29 results about "Reactive intermediate" patented technology

The present application belongs to the technical field of the synthesis of chiral boron compounds, and in particular relates to an MOF-Cu(II) / CMC composite material, and a preparation method therefor and the use thereof. The preparation method for an MOF-Cu(II) / CMC composite material of the present application comprises: dropwise adding an aqueous solution of sodium carboxymethyl cellulose to an aqueous solution of a bivalent copper salt, performing solid-liquid separation, mixing obtained composite microspheres with an organic solution of trimesic acid, heating the resulting mixture, and subjecting same to solid-liquid separation, so as to obtain an MOF-Cu(II) / CMC composite material. The MOF-Cu(II) / CMC composite material is used in an asymmetric chiral boron addition reaction. The reaction is performed at room temperature, involves mild conditions, is applicable to a wide range of substrates and has a high yield and enantioselectivity. Moreover, the method can achieve the synthesis of a chiral organic boride in a solvent having simple components, providing an efficient new method for the preparation of drug molecules and active intermediates, and also broadening the range of substrates used for the preparation of chiral organic borides.

The invention belongs to the field of pharmaceutical chemicals, and relates to a preparation method of an anti-influenza virus derivative intermediate. According to the invention, a compound (a) and a compound (b) are taken as initial raw materials, and an alcoholic hydroxyl group is directly converted into an active intermediate by utilizing trimethylsilyl trifluoromethanesulfonate (TMSOTf), so that the tedious operation of firstly protecting the hydroxyl group and then carrying out substitution reaction in the traditional method is avoided, and a key intermediate (d) required for preparing the anti-influenza virus derivative can be obtained in one step. The method has the advantages of simplicity and convenience in operation, high yield, easiness in industrial amplification and the like, and is suitable for large-scale preparation of the anti-influenza virus medicine and pharmaceutically acceptable salts, esters or solvates thereof.

The invention relates to a polymer for treating a surface, which polymer comprises: n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups which comprise an atom-transfer radical polymerization (ATRP) initiator, wherein m is an integer equal to or greater than 3, wherein the reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups, wherein the carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D), wherein R1 is H or -S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for surface -initiated atom-transfer radical polymerization (SIATRP). The invention also relates to a treated substrate having a surface suitable for SIATRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIATRP, bonded to the reacted polymer.

The invention relates to the field of biological materials, in particular to collagen hydrogel for filling injection and a preparation method of the collagen hydrogel. The recombinant collagen is dissolved in a citric acid solution to form a collagen and citric acid composite solution, and the concentration of the collagen is 100 mg / mL to 200 mg / mL; heating the composite solution to 80-100 DEG C, reacting for more than 6 hours, dehydrating citric acid molecules to form an anhydride intermediate, and performing esterification reaction on the anhydride intermediate and hydroxyl on a collagen molecular chain to form the three-dimensional network hydrogel taking an ester bond as a main crosslinking bond. A natural metabolite citric acid in an organism is used as a unique cross-linking agent, an active intermediate is formed through intramolecular dehydration under the heating condition of 80-100 DEG C, and the active intermediate and collagen are subjected to a specific esterification reaction to form a covalent cross-linked network. No exogenous chemical cross-linking agent is introduced in the process, so that the risk of toxic cross-linking agent residue is avoided, and the final product has extremely high biocompatibility.

The application discloses an electrochemical synthesis N α A method for synthesizing azole compounds under mild electrochemical conditions through a three-component reaction of azole, aldehyde and alcohol N α In the electrolysis process, azole is oxidized into a nitrogen free radical at the anode, and aldehyde is reduced into a hydroxyalkyl free radical at the cathode, then the free radical coupling is carried out, and finally, intermolecular dehydration of alcohol is carried out to synthesize a series of azole compounds with an alkoxyalkyl group N α The reaction avoids the use of an acid catalyst, an additional oxidant and a reducing agent through a free radical active intermediate route, is low in production cost, is friendly to the environment, and is suitable for industrial large-scale production as shown by the feasibility of a kilogram-scale amplification experiment.​​​

