57results about "Sulfonyl/sulfinyl group formation/introduction" patented technology

There is provided a method for preparing a sulfone or sulfoxide compound, characterized in that a sulfide compound is allowed to react with hydrogen peroxide in the presence of a metal oxide catalyst formed by the reaction of hydrogen peroxide with at least one metal or metal compound selected from tungsten metal; molybdenum metal; a tungsten compound comprising tungsten and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen; and a molybdenum compound comprising molybdenum and a Group IIIb, IVb, Vb, or VIb element exclusive of oxygen.

The invention discloses a method for preparing sulfonamide and derivatives thereof. The method comprises the following step of in the absence of a metal catalyst and in the presence of iodine serving as a catalyst and an oxidant, reacting sodium sulfinate and derivatives of sodium sulfinate with amine and derivatives of amine or ammonia water to form corresponding sulfonamide and derivatives of sulfonamide. According to the method, by adopting the characteristics of mild reaction conditions and no addition of transition metals, alkali, ligand and additives, sulfonamide and derivatives thereof are efficiently prepared, and the method has the advantages of broad substrate range and universality, inexpensive raw materials and mild conditions, easiness for treatment and safety, so that the reaction has good practicability and wide application.

The invention relates to a preparation method of a sulfuryl fluoride compound. A sulfonyl hydrazide compound and a fluoride reagent serve as reaction raw materials. The preparation method includes the steps that a, the sulfonyl hydrazide compound with the structure (I) and the fluoride reagent are dispersed in a solvent, wherein the structure (I) is shown in the specification; b; a mixture obtained from the step a is stirred and heated to obtain the sulfuryl fluoride compound with the structure (II), wherein the structure (II) is shown in the specification (II). Compared with existing related technologies in the chemical synthesis field, the method of preparing sulfuryl fluoride from sulfonyl hydrazide is achieved for the first time. In the method, no catalyst needs to be added, reaction conditions are moderate, good compatibility can be achieved for water and air, and large-scale production is easy to achieve. The experimental result indicates that the yield of the obtained sulfuryl fluoride compound can reach up to 98%.

The invention relates to a method for selectively oxidizing sulfide. A mesoporous carbon nitride material is taken as a catalyst; oxygen is taken as an oxidant; the mass ratio of the raw material sulfide to the catalyst is (2000:1) to (1:1); the reaction temperature is 0-250 DEG C; the reaction time is 4-24 hours; and the sulfide is selectively oxidized, thereby obtaining the corresponding sulphoxide compound. The technology of preparing the sulphoxide compound by selectively oxidizing the sulfide provided by the invention has the advantages that the process flow is short, the three wastes are few, the conversion rate of the raw material sulfide is high and the selectivity of the product sulphoxide is high; the cheap oxygen is taken as the oxidant, so that the production cost is lowered; and after the reaction is ended, the catalyst is recycled according to a simple filtering method.

The present invention relates generally to methods for producing detergent compounds from waste plastic feedstocks. More specifically, the invention relates to methods for producing detergent intermediates, including alkylbenzenes, paraffins, olefins, oxo alcohols, and surfactant derivatives thereof from waste plastic feedstock.

The invention provides an aryl sulfonamide tertiary amine compound synthesizing method. According to the method, in an anhydrous aprotic solvent and under nitrogen protection, acryl sulfonyl chlorideand di-tertiary amine react for 1 to 12 hours according to a molar ratio of (1 to 1) to (1 to 20) under the condition of 50 to 150 DEG C, and the aryl sulfonamide tertiary amine compound can be obtained by purification. According to the method disclosed by the invention, the acryl sulfonyl chloride and the di-tertiary amine can directly generate C-S bond formation in the aprotic solvent and generate C-N bond breakage at the same time. According to the one-step aryl sulfonamide synthesizing method, raw materials are easy to obtain, a synthesizing technology is simple, operation is convenient, cost is low, and yield is high.

The invention discloses a method for preparing beta-carbonyl sulfone. The preparation method comprises the following steps: by taking an alpha-carbonyl diazo compound and sodium arylsulfinate as reaction substrates, cheap silver nitrate as an optimal catalyst, 1, 10-phenanthroline as a ligand and potassium persulfate as an oxidant, carrying out coupling reaction in a mixed solvent of acetonitrileand water to obtain the beta-carbonyl sulfone compound. Compared with the prior art, the method has the advantages of wide reaction substrate range, short reaction time, high reaction yield, mild reaction conditions and the like. Non-toxic and harmless reagents are used as reaction raw materials, so that the method is harmless to the environment and meets the requirements of modern green chemicaldevelopment. Post-reaction treatment is simple, and separation and purification are facilitated. In addition, the reaction can realize gram-scale synthesis, and lays a foundation for practical application.

