50 results about "Sulfohydrazide" patented technology

The invention discloses a perovskite solar cell doped with a sulfonyl hydrazide foaming agent and a preparation method thereof, and belongs to the field of photovoltaic power generation, a perovskite light absorption layer is FA1-x-yMAxCsyPb (I1-zBrz) 3 doped with the sulfonyl hydrazide foaming agent, x is equal to 0-1, y is equal to 0-1, and z is equal to 0-1. The sulfonyl hydrazine foaming agent interacts with uncoordinated Pb < 2 + > and I <->, and the sulfonyl hydrazine foaming agent is decomposed in the thermal annealing process to induce crystal grains to realize secondary fusion growth, so that defects in the perovskite light absorption layer are effectively passivated, recombination of photon-generated carriers of the perovskite solar cell is reduced, and the photoelectric conversion efficiency of the perovskite solar cell is improved. The open-circuit voltage, the fill factor and the photoelectric conversion efficiency of the perovskite solar cell are obviously improved, and the device efficiency PCE exceeds 26%; according to the preparation method provided by the invention, the p-i-n inversion structure device is prepared by spin coating through a one-step method, the preparation process is simple and convenient, and the cost is low.

The application provides a reverse Markovnikov hydroamination reaction of trifluoromethyl enone under catalyst-free and base-free conditions, uses a sulfonhydrazide compound with good functional group tolerance as a nitrogen source, realizes the introduction of a nitrogen-containing functional group in a green and environment-friendly manner, and synthesizes a series of alpha-sulfonhydrazine-alpha-hexafluoroisopropyl-substituted carbonyl compounds. The method has the characteristics of no transition metal participation, mild conditions, wide substrate universality and the like.

The invention discloses benzaldehyde p-toluenesulfonyl hydrazone and a synthesis method thereof, and belongs to the technical field of organic compounds. The preparation method comprises the following steps: mixing benzaldehyde, p-toluenesulfonyl hydrazide and water, and carrying out condensation reaction to obtain benzaldehyde p-toluenesulfonyl hydrazone. According to the method, green and environment-friendly water is adopted as a solvent, the reaction temperature is mild, purification is easy, the requirement for equipment is low, the purity of the obtained benzaldehyde p-toluenesulfonyl hydrazone is larger than 99.5%, and the yield reaches up to 99.9% or above.

The invention relates to a thermally expandable composition comprising: a) At least one thermoplastic polymer TP and / or at least one solid rubber R and b) At least one polymeric blowing agent BA selected from the group consisting of sulfonyl hydrazide-functionalized polymers, sulfonyl semicarbazide-functionalized polymers, carbamate-functionalized polymers, and ureido carbamate-functionalized polymers, wherein the polymeric blowing agent BA has a number average molecular weight (Mn) determined by gel permeation-chromatography (GPC) using polystyrene 0 as standard of at least 500 g / mol, preferably at least 750 g / mol.

The application belongs to the technical field of polyvinyl chloride foam material preparation, and particularly relates to a polyvinyl chloride foam material for offshore operation and a preparation method thereof. The polyvinyl chloride foam material for offshore operation comprises polyvinyl chloride resin as a base resin, silane-modified aluminum borate nanometer whisker, 1-(9,10-epoxy octadecanoyloxy)-3-(2-methylprop-2-enoyloxy)propan-2-ol and oleic acid-modified Mg-Al-Zn ternary intercalation hydrotalcite as modified raw materials, 4,4'-diphenyl methane diisocyanate and 4,4'-dicyclohexyl methane diisocyanate are compounded to construct a soft and hard synergistic crosslinking network, azodicarbonamide, benzene-1,3-disulfonyl hydrazide and zinc oxide are compounded to form a foaming agent to realize gradient nucleation foaming, and a heat stabilizer, a light stabilizer and an antioxidant are further added. As a result, the synergistic effect between the raw materials enables the polyvinyl chloride foam material to have excellent salt mist resistance and impact resistance.