The invention belongs to the technical field of medicinal chemistry, and discloses a synthesis method of a flutomil compound, which comprises the following steps: (1) taking 4-fluoromethylbenzylamine and dihydroxy acetone as raw materials, and reacting with potassium thiocyanate in an acidic acetonitrile solution to synthesize an intermediate A; (2) carrying out oxidative desulfurization on the intermediate A and 2-6eq of peroxidant sodium nitrite in an acidic solvent to prepare an intermediate B; (3) further oxidizing the intermediate B into an intermediate C; and (4) reacting the intermediate C in the reaction mixed solution with n-heterocyclic carbene under a DBU alkaline condition to generate an active intermediate, and then degrading the active intermediate into the flutomi ester compound. The synthesis route is high in atom utilization rate, simple in post-treatment, free of high temperature and high heat in the reaction process, less in reaction waste liquid and low in environmental protection pressure, and compared with original literature patents, the reaction steps are few, reagents are cheap, and the process route is easy to implement, economical and efficient.

The invention provides a bisphenol A synthesis catalyst and a preparation method of bisphenol A. The catalyst comprises cation exchange resin and a modified molecular sieve, the surface of the modified molecular sieve is connected with a modified group, and the modified group is selected from any one or two of sulfydryl alkyl and amino alkyl. The modified molecular sieve can promote the generation of active intermediate acetone carbon cations in the reaction process, improve the reaction rate and accelerate the reaction with phenol to generate bisphenol A. The mixed catalyst is adopted, the advantages of high activity of a hydrochloric acid method and high purity of a resin method are considered, free acid content in a product is less, and the product quality is higher than that of a hydrochloric acid catalysis method.

The invention belongs to the technical field of photocatalysis and functional coordination chemistry, and particularly relates to a metal organic cage catalyst based on ligand engineering regulation and a method for photocatalytic synthesis of hydrogen peroxide in pure water. According to the invention, a tripyridine ligand containing pyridinium substituent groups is designed through a ligand engineering strategy, and the tripyridine ligand and zinc ions are self-assembled to form the metal organic cage catalyst with a tetrahedral structure. By introducing a pyridinium group into a ligand structure, the electron attraction capability of a system is enhanced, and an efficient charge transfer channel is formed. Active intermediates (such as hydroxyl free radicals and superoxide free radicals) are effectively stabilized by the confinement space of the cage body, and the decomposition reaction of hydrogen peroxide is inhibited. The structure can efficiently separate photo-induced electrons and holes under the illumination condition and promote the double-two-electron synergistic process of oxygen reduction reaction and water oxidation reaction, so that hydrogen peroxide is efficiently generated in a pure water system without a sacrificial agent.

The invention relates to a synthesis method and a synthesis processing system of quinclorac oxadiazon, and belongs to the technical field of pesticide synthesizing.The synthesis method comprises the steps that firstly, through mediation of a silane coupling agent, nanometer copper oxide particles are evenly loaded in mesopores of an adsorption type molecular sieve, and then the adsorption type molecular sieve, 3, 7-dichloro-8-quinolinecarboxylic acid and N, N-dimethylformamide are mixed to form the quinclorac oxadiazon. According to the present invention, substances such as N, N-dimethylformamide and the like are subjected to acyl chloride, esterification and transposition rearrangement reactions, the copper oxide nanoparticles in the adsorption type molecular sieve and N, N-dimethylformamide achieve the synergistic effect, and can form the active intermediate with thionyl chloride, such that the activation energy of the acylating chlorination reaction is reduced, and the acylating chlorination reaction time is shortened; the mesoporous structure of the MCM-41 molecular sieve can adsorb hydrogen chloride gas generated in the acylating chlorination reaction in situ through Van der Waals' force and capillary coagulation, the conversion rate of the acylating chlorination reaction is improved, and the in-situ removal of hydrogen chloride can also reduce the use amount of an acid-binding agent triethylamine in the subsequent esterification reaction, so that the generation of triethylamine hydrochloride by-products is reduced, and the material loss is reduced.

