204 results about "Sulfohydrazide" patented technology

The invention provides a method for preparing sludge-based formed magnetic active carbon. The method comprises the steps as follows: sludge is used as a raw material, an activating agent is added for carbonizing and activating the sludge; nano-sized Fe3O4 is used as a magnetic source for magnetizing the sludge active carbon; and sodium carboxymethylcellulose and aluminum salt are composited to an organic-inorganic binding agent, the binding agent and a p-toluenesulfonhydrazide foaming agent are used for uniformly binding powdery magnetic active carbon into a formed magnetic active carbon precursor with abundant pore structures, and finally, the formed magnetic active carbon precursor is heated to obtain the sludge-based formed magnetic active carbon. According to the method, the sludge is used as a main raw material, the resource utilization of the sludge is achieved, the recycling is convenient, and reutilization can be achieved; and further, the sludge-based formed magnetic active carbon has a stable structure and good magnetic stability, and can be widely used in the fields such as sewage treatment, soil pollution treatment and the like.

A multi-stage emulsion processing aid polymer comprising one or more functionalized ethylenically unsaturated monomer into the emulsion polymerization reactor, wherein the functionality is selected from the group consisting of β-keto esters, β-keto amides, β-diketones, cyanoacetic esters, malonates, nitroalkanes, β-nitro esters, sulfonazides, thiols, thiol-s-triazines, and amine, where the functionality is incorporated into polymers by polymerizing, ethylenically unsaturated monomers containing these functionalities or by post functionalization of a polymer with additional reactions after polymerization in one of the first or second stages. Foamable halogenated polymers comprising the multi-stage emulsion processing aid polymer is also provided. Also provided are methods for making the multi-stage emulsion processing aid polymer and foamable halogenated polymers.

The invention discloses an electrochemical catalysis synthesis method of a 3-sulfonyl substituted oxo indoles compound, and belongs to synthesis of compounds. The method uses a sulfoacid reagent represented by a formula (III) or sulfonyl hydrazine represented by a formula (V) or N-substituted acrylamide represented by a formula (II) as a raw material in a single-cell electrolytic tank; and in presence of an electrocatalyst, the raw material is electrolyzed in electrolyte at a certain temperature to obtain the 3-sulfonyl substituted oxo indoles compound represented by a formula (I). The method firstly adopts an operation-simple electrochemical catalysis indirect electrolysis method to synthesize the 3-sulfonyl substituted oxo indoles compound, uses the single-cell electrolytic tank and constant-current electrolysis, uses a cheap and easy-obtained graphite piece as a working electrode, largely reduces the cost, in particular, reduces heavy metal or chemical-metered oxidant, prevents generation of chemical wastes, is simpler in operation, and is more suitable for industrial production.

The invention discloses a method for synthesizing 2-sulfonyl ketone compounds. The method comprises the following steps: mixing substituted N-vinyl acetamide, sulfohydrazide compounds, a catalyst, an oxidant and a solvent to obtain a mixed liquid; and reacting for 2-12 hours at 20-120 DEG C; and then, decompressing to remove the solvent and separating to obtain the 2-sulfonyl ketone compounds, wherein the catalyst is organic amine salt, the oxidant is peroxide and the molar ratio of the sulfohydrazide compound to the substituted N-vinyl acetamide is (1-3):1. The invention provides a new route for synthesizing the 2-sulfonyl ketone compounds. By taking N-vinyl acetamide and the sulfohydrazide compounds as raw materials, the substrate is good in adaptability and corresponding 2-sulfonyl ketone compounds can be synthesized by various substituents. The method is mild in reaction condition, safe and environmental friendly and free from exhaust gases.

The invention discloses a convenient and efficient preparation method of benzofuran or indole. The preparation method comprises the following steps of: reacting various natural or non-natural aldehyde ketone with sulfonylhydrazine to obtain corresponding hydrazone; and reacting the hydrazone with substituted ortho-hydroxybenzene acetylene or substituted ortho-aminobenzene acetylene in a basic condition by using a copper compound as a catalyst in an organic solvent to obtain the derivative of benzofuran or indole. The method has wide substrate adaptability, can be used for synthesizing various benzofuran or indole compounds carrying different substituents, uses the copper compound with low price as a catalyst, has low price and easily available initial raw materials in the reaction, namely aldehyde ketone and ortho-hydroxybenzene acetylene or ortho-aminobenzene acetylene, as well as is convenient operation in the reaction process, and is suitable for large-scale synthesis.

