparation method and application thereof.The self-repairing stretch silver paste comprises the following raw materials: conductive silver paste, pore-forming agent and silicon modified resin; and the pore-forming agent is at least one of p-toluenesulfonyl hydrazide, sodium bicarbonate, molecular sieve and 4,4'-oxobenzene sulfonyl hydrazide.The self-repairing stretch silver paste of the application comprises the pore-forming agent and the silicon modified resin in addition to the conventional conductive silver paste, so that the silver paste can form an elastic conductor with porous cavities after gradient curing, the displacement of the conductive filler is reduced through the stress deformation of the cavities, the resistance recovery hysteresis is significantly improved, and the resistance deterioration is reduced; the obtained silver paste has fast resistance recovery speed, low hysteresis and excellent conductive stability under 50% stretch deformation, and is suitable for repeated deformation scenes such as flexible sensors, wearable devices and flexible circuits.

This invention discloses a sulfonylpyridinone compound, its preparation method, and its applications. The compound is prepared by introducing a sulfonyl group at the 4-position of pyridazin-3(2H)one, giving it multiple functional groups such as sulfone, phenyl, and pyridazinone. The sulfonylpyridinone compound of this invention exhibits a certain antibacterial effect against *Escherichia coli* / *Staphylococcus aureus* and can be used to prepare broad-spectrum antibacterial drugs. Due to its multifunctional nature involving flame retardant groups, this compound is expected to be applied in the flame retardant field. This invention also provides a method for preparing the above-mentioned sulfonylpyridinone compound, achieved through a dehalogenation sulfonation reaction of 4,5-dihalo-2-phenylpyridazin-3(2H)one with sulfonylhydrazine. This reaction process not only avoids transition metal catalysis and the addition of oxidizing or reducing agents, but also features a simple reaction system, a wide range of applicable substrates, and a high yield, which is beneficial for industrial production.

The application relates to a method for preparing 1,2-bis(4-vinylphenyl)ethane and relates to the technical field of organic chemistry, wherein the preparation method comprises the following steps: (1) mixing compound 1, p-toluenesulfonyl hydrazide and organic solvent 1, and then performing reaction to obtain compound 2; (2) reacting the compound 2 in organic solvent 2 under the action of alkali and a polymerization inhibitor to generate 1,2-bis(4-vinylphenyl)ethane. The method has the advantages of mild reaction conditions, simple operation, high product purity, high yield and suitability for industrial production.

This invention relates to an electrochemical synthesis method for fully substituted sulfonated pyrazole compounds. The method includes the following steps: mixing acetylacetone, substituted arylsulfonyl hydrazides, and an electrolyte, adding the mixture to a mixed solvent to obtain a mixed solution; subjecting the mixed solution to an electrochemical reaction to obtain a reaction mixture; and separating and purifying the reaction mixture to obtain the fully substituted sulfonated pyrazole compounds. Compared with existing technologies, this invention uses an electrochemical method to prepare fully substituted sulfonated pyrazole compounds. During the reaction, an iodine-containing electrolyte undergoes an oxidation reaction at the anode to generate iodine free radicals. These iodine free radicals then react with arylsulfonyl hydrazides and acetylacetone with different substituents to form the fully substituted sulfonated pyrazole compounds. This method has advantages such as simple preparation, convenient operation, high atom utilization, and mild reaction conditions.