49 results about "Reactive intermediate" patented technology

The invention discloses an amino alcohol nickel complex as well as a preparation method and application thereof, and belongs to the technical field of organic metal synthesis. The molecular formula of the amino alcohol nickel complex is Ni [OCR1R2 (CH2) mNR3R4] 2, comprising the following raw materials: a nickel-containing complex, 60wt.% of NaH and HOCR1R2 (CH2) mNR3R4, the preparation method specifically comprises the following steps: (1) under the protection of nitrogen, mixing a nickel-containing complex, 60wt.% NaH, HOCR1R2 (CH2) mNR3R4 and toluene, carrying out heating reaction, and carrying out heating reaction again; and (2) filtering, concentrating, cooling, filtering again, and washing to obtain the product. The nickel-containing complex, sodium hydride and amino alcohol are synthesized into the amino alcohol nickel complex through a one-pot method, the raw materials are simple, easy to obtain and convenient to store, expensive active intermediates do not need to be synthesized or purchased, and the cost and risk of amplified production are reduced. Meanwhile, the purification method of the product is improved, the high-purity amino alcohol nickel complex is obtained through a low-temperature crystallization method, operation is safe and convenient, the industrial purification efficiency is improved, and the purity of the obtained product is as high as 6N-7N through ICP-MS testing.

The present application belongs to the technical field of the synthesis of chiral boron compounds, and in particular relates to an MOF-Cu(II) / CMC composite material, and a preparation method therefor and the use thereof. The preparation method for an MOF-Cu(II) / CMC composite material of the present application comprises: dropwise adding an aqueous solution of sodium carboxymethyl cellulose to an aqueous solution of a bivalent copper salt, performing solid-liquid separation, mixing obtained composite microspheres with an organic solution of trimesic acid, heating the resulting mixture, and subjecting same to solid-liquid separation, so as to obtain an MOF-Cu(II) / CMC composite material. The MOF-Cu(II) / CMC composite material is used in an asymmetric chiral boron addition reaction. The reaction is performed at room temperature, involves mild conditions, is applicable to a wide range of substrates and has a high yield and enantioselectivity. Moreover, the method can achieve the synthesis of a chiral organic boride in a solvent having simple components, providing an efficient new method for the preparation of drug molecules and active intermediates, and also broadening the range of substrates used for the preparation of chiral organic borides.

The invention relates to a method for preparing anionic polymerized polyamide 6 with a high reaction rate by adopting a double-activation system. S2, putting the caprolactam dried in the step S1 into a beaker at room temperature, then putting the beaker into an oil bath pan, heating until the caprolactam is completely melted, and starting stirring; the method comprises the following steps: putting caprolactam into a 500ml three-necked flask at room temperature, then putting the three-necked flask into a 500ml electric heating jacket, heating until the caprolactam is completely melted, and starting mechanical stirring by using a stirring paddle to generate two active intermediates and three block structures, and the polymer has the advantages of stable polymerization time, excellent mechanical properties, high polymerization rate, good thermal stability, high antioxidant degree, high crystallinity and the like.

The invention belongs to the field of pharmaceutical chemicals, and relates to a preparation method of an anti-influenza virus derivative intermediate. According to the invention, a compound (a) and a compound (b) are taken as initial raw materials, and an alcoholic hydroxyl group is directly converted into an active intermediate by utilizing trimethylsilyl trifluoromethanesulfonate (TMSOTf), so that the tedious operation of firstly protecting the hydroxyl group and then carrying out substitution reaction in the traditional method is avoided, and a key intermediate (d) required for preparing the anti-influenza virus derivative can be obtained in one step. The method has the advantages of simplicity and convenience in operation, high yield, easiness in industrial amplification and the like, and is suitable for large-scale preparation of the anti-influenza virus medicine and pharmaceutically acceptable salts, esters or solvates thereof.

