70 results about "Reactive intermediate" patented technology

The invention discloses an amino alcohol nickel complex as well as a preparation method and application thereof, and belongs to the technical field of organic metal synthesis. The molecular formula of the amino alcohol nickel complex is Ni [OCR1R2 (CH2) mNR3R4] 2, comprising the following raw materials: a nickel-containing complex, 60wt.% of NaH and HOCR1R2 (CH2) mNR3R4, the preparation method specifically comprises the following steps: (1) under the protection of nitrogen, mixing a nickel-containing complex, 60wt.% NaH, HOCR1R2 (CH2) mNR3R4 and toluene, carrying out heating reaction, and carrying out heating reaction again; and (2) filtering, concentrating, cooling, filtering again, and washing to obtain the product. The nickel-containing complex, sodium hydride and amino alcohol are synthesized into the amino alcohol nickel complex through a one-pot method, the raw materials are simple, easy to obtain and convenient to store, expensive active intermediates do not need to be synthesized or purchased, and the cost and risk of amplified production are reduced. Meanwhile, the purification method of the product is improved, the high-purity amino alcohol nickel complex is obtained through a low-temperature crystallization method, operation is safe and convenient, the industrial purification efficiency is improved, and the purity of the obtained product is as high as 6N-7N through ICP-MS testing.

The present application belongs to the technical field of the synthesis of chiral boron compounds, and in particular relates to an MOF-Cu(II) / CMC composite material, and a preparation method therefor and the use thereof. The preparation method for an MOF-Cu(II) / CMC composite material of the present application comprises: dropwise adding an aqueous solution of sodium carboxymethyl cellulose to an aqueous solution of a bivalent copper salt, performing solid-liquid separation, mixing obtained composite microspheres with an organic solution of trimesic acid, heating the resulting mixture, and subjecting same to solid-liquid separation, so as to obtain an MOF-Cu(II) / CMC composite material. The MOF-Cu(II) / CMC composite material is used in an asymmetric chiral boron addition reaction. The reaction is performed at room temperature, involves mild conditions, is applicable to a wide range of substrates and has a high yield and enantioselectivity. Moreover, the method can achieve the synthesis of a chiral organic boride in a solvent having simple components, providing an efficient new method for the preparation of drug molecules and active intermediates, and also broadening the range of substrates used for the preparation of chiral organic borides.

The invention relates to a method for preparing anionic polymerized polyamide 6 with a high reaction rate by adopting a double-activation system. S2, putting the caprolactam dried in the step S1 into a beaker at room temperature, then putting the beaker into an oil bath pan, heating until the caprolactam is completely melted, and starting stirring; the method comprises the following steps: putting caprolactam into a 500ml three-necked flask at room temperature, then putting the three-necked flask into a 500ml electric heating jacket, heating until the caprolactam is completely melted, and starting mechanical stirring by using a stirring paddle to generate two active intermediates and three block structures, and the polymer has the advantages of stable polymerization time, excellent mechanical properties, high polymerization rate, good thermal stability, high antioxidant degree, high crystallinity and the like.

The invention belongs to the field of pharmaceutical chemicals, and relates to a preparation method of an anti-influenza virus derivative intermediate. According to the invention, a compound (a) and a compound (b) are taken as initial raw materials, and an alcoholic hydroxyl group is directly converted into an active intermediate by utilizing trimethylsilyl trifluoromethanesulfonate (TMSOTf), so that the tedious operation of firstly protecting the hydroxyl group and then carrying out substitution reaction in the traditional method is avoided, and a key intermediate (d) required for preparing the anti-influenza virus derivative can be obtained in one step. The method has the advantages of simplicity and convenience in operation, high yield, easiness in industrial amplification and the like, and is suitable for large-scale preparation of the anti-influenza virus medicine and pharmaceutically acceptable salts, esters or solvates thereof.

The invention discloses an alcohol modified TS-1 catalyst as well as a preparation method and application thereof, and belongs to the technical field of molecular sieve catalysts. The alcohol modified TS-1 catalyst is prepared by the following steps: preparing a mixed solution from SiO2, 0.04 TiO2, 0.30 TPAOH, 50 H2O and nMOH according to the molar ratio of SiO2: 0.04 TiO2: 0.30 TPAOH: 50 H2O: nMOH; carrying out hydrothermal reaction on the mixed solution to obtain the alcohol modified TS-1 molecular sieve catalyst in one step; the preparation method is simple, the crystallization rate of the molecular sieve is increased by adding alcohols, more titanium atoms can be promoted to enter a skeleton, formation of a Ti-OOH active intermediate is facilitated, and generation of non-active anatase is reduced; the TS-1 molecular sieve is high in crystallinity and shows relatively high activity and alkylene oxide selectivity in a long-chain olefin epoxidation reaction.

