27results about "Hydroxy group formation/introduction" patented technology

The present application relates to a kind of catalyst composition and its application in catalytic preparation optically active secondary alcohol, the catalyst composition includes chiral ionic bridged aryloxyalkane rare earth complex and additive, the additive is selected from one or more of pyrimidine, N,N-dicyclohexylmethylamine, 4,4'-dipyridyl.The above-mentioned catalyst composition can be used for synergistically catalyzing asymmetric borohydration of chalcone and its derivatives with pinacol borane, and show high catalytic activity and high enantioselectivity, product yield is as high as 99%, ee value can reach 84%, provide a reliable new way for the efficient, high selective synthesis of optically active secondary alcohol.

The invention discloses a method for preparing monophenol compounds from lignin. The method comprises the following steps: mixing a raw material lignin with a solvent, and carrying out a one-step hydrogenation reaction in a hydrogen atmosphere under the action of a nickel-molybdenum-based catalyst to prepare the monophenol compound, the nickel-molybdenum-based catalyst comprises metal nickel and nickel oxide, molybdenum oxide and silicon oxide. The method provided by the invention has the characteristics of low production cost, simple separation, high monophenol compound yield and the like.

The application belongs to the technical field of chemical synthesis, and specifically provides a chiral hydroxyphosphonate, a preparation method and application thereof. The chiral hydroxyphosphonate has a structure as shown in formula II: each R is independently H, an alkyl group, an alkenyl group, an alkynyl group or a halogenated alkyl group; Ar is an aromatic ring or a heteroaromatic ring; X is a bond, -O-, -N(R 1 )- 2 q , -S(=O) m -; the chiral hydroxyphosphonate is obtained by reducing an alpha phosphonate substituted benzocycloalkanone compound through an asymmetric hydrogenation method, has two chiral centers, and has a yield of up to 99% and an enantiomeric selectivity of up to 99%. The chiral hydroxyphosphonate has wide application potential and value in skin tissue soothing, repairing, anti-aging and the like.​

[Abstract] [Problem] To provide a method for producing a dealkoxyphenylation product with high yield from a substrate, e.g., a sugar, which is bonded to an alkoxyphenyl group through an oxygen atom. [Solution] A substrate that is bonded to a phenyl group substituted by a C1 to C5 alkoxy group at a para- or ortho-position through an oxygen atom is reacted with a λ3-iodane in a fluorous alcohol and water, whereby a dealkoxyphenylation product can be obtained with high yield under mild conditions.

A method for producing a higher alcohol from a waste plastic feedstock is disclosed, comprising: (a) providing a hydrocarbon feed stream comprising a pyrolysis oil feed obtained from pyrolysis of plastic waste, wherein the pyrolysis oil comprises at least 20 wt % higher olefins with a carbon number in the range C5-C20, based on its total hydrocarbon content; (b) contacting the hydrocarbon feed stream with synthesis gas under hydroformylation conditions in the presence of a hydroformylation catalyst and recovering a hydroformylation product; (c) subjecting the hydroformylation product to hydrogenation and / or a distillation to recover a higher alcohol product.

The application discloses a novel zirconium-nitrogen coordination polymer catalyst, which has a porous structure and is prepared by a coordination self-assembly method at normal temperature from zirconium ions and non-cyclic nitrogen-containing organic ligands, only introduces Lewis acid-base sites, and does not introduce Brønsted acid sites. The presence of the Lewis acid-base sites can efficiently catalyze MPV transfer hydrogenation reaction of biomass-based aldehyde ketone compounds, the absence of the Brønsted acid sites can avoid side reactions such as etherification and acetalization, and the porous structure can greatly promote the mass and heat transfer processes during the reaction, and the synergistic effect between them further improves the yield and selectivity of the target product.

This invention discloses a chiral monophosphine ligand, its preparation method, and its application in asymmetric synthesis. The ligand preparation method involves mixing an N,N',1,2-tetrasubstituted ethane-1,2-diamine compound, phosphorus trichloride, triethylamine, and solvent under a nitrogen or argon atmosphere at -80 to -70°C, and reacting at 60 to 80°C for 6 to 8 hours. The resulting reaction mixture is then cooled to room temperature, and an alcohol, phenol, or Grignard reagent is added dropwise, reacting at 60 to 80°C for 8 to 12 hours. The resulting mixture is then post-treated to obtain the chiral monophosphine ligand. The application involves stirring a nickel catalyst, a chiral monophosphine ligand, a solvent, a diene, and an aldehyde under an argon or nitrogen atmosphere at a specified temperature for 12 to 15 hours. The mixture is then post-treated to obtain the target product. This method utilizes widely available and inexpensive raw materials, and the operation is simple, achieving high stereoselectivity and enantioselectivity in the synthesis of alcohol compounds containing chiral conjugated dienes through a one-step reaction.