The invention relates to a preparation method of a sulfuryl fluoride compound. A sulfonyl hydrazide compound and a fluoride reagent serve as reaction raw materials. The preparation method includes the steps that a, the sulfonyl hydrazide compound with the structure (I) and the fluoride reagent are dispersed in a solvent, wherein the structure (I) is shown in the specification; b; a mixture obtained from the step a is stirred and heated to obtain the sulfuryl fluoride compound with the structure (II), wherein the structure (II) is shown in the specification (II). Compared with existing related technologies in the chemical synthesis field, the method of preparing sulfuryl fluoride from sulfonyl hydrazide is achieved for the first time. In the method, no catalyst needs to be added, reaction conditions are moderate, good compatibility can be achieved for water and air, and large-scale production is easy to achieve. The experimental result indicates that the yield of the obtained sulfuryl fluoride compound can reach up to 98%.

The invention relates to the technical field of medicine chemical engineering and particularly relates to a synthesis method of 25-hydroxycholesteryl acetate-7-p- toluenesulfonylhydrazone. The synthesis method includes following steps: (1) performing a reaction between 25-hydroxy-7-ketocholesteryl acetate and p-toluenesulfonylhydrazide under a mechanical grinding condition; and (2) performing recrystallization to a reaction product in the step (1) to obtain the 25-hydroxycholesteryl acetate-7-p-toluenesulfonylhydrazone. The method is free of an acidic catalyst, is greatly reduced in usage of organic solvent, is simple in operation, is high in yield, is less in waste gas, waste water and solid waste and is simple in post-treatment. The product is easy to separate and purify.

The invention provides a preparation method for alpha-iodo-beta-arylketo-substituted sulfone compounds. The preparation method comprises the following steps: taking olefin nitrine, sulfohydrazide and potassium iodide as starting raw materials; and in an organic solvent, taking tert-butyl hydroperoxide as an oxidizing agent, and reacting to generate the alpha-iodo-beta-arylketo-substituted sulfone compounds, wherein a molar ratio of olefin nitrine to sulfohydrazide to potassium iodide to tert-butyl hydroperoxide is 1:2:2:2, the reaction temperature is the room temperature, and the reaction time is 2-4 hours. The preparation method provided by the invention is reasonable in design, adopts easily available raw materials, does not need a metal catalyst, is gentle in reaction condition, is free of high-temperature flux, is safe and convenient and is high in yield, and the yield of most products is 70% or higher, so that the preparation method is a method, which is simple to operate, quick, gentle and diversified, for constructing the alpha-iodo-beta-arylketo-substituted sulfone compounds, wherein the three starting raw materials can be obtained through a one-step process, and the reaction raw materials are cheap and easily available; and the formulas of the alpha-iodo-beta-arylketo-substituted sulfone compounds are as shown in the specification.

The invention relates to a synthetic method of biphenyl compounds. Based on novel coupling reaction of phenylhydrazine or benzenesulfonyl hydrazide, the phenylhydrazine or benzenesulfonyl hydrazide is used as a substrate, and coupled after being acted by transition metal in a catalytic manner, so that the biphenyl compounds can be conveniently and effectively combined. Compared with the existing method, the synthetic method disclosed by the invention is extensive in applicable substrate range, mild in reaction condition, simple and convenient to operate and high in reaction efficiency, and is a method with important application value. The method disclosed by the invention is further used for synthesizing biphenyl compounds containing halogens. The invention provides a simple, novel and efficient method.

The invention relates to a preparation method of ivermectin. The ivermectin is prepared by taking an abamectin B2 component as a raw material and removing 23-position sulfonyl hydrazone of the abamectin B2 through reduction, and the process comprises the following steps: (1) protecting 4''-position hydroxyl and 5-position hydroxyl of the abamectin B2 with allyl carbonate; (2) oxidizing 23-position hydroxyl of the abamectin B2 into keto carbonyl; (3) converting the 23-position keto carbonyl of the abamectin B2 with organic sulfonyl hydrazine into hydrazone, thus generating the 23-position sulfonyl hydrazone of the abamectin B2; and (4) reducing with hydroborate to remove the 23-position sulfonyl hydrazone of the abamectin B2, and simultaneously removing the 4''-position protecting group and the 5-position protecting group to obtain the ivermectin. The total yield of the reaction is up to 67-72%. According to the invention, the ivermectin is prepared by taking the abamectin B2 component as the raw material, the utilization range of the abamectin B2 is widened, the cost of the ivermectin is reduced, the preparation conditions are mild, the yield is high, and the use of virulent tributyltin hydride Bu3SnH is avoided. Thus, the invention is suitable for industrial production.