The invention relates to a method for preparing 1, 2-bis (4-vinylphenyl) ethane, and relates to the technical field of organic chemistry, the preparation method comprises the following steps: (1) mixing a compound 1, p-toluenesulfonhydrazide and an organic solvent 1, and reacting to obtain a compound 2; and (2) reacting the compound 2 in an organic solvent 2 under the action of alkali and a polymerization inhibitor to generate the 1, 2-bis (4-vinyl phenyl) ethane. The method is mild in reaction condition, simple and convenient to operate, high in product purity, high in yield and suitable for industrial production.

The invention relates to the technical field of yoga mat production, in particular to a uniformly foamed yoga mat and a preparation method thereof, polyvinyl chloride resin is used as a main component, and polyformaldehyde resin and polymethyl methacrylate resin are added as reinforcing components; the wear resistance, the elasticity, the heat resistance, the cold resistance and the corrosion resistance of the traditional PVC yoga mat can be improved; moreover, aiming at the mixed raw material of the polyvinyl chloride resin, the polyformaldehyde resin and the polymethyl methacrylate resin, three foaming agents with different decomposition temperatures, namely toluenesulfonyl hydrazide, di (benzenesulfonyl hydrazide) ether and p-toluenesulfonyl semicarbazide, are added, and three stages are set in the foaming stage, so that the foaming performance of the polyvinyl chloride resin, the polyformaldehyde resin and the polymethyl methacrylate resin is improved. Different foaming temperatures and foaming time are controlled in each stage, so that the mixed raw materials can be foamed more sufficiently, the foaming of the foaming materials is ensured to be more uniform, and the quality of the yoga mat is improved.

The application relates to the technical field of pharmaceutical chemistry, and discloses a sulfuryl hydrazone compound, a preparation method thereof and anti-tumor application. The compound is synthesized from isatin derivatives and sulfuryl hydrazine through two-step nucleophilic substitution-elimination reaction, has a chemical structure as shown in formula (I), and is characterized by 1H NMR, 13C NMR and HRMS. The sulfuryl hydrazone compound has significant inhibitory activity on A549 (lung cancer), HepG2 (liver cancer) and Hela (cervical cancer) three human cancer cell strains, the value of some compounds is as low as 0.03 micromole / L, the compound can induce cell apoptosis by mediating ROS generation in tumor cells, inhibiting the NF-kappa B signal pathway and activating Caspase-3 activity, and can effectively inhibit cancer cell migration and colony formation. The compound has a mild synthesis process, simple operation and wide substrate applicability, can be used as a potential anti-tumor active ingredient, can be used for preparing drugs for resisting lung cancer, liver cancer, cervical cancer and other tumors, and can provide new candidate compounds and technical support for cancer treatment.

This invention discloses a method for preparing high-performance tin-containing perovskite solar cells using bifunctional acylhydrazide small molecules. The method focuses on selecting bifunctional acylhydrazide small molecules such as p-toluenesulfonylhydrazide (PTSH) and oxaloyl dihydrazide (ODZ) as additives to enhance the performance of tin-containing perovskite (ASn) solar cells. x Pb 1‑x X3) Modification of the active layer of solar cells. Compared to traditional Sn 2+ The coordination strategy of the bifunctional hydrazide small molecule selected in this invention can, in addition to coordinating with Sn... 2+ In addition to providing an antioxidant environment through coordination, Sn can also achieve... 4+ To Sn 2+ The reduction of Sn in perovskite films can be minimized. 4+ This leads to the P-type self-doping effect and defect density. The photoelectric conversion efficiency and device stability of the tin-containing perovskite solar cells prepared based on this invention are effectively improved.

The invention discloses a sulfonylation method of halogenated quinoline and aryl sulfonyl hydrazide, which is characterized in that a halogenated quinoline compound and aryl sulfonyl hydrazide are subjected to sulfonylation reaction in a solvent to obtain a target compound. The invention provides a simple method for the composition of the sulfonylquinoline without adding any catalyst and additive, and the method is green and environment-friendly, the reaction conditions are simpler and milder, and the method has the characteristics of simple post-treatment, green steps, low pollution, high economic benefit and the like.

The invention relates to a process for producing polyurethanes using a component A comprising a polyhydrazide, a polysemicarbazide, a polysulfonyl hydrazide and / or carbodihydrazide, in particular a polyhydrazide, wherein the component A is employed in the form of a mixture C which further comprises a component B comprising a dispersion medium.