The present application relates to the technical field of thermal insulation materials, and discloses a flame-retardant thermal insulation material for an electric core and a preparation method thereof. The flame-retardant thermal insulation material for the electric core is obtained through cellulose dissolution, crosslinking and flame-retardant modification, gel forming and drying. The active intermediates released by the oxazine ring during ring-opening polymerization at high temperature can catalyze the crosslinking reaction between molecular chains, forming a three-dimensional network structure and improving the flame-retardant performance of the material. Borate ester decomposes into boron oxide or boric acid at high temperature, and forms a transparent glassy coating after melting, which tightly covers the surface of the material, physically blocks the transmission of oxygen and heat, and has a flame-retardant effect. The phosphoric acid ester decomposes to generate phosphorus-containing free radicals, which can combine with active free radicals in the flame to interrupt the combustion chain reaction, reduce the flame temperature, and further improve the flame-retardant performance of the material. The silane decomposes to generate non-combustible or difficult-to-combust substances such as silicon dioxide, which form a dense protective layer on the surface of the material, thereby preventing the spread of the flame and having a flame-retardant effect.

The invention provides an ester oxidation synthesis method, and belongs to the technical field of ester synthesis. According to the invention, an N-halogenated amine compound is used as an oxidizing agent and can be subjected to oxidation reaction with carbon disulfide to generate an active intermediate and a water-soluble amine salt, and the active intermediate reacts with a carboxylic acid substance to generate an active ester intermediate, hydrogen halide and elemental sulfur precipitate; carrying out esterification reaction on the active ester intermediate and hydroxyl of the hydroxyl compound to generate ester and carbon dioxide gas; organic alkali is added to neutralize halogen hydride, so that the reaction is promoted; meanwhile, the alkalinity of the organic base is weak, the organic base cannot react with carboxylic acid, and the situation that the reaction yield is reduced due to hydrolysis of the N-halogenated amine compound can be avoided; in the preparation process, no by-product with the solubility similar to that of the product ester exists, and the product is easy to separate.

The invention discloses a nickel-loaded semiconductor oxide-based catalyst for methanation of carbon dioxide in photo-thermal catalytic flue gas as well as a preparation method and application of the nickel-loaded semiconductor oxide-based catalyst. The photo-thermal catalyst takes a semiconductor oxide as a carrier, and nickel metal is loaded through impregnation, calcination and reduction treatment. The Ni metal nanoparticles serve as carbon dioxide hydrogenation sites, the semiconductor oxide material stimulates oxygen in flue gas to be combined with reactants under light driving to generate more reactivity intermediates, and surface oxygen vacancies formed by the reduction treatment material further enhance the adsorption and activation capacity of the catalyst to the reactants. The preparation process is simple and the cost is low. In the reaction of methanation of carbon dioxide in photo-thermal catalytic flue gas, the catalyst shows high-efficiency activity, and the selectivity gt of methane in the product is realized; 99%. Besides, the method has the advantages of mild reaction conditions, simplicity and convenience in operation, environmental friendliness and the like, provides an efficient and feasible way for resource utilization of carbon dioxide, and has a wide application prospect.

The invention relates to the technical field of organic synthesis, and provides an asymmetric carbon-hydrogen bond boronation reaction catalyst and a preparation method of chiral dicyclobutane. A catalyst composed of a chiral boron-based ligand and an iridium salt is adopted to catalyze an asymmetric carbon-hydrogen bond boronation reaction of prochiral dicyclobutane, in a reaction system, the iridium salt and the chiral boron-based ligand are combined to form a complex, the complex reacts with B2pin2 to form an active intermediate, and the active intermediate is separated from the chiral boron-based ligand to form the chiral dicyclobutane. Then the iridium center and a carbon-hydrogen bond of a 3-substituted dicyclobutane-1-formamide compound are subjected to an asymmetric oxidative addition reaction to form an iridium-carbon bond, then reduction elimination is carried out, and the target product chiral dicyclobutane is generated. The reaction condition for constructing the chiral dicyclobutane is mild, the selectivity is high, the enantioselectivity is 95% or above, the substrate universality is wide, and chiral dicyclobutane compounds of different structures can be synthesized.