The invention discloses an alcohol modified TS-1 catalyst as well as a preparation method and application thereof, and belongs to the technical field of molecular sieve catalysts. The alcohol modified TS-1 catalyst is prepared by the following steps: preparing a mixed solution from SiO2, 0.04 TiO2, 0.30 TPAOH, 50 H2O and nMOH according to the molar ratio of SiO2: 0.04 TiO2: 0.30 TPAOH: 50 H2O: nMOH; carrying out hydrothermal reaction on the mixed solution to obtain the alcohol modified TS-1 molecular sieve catalyst in one step; the preparation method is simple, the crystallization rate of the molecular sieve is increased by adding alcohols, more titanium atoms can be promoted to enter a skeleton, formation of a Ti-OOH active intermediate is facilitated, and generation of non-active anatase is reduced; the TS-1 molecular sieve is high in crystallinity and shows relatively high activity and alkylene oxide selectivity in a long-chain olefin epoxidation reaction.

The present invention belongs to the technical field of organic chemical synthesis, and specifically relates to a nitrogen oxide free radical derivative of rhubarb and its synthesis method and application. The present invention takes rhubarb, a lipid-lowering medicinal substance of traditional Chinese medicine, as the research object, selects its 3rd hydroxyl group as the modification site, and based on different length carbon chain substitution, A 3 Based on the reaction mechanisms of coupling, esterification and pharmacophore splicing, six active intermediate nitroxide free radicals were introduced into the structure of emodin. 50 nitroxide free radical derivatives of emodin in three series and 8 other derivatives were designed and synthesized. Several synthetic methods for novel nitroxide free radical derivatives of emodin with mild reaction conditions, environmental friendliness and high yield were established. The novel nitroxide free radical derivatives of emodin provided have low toxicity to normal liver cells, significant anti-proliferative activity against liver cancer cells, and are novel active molecules with better effects than emodin, providing a new idea for the preparation of anti-tumor drugs.

The invention relates to a polymer for treating a surface, which polymer comprises: n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups which comprise an atom-transfer radical polymerization (ATRP) initiator, wherein m is an integer equal to or greater than 3, wherein the reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups, wherein the carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D), wherein R1 is H or -S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for surface -initiated atom-transfer radical polymerization (SIATRP). The invention also relates to a treated substrate having a surface suitable for SIATRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIATRP, bonded to the reacted polymer.

The present invention belongs to the technical field of organic chemical synthesis, and specifically relates to a rhein nitroxide derivative, a synthesis method, and an application thereof. The present invention uses rhein, an antioxidant pharmacological substance from the traditional Chinese medicine rhubarb, as a research object, selects its carboxyl group at position 3 as a modification site, and introduces four active intermediate nitroxides into the rhein structure based on the amide condensation and esterification reaction mechanisms and the pharmacophore splicing principle. Thirty rhein nitroxide derivatives were designed and synthesized, thereby establishing a method for synthesizing novel rhein nitroxide derivatives with mild reaction conditions, environmental friendliness, and high yield. The provided novel rhein nitroxide derivatives have the ability to scavenge DPPH and ABTS free radicals, have a protective effect on oxidatively damaged cells, and have the ability to delay the lifespan of Caenorhabditis elegans. Their effects are superior to those of rhein, providing a new approach for the development of antioxidant and anti-aging drugs.

The invention relates to the field of biological materials, in particular to collagen hydrogel for filling injection and a preparation method of the collagen hydrogel. The recombinant collagen is dissolved in a citric acid solution to form a collagen and citric acid composite solution, and the concentration of the collagen is 100 mg / mL to 200 mg / mL; heating the composite solution to 80-100 DEG C, reacting for more than 6 hours, dehydrating citric acid molecules to form an anhydride intermediate, and performing esterification reaction on the anhydride intermediate and hydroxyl on a collagen molecular chain to form the three-dimensional network hydrogel taking an ester bond as a main crosslinking bond. A natural metabolite citric acid in an organism is used as a unique cross-linking agent, an active intermediate is formed through intramolecular dehydration under the heating condition of 80-100 DEG C, and the active intermediate and collagen are subjected to a specific esterification reaction to form a covalent cross-linked network. No exogenous chemical cross-linking agent is introduced in the process, so that the risk of toxic cross-linking agent residue is avoided, and the final product has extremely high biocompatibility.