The invention belongs to the technical field of organic synthesis, and particularly relates to a universal selective co-production method of monosubstituted alkynyl tertiary alcohol, which comprises the following steps: 1) adding alkali and an organic solvent into a reaction container, replacing air in the reaction container with acetylene gas, and continuously introducing the acetylene gas into the reaction container to keep the acetylene pressure in the reaction container at 0.10-0.25 MPa; 2) stirring and heating to 20-80 DEG C, dropwise adding ketone into the reaction container, and carrying out heat preservation reaction until the reaction is finished; and 3) quenching the reaction liquid, taking an organic phase material, washing, drying, and carrying out rotary evaporation concentration to obtain the target product. Acetylene and ketone are used as raw materials for co-production of the monosubstituted alkynol and the disubstituted alkynol, the yield of the monosubstituted alkynol can reach 24.86% at most, and the method is suitable for various ketone compounds and has good universality, and the process is simple to operate and easy to industrially popularize.

The application discloses a metal complex and a preparation method and application thereof. Specifically, the metal complex catalyst is prepared by complexing a chiral tetradentate ligand with a metal precursor, the catalyst can realize asymmetric hydrogenation of a ketone, and through comparison of different preparation catalyst processes, an easy-to-prepare and simple-to-operate method is determined, the metal complex catalyst prepared by the method is stable in property, has certain tolerance to water and oxygen, can greatly improve catalytic efficiency, is suitable for industrial production, has a wide substrate application range, and has important practical value and industrialization prospect.

The application provides a kind of chiral P, N, N ligand and its preparation method and application in asymmetric hydrogenation reaction. 2-diphenylphosphinyl phenethylamine is mixed with 6-phenylpyridine-2-formaldehyde, nitrogen is filled, methanol is added, the formed mixture is refluxed, after cooling, NaBH4 is added. Then, the mixture is refluxed again. Cooling, water is added, dichloromethane is extracted, anhydrous sodium sulfate is dried, after removing solvent, the desired chiral P, N, N ligand is obtained by column chromatography. The catalyst formed by the chiral ligand described in the application and Mn, Ir-, Ru- and other metal precursors has excellent catalytic activity and stereoselectivity in the catalytic asymmetric hydrogenation reaction of C=C, C=N and C=O double bond. The enantioselectivity is as high as 99% ee, and the TON is as high as 100000.

The invention relates to the technical field of organic chemical synthesis, and discloses a preparation method of a beta-aryl arylacetone compound. The chemical structural formula of the beta-aryl arylacetone compound is shown as a formula (I), the method comprises the following steps: in the presence of a protective gas, an organic solvent and a catalyst, water and a chalcone compound shown as a formula (II) are subjected to a hydrogenation reduction reaction, and a component A is sodium sulfide and / or sodium sulfide nonahydrate. The preparation method provided by the invention has the advantages of mild reaction conditions, high yield, simplicity and convenience in operation, no need of metal and the like.

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthetic method of a chlorinated alcohol compound. The method comprises the following steps: adding an acetonitrile solution of a compound 1 into 1, 1, 2, 2-tetrachloroethane in a nitrogen atmosphere, then adding tert-butyl hydroperoxide, alkali and trimethylsilyl cyanide, stirring at room temperature, heating, stirring and reacting, removing a solvent under reduced pressure after the reaction is completed, and then performing silica gel column chromatography on a crude product to obtain a product, namely the chlorohydrin compound. According to the synthesis method disclosed by the invention, by regulating and controlling reaction conditions and optimizing raw material selection, the yield of the chlorinated alcohol compound is effectively improved, the atom economy is improved, the raw materials are efficiently utilized, and the emission of wastes is reduced.

The invention provides a thioether covalent organic framework material as well as a preparation method and application thereof, belongs to the technical field of photocatalysts, and can solve the ubiquitous problems of difficulty in catalyst recovery, high cost of noble metals, possibility of causing metal pollution and relatively high energy consumption existing in an existing photocatalytic system. The thioether covalent organic framework material has a structural formula shown in the specification. The thioether covalent organic framework material can be used as a photocatalyst to be applied to green and efficient conversion of arylboronic acid into phenolic compounds.

The invention discloses a method for preparing vicinal diol, which comprises the following steps: carrying out contact reaction on raw materials containing olefin, an oxidant and halogenated alcohol in the presence of a titanium silicalite molecular sieve catalyst and a hydration catalyst to obtain a vicinal diol-containing product, and has the advantages of mild reaction conditions, simple operation process and high yield. The method has the characteristics of high oxidant conversion rate and effective utilization rate, high vicinal diol selectivity and low product separation energy consumption.

The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C—H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,

The present invention provides a method for obtaining a dealkoxyphenylated product in high yield from a substrate such as a sugar bonded via an oxygen atom to an alkoxyphenyl group. By reacting a lambda 3 -iodide with a substrate bonded via an oxygen atom to a phenyl group substituted with a C1-C5 alkoxy group in the para or ortho position in a fluorine-containing alcohol and water, a dealkoxyphenylated product can be obtained in high yield under mild conditions.