This invention discloses the preparation and application of an oxygen-modified carbon catalyst with adjustable surface carbon group number. The catalyst is prepared by using Ketjen black as a carbon substrate and ethylenediaminetetraacetic acid as an oxygen source, through stepwise oxygen addition (including surface oxidation and pyrolysis of oxygen-containing precursors) to modify the carbon substrate, thus obtaining the target catalyst. The number (concentration) of carbonyl groups at activated persulfate sites on the catalyst surface can be controlled by adjusting the pyrolysis temperature or by modifying the surface with glutaraldehyde or / and dansyl hydrazine. This concentration change causes an electron distribution between adjacent carbonyl groups, i.e., the intersitu spacing effect; utilizing this effect, efficient purification of water bodies contaminated with organic pollutants and effective soil remediation can be achieved.

The invention discloses a composite sewage treatment agent as well as a preparation method and application thereof, and relates to the technical field of water treatment. When the composite sewage treatment agent is prepared, firstly, 1, 3, 6, 8-pyrene tetrasulfonic acid tetrasodium salt is treated through thionyl chloride and then reacts with hydrazine hydrate to obtain pyrene sulfonyl hydrazide, and oxidized cellulose, pyrene sulfonyl hydrazide and polyethylene glycol react to obtain porous cellulose; secondly, reacting the maleic anhydride esterified starch with 4-mercaptophthalonitrile, then carrying out ammonia gas treatment, and then reacting with boron chloride subphthalocyanine to obtain modified starch; finally, mixing the modified cellulose, the modified starch and an initiator to obtain the composite sewage treatment agent. The composite sewage treatment agent prepared by the invention has good adsorbability, antibacterial property and photocatalytic degradation property.

The invention belongs to the technical field of organic synthesis, and particularly relates to a benzenesulfonyl hydrazide derivative, a preparation method and application. Under electrochemical reaction conditions, cheap and easily available ketone, benzenesulfonyl hydrazide and corresponding sodium benzenesulfinate are used as raw materials, acetonitrile (CH3CN) / water (H2O) is used as a solvent, triethylamine (Et3N) is used as alkali, the benzenesulfonyl hydrazide derivative is prepared at room temperature and in an air atmosphere, and the benzenesulfonyl hydrazide derivative has potential medicinal value and is widely applied to the fields of pesticides and medicines. Compared with a previously reported preparation method, the method has the advantages of being green, environmentally friendly, safe, efficient and energy-saving, raw materials are easy to obtain, operation is easy and convenient, and potential industrial application prospects are achieved.

The invention relates to the technical field of vitamin intermediates, and particularly discloses a preparation process of a vitamin D3 key intermediate 7-p-toluenesulfonyl epide-3-cholesteryl ester. The invention relates to a preparation process of a vitamin D3 key intermediate 7-p-toluenesulfonylepide-3-cholesteryl ester, which comprises the following steps: reaction: adding 7-keto-3-cholesteryl ester, p-toluenesulfonhydrazide and concentrated hydrochloric acid into methanol, heating to 45-50 DEG C, and carrying out heat preservation reaction for 6.5-7.5 hours; post-treatment: after the reaction is finished, cooling crystallization and suction filtration are performed to obtain a solid, the solid is eluted by using iced methanol, suction drying is performed to obtain a washing solution and a filter cake, and the filter cake is subjected to vacuum drying to constant weight to obtain the product 7-p-toluenesulfonylepide-3-cholesteryl ester. The concentrated hydrochloric acid is used as a catalyst, and the reaction is carried out at 45-50 DEG C for 6.5-7.5 h, so that the reaction is mild, the energy consumption is reduced, and the production efficiency of the 7-p-toluenesulfonylepide-3-cholesteryl ester is improved.