The invention belongs to the field of textile finishing agents, and discloses an amphoteric macromolecular deodorization finishing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out a ring-opening reaction on epoxy silane and a taurine monomer to obtain an active intermediate, and adding a cyclic silane monomer to copolymerize the active intermediate and the cyclic monomer to obtain the self-curing amphoteric long-acting macromolecular deodorization finishing agent with good safety performance. The problems that a micromolecular deodorant is not resistant to washing and migrates to a human body are solved, and the obtained amphoteric macromolecular deodorization finishing agent can be applied to the field of deodorization finishing of high-end cotton and linen textiles.

The application discloses an electrochemical synthesis N α A method for synthesizing azole compounds under mild electrochemical conditions through a three-component reaction of azole, aldehyde and alcohol N α In the electrolysis process, azole is oxidized into a nitrogen free radical at the anode, and aldehyde is reduced into a hydroxyalkyl free radical at the cathode, then the free radical coupling is carried out, and finally, intermolecular dehydration of alcohol is carried out to synthesize a series of azole compounds with an alkoxyalkyl group N α The reaction avoids the use of an acid catalyst, an additional oxidant and a reducing agent through a free radical active intermediate route, is low in production cost, is friendly to the environment, and is suitable for industrial large-scale production as shown by the feasibility of a kilogram-scale amplification experiment.​​​

The invention belongs to the technical field of medicinal chemistry, and discloses a synthesis method of a flutomil compound, which comprises the following steps: (1) taking 4-fluoromethylbenzylamine and dihydroxy acetone as raw materials, and reacting with potassium thiocyanate in an acidic acetonitrile solution to synthesize an intermediate A; (2) carrying out oxidative desulfurization on the intermediate A and 2-6eq of peroxidant sodium nitrite in an acidic solvent to prepare an intermediate B; (3) further oxidizing the intermediate B into an intermediate C; and (4) reacting the intermediate C in the reaction mixed solution with n-heterocyclic carbene under a DBU alkaline condition to generate an active intermediate, and then degrading the active intermediate into the flutomi ester compound. The synthesis route is high in atom utilization rate, simple in post-treatment, free of high temperature and high heat in the reaction process, less in reaction waste liquid and low in environmental protection pressure, and compared with original literature patents, the reaction steps are few, reagents are cheap, and the process route is easy to implement, economical and efficient.

The invention provides a bisphenol A synthesis catalyst and a preparation method of bisphenol A. The catalyst comprises cation exchange resin and a modified molecular sieve, the surface of the modified molecular sieve is connected with a modified group, and the modified group is selected from any one or two of sulfydryl alkyl and amino alkyl. The modified molecular sieve can promote the generation of active intermediate acetone carbon cations in the reaction process, improve the reaction rate and accelerate the reaction with phenol to generate bisphenol A. The mixed catalyst is adopted, the advantages of high activity of a hydrochloric acid method and high purity of a resin method are considered, free acid content in a product is less, and the product quality is higher than that of a hydrochloric acid catalysis method.

The invention provides a method for marking RNA (Ribonucleic Acid) molecules related to epigenetic modification of chromatin in living cells in real time. According to the method, module protein for recognizing epigenetic modification, engineered ascorbic acid peroxidase and a biotin-aniline probe are introduced into cells. The engineered ascorbic acid peroxidase can catalyze the oxidation reaction of hydrogen peroxide on a biotin-aniline substrate, so that the biotin-aniline substrate generates a high-reaction-activity intermediate with oxygen free radicals, covalent bonds are formed between the intermediate and RNA molecules around epigenetic modification of chromatin, and further RNA molecules with biotin labels are generated. And finally, purifying the RNA molecule with the biotin label by using streptavidin magnetic beads for subsequent sequencing analysis so as to determine the RNA variety related to the epigenetic modification of the chromatin.