Sulfone is an important drug and bioactive compound. Sulfone is widely used as a medicament, such as a medicament gamma-secretase inhibitor for preventing Alzheimer's disease, and is widely applied tobioactive compounds, natural products and agricultural chemicals, such as currently popular herbicide mesotrione. Sulfone is also most often used as an intermediate for organic synthesis. On the other hand, a chalcogen heterocyclic stent has biological activity, such as antitumor drugs and antiproliferative drugs. As is well-known, thiophene, furan and selenium compounds have a variety of biological activities, such as anti-inflammatory agents, anti-HIV PR inhibitors, NQO2 inhibitors, and anticancer agents. The invention develops a simple, convenient and efficient Bronsted acid, i.e., sulfuric acid and catalyzed three components react in water to synthesize aryl(chalcogen-heteroaryl)methyl sulfone, the yield is good to be very high, and the substrate range is wide. The synthesis method isenvironment-friendly and economic, and does not need metal catalysis. The sulfone product can be effectively converted into bactericide analogues and aryl heteroaryl ketones.

The invention relates to a method for using alcohol as a green cheap reduction agent and carrying out an intermolecular reductive coupling reaction on ordinary imine and ordinary alkyne under catalysis of cheap transition metal to efficiently produce a polysubstituted allyl amine derivative. The method is economic and practical. The critical points of the method for solving problems lie in the facts that a large-steric hindrance high-electronegativity carbene ligand is found to improve the reaction activity, and meanwhile, by designing a chiral carbene ligand, chiral control of part of substrates is achieved; and the cheap metal nickle and the green reduction agent isopropyl alcohol are used jointly, so that the method is economic, practical and environmentally friendly, and is in accord with principles of sustainable development.

The invention discloses a synthesis process of sulfonamide compounds in a microwave system. The synthesis process is realized by the following steps: by using CuCl as a catalyst and FeCl3 as an oxidant, carrying out carbon-hydrogen activating and carbon-nitrogen coupling reaction in a DMF (Dimethyl Formamide) by substituting sulfanilamide and methylbenzene through microwave heating and efficient catalysis for 10 to 60 minutes; extracting a product by using ethyl acetate; carrying out vacuum concentration; carrying out column chromatographic purification on a product to obtain the sulfonamide compounds. The synthesis process is a method for efficiently preparing the sulfonamide compounds, which is environment-friendly and is simple and convenient to operate. Compared with the prior art, the synthetic process disclosed by the invention has the advantages of remarkably-increased reaction speed compared with that under a conventional heating condition, mild reaction conditions, simple operation, high yield, safety, low cost and environmental protection.

The invention relates to a method for preparing a beta-ketosulfone compound through a visible light mediated atopic acid decarboxylation ketonization reaction, and belongs to the field of compound preparation. According to the method disclosed by the invention, environment-friendly atortic acid with wide sources and stable odorless sulfonyl hydrazine are used as reactants, fluorescein, inorganic base and potassium iodide are added and then fully dissolved in a mixed solvent of acetonitrile and water, a reaction is carried out in an oxygen atmosphere (communicated with oxygen spheres), and thebeta-ketosulfone compound can be obtained through the reaction under visible light irradiation. The preparation method disclosed by the invention has the characteristics of simple and easily availableraw materials, simple operation, mild reaction conditions, no metal residue and insensitivity of a reaction system to water.

The invention discloses application of 2,6-dimethyl-1,4-dihydro-3,5-pyridine diethyl dicarboxylate as a visible light reduction catalyst to induce transition-metal-free catalysis of aryl halogen and aryl sulfinate so as to prepare sulfone compounds. The method comprises the following steps: under inert gas protection, adding the reactants into a reaction container provided with a stirring device according to the molar ratio of aryl halogen compounds, sulfinate compounds, inorganic alkali to HEH being 1:2:1.5:0.2, then adding dimethyl sulfoxide, and carrying out stirring reaction for 24 hours at room temperature under blue LED irradiation to obtain the sulfone compounds. According to the method, the HEH is used as a catalyst for the first time under the condition that no auxiliary transition metal catalyst is added, and a series of cross-coupling reactions of aryl halogen and sulfinate are realized. In addition, the whole process is green, efficient and easy to operate, and the method is a good method for synthesizing sulfone compounds.