The invention relates to the technical field of synthesis of ethylene sulfate, provides a method for directly oxidizing ethylene sulfite by using oxygen, and overcomes the defects that an ethylene sulfate synthesis method in the prior art is not environment-friendly, and a used catalyst is difficult to recover and high in price. According to the method, O2 is reduced into peroxide radicals (OOH-) through a catalyst firstly, the peroxide radicals (OOH-) are adsorbed to the surface of a carrier to form an active intermediate (Ti-OOH), and then S = O in ethylene sulfite is oxidized into O = S = O through the Ti-OOH. The method specifically comprises the following steps: 1) preparation of a catalyst and 2) synthesis of ethylene sulfate.

The present invention belongs to the technical field of organic chemical synthesis, and specifically relates to a nitrogen oxide free radical derivative of rhubarb and its synthesis method and application. The present invention takes rhubarb, a lipid-lowering medicinal substance of traditional Chinese medicine, as the research object, selects its 3rd hydroxyl group as the modification site, and based on different length carbon chain substitution, A 3 Based on the reaction mechanisms of coupling, esterification and pharmacophore splicing, six active intermediate nitroxide free radicals were introduced into the structure of emodin. 50 nitroxide free radical derivatives of emodin in three series and 8 other derivatives were designed and synthesized. Several synthetic methods for novel nitroxide free radical derivatives of emodin with mild reaction conditions, environmental friendliness and high yield were established. The novel nitroxide free radical derivatives of emodin provided have low toxicity to normal liver cells, significant anti-proliferative activity against liver cancer cells, and are novel active molecules with better effects than emodin, providing a new idea for the preparation of anti-tumor drugs.

The invention relates to a polymer for treating a surface, which polymer comprises: n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups which comprise an atom-transfer radical polymerization (ATRP) initiator, wherein m is an integer equal to or greater than 3, wherein the reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups, wherein the carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D), wherein R1 is H or -S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for surface -initiated atom-transfer radical polymerization (SIATRP). The invention also relates to a treated substrate having a surface suitable for SIATRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIATRP, bonded to the reacted polymer.

The present invention belongs to the technical field of organic chemical synthesis, and specifically relates to a rhein nitroxide derivative, a synthesis method, and an application thereof. The present invention uses rhein, an antioxidant pharmacological substance from the traditional Chinese medicine rhubarb, as a research object, selects its carboxyl group at position 3 as a modification site, and introduces four active intermediate nitroxides into the rhein structure based on the amide condensation and esterification reaction mechanisms and the pharmacophore splicing principle. Thirty rhein nitroxide derivatives were designed and synthesized, thereby establishing a method for synthesizing novel rhein nitroxide derivatives with mild reaction conditions, environmental friendliness, and high yield. The provided novel rhein nitroxide derivatives have the ability to scavenge DPPH and ABTS free radicals, have a protective effect on oxidatively damaged cells, and have the ability to delay the lifespan of Caenorhabditis elegans. Their effects are superior to those of rhein, providing a new approach for the development of antioxidant and anti-aging drugs.

The invention relates to the field of biological materials, in particular to collagen hydrogel for filling injection and a preparation method of the collagen hydrogel. The recombinant collagen is dissolved in a citric acid solution to form a collagen and citric acid composite solution, and the concentration of the collagen is 100 mg / mL to 200 mg / mL; heating the composite solution to 80-100 DEG C, reacting for more than 6 hours, dehydrating citric acid molecules to form an anhydride intermediate, and performing esterification reaction on the anhydride intermediate and hydroxyl on a collagen molecular chain to form the three-dimensional network hydrogel taking an ester bond as a main crosslinking bond. A natural metabolite citric acid in an organism is used as a unique cross-linking agent, an active intermediate is formed through intramolecular dehydration under the heating condition of 80-100 DEG C, and the active intermediate and collagen are subjected to a specific esterification reaction to form a covalent cross-linked network. No exogenous chemical cross-linking agent is introduced in the process, so that the risk of toxic cross-linking agent residue is avoided, and the final product has extremely high biocompatibility.