The invention discloses a (2, 3-indoline-(thio) carbonyl) substituted sulfonyl hydrazide compound as well as a preparation method and application of the (2, 3-indoline-(thio) carbonyl) substituted sulfonyl hydrazide compound. The structural formula is shown as a formula I. The N '-(2, 3-indoline-1-(thio) carbonyl) substituted sulfonyl hydrazine compound is obtained by introducing a sulfonyl fragment into a substituted benzaldehyde semicarbazone (thio) urea skeleton containing a 2, 3-indoline-1-(thio) carbonyl fragment, and the N'-(2, 3-indoline-1-(thio) carbonyl) substituted sulfonyl hydrazine compound is novel in structure, the preparation method is simple to operate, raw materials are easy to obtain, and harmful by-products are not easy to generate; the compound disclosed by the invention shows an inhibition effect on various plant pathogenic bacteria, particularly has an obvious inhibition effect on cucumber bacterial angular leaf spot bacteria, can be used as an agricultural bactericide, and has a great application value.

The invention discloses a method for synthesizing a thiosulfonate compound through aerobic oxidative coupling, and relates to the technical field of organic synthesis.The synthesis method comprises the steps that a nitrogen-doped carbon-loaded cobalt-based catalyst is adopted, and in the oxygen or air atmosphere, a sulfydryl-containing compound and sulfonyl hydrazide are catalyzed to be subjected to an oxidative coupling reaction; the preparation process of the catalyst comprises the following steps: reacting cobalt salt with sodium dicyandiamide in a water phase to generate a dicyandiamide cobalt complex; mixing the complex with an ionic liquid containing dicyandiamide anions in proportion, stirring and drying to obtain an ionic liquid precursor of metal cobalt; and carbonizing the obtained precursor at a high temperature of 500-1000 DEG C in an inert atmosphere, etching for 2-10 hours by using a 1-6 mol / L hydrochloric acid solution, washing to be neutral, and drying to obtain the nitrogen-doped carbon-loaded cobalt-based catalyst. The catalyst used in the method is green, economical and recyclable, the reaction process is mild in condition and simple and convenient to operate, the product yield is excellent, and the method has a good application prospect.

The application discloses a method for sulfonylating halogenated quinoline and aryl sulfonohydrazide, wherein the halogenated quinoline compound and the aryl sulfonohydrazide are subjected to a sulfonylating reaction in a solvent to obtain a target compound. The application provides a simple method for forming a sulfonyl quinoline without adding any catalyst and additive, and the method is green and environment-friendly, and the reaction condition is simple and mild, and the method has the characteristics of simple post-treatment, green step, low pollution, high economic benefit and the like.

The application provides a self-repairing stretch silver paste, a preparation method and application thereof.The self-repairing stretch silver paste comprises the following raw materials: conductive silver paste, pore-forming agent and silicon modified resin; and the pore-forming agent is at least one of p-toluenesulfonyl hydrazide, sodium bicarbonate, molecular sieve and 4,4'-oxobenzene sulfonyl hydrazide.The self-repairing stretch silver paste of the application comprises the pore-forming agent and the silicon modified resin in addition to the conventional conductive silver paste, so that the silver paste can form an elastic conductor with porous cavities after gradient curing, the displacement of the conductive filler is reduced through the stress deformation of the cavities, the resistance recovery hysteresis is significantly improved, and the resistance deterioration is reduced; the obtained silver paste has fast resistance recovery speed, low hysteresis and excellent conductive stability under 50% stretch deformation, and is suitable for repeated deformation scenes such as flexible sensors, wearable devices and flexible circuits.

The invention provides an alkyl chain terminal deuterium-labeled fatty aldehyde compound as well as a preparation method and application thereof, and aims to overcome the defects of high cost, complicated steps, expensive raw materials and the like in the conventional alkyl chain terminal deuterium-labeled fatty aldehyde preparation technology in view of the demand of research on fatty aldehyde, sphingosine and ceramide on labeled compounds thereof. According to the preparation method, the aliphatic methyl ketone compound is taken as a raw material, and the preparation problem is successfully solved through multiple steps of reactions such as hydroxyl protection, D-H exchange, reaction with p-toluenesulfonhydrazide, deprotection group, oxidation reaction and the like and by optimizing conditions of each step, such as the ratio of a specific protection group reagent to alkali, the accurate reaction material ratio, the proper reaction temperature and the like. The method synthesizes a high-abundance and high-quality target compound, can be used for researching metabolic pathways and disease mechanisms in organisms, can be used as an internal standard substance to improve the quantitative detection precision, provides powerful support for related research and synthesis of various hot compounds, and promotes the field development.