The invention discloses an iron / molecular sieve catalyst with a core-shell structure, a preparation method of the iron / molecular sieve catalyst and application of the iron / molecular sieve catalyst in preparation of formic acid by catalyzing methane oxidation, and belongs to the technical field of natural gas conversion and energy. The catalyst is formed by taking a Fe-ZSM-5 molecular sieve with catalytic activity as an inner core and taking a porous and inert oxide shell as a shell layer. In the core-shell structure, the internal Fe-ZSM-5 provides a high-dispersion iron active site and an acid site for activating methane; the external porous oxide shell promotes mass transfer of reaction active intermediates, meanwhile, the catalytic inertia of the oxide shell effectively inhibits excessive reaction and loss of active species, and retention of the target product formic acid is remarkably promoted. Therefore, the synergistic effect of the structure provided by the invention can greatly improve the activity and stability of the catalyst in the reaction of preparing formic acid by methane oxidation, especially the selectivity to formic acid.

The invention belongs to the technical field of photocatalysis and functional coordination chemistry, and particularly relates to a metal organic cage catalyst based on ligand engineering regulation and a method for photocatalytic synthesis of hydrogen peroxide in pure water. According to the invention, a tripyridine ligand containing pyridinium substituent groups is designed through a ligand engineering strategy, and the tripyridine ligand and zinc ions are self-assembled to form the metal organic cage catalyst with a tetrahedral structure. By introducing a pyridinium group into a ligand structure, the electron attraction capability of a system is enhanced, and an efficient charge transfer channel is formed. Active intermediates (such as hydroxyl free radicals and superoxide free radicals) are effectively stabilized by the confinement space of the cage body, and the decomposition reaction of hydrogen peroxide is inhibited. The structure can efficiently separate photo-induced electrons and holes under the illumination condition and promote the double-two-electron synergistic process of oxygen reduction reaction and water oxidation reaction, so that hydrogen peroxide is efficiently generated in a pure water system without a sacrificial agent.

The invention relates to a synthesis method and a synthesis processing system of quinclorac oxadiazon, and belongs to the technical field of pesticide synthesizing.The synthesis method comprises the steps that firstly, through mediation of a silane coupling agent, nanometer copper oxide particles are evenly loaded in mesopores of an adsorption type molecular sieve, and then the adsorption type molecular sieve, 3, 7-dichloro-8-quinolinecarboxylic acid and N, N-dimethylformamide are mixed to form the quinclorac oxadiazon. According to the present invention, substances such as N, N-dimethylformamide and the like are subjected to acyl chloride, esterification and transposition rearrangement reactions, the copper oxide nanoparticles in the adsorption type molecular sieve and N, N-dimethylformamide achieve the synergistic effect, and can form the active intermediate with thionyl chloride, such that the activation energy of the acylating chlorination reaction is reduced, and the acylating chlorination reaction time is shortened; the mesoporous structure of the MCM-41 molecular sieve can adsorb hydrogen chloride gas generated in the acylating chlorination reaction in situ through Van der Waals' force and capillary coagulation, the conversion rate of the acylating chlorination reaction is improved, and the in-situ removal of hydrogen chloride can also reduce the use amount of an acid-binding agent triethylamine in the subsequent esterification reaction, so that the generation of triethylamine hydrochloride by-products is reduced, and the material loss is reduced.

The present application relates to the technical field of thermal insulation materials, and discloses a flame-retardant thermal insulation material for an electric core and a preparation method thereof. The flame-retardant thermal insulation material for the electric core is obtained through cellulose dissolution, crosslinking and flame-retardant modification, gel forming and drying. The active intermediates released by the oxazine ring during ring-opening polymerization at high temperature can catalyze the crosslinking reaction between molecular chains, forming a three-dimensional network structure and improving the flame-retardant performance of the material. Borate ester decomposes into boron oxide or boric acid at high temperature, and forms a transparent glassy coating after melting, which tightly covers the surface of the material, physically blocks the transmission of oxygen and heat, and has a flame-retardant effect. The phosphoric acid ester decomposes to generate phosphorus-containing free radicals, which can combine with active free radicals in the flame to interrupt the combustion chain reaction, reduce the flame temperature, and further improve the flame-retardant performance of the material. The silane decomposes to generate non-combustible or difficult-to-combust substances such as silicon dioxide, which form a dense protective layer on the surface of the material, thereby preventing the spread of the flame and having a flame-retardant effect.