The invention belongs to the field of textile finishing agents, and discloses an amphoteric macromolecular deodorization finishing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out a ring-opening reaction on epoxy silane and a taurine monomer to obtain an active intermediate, and adding a cyclic silane monomer to copolymerize the active intermediate and the cyclic monomer to obtain the self-curing amphoteric long-acting macromolecular deodorization finishing agent with good safety performance. The problems that a micromolecular deodorant is not resistant to washing and migrates to a human body are solved, and the obtained amphoteric macromolecular deodorization finishing agent can be applied to the field of deodorization finishing of high-end cotton and linen textiles.

The present invention relates to a glycosphingolipid derivative and a preparation method and application thereof. Pullulan is activated, DMEDA is used to selectively remove part of the acetyl group, and trichloroacetonitrile (Cl3CCN) is introduced to generate an active intermediate, and the hydroxyl group of phytosphingosine is protected to form a stable ketal structure to avoid the occurrence of side reactions. The activated pullulan and the hydroxyl-protected phytosphingosine are subjected to a condensation reaction under the action of an acidic catalyst, and then a high-purity glycosphingolipid derivative is prepared by deprotection treatment and purification. The compound has excellent amphiphilicity, exhibits good moisturizing properties and anti-photoaging ability, and can be widely used in the fields of cosmetics, medicine and functional materials. The method of the present invention has mild reaction conditions and high efficiency, and avoids the problems of poor reaction selectivity and many impurities in traditional technologies.

The application discloses an electrochemical synthesis N α A method for synthesizing azole compounds under mild electrochemical conditions through a three-component reaction of azole, aldehyde and alcohol N α In the electrolysis process, azole is oxidized into a nitrogen free radical at the anode, and aldehyde is reduced into a hydroxyalkyl free radical at the cathode, then the free radical coupling is carried out, and finally, intermolecular dehydration of alcohol is carried out to synthesize a series of azole compounds with an alkoxyalkyl group N α The reaction avoids the use of an acid catalyst, an additional oxidant and a reducing agent through a free radical active intermediate route, is low in production cost, is friendly to the environment, and is suitable for industrial large-scale production as shown by the feasibility of a kilogram-scale amplification experiment.​​​

The present invention provides a method for synthesizing allyl azaaryl methylamine compounds. By reacting azaaryl derivatives with allyl carbonates under the catalysis of palladium acetate, a series of allyl azaaryl methylamine compounds are prepared. Azaaryl methylamine derivatives are commonly found in biological medicines and natural products, and their allylated products with deprotonated benzyl positions can serve as a kind of active intermediate with medicinal value and have certain antifungal activity against dermatophytes. Compared with traditional methods, the palladium-catalyzed allylic alkylation reaction of the present invention has the characteristics of economical and efficient synthesis. The reaction is carried out by a simple one-pot method without relatively harsh reaction conditions such as high temperature and high pressure, greatly improving the synthesis process.

The present invention discloses a method for depolymerizing lignin. The method is based on screening the types of Lewis acid catalysts and organic acids, allowing a lignin model to depolymerize under the synergistic action of the Lewis acid catalyst and the organic acid. During the depolymerization process, the organic acid not only acts as a solvent to dissolve the lignin, but also participates in the reaction as a nucleophile, capturing active intermediates during the reaction to generate a target compound. Compared with existing methods for degrading lignin model materials, the present invention depolymerizes lignin under normal pressure, with mild reaction conditions and a higher product yield. This provides a new technical route for effectively utilizing lignin resources to produce high-value-added chemicals.

The present invention provides a method for preparing a paper-based cobalt-doped terbium metal-organic framework material with reasonable design and simple operation. Isophthalic acid is used as a metal ion ligand to prepare a cobalt-doped terbium metal-organic framework. The prepared cobalt-doped terbium metal-organic framework material can be used as an electrochemiluminescent luminescent reagent and a co-reaction promoter. The cobalt-doped terbium metal-organic framework has a larger pore size and volume, a higher surface area and a lower electron transfer resistance, which makes it easier for reactants and active intermediates to approach the electrochemiluminescent internal luminescent reagent, thereby improving the electrochemiluminescent emission performance. At the same time, the catalytic effect of cobalt ions on hydrogen peroxide can be used to construct an electrochemiluminescence mechanism in which a double co-reaction promoter enhances the signal intensity, thereby amplifying the electrochemiluminescence signal. The lanthanide metal-organic framework has the advantages of high sensitivity, wide detection range, stable response, etc., and has broad application prospects in the field of electrochemiluminescence.