The invention relates to a polymer for treating a surface, which polymer comprises n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups for controlling surface-initiated reversible-deactivation radical polymerization (SIRDRP), wherein m is an integer equal to or greater than 3. The groups for controlling SIRDRP are selected from groups which comprise an initiator and groups which comprise a chain transfer agent (CTA). The reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups. The carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D): wherein R1 is H or –S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for SIRDRP. The invention also relates to a treated substrate having a surface suitable for SIRDRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIRDRP, bonded to the reacted polymer.

The invention relates to the technical field of photoresist, in particular to photoresist for a capacitive touch sensor and a preparation process of the photoresist. The invention discloses a preparation process of photoresist for a capacitive touch sensor. The preparation process comprises the following steps: preparing a modified photoreaction agent; preparing modified polyimide resin powder; preparing silicon dioxide hollow carbon spheres and nano titanium dioxide hybrid particles; and preparing the photoresist. The preparation method comprises the following steps: firstly carrying out nitration reaction on 4-tert-butylphenol, then reducing nitryl into amino to obtain amino substituted 4-tert-butylphenol, protecting the amino by di-tert-butyl dicarbonate ester, then oxidizing iodobenzene into a high-valence iodine active intermediate by taking m-chloroperoxybenzoic acid as an oxidizing agent, and reacting with Boc-amino substituted 4-tert-butylphenol to obtain the high-valence iodine-substituted 4-tert-butylphenol. And finally, carrying out a replacement reaction with silver trifluoromethanesulfonate, carrying out deprotection to obtain a modified photoreaction agent, and carrying out a condensation polymerization reaction on the modified photoreaction agent, 4, 4 '-hexafluoroisopropyl phthalic anhydride and the like to generate a polyamic acid prepolymer, so that the photoetching resolution can be greatly improved.

This invention relates to a method for the electrocatalytic oxidation of anisole to anisole sulfoxide using iron-based complexes, belonging to the fields of homogeneous catalysts and electrocatalytic oxidation technology. The invention utilizes an iron-based complex formed by coordination between a tetraamide macrocyclic ligand (TAML-H4) and metallic iron as a homogeneous molecular catalyst, with water as the sole oxygen source, to construct an electrocatalytic anisole oxidation system. Through the synergistic effect of the catalyst and water, a proton-coupled electron transfer and single-electron oxidation process occurs at the anolyte, resulting in the loss of two electrons and two protons to generate a high-valence iron-oxygen active intermediate [Fe]. Ⅴ (O)(TAML)] – This invention achieves highly efficient and selective oxidation of anisole, generating the high-value-added product benzyl sulfoxide at the anode. It eliminates the need for additional strong oxidants, employs mild reaction conditions, boasts high atom economy, and is environmentally friendly, making it suitable for the green conversion of sulfides in the synthesis of fine chemicals. This provides a feasible pathway for the industrial production of sulfoxide compounds.

The invention discloses an inorganic plastic oxygen composite material and application thereof in preservation and sterilization of cold-chain logistics. The inorganic plastic oxygen composite material comprises the following components: an inorganic internal peroxide bridge composite compound, a composite catalytic component and a material balancing and stabilizing system, the calcium peroxide and the sodium percarbonate are compounded according to the mass ratio to form an inorganic internal peroxide bridge compound, crystal structures of the two peroxides are complementary, a synergistic slow-release effect is formed in water, waste of active ingredients caused by rapid decomposition of a single peroxide is avoided, and therefore an active intermediate containing a peroxide bridge bond is continuously released. Due to the slow-release characteristic, even in a cold-chain low-temperature environment of-20 DEG C to 10 DEG C, stable supply of the active intermediate can still be ensured, and the requirements of long-term preservation and sterilization are met, so that the problems that a traditional single peroxide material is quick in activity attenuation and short in sterilization period at low temperature are solved.