The invention relates to the technical field of thermal insulation materials, and discloses a flame-retardant thermal insulation material for a battery cell and a preparation method of the flame-retardant thermal insulation material. According to the invention, cellulose is subjected to dissolution, crosslinking and flame-retardant modification, and gel forming and drying, such that the flame-retardant thermal insulation material for the battery cell is obtained. An active intermediate released by an oxazine ring during ring-opening polymerization at a high temperature can catalyze a cross-linking reaction between molecular chains to form a three-dimensional network structure, so that the flame retardant property of the material is improved; boric acid ester is decomposed at a high temperature to generate boric oxide or boric acid, a transparent glassy coating is formed after melting, the surface of the material is tightly covered, oxygen and heat transfer are physically blocked, and the flame-retardant effect is achieved; phosphorus-containing free radicals generated by decomposition of phosphate can be combined with active free radicals in flames, so that a combustion chain reaction is interrupted, the flame temperature is reduced, and the flame retardant property of the material is further improved. And non-combustible or flame-retardant substances such as silicon dioxide generated by decomposition of silane can form a compact protective layer on the surface of the material, so that flame propagation is prevented, and a flame-retardant effect is achieved.

The invention discloses a Pd / Al2O3 hollow sphere catalyst rich in alkaline sites and an application of the Pd / Al2O3 hollow sphere catalyst in efficient catalysis of formic acid dehydrogenation reaction, a preparation method is as follows: Al2O3 hollow sphere Al2O3HS rich in intrinsic alkaline sites is successfully prepared by a controllable hydrothermal synthesis method, an Al2O3HS carrier has both high specific surface area and high-density alkaline sites, and the Pd / Al2O3 hollow sphere catalyst is a Pd / Al2O3 hollow sphere catalyst rich in alkaline sites. The generation of formate radicals and the formation of Pd-HCOO * active intermediates are obviously promoted, so that the hydrogen generation rate up to 4606h <-1 > is realized; the invention not only provides a feasible strategy for the design of the efficient formic acid dehydrogenation catalyst, but also provides an important reference for the development of an advanced hydrogen production catalytic system and other energy related applications; good popularization and application prospects are realized.

The invention provides an ester oxidation synthesis method, and belongs to the technical field of ester synthesis. According to the invention, an N-halogenated amine compound is used as an oxidizing agent and can be subjected to oxidation reaction with carbon disulfide to generate an active intermediate and a water-soluble amine salt, and the active intermediate reacts with a carboxylic acid substance to generate an active ester intermediate, hydrogen halide and elemental sulfur precipitate; carrying out esterification reaction on the active ester intermediate and hydroxyl of the hydroxyl compound to generate ester and carbon dioxide gas; organic alkali is added to neutralize halogen hydride, so that the reaction is promoted; meanwhile, the alkalinity of the organic base is weak, the organic base cannot react with carboxylic acid, and the situation that the reaction yield is reduced due to hydrolysis of the N-halogenated amine compound can be avoided; in the preparation process, no by-product with the solubility similar to that of the product ester exists, and the product is easy to separate.

The invention discloses a nickel-loaded semiconductor oxide-based catalyst for methanation of carbon dioxide in photo-thermal catalytic flue gas as well as a preparation method and application of the nickel-loaded semiconductor oxide-based catalyst. The photo-thermal catalyst takes a semiconductor oxide as a carrier, and nickel metal is loaded through impregnation, calcination and reduction treatment. The Ni metal nanoparticles serve as carbon dioxide hydrogenation sites, the semiconductor oxide material stimulates oxygen in flue gas to be combined with reactants under light driving to generate more reactivity intermediates, and surface oxygen vacancies formed by the reduction treatment material further enhance the adsorption and activation capacity of the catalyst to the reactants. The preparation process is simple and the cost is low. In the reaction of methanation of carbon dioxide in photo-thermal catalytic flue gas, the catalyst shows high-efficiency activity, and the selectivity gt of methane in the product is realized; 99%. Besides, the method has the advantages of mild reaction conditions, simplicity and convenience in operation, environmental friendliness and the like, provides an efficient and feasible way for resource utilization of carbon dioxide, and has a wide application prospect.