The present invention discloses a gem-difluoroallyl compound and a preparation method thereof, and belongs to the technical field of pharmaceutical intermediates and organic synthesis. The present invention uses various natural or non-natural aldehydes and ketones to react with sulfonyl hydrazide to obtain the corresponding N ‑Sulfonylhydrazone, with 3,3‑difluoroallyl sulfide in NaOH, KOH, LiO t Bu、NaO t Bu、Cs 2 CO 3 Under alkaline conditions, Rh(OPiv) 2 ] 2 、[Rh(OAc) 2 ] 2 , [Rh(esp)] 2 、Ru(PPh 3 ) 2 Cl 2 、[Ru( p ‑cymene)Cl 2 ] 2 , Pd 2 (dba) 3 、Ag 2 CO 3 、AgSbF 6 、Cu(MeCN) 4 PF 6 The method of the present invention has a very wide substrate adaptability, the starting raw materials of the reaction, aldehydes and ketones, are cheap and easy to obtain, the reaction process is simple to operate, suitable for large-scale synthesis, and can also provide a new method and new target for the synthesis and modification of drugs.

The invention discloses a preparation method of a thiocarbamate compound. According to the method, an isocyanide compound and a sulfinic acid compound are used as raw materials, and a series of target products are conveniently prepared under the condition of an oxidizing agent. The method disclosed by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, very simple reaction system, convenience in operation, good substrate universality, high target product yield, safe production and environmental friendliness, and is suitable for industrial production. According to the process, sulfinic acid compounds are used as raw materials, so that the unpleasant smell of thioether and mercaptan and the hidden danger of safe production in the prior art are avoided; meanwhile, a series of problems that thiosulfonate, sulfonyl hydrazide and the like need to be prepared in advance, the technological process is tedious and the like are solved.

The present invention discloses a preparation method of a polycyclic ketone derivative, which is obtained by adding a cyano-containing 1,6-enyne compound and a sulfonylhydrazide compound into a reactor, then adding a solvent and an oxidant, and after the reaction is complete, separating and purifying. The present invention only needs one step to construct four new chemical bonds and form two new rings, providing a new method for synthesizing polycyclic ketone derivatives. Moreover, this method does not require the use of a catalyst and a base, greatly reducing the manufacturing cost; and the substrate has a wide adaptability range, the operation is simple, the reaction is green and mild, and it is particularly suitable for industrial production.

The invention belongs to the technical field of organic synthesis, and discloses a toluenesulfonyl diazo diphenyl phosphorus compound as well as a preparation method and application thereof. The structural formula of the toluenesulfonyl diazo diphenylphosphine compound is as shown in formula I in the specification. The preparation method comprises the following preparation steps: adding p-toluenesulfonyl hydrazide into an organic solvent, stirring and dissolving uniformly, cooling to 5-10 DEG C, dropwise adding diphenyl phosphorus chloride, and stirring at room temperature for reaction; and after the reaction is finished, heating to 40-50 DEG C, dropwise adding hydrogen peroxide, heating to reflux temperature, carrying out reflux reaction, standing and layering after the reaction is finished to remove a water phase layer, and concentrating and crystallizing an organic phase to obtain the toluenesulfonyl diazo diphenylphosphine compound. The toluenesulfonyl diazo diphenyl phosphorus compound disclosed by the invention can be applied as a photoinitiator. And the synthesis method is simple, mild in reaction condition, wide in raw material source, relatively low in production cost and easy for industrial application. # imgabs0 #

The invention discloses a method for preparing deoxycholic acid. Specifically, the preparation method comprises the following steps: step 1, in the presence of a solvent and N-bromosuccinimide, carrying out oxidation reaction on a compound 2 to prepare a compound 3; 2, under the condition of a solvent, the compound 3 and p-toluenesulfonhydrazide are subjected to a condensation reaction, and a compound 4 is prepared; 3, in the presence of a solvent and sodium borohydride, the compound 4 is subjected to a reduction reaction, and deoxycholic acid is prepared. The method is mild in reaction condition, environmentally friendly, high in efficiency, low in cost and suitable for industrial production.