The invention discloses an electrochemical catalytic synthesis method of a macrolide compound, and belongs to the field of electrochemical catalytic synthesis. According to the method, triphenylphosphine is taken as a deoxidizing reagent, halide ions are taken as an electrocatalyst, a graphite flake is taken as an anode, foamed nickel is taken as a cathode, in the presence of additives DBU and the like, omega-hydroxycarboxylic acid shown in a structure I is subjected to constant-current electrolysis in a single-chamber electrolytic bath, and the lactone compound shown in a structure II is prepared in one step. The method is characterized in that the concentration of the active reaction intermediate is regulated and controlled by controlling the current density, so that a high dilution condition which must be adopted in a conventional method is avoided, and the synthesis of the macrolide compound under a high concentration condition is realized. The method can be carried out at the concentration up to 250 mM, complex slow dropwise adding operation is not needed, use of a large amount of solvent is avoided, and meanwhile the final product can be obtained only through one-step reaction. Compared with different methods under the same concentration, the method provided by the invention has more advantages. .

The invention discloses a method, equipment and a micro-display device for low-temperature atomic layer deposition of a film, and a hafnium oxide film is deposited at a low temperature through circulation steps of surface activation, hafnium source adsorption, ligand promotion and oxidation film formation. The method specifically comprises the following steps: activating the substrate surface by ammonia plasma; introducing a hafnium precursor to adsorb the hafnium precursor; mixed gas of trifluoroacetic acid and ozone is introduced, trifluoroacetic acid serves as an acid accelerant to be subjected to ligand exchange with the adsorbed hafnium precursor to generate an active intermediate, and the intermediate is oxidized into hafnium oxide through ozone at the low temperature. By introducing the ligand promotion step, the traditional oxidation path is changed, the low-temperature deposition bottleneck of the high-quality hafnium oxide thin film is successfully broken through, the method is particularly suitable for thin film packaging of micro-display devices sensitive to temperature, and the advantages of high dielectric, low electric leakage and high thermal stability of hafnium oxide can be exerted while an organic functional layer is protected. The invention also provides special atomic layer deposition equipment for implementing the method.

The invention discloses a preparation method of high-purity dihydrooat alkaloid, which comprises two continuous reaction stages of nucleophilic substitution and electrophilic addition and a post-treatment stage of separation and purification, and comprises the following steps: under the condition of nitrogen protection, carrying out nucleophilic substitution reaction on p-hydroxyphenylpropionic acid and carbonyl diimidazole to generate an N-acyl imidazole active intermediate; dropwise adding into an organic solvent of o-aminobenzoic acid without separation to complete electrophilic addition reaction, so as to generate a dihydrooat alkaloid solution with high selectivity; after the reaction is finished, cooling to room temperature, extracting, separating and concentrating an organic phase to separate out a crude product or concentrating a reaction solution until the reaction solution is dry and separating out a crude product in an acidic aqueous solution, and recrystallizing to obtain the high-purity dihydrooat alkaloid. The one-pot process strategy of step-by-step activation and controllable addition is adopted, the reaction has the advantages of being high in chemical selectivity, mild in reaction condition, high in raw material conversion rate and simple and convenient in aftertreatment, phenolic hydroxyl protection is avoided, the problem of high-selectivity amidation is solved, and the preparation cost is effectively reduced.