The invention relates to piperine hydrazone, acylhydrazone or sulfonyl hydrazone derivative substances and application for preparing a botanical insecticide. The piperine hydrazone, acylhydrazone or sulfonyl hydrazone derivative substance takes the piperine hydrazone as raw materials, piperine aldehyde is obtained by means of hydrolysis, esterification, reduction and oxidation, and the piperine aldehyde is respectively reacted with replaced phenylhydrazine, the acylhydrazone and sulfonyl hydrazide. The structural formula is shown as follows. The experiment shows that the piperine hydrazone, or the acylhydrazone or the sulfonyl hydrazone derivative substances has the advantages of having good antifeedant and insecticidal activity, partly exceeds the parent piperine, wherein the insecticidal activity of some components is higher than the commercialized botanical pesticide toosendanin, and therefore the piperine hydrazone, or the acylhydrazone or the sulfonyl hydrazone derivative substances is expected to be used for preparing high-efficient, environment-friendly and low-toxic botanical insecticides.

The invention relates to a synthetic method of a marine terpenoid natural product namely ent-chromazonarol, and belongs to the field of chemical synthesis. The synthetic method provided by the invention uses salvia sclarea aldehyde and 2-iodo-1,4-dimethoxybenzene as starting materials. Salvia sclarea sulfonyl hydrazone is generated by a condensation reaction between salvia sclarea aldehyde and p-toluenesulfonyl hydrazide, an olefinic alcohol compound is obtained by a coupling reaction between salvia sclarea sulfonyl hydrazone and 2-iodo-1,4-dimethoxybenzene, an olefinic terpene compound is obtained by an intra-molecular reductive reaction and a double-bond isomerization reaction of the olefin alcohol compound, an olefinic phenol compound is obtained by an oxidation reaction and a reduction reaction of the olefinic terpene compound, and a target marine terpenoid natural product namely ent-chromazonarol is obtained by a cyclization reaction of the olefinic phenol compound. The synthetic method provided by the invention has the characteristics of few reaction steps, simple and convenient operation, good product selectivity, suitability of industrial production, and the like.

The invention discloses a preparation method of a white carbon black high-activity dispersing agent composition. The preparation method comprises the following steps: weighing the following materials in percentages by weight: 20%-60% of at least one of hydrazide and sulfohydrazide, 25%-50% of long-chain fatty acid, 1%-15% of octadecanol, 1%-15% of diethylene glycol, 1%-15% of monoglyceride, 1%-20% of hexadecyl trimethyl ammonium chloride and 1%-20% of C9 resin; putting the long-chain fatty acid, octadecanol, diethylene glycol, monoglyceride, hexadecyl trimethyl ammonium chloride and the C9 resin into a negative-pressure reaction kettle; increasing the temperature; adding at least one of hydrazide and sulfohydrazide into the reaction kettle, thus obtaining the white carbon black high-activity dispersing agent composition after the reaction is finished. The preparation method is simple in technology and easy to operate; in a formula of rubber filled with white carbon black, the added composition is capable of increasing the activity of the white carbon back and improving the dispersing effect of the white carbon back in the rubber, and then enhancing the physical mechanical property of vulcanized rubber.

The invention discloses a light sensitization composition using a sulfonyl hydrazone compound. The composition comprises a dissolving resistant / dissolving promotion agent, an alkali soluble line type phenolic resin, an infrared absorption dye, a background dye and a solvent, wherein the dissolving resistant / dissolving promotion agent is a cyclohexanone sulfonyl hydrazone compound. The sulfonyl hydrazone compound provided by the invention is added into the light sensitization composition and can be quickly subjected to chemolysis to generate N2 for foaming only when the temperature of a scanning area is higher than 170 DEG C. In the decomposition foaming process, the membranous layer of the scanning area is loosened and is easy to develop, and most of small segments remained on the membranous layer after the decomposition are acidic materials of different types, so that an obvious dissolving promotion effect is generated during alkali development, and the composition has high thermal stability and long service life. Therefore, the cyclohexanone sulfonyl hydrazone compound is used as the dissolving resistant / dissolving promotion agent of the light sensitization composition, so that a thermosensitive computer to plate (CTP) board with high sensitivity and high development speed can be obtained.