The present invention discloses a β-ketosulfone compound and a synthesis method thereof, belonging to the field of chemical synthesis technology. The present invention uses an enol ester compound and a sulfonylhydrazide compound to synthesize the β-ketosulfone compound through electrochemical redox catalysis. This method has the advantages of being green, sustainable, highly efficient, and using mild conditions, and avoids the use of additional oxidants or reducing agents.

The application discloses a novel and efficient electrochemical catalytic synthesis of sulfone isoxazole derivatives. The method uses beta, gamma-unsaturated ketone oxime and p-toluenesulfonyl hydrazine as starting materials, under the condition of C(+) / C(-) as an electrode, a current of 10 mA, and reaction at room temperature for 4 h, the oxidation sulfonation reaction of the alkenyl oxime substrate can be smoothly realized, and sulfone isoxazole derivatives are obtained. The sulfone radical is generated by anodic single electron oxidation of p-toluenesulfonyl hydrazine, then the radical addition is carried out on the alkenyl oxime, the benzyl radical is generated, then the radical oxidation reaction of the benzyl position and the intramolecular nucleophilic cyclization reaction are further carried out at the anode to generate the sulfone isoxazole product. Compared with the traditional synthesis scheme, the application only needs to add inorganic electrolyte as a conductive medium under mild conditions, without the addition of metal and additional oxidants, and the sulfone group can be introduced into the skeleton of the isoxazole ring under the electrochemical condition, and the aryl alkyl sulfone compound constructed is widely used in medicines, biologically active products and materials, and has important biological and synthetic research value.

The invention discloses a synthesis method of 2, 4, 5-trifluorophenylacetic acid, and relates to the technical field of organic chemical industry, 2, 4-dichloro-5-fluorobenzoyl chloride is firstly subjected to cyanation to generate 2, 4-dichloro-5-fluorobenzoyl nitrile, then the 2, 4-dichloro-5-fluorobenzoyl nitrile and potassium fluoride are subjected to halogen exchange reaction in the presence of a phase transfer catalyst to generate 2, 4, 5-trifluorobenzoyl nitrile, and the 2, 4, 5-trifluorophenylacetic acid is obtained. The 2, 4, 5-trifluorophenylacetic acid is prepared from 2, 4, 5-trifluorophenylacetic acid and 2, 4, 5-trifluorophenylacetic acid as raw materials, then reduction is performed under p-toluenesulfonhydrazide and sodium borohydride, and hydrolysis is performed under an acidic condition to generate 2, 4, 5-trifluorophenylacetic

The invention relates to a method for preparing alpha-hydroxyamide by reducing alpha-ketoamide through sulfonyl hydrazide. The method comprises the following steps: in the presence of alkali and aryl sulfonyl hydrazide, reacting alpha-ketoamide in an organic solvent at 80-100 DEG C for 3-5 hours, and selectively reducing keto carbonyl in the alpha-ketoamide to obtain alpha-hydroxyamide. The preparation method disclosed by the invention is efficient, novel, simple and convenient to operate, cheap and easily available in raw materials and high in yield, and the obtained alpha-hydroxyamide intermediate is expected to be widely applied to the fields of medicine and chemical industry.

The invention discloses a sulfonyl pyridazinone compound as well as a preparation method and application thereof, and the compound is characterized in that sulfonyl is introduced into 4-position C of pyridazine-3 (2H) ketone, so that the compound has multiple functional groups such as sulfonyl, phenyl and pyridazinone. The sulfonyl pyridazinone compound disclosed by the invention has a certain antibacterial effect on escherichia coli / staphylococcus aureus, and can be used for preparing broad-spectrum antibacterial drugs. Due to the characteristic of multiple flame-retardant functional groups, the compound is expected to be applied to the field of flame retardance. The invention also provides a preparation method of the sulfonyl pyridazinone compound, the preparation method is realized through a dehalogenation sulfonylation reaction of 4, 5-dihalo-2-phenylpyridazine-3 (2H) ketone and sulfonyl hydrazine, the reaction process does not have transition metal catalysis and does not need to add an oxidizing agent or a reducing agent, and the preparation method also has the characteristics of simple reaction system, wide substrate application range and relatively high yield, and is suitable for industrial production. The industrial production is facilitated.