The invention relates to the field of catalyst preparation, in particular to a propylene dimerization catalyst and a preparation method and application thereof. The propylene dimerization catalyst provided by the invention comprises a composite carrier and alkali metal loaded on the composite carrier, the composite carrier comprises gamma-aluminum oxide; the inorganic salt modified layer is loaded on the surface of the gamma-aluminum oxide; the transition metal and the graphite modification layer are loaded on the surface of the inorganic salt modification layer. According to the propylene dimerization catalyst provided by the invention, gamma-aluminum oxide is adopted as a basic framework and interacts with a super-strong base site active center formed by an alkali metal system, and the formed super-strong base site is more beneficial to generation of an active intermediate allyl carbon negative ion, so that the selectivity of 4-methyl-1-pentene is improved; meanwhile, gamma-aluminum oxide is adopted, so that the strength of the catalyst structure is ensured, disintegration and pulverization are not easily caused in the industrial production process, and the service life is effectively prolonged.

The preparation method comprises the following steps: uniformly mixing a nitro aromatic compound, an alkyl aldehyde compound / aromatic aldehyde compound, an inorganic ammonium salt and an organic solvent, carrying out a reaction in an air or inert atmosphere at 50-150 DEG C under the irradiation of a light source with the wavelength of 254-580 nm, and then cooling to room temperature to obtain the quinazoline compound. And performing concentration and column chromatography purification to obtain the compound. The method realizes visible light promotion of quinazoline construction without an additional photocatalyst, metal and an additional oxidant, utilizes ingenious combination of weak photosensitivity of nitro-aromatic hydrocarbon and 2-nitrobenzyl structural design, generates a key active intermediate in situ under mild conditions, realizes high-efficiency tandem cyclization and oxidative aromatization, and improves the yield of quinazoline. The method thoroughly gets rid of dependence on precious metal or dye in a traditional method, and is green, environment-friendly and low in cost.

The invention discloses a synthesis method of an N-aryl amide compound, which comprises the following steps: dissolving a carboxylic acid compound, a propiolic acid ester compound and an organic base catalyst in an organic solvent, reacting at 80-130 DEG C for 5-60 minutes to obtain an active intermediate, adding an aromatic amine compound into the organic solvent, and continuously reacting at 80-130 DEG C for 0.5-12 hours to obtain the N-aryl amide compound. The invention provides a method for synthesizing the N-aryl amide compound by directly mediating carboxylic acid and aromatic amine to perform one-pot reaction by utilizing propiolic acid ester by utilizing a propiolic acid ester mediating strategy, and the synthesis method is efficient, simple and convenient to operate, strong in substrate universality and mild in reaction condition, and can be used for preparing intermediates.

The invention discloses linear nitrogen-sulfur-containing polyborosiloxane as well as a preparation method and application thereof. According to the technical scheme, a two-step method is innovatively adopted to precisely regulate and control the polymerization process: firstly, a functional flame-retardant unit is constructed through directional reaction of boric acid and a phenyl sulfonic acid compound with amino, then the functional flame-retardant unit is used as an active intermediate to be polymerized with hydroxyl-terminated silicone oil, controllable growth of molecular chains is achieved, and finally linear nitrogen-sulfur-containing polyborosiloxane is prepared. Only 0.2-0.4 wt% of nitrogen-sulfur-containing polyborosiloxane prepared by the preparation method disclosed by the invention is added, and the nitrogen-sulfur-containing polyborosiloxane has excellent effects of promoting PC charring and resisting molten drops, so that the polycarbonate composite material is good in thermal stability and high in carbon residue, passes a UL-94 V0 level test and an S2 needle flame test, and meanwhile, keeps excellent impact resistance.

This invention relates to a method for preparing fluorosulfonyl carboxylic acid esters, the esters prepared therefrom, and the uses of the esters. It is used in the preparation of FSO2R. 1 C(O)OR 2 The method of representing an ester, the method comprising making acid FSO2R 1 COOH reacts with pentanoyl chloride, N,N'-carbonyl diimidazole, acetyl chloride, or acetic anhydride under alkaline conditions to generate the reactive intermediate acid anhydride, and the reactive intermediate acid anhydride reacts with alcohol R. 2 The OH reaction produces an ester represented by formula (I). By using the method of the present invention, the problems of unsafe raw materials, difficulty in use, low product yield, difficult reaction operation, and environmental pollution caused by the prior art are solved.