The invention relates to a synthesis method of a marine natural product Puupehedione, and belongs to the field of chemical synthesis. (-)salvia sclarea aldehyde and 1-iodine-2,4,5-trialkoxy benzene are used as starting materials, (-)salvia sclarea aldehyde and p-toluenesulfonhydrazide generate salvia sclarea hydrazone 2, salvia sclarea hydrazone 2 and 1-iodine-2,4,5-trialkoxy benzene form a framework compound 4 of Puupehedione under the catalysis of palladium in a coupling manner, the framework compound 4 is oxidized into an intermediate quinine under the action of an oxidizing agent, and quinine and C-8 site hydroxyl are subjected to reaction, so as to realize cyclization, isomerization and dealcoholization reactions to obtain natural product Puupehedione in one step. The synthesis method has the characteristics of being few in reaction steps, simple and convenient to operate, good in product selectivity and suitable for industrial production.

The invention relates to a synthetic method of a sea natural product 8-epi-puupehedione, which belongs to the field of chemical synthesis. According to the invention, salvia sclarea aldehyde and 1-iodine-2,4,5-trialkoxy benzene are used as starting materials, salvia sclarea aldehyde and p-toluenesulfonhydrazide generate salvia sclarea hydrazone 2, the salvia sclarea hydrazone 2 and 1-iodine-2,4,5-trialkoxy benzene form a framework compound 4 of puupehedione under the catalysis of palladium in a coupling manner, the framework compound 4 is subjected to one-step hydroxyl reduction and double-bond isomerization under the action of a reducing agent to obtain an intermediate 5, the intermediate 5 is oxidized into an intermediate quinone compound 6 under the action of an oxidizing agent, and isomerization and Diels-Alder ring closure are realized for the quinone compound 6 under alkaline condition, then an intermediate 7 is obtained, and the intermediate 7 is further oxidized to obtain the final product 8-epi-puupehedione. The method has the characteristics of less reaction step, simple operation, and good products selectivity, and is suitable for industrial production.

The present invention relates to a preparation method for a diaryl diazonium methane derivative containing double bonds and an application thereof. The present invention aims to solve the problem that a stable carbene reactive intermediate with functional groups cannot be prepared from inexpensive chemistry reagents under mild conditions in the prior art. The method comprises the following steps: taking 4,4'-dihydroxybenzophenone as a raw material, performing substitution reaction on the 4,4'-dihydroxybenzophenone and halogenated olefin, performing hydrazonization reaction on the 4,4'-dihydroxybenzophenone and p-toluenesulfonohydrazide, and removing a p-toluenesulfonyl protecting group under the alkaline condition to obtain the diaryl diazonium methane derivative containing double bonds. According to the preparation method for the diaryl diazonium methane derivative containing double bonds and the application thereof, the diaryl diazonium methane derivative containing double bonds is used as a precursor for preparing the carbene.

The invention discloses a synthetic method of (E)-alkenyl sulfone compounds. The method comprises the following steps: beta-nitroolefin compounds shown as formula I in the description, sulfohydrazidecompounds shown as formula II in the description, an iodine-containing nonmetal catalyst and a peroxide oxidizing agent are mixed for a reaction, and a mixture obtained after the reaction is subjectedto postprocessing, and the (E)-alkenyl sulfone compounds shown as formula III in the description are obtained. Beta-nitroolefin compounds, the sulfohydrazide compounds, the iodine-containing nonmetalcatalyst and the peroxide oxidizing agent are taken as main raw materials, the corresponding (E)-alkenyl sulfone compounds are synthesized through free radical reaction, the iodine-containing nonmetal catalyst iodine or tetrabutylammonium iodide is used, the raw materials are simple, easily available, cheap, non-toxic and pollution-free to the environment, the dosage of the catalyst is small, thecatalyst has higher specificity for the reaction, synthetic reaction time can be shortened, the problem that the metal catalyst is difficult to separate in the prior art can be well solved, postprocessing difficulty is reduced, yield of the final product is increased, and purity of the final product is improved.

Sulfonyl hydrazide compounds according to formula Igeometrical isomers thereof, optically active enantiomers thereof, diastereomers thereof, racemates thereof, and / or pharmaceutically acceptable salts thereof are useful in method for treating a neuronal disorder, an autoimmune disease, a cardiovascular disease, or cancer in a patient in need of such treatment.

Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy.where R is C1-C10 alkyl or haloalkyl;R′ and R″ are each independently C1-C10 alkyl;R1 is CH3; andX is O;or a pharmaceutically acceptable salt, solvate, polymorph or metabolite thereof.

The invention discloses a method for synthesizing 3, 6-dihydro-2H-pyrazine (thiazine) furan-4-boric acid ester. According to the method, tetrahydropyrazole (thiazine) furan-4-ketone serves as the raw material, generates hydrazone with p-toluenesulfonhydrazide, then reacts with NBS / organic alkali to generate alkenyl bromide and next forms Grignard reagent with magnesium metal, after the Grignard reagent is formed, boron reagent is added for a reaction, and the 3, 6-dihydro-2H-pyrazine (thiazine) furan-4-boric acid ester is obtained. By means of the method, ultralow temperature, column chromatography and palladium catalyzed coupling in a literature method are avoided, raw materials are easy to obtain, cost is low, conditions are mild, and the method has potential industrial application and amplification prospect.

The invention discloses a preparation method of sulfonyl-containing completely substituted parazole. The preparation method of the sulfonyl-containing completely substituted parazole comprises the step of carrying out a condensation reaction on 1,3-diketone and aromatic sulfonyl hydrazine as reaction substrates, iodide as a catalyst, peroxy-tertiary butanol as an oxidant, and cobalt acetate tetrahydrate or anhydrous cobalt chloride as an additive in ethyl acetate or benzene as a solvent, so that the sulfonyl-containing completely substituted parazole is obtained. The preparation method disclosed by the invention has the advantages that good and even excellent yield can be realized for multiple aryl sulfonyl hydrazides and 1,3-diketones, and the highest yield can be 97%; compatibility of functional groups of the substrates is high, and application range of the substrates is wide compared with the traditional method; meanwhile, a preparation process is controllable, so that the preparation method disclosed by the invention is applicable to industrial production of the sulfonyl-containing completely substituted parazole.

the invention discloses a preparing method of foaming magnesium polyacrylate imbibition resin, which comprises the following steps: adopting 63-72% acrylic emulsion and 27-36% magnesium hydroxide as raw material; adding compound 0.2-0.5% foamer, 0.04-0.09% crosslinking agent and 0.4-0.8% potassium persulphate; neutralizing; crosslinking; squeezing; drying; breaking; foaming; metering; packing. the compound foamer is composed of benzene disulfonate hydrazide and nitrourea and the compound crosslinking agent is composed of epichlorohydrin and methylene diacrylamide.

The invention relates to the technical field of electronic paste, and discloses a method for improving dispersity of photovoltaic panel electronic paste. The method comprises the following steps: preparing nano-copper powder from copper acetate and hydrazine hydrate under proper conditions, treating the nano-copper powder with toluenesulfonyl hydrazine, and aggregating toluenesulfonyl hydrazine on nano-copper tiny agglomerates; countless tiny bubbles are generated by decomposing in hot water, the bubbles burst and gas driving force generated by the bubbles promote tiny agglomerates formed by agglomeration of the nano-copper particles to be dispersed and fully infiltrated, and the sodium p-toluenesulfonate generated after the p-toluenesulfonylhydrazine is decomposed can promote effective infiltration of paste to the nano-copper particles. P-toluenesulfonyl hydrazide can hydrolyze on the surfaces of the nano-copper tiny agglomerates to generate countless small bubbles to crush the tiny agglomerates to be fully dispersed, and the generated sodium p-toluenesulfonate can also promote the slurry to fully infiltrate the nano-copper particles, so that the problem of agglomeration of the filler tiny agglomerates, which is difficult to solve by traditional mechanical stirring and ball milling, is effectively solved; therefore, uniform and stable dispersion of the conductive phase in the electronic paste is realized.

The invention discloses a preparation method for diphenyl ether serial sulfonyl azide compounds. The preparation method comprises taking a diphenyl ether sulfohydrazide compound (I) as a raw material, dropwise adding a sodium nitrite aqueous solution into an alcohol-acid solution system dissolving all of the raw materials, reacting, so as to directly obtain the corresponding diphenyl ether serial sulfonyl azide compound (II) target product. The alcohol in the alcohol-acid solution system is at least one of C1-4 alcohols, and the acid is at least one of hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetate and propionic acid. The method avoids currently-used severely-toxic sodium azide and also avoids disadvantages of usage of a large amount of high-boiling-point organic acids, generation of a large amount of waste acid water, and the like. Because the reactions are all homogeneous reactions, the method possesses obvious advantages of being fast in reaction speed, high in yield, easy for recovery and recycling of low-boiling-point alcohol solvents, and the like.