The invention discloses a synthesis strategy for constructing a 2-cyanoalkyl sulfonyl substituted 3,4-dihydronaphthalene compound by taking MCPs, a cyclobutanone oxime ester compound and K2S2O5 as rawmaterials through visible light catalysis, wherein two carbon-carbon sigma bonds are broken in a one-pot reaction to form a carbon-carbon bond and two carbon-sulfur bonds. According to the invention,cyanoalkyl free radicals are formed to capture SO2, and subsequently sulfonyl free radicals are formed to carry out ring-opening and cyclizing on MCPs; and the synthesis method disclosed by the invention has the advantages of mild reaction conditions, simplicity, high efficiency, easily available raw material sources, wide substrate application range and high target product yield.

The invention belongs to the technical field of organic chemistry, and particularly relates to a preparation method of sulfonyl acetonitrile compounds. The structure of the compound is characterized by 1H NMR, 13C NMR and other methods and is confirmed. The method comprises the following steps: taking 2, 2-dichloroethane as a solvent and aryl diazonium salt and sodium pyrosulfite (Na2S2O5) as a catalyst without metal catalyst, generating aryl sulfonyl free radicals on site at room temperature, carrying out free radical addition reaction on 3-azido-2-methylbutyl-3-ene-2-ol, and removing monomolecular nitrogen and 2-hydroxypropyl free radicals to obtain the sulfonyl acetonitrile compound. The preparation method of the sulfonyl acetonitrile compound has the advantages of being mild in condition, simple, efficient, high in reaction yield, wide in substrate application range, good in product purity, convenient to separate and purify and good in application value.

A process for transforming a group >C═O (I) in a compound into a group >C═S (II) or into a tautomeric form of group (II) in a reaction giving a thionated reaction product, by use of crystalline P₂S₅.2 C₅H₅N as a thionating agent. A thionating agent which is crystalline P₂S₅.2 C₅H₅N.

The invention discloses a synthesis method of an N-diarylmethyl sulfonamide compound, and belongs to the technical field of organic synthesis intermediates. According to the synthesis method, the N-diarylmethyl sulfonamide compound is synthesized by utilizing a cascade reaction; the method specifically comprises the following steps: (1) adding an aromatic aldehyde, a sulfonamide, trimethoxybenzeneor a derivative thereof, and Lewis acid into a reaction tube according to a molar ratio of 1.0: 1.0: 1.0: 0.1, and carrying out magnetic stirring reaction at room temperature for 8-24 hours by taking1, 2-dichloroethane as a solvent; and (2) after the reaction is finished, evaporating under reduced pressure to remove most of the solvent, and carrying out column chromatography separation and purification on a residual mixed solution by using petroleum ether and ethyl acetate in a volume ratio of (1: 1)-(2: 1) as leacheate to obtain the product. The N-diarylmethyl sulfonamide compound synthesized by the method has wide application in the fields of medicines, pesticides and the like. The synthesis method disclosed by the invention has the advantages of low cost, simplicity in operation, highyield, mild conditions and the like, and has a good application prospect.

The invention discloses a chiral sulfonamide derivative. The structural formula of the chiral sulfonamide ramification is shown in the description, wherein R is aryl, alkyl, cycloalkyl, heterocyclyl,substituted aryl, substituted alkyl and substituted heterocyclyl; Ar1 is aryl and substituted aryl; Ar2 is aryl, substituted aryl and heterocyclyl; Ar3 is aryl, substituted aryl and heterocyclyl; sulfonamide, aryl diazonium acetate and imine are taken as raw materials, 4-molecular sieve is taken as a water absorbing agent, rhodium acetate and chiral phosphoric acid are combined to be a catalytic system, and the chiral sulfonamide derivative is obtained by a one-step reaction in an organic solvent. The synthesis method has the advantages that the atomic economy is high, the selectivity is high,the yield is high, the reaction condition is mild, the operation is simple and safe; the chiral sulfonamide derivative with two quaternary carbon centers is a potential pharmaceutically active molecule, is widely used in the field of medicine, and has great application prospects.