The invention belongs to the technical field of medicinal chemistry, and discloses a synthesis method of a flutomil compound, which comprises the following steps: (1) taking 4-fluoromethylbenzylamine and dihydroxy acetone as raw materials, and reacting with potassium thiocyanate in an acidic acetonitrile solution to synthesize an intermediate A; (2) carrying out oxidative desulfurization on the intermediate A and 2-6eq of peroxidant sodium nitrite in an acidic solvent to prepare an intermediate B; (3) further oxidizing the intermediate B into an intermediate C; and (4) reacting the intermediate C in the reaction mixed solution with n-heterocyclic carbene under a DBU alkaline condition to generate an active intermediate, and then degrading the active intermediate into the flutomi ester compound. The synthesis route is high in atom utilization rate, simple in post-treatment, free of high temperature and high heat in the reaction process, less in reaction waste liquid and low in environmental protection pressure, and compared with original literature patents, the reaction steps are few, reagents are cheap, and the process route is easy to implement, economical and efficient.

The invention provides a bisphenol A synthesis catalyst and a preparation method of bisphenol A. The catalyst comprises cation exchange resin and a modified molecular sieve, the surface of the modified molecular sieve is connected with a modified group, and the modified group is selected from any one or two of sulfydryl alkyl and amino alkyl. The modified molecular sieve can promote the generation of active intermediate acetone carbon cations in the reaction process, improve the reaction rate and accelerate the reaction with phenol to generate bisphenol A. The mixed catalyst is adopted, the advantages of high activity of a hydrochloric acid method and high purity of a resin method are considered, free acid content in a product is less, and the product quality is higher than that of a hydrochloric acid catalysis method.

The invention provides a method for marking RNA (Ribonucleic Acid) molecules related to epigenetic modification of chromatin in living cells in real time. According to the method, module protein for recognizing epigenetic modification, engineered ascorbic acid peroxidase and a biotin-aniline probe are introduced into cells. The engineered ascorbic acid peroxidase can catalyze the oxidation reaction of hydrogen peroxide on a biotin-aniline substrate, so that the biotin-aniline substrate generates a high-reaction-activity intermediate with oxygen free radicals, covalent bonds are formed between the intermediate and RNA molecules around epigenetic modification of chromatin, and further RNA molecules with biotin labels are generated. And finally, purifying the RNA molecule with the biotin label by using streptavidin magnetic beads for subsequent sequencing analysis so as to determine the RNA variety related to the epigenetic modification of the chromatin.

The invention relates to a glycosphingolipid derivative as well as a preparation method and application thereof. Pulullan is activated, DMEDA is adopted to selectively remove part of acetyl, trichloroacetonitrile (Cl3CCN) is introduced to generate an active intermediate, meanwhile, hydroxyl of phytosphingosine is protected to form a stable ketal structure, and side reaction is avoided. Activated pullulan and hydroxyl-protected phytosphingosine are subjected to a condensation reaction under the action of an acid catalyst, and then high-purity glycosphingolipid derivatives are prepared through deprotection treatment and purification. The compound has excellent amphipathy, shows good moisturizing performance and light aging resistance, and can be widely applied to the fields of cosmetics, medicines and functional materials. The method has the advantages of mild reaction conditions and high efficiency, and avoids the problems of poor reaction selectivity and many impurities in the traditional technology.

The invention discloses an iron / molecular sieve catalyst with a core-shell structure, a preparation method of the iron / molecular sieve catalyst and application of the iron / molecular sieve catalyst in preparation of formic acid by catalyzing methane oxidation, and belongs to the technical field of natural gas conversion and energy. The catalyst is formed by taking a Fe-ZSM-5 molecular sieve with catalytic activity as an inner core and taking a porous and inert oxide shell as a shell layer. In the core-shell structure, the internal Fe-ZSM-5 provides a high-dispersion iron active site and an acid site for activating methane; the external porous oxide shell promotes mass transfer of reaction active intermediates, meanwhile, the catalytic inertia of the oxide shell effectively inhibits excessive reaction and loss of active species, and retention of the target product formic acid is remarkably promoted. Therefore, the synergistic effect of the structure provided by the invention can greatly improve the activity and stability of the catalyst in the reaction of preparing formic acid by methane oxidation, especially the selectivity to formic acid.