The invention discloses a process method suitable for amplification preparation of 4-(6-aminopyridin-3-yl) substituted piperidine, and belongs to the synthesis field of a medicine intermediate. N-substituted piperidone, aryl sulfohydrazide and 2-amino-5-bromopyridine are subjected to a coupling reaction under a palladium catalyst, and then are subjected to a hydrogenation to obtain 4-(6-aminopyridin-3-yl) substituted piperidine. According to the process, the raw materials in pyridine do not need to be protected; the condensation and the coupling are carried out in the same reaction kettle, sothat the operation cost is reduced, the steps of performing protection at first and then performing protection removal as in documents can be avoided, and production cost of the existing biological, medicine and chemical intermediates is greatly reduced; and the process is subjected to amplification verification in kilogram-scale, and the verification proves that the yield and the product purity are basically equal to those of gram-scale, so that the method can be used as a process for industrial scale production.

The invention relates to a 6-azabicyclo (3.2.1) nonane-3-substituted derivative and a preparation method thereof, which mainly solve the technical problems that the extension of the prior endocyclic compound with 6-azabicyclo (3.23.1) nonane structure in a space structure is limited and the water solubility of the compound is poor. The reaction formula of the 6-azabicyclo (3.2.1) nonane-3-substituted derivative is shown as above. 3-nitrile-6-azabicyclo (3.2.1) nonane compound IV is obtained by adopting 6-azabicyclo (3.2.1) nonane-3-ketone III as raw materials through nitrile addition, and then the compound IV is reacted with ethanol under acid condition to generate ester compound I; or the compound III is reacted with oxyammonia, aminos, hydrazines, amides, sulfonamides, hydrazides or sulfonyl hydrazides to generate compound V, and the compound V is reduced to generate compound II.

The invention discloses a method for synthesizing alkyne sulfone compounds from terminal alkyne and sulfonyl hydrazine. According to the method, a series of the alkynyl sulfone compounds are synthesized through an oxidative cross-coupling reaction of terminal alkyne and sulfonyl hydrazine, and the method does not need pre-functionalization of alkyne, and has the advantages of high atom economy, nometal or oxidant, good functional group tolerance and the like. The compounds synthesized by the method are subjected to in-vitro antitumor activity screening, and experimental results show that mostof the compounds have relatively strong inhibitory activity on tumor cells.

The invention relates to a synthesis method for synthesizing a 3-sulfonylated thioflavonoid compound. The method comprises the following steps: under the action of a catalyst and an oxidizing agent, putting a methylthio aromatic alkyne ketone compound and an aryl sulfonyl hydrazine compound into a solvent, performing reaction under the conditions of blue light irradiation and a nitrogen environment, and performing separation after the reaction is finished, thereby obtaining the 3-sulfonylated thioflavone compound. According to the method, a transition metal catalyst is not needed, a traditional volatile organic solvent is not needed, a green solvent ethylene glycol or water is used as a reaction medium, an organic photosensitizer is used as a catalyst under the catalysis of visible light,and a target product is synthesized through a one-pot reaction. The method is simple, convenient and safe to operate and mild in reaction condition, the light source used in the method is visible light which is green and pollution-free, the catalyst and the reaction medium are environmentally friendly, and in addition, the yield of the product synthesized by the method is high.

The invention relates to a method for preparing a beta-ketosulfone compound through a visible light mediated atopic acid decarboxylation ketonization reaction, and belongs to the field of compound preparation. According to the method disclosed by the invention, environment-friendly atortic acid with wide sources and stable odorless sulfonyl hydrazine are used as reactants, fluorescein, inorganic base and potassium iodide are added and then fully dissolved in a mixed solvent of acetonitrile and water, a reaction is carried out in an oxygen atmosphere (communicated with oxygen spheres), and thebeta-ketosulfone compound can be obtained through the reaction under visible light irradiation. The preparation method disclosed by the invention has the characteristics of simple and easily availableraw materials, simple operation, mild reaction conditions, no metal residue and insensitivity of a reaction system to water.