The invention relates to the technical field of organic synthesis, and provides an asymmetric carbon-hydrogen bond boronation reaction catalyst and a preparation method of chiral dicyclobutane. A catalyst composed of a chiral boron-based ligand and an iridium salt is adopted to catalyze an asymmetric carbon-hydrogen bond boronation reaction of prochiral dicyclobutane, in a reaction system, the iridium salt and the chiral boron-based ligand are combined to form a complex, the complex reacts with B2pin2 to form an active intermediate, and the active intermediate is separated from the chiral boron-based ligand to form the chiral dicyclobutane. Then the iridium center and a carbon-hydrogen bond of a 3-substituted dicyclobutane-1-formamide compound are subjected to an asymmetric oxidative addition reaction to form an iridium-carbon bond, then reduction elimination is carried out, and the target product chiral dicyclobutane is generated. The reaction condition for constructing the chiral dicyclobutane is mild, the selectivity is high, the enantioselectivity is 95% or above, the substrate universality is wide, and chiral dicyclobutane compounds of different structures can be synthesized.

The application discloses an electrochemical DNA synthesis method based on pulse direct current voltage, and comprises the following steps: performing hydroxylation modification on an electrode surface to obtain a modified electrode; coupling an active intermediate, which is obtained by mixing a phosphoramidite synthesis monomer with an activating agent, with a hydroxyl active site on the modified electrode to form a phosphite triester bond; after flushing the modified electrode with anhydrous acetonitrile, adding an oxidizing agent on the modified electrode to perform oxidation, and the phosphite triester bond is oxidized into a stable phosphate ester bond by the oxidizing agent; adopting electrochemical deprotection to remove a DMT protective group to expose the hydroxyl active site, which is used for addition of a next base; and repeating the above steps to perform synthesis of an oligonucleotide sequence. In the electrochemical deprotection step, hydrogen ions are generated more uniformly, so that the synthesis quality of DNA can be guaranteed and improved while the gold layer of the gold electrode is slowed down in falling off and the service life of the gold electrode is prolonged.

The invention relates to a polymer for treating a surface, which polymer comprises n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups for controlling surface-initiated reversible-deactivation radical polymerization (SIRDRP), wherein m is an integer equal to or greater than 3. The groups for controlling SIRDRP are selected from groups which comprise an initiator and groups which comprise a chain transfer agent (CTA). The reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups. The carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D): wherein R1 is H or –S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for SIRDRP. The invention also relates to a treated substrate having a surface suitable for SIRDRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIRDRP, bonded to the reacted polymer.

The invention relates to the technical field of photoresist, in particular to photoresist for a capacitive touch sensor and a preparation process of the photoresist. The invention discloses a preparation process of photoresist for a capacitive touch sensor. The preparation process comprises the following steps: preparing a modified photoreaction agent; preparing modified polyimide resin powder; preparing silicon dioxide hollow carbon spheres and nano titanium dioxide hybrid particles; and preparing the photoresist. The preparation method comprises the following steps: firstly carrying out nitration reaction on 4-tert-butylphenol, then reducing nitryl into amino to obtain amino substituted 4-tert-butylphenol, protecting the amino by di-tert-butyl dicarbonate ester, then oxidizing iodobenzene into a high-valence iodine active intermediate by taking m-chloroperoxybenzoic acid as an oxidizing agent, and reacting with Boc-amino substituted 4-tert-butylphenol to obtain the high-valence iodine-substituted 4-tert-butylphenol. And finally, carrying out a replacement reaction with silver trifluoromethanesulfonate, carrying out deprotection to obtain a modified photoreaction agent, and carrying out a condensation polymerization reaction on the modified photoreaction agent, 4, 4 '-hexafluoroisopropyl phthalic anhydride and the like to generate a polyamic acid prepolymer, so that the photoetching resolution can be greatly improved.