The invention belongs to the technical field of photocatalysis and functional coordination chemistry, and particularly relates to a metal organic cage catalyst based on ligand engineering regulation and a method for photocatalytic synthesis of hydrogen peroxide in pure water. According to the invention, a tripyridine ligand containing pyridinium substituent groups is designed through a ligand engineering strategy, and the tripyridine ligand and zinc ions are self-assembled to form the metal organic cage catalyst with a tetrahedral structure. By introducing a pyridinium group into a ligand structure, the electron attraction capability of a system is enhanced, and an efficient charge transfer channel is formed. Active intermediates (such as hydroxyl free radicals and superoxide free radicals) are effectively stabilized by the confinement space of the cage body, and the decomposition reaction of hydrogen peroxide is inhibited. The structure can efficiently separate photo-induced electrons and holes under the illumination condition and promote the double-two-electron synergistic process of oxygen reduction reaction and water oxidation reaction, so that hydrogen peroxide is efficiently generated in a pure water system without a sacrificial agent.

The invention belongs to the technical field of synthesis of active intermediates, and particularly discloses a method for preparing a photoactive polyester oligomer through ring opening of lactone. The preparation method comprises the following steps: adding acrylic acid, a ring-opening catalyst, an esterification catalyst, a polymerization inhibitor and a solvent into a reaction container, heating to reflux, and then starting to continuously dropwise add lactone monomers to carry out heat preservation reaction; and after the reaction is finished, cooling the obtained reaction product, filtering, and evaporating to remove the solvent and unreacted acrylic acid under reduced pressure to obtain the target product photoactive polyester oligomer. The photoactive polyester oligomer prepared by the method is controllable in chain segment, small in molecular weight and flexible to adjust, raw materials do not need to be dehydrated, and reaction conditions are mild. The obtained product photoactive polyester oligomer can be used as a high-activity cross-linking agent and is suitable for the fields of free radical polymerization and photocuring.

The present invention relates to a method for producing trans-1-chloro-3,3,3-trifluoropropene. The present invention provides a method for efficiently producing 1-chloro-3,3,3-trifluoropropene from a low-reactive intermediate product. A method for producing trans-1-chloro-3,3,3-trifluoropropene is provided, characterized in that a halogenated hydrocarbon compound having 3 carbon atoms represented by the following general formula (1) is reacted with hydrogen fluoride in a gas phase in the presence of a solid catalyst and chlorine gas. C3H X Cl Y F Z (1) (wherein, X is 2 or 3, when X=2, Y is an integer of 1 to 4, and Z is an integer of 0 to 3, satisfying Y+Z=4. When X=3, Y is an integer of 1 to 5, and Z is an integer of 0 to 4, satisfying Y+Z=5. The general formula (1) represents a halogenated hydrocarbon compound having 3 carbon atoms other than trans-1-chloro-3,3,3-trifluoropropene.)

The invention discloses a synthesis method of a key intermediate of tirpotide, and belongs to the field of polypeptide synthesis. The specific synthesis method comprises the following steps: firstly, mixing Fmoc-Ile-OH with a solvent, then reacting with an activating reagent under the action of alkali to obtain an active intermediate, and then carrying out condensation reaction on the active intermediate and H-Aib-OH to obtain Fmoc-Ile-Aib-OH, namely the key intermediate of the tilpotide; the key intermediate of the tilpotide prepared by the invention has relatively high yield and purity, the yield of the key intermediate of the tilpotide is more than 80%, the purity of the key intermediate of the tilpotide is more than 95%, and the synthesis method has few reaction steps and is beneficial to industrial production.

The invention relates to a synthesis method and a synthesis processing system of quinclorac oxadiazon, and belongs to the technical field of pesticide synthesizing.The synthesis method comprises the steps that firstly, through mediation of a silane coupling agent, nanometer copper oxide particles are evenly loaded in mesopores of an adsorption type molecular sieve, and then the adsorption type molecular sieve, 3, 7-dichloro-8-quinolinecarboxylic acid and N, N-dimethylformamide are mixed to form the quinclorac oxadiazon. According to the present invention, substances such as N, N-dimethylformamide and the like are subjected to acyl chloride, esterification and transposition rearrangement reactions, the copper oxide nanoparticles in the adsorption type molecular sieve and N, N-dimethylformamide achieve the synergistic effect, and can form the active intermediate with thionyl chloride, such that the activation energy of the acylating chlorination reaction is reduced, and the acylating chlorination reaction time is shortened; the mesoporous structure of the MCM-41 molecular sieve can adsorb hydrogen chloride gas generated in the acylating chlorination reaction in situ through Van der Waals' force and capillary coagulation, the conversion rate of the acylating chlorination reaction is improved, and the in-situ removal of hydrogen chloride can also reduce the use amount of an acid-binding agent triethylamine in the subsequent esterification reaction, so that the generation of triethylamine hydrochloride by-products is reduced, and the material loss is reduced.