This invention relates to a photo-initiated method for synthesizing asymmetric azo aromatic compounds and its applications, belonging to the field of organic synthesis technology. A 1-hydroxybenzotriazole compound is deprotonated under alkaline conditions and then undergoes a cleavage reaction under visible light excitation to generate a highly reactive diradical intermediate. This intermediate is unstable and rapidly tautomerizes to a more stable nitrosophenyl anion intermediate. Under aprotic polar solvent conditions, this highly reactive intermediate is proton-quenched to obtain a highly reactive nitrosobenzene intermediate, which subsequently polymerizes with aniline compounds to generate asymmetric azo aromatic compounds. The raw materials are readily available, the synthetic route is short, the process is simple, and the products are easily separated and purified, making it suitable for large-scale synthesis. This provides a new route for the rapid preparation of asymmetric azo aromatic compounds. The synthesized asymmetric azo aromatic compounds exhibit good antibacterial activity and have significant application potential in the control of anthracnose in tea trees.

The application provides a bisphenol A synthesis catalyst and a bisphenol A preparation method. The catalyst comprises a cation exchange resin and a modified molecular sieve. The surface of the modified molecular sieve is connected with a modified group. The modified group is any one or both of a mercaptoalkyl group and an amine alkyl group. The modified molecular sieve can promote the generation of an active intermediate, an acetone carbon cation, in a reaction process, improve a reaction rate, and accelerate the reaction of the acetone carbon cation with phenol to generate bisphenol A. The mixed catalysts simultaneously consider the advantages of high activity of a hydrochloric acid method and high purity of a resin method, and the product has less free acid, and the product quality is higher than that of a hydrochloric acid catalysis method.

The application belongs to the technical field of herbicide purification, and particularly relates to a continuous washing process of low nitrosamine trifluralin. The washing process comprises the following steps: S1: mixing hydrochloric acid with a bromide salt nucleophilic catalyst and sulfamic acid to obtain a catalytic acid phase; S2: pumping the crude trifluralin and the catalytic acid phase into a static mixer for mixing, and then pumping the mixture into an automatic phase separator to obtain acid-washed crude products and separated catalytic acid phase; S3: pumping the acid-washed crude products and water into a static mixer for mixing and phase separation to obtain wet trifluralin products; and performing post-treatment on the wet trifluralin products to obtain low nitrosamine trifluralin. The application utilizes nucleophilic catalysis to enhance the nitrosamine degradation efficiency, and simultaneously removes nitrous acid active intermediates through sulfamic acid, so that the content of nitrosamine in trifluralin can be less than or equal to 1.0 ppm under mild conditions.

The invention discloses an exosome compound containing NMN-ergothioneine as well as a preparation method and application thereof, and relates to the technical field of exosome preparations, the exosome compound comprises an exosome matrix and an amphiphilic active intermediate loaded on the exosome matrix; the amphiphilic active intermediate is formed by assembling or physically embedding a lipophilic carrier material and an active composition through an intermolecular force; the active composition comprises nicotinamide mononucleotide and ergothioneine; the amphiphilic active intermediate is embedded into a lipid bilayer of the exosome matrix or entrapped in an inner cavity of the exosome matrix to form a compound with a core-shell structure or a membrane fusion structure. By constructing a unique membrane embedding structure, the entrapment efficiency and stability of hydrophilic components are improved, medicine leakage is effectively prevented, meanwhile, the biological activity of exosomes is reserved, the cellular uptake ability and intracellular delivery efficiency are enhanced, and effective repair and lasting anti-oxidation effects on mitochondrial functions are achieved.