The invention relates to the technical field of organic synthesis, in particular to a method for preparing diazonium ketone by a one-pot method, which comprises the following steps: reacting carboxylic acid active intermediates such as acyl chloride and mixed anhydride with diazomethane precursor N-methyl-N-nitrosourea in an organic solvent under the action of alkali to obtain a corresponding diazonium ketone compound with medium to good yield. According to the method disclosed by the invention, the diazomethane is generated in situ by using the cheap and easily available diazomethane precursor N-methyl-N-nitrosourea to participate in the reaction, so that the direct use of a highly toxic reagent diazomethane is avoided, and the danger in the process of preparing the diazoketone by the Ardt-Eistern reaction is greatly reduced; and the carboxylic acid substrate can be directly converted into corresponding active intermediates for further serial preparation to obtain corresponding diazonium ketone, and the method has the characteristics of wide application range of the substrate, mild and simple reaction conditions, green steps, low pollution, high economic benefit and the like.

The invention discloses a PtSe2 / PtCu heterojunction hydrogen evolution reaction electrocatalyst and a preparation method thereof, and belongs to the technical field of electrochemical catalysis. Firstly, growing PtCu3 alloy hollow nanospheres through a hydrothermal method; then, the PtCu3 alloy hollow nanospheres are selenized in a tubular furnace, and PtSe2 / PtCu nanospheres are obtained; in the PtSe2 / PtCu heterojunction nanosphere, lattice mismatch of a heterogeneous interface can adjust the local electronic environment of an active site and the adsorption energy of the active site to an intermediate, so that the intrinsic catalytic activity of the active site is improved; the adsorption and catalytic conversion efficiency of water molecules and active intermediates on active sites is increased to the maximum extent; meanwhile, the non-noble metal Cu is doped, so that the activity of the catalyst is improved, the use amount of noble metal Pt is reduced, and the cost of the catalyst is reduced.

This invention relates to a method for the electrocatalytic oxidation of anisole to anisole sulfoxide using iron-based complexes, belonging to the fields of homogeneous catalysts and electrocatalytic oxidation technology. The invention utilizes an iron-based complex formed by coordination between a tetraamide macrocyclic ligand (TAML-H4) and metallic iron as a homogeneous molecular catalyst, with water as the sole oxygen source, to construct an electrocatalytic anisole oxidation system. Through the synergistic effect of the catalyst and water, a proton-coupled electron transfer and single-electron oxidation process occurs at the anolyte, resulting in the loss of two electrons and two protons to generate a high-valence iron-oxygen active intermediate [Fe]. Ⅴ (O)(TAML)] – This invention achieves highly efficient and selective oxidation of anisole, generating the high-value-added product benzyl sulfoxide at the anode. It eliminates the need for additional strong oxidants, employs mild reaction conditions, boasts high atom economy, and is environmentally friendly, making it suitable for the green conversion of sulfides in the synthesis of fine chemicals. This provides a feasible pathway for the industrial production of sulfoxide compounds.

The invention discloses an inorganic plastic oxygen composite material and application thereof in preservation and sterilization of cold-chain logistics. The inorganic plastic oxygen composite material comprises the following components: an inorganic internal peroxide bridge composite compound, a composite catalytic component and a material balancing and stabilizing system, the calcium peroxide and the sodium percarbonate are compounded according to the mass ratio to form an inorganic internal peroxide bridge compound, crystal structures of the two peroxides are complementary, a synergistic slow-release effect is formed in water, waste of active ingredients caused by rapid decomposition of a single peroxide is avoided, and therefore an active intermediate containing a peroxide bridge bond is continuously released. Due to the slow-release characteristic, even in a cold-chain low-temperature environment of-20 DEG C to 10 DEG C, stable supply of the active intermediate can still be ensured, and the requirements of long-term preservation and sterilization are met, so that the problems that a traditional single peroxide material is quick in activity attenuation and short in sterilization period at low temperature are solved.