The present invention provides a highly efficient biomacromolecule covalent labeling compound (compound of formula I) containing multiple "anchor points" and its preparation method and application. The labeling reagent or compound of the present invention has an o, p-methylene benzoquinone (o, p-QM) precursor, which can generate methylene benzoquinone (QM) active intermediates multiple times, thereby achieving the purpose of multiple protein labeling, and can significantly reduce the inefficient labeling caused by quenching of QM active intermediates by other nucleophilic reagents, thereby achieving the purpose of "efficient and stable" labeling of biomacromolecules. It can specifically label tumor cells expressing alkaline phosphatase (ALP) and perform live cell imaging on them.

The present application relates to the technical field of thermal insulation materials, and discloses a flame-retardant thermal insulation material for an electric core and a preparation method thereof. The flame-retardant thermal insulation material for the electric core is obtained through cellulose dissolution, crosslinking and flame-retardant modification, gel forming and drying. The active intermediates released by the oxazine ring during ring-opening polymerization at high temperature can catalyze the crosslinking reaction between molecular chains, forming a three-dimensional network structure and improving the flame-retardant performance of the material. Borate ester decomposes into boron oxide or boric acid at high temperature, and forms a transparent glassy coating after melting, which tightly covers the surface of the material, physically blocks the transmission of oxygen and heat, and has a flame-retardant effect. The phosphoric acid ester decomposes to generate phosphorus-containing free radicals, which can combine with active free radicals in the flame to interrupt the combustion chain reaction, reduce the flame temperature, and further improve the flame-retardant performance of the material. The silane decomposes to generate non-combustible or difficult-to-combust substances such as silicon dioxide, which form a dense protective layer on the surface of the material, thereby preventing the spread of the flame and having a flame-retardant effect.

The invention discloses a preparation method of erianin, and relates to the technical field of erianin preparation, S1, aldol condensation reaction: carrying out aldol condensation reaction on a compound as shown in a general formula (I) and a compound as shown in a general formula (II) to prepare a compound as shown in a formula (III), and carrying out the reaction in an organic solvent containing a catalyst; s2, decarboxylation reaction: enabling the compound of the formula (III) obtained in the S1 to react with the formed complex catalyst under the condition of microwave irradiation, and separating and purifying to obtain a compound of a formula (IV). According to the preparation method of erianin, homovanillic acid and 3, 4, 5-trimethoxybenzaldehyde are used as raw materials, the erianin is successfully prepared through aldol condensation, decarboxylation, double bond reduction under mild conditions and three-step reaction, the total yield is 45.3%, meanwhile, an active intermediate Combretastatin A-4 (CA-4) can be synthesized in a high-selectivity mode through the route, and the scheme is convenient for obtaining bioactive natural products of erianin and CA-4. And harsh reaction conditions are avoided, and the method is suitable for industrial large-scale production.

The invention relates to the technical field of thermal insulation materials, and discloses a flame-retardant thermal insulation material for a battery cell and a preparation method of the flame-retardant thermal insulation material. According to the invention, cellulose is subjected to dissolution, crosslinking and flame-retardant modification, and gel forming and drying, such that the flame-retardant thermal insulation material for the battery cell is obtained. An active intermediate released by an oxazine ring during ring-opening polymerization at a high temperature can catalyze a cross-linking reaction between molecular chains to form a three-dimensional network structure, so that the flame retardant property of the material is improved; boric acid ester is decomposed at a high temperature to generate boric oxide or boric acid, a transparent glassy coating is formed after melting, the surface of the material is tightly covered, oxygen and heat transfer are physically blocked, and the flame-retardant effect is achieved; phosphorus-containing free radicals generated by decomposition of phosphate can be combined with active free radicals in flames, so that a combustion chain reaction is interrupted, the flame temperature is reduced, and the flame retardant property of the material is further improved. And non-combustible or flame-retardant substances such as silicon dioxide generated by decomposition of silane can form a compact protective layer on the surface of the material, so that flame propagation is prevented, and a flame-retardant effect is achieved.