The application belongs to the technical field of catalysts, and discloses a catalyst for encapsulating rare alloy nanoparticles as well as a preparation method and application thereof. The catalyst uses oxygen-doped porous carbon as a carrier, and rare alloy nanoparticles are encapsulated in the carrier. The rare alloy nanoparticles include M metal and base metal Cu. The M metal is selected from at least one of Ni, Co, Zn, Fe, V and Ti. In the catalyst, the content of the M metal is 0.5-3.0 wt%. The catalyst involves a simple synthesis strategy. The trace M metal doped in the MCu rare alloy induces atomic-level metal M-Cu synergistic effect and enhanced Schottky junction, so that the synthesis of cost-effective multi-catalysts is universal. The catalyst can effectively catalyze a wide range of selective hydrogenation reduction under mild aqueous conditions, is environmentally friendly and has excellent stability, and shows great industrial application prospect.

Selective hydrogenation processes are disclosed that can upgrade impure feeds, such as those obtained from biomass and containing a number of small (e.g., 2-6 carbon atom) molecules having aldehyde and / or ketone carbon atoms. For example, whereas glycolaldehyde and its methylated derivative, hydroxyacetone (acetol) are both high value intermediates for certain downstream processing reactions, they are normally recovered in a condensate from pyrolysis of carbohydrates (e.g., aldose-containing sugars) together with glyoxal and its methylated derivative, pyruvaldehyde. The selective hydrogenation of these compounds bearing two carbonyl carbon atoms, without over-hydrogenation to ethylene glycol and propylene glycol, can increase the concentration of the desired intermediates. These beneficial effects of selective hydrogenation may be achieved through the use of a hydrogenation catalyst comprising noble metals such as Ru and Pt.

Described herein is the preparation of a compound for treating gout or hyperuricemia and chemical intermediates used in the synthetic process.

Disclosed is a method for producing higher alcohols from a waste plastic feedstock, the method comprising the steps of: (a) providing a hydrocarbon feedstream comprising a pyrolysis oil feed obtained from the pyrolysis of plastic waste, the pyrolysis oil comprising at least 20 wt. % higher olefins having carbon numbers in the range of C5 to C20, based on the total hydrocarbon content of the pyrolysis oil; (b) contacting the hydrocarbon feedstream with a synthesis gas under hydroformylation conditions in the presence of a hydroformylation catalyst and recovering a hydroformylation product; and (c) subjecting the hydroformylation product to hydrogenation and / or distillation to recover a higher alcohol product.

The invention relates to the technical field of synthesis of organic compounds, in particular to an asymmetric catalytic relay hydrogenation synthesis method of a chiral 1, 3-amino alcohol compound. According to the method, at a certain temperature and hydrogen pressure, in a solvent and in the presence of alkali, a compound as shown in a formula I is sequentially catalyzed by a chiral catalyst Rh complex and a chiral catalyst Ru complex for asymmetric relay hydrogenation reduction within a certain period of time, and a compound as shown in a formula III is formed through an intermediate as shown in a formula II. The asymmetric catalytic relay hydrogenation synthesis method has the advantages of low catalyst cost, high yield, high stereoselectivity and wide substrate application range, and realizes the stereodivergent synthesis of the compound shown in the formula III by adjusting the configuration combination of the two catalysts.

This invention discloses an iron-catalyzed method for the hydroxylation of alkenes. The method includes the following steps: in a solvent, using nitrostyrene compounds and alkenes as substrates, peroxides as oxidants, iron as catalysts, and amino acids and their derivatives as ligands, the hydroxylation of alkenes is catalyzed to generate alkenylated alcohols. This method can synthesize alkenylated alcohols in one step, is simple, and utilizes widely available and inexpensive catalysts and oxidants. The reaction conditions are mild and highly selective. It uses 1-2 equivalents of olefin substrates, exhibiting good functional group compatibility and a wide range of substrate applicability. Drug molecules and their derivatives are compatible, achieving the hydroxylation of alkenes. Under optimized reaction conditions, the yield of the target product after separation can reach 86%.

The invention relates to a catalyst composition and application thereof in catalytic preparation of optically active secondary alcohols, the catalyst composition comprises a chiral ionic bridged aryloxy alkoxy rare earth complex and an additive, and the additive is selected from one or more of pyrimidine, N, N-dicyclohexylmethylamine and 4, 4 '-dipyridyl. The catalyst composition can be used for synergistically catalyzing an asymmetric hydroboration reaction of chalcone and derivatives thereof and pinacolborane, and shows high catalytic activity and high enantioselectivity, the product yield is up to 99%, the ee value can reach 84%, and a reliable new way is provided for efficient and high-selectivity synthesis of optically active secondary alcohol.

The present invention is directed to a process for preparing a binder, wherein lignin is subjected to demethylation whereby methoxy groups of lignin are converted to hydroxy groups. The demethylated lignin is mixed with a cross-linker and heated. The invention is also directed a binder obtained according to the process and to the use thereof.

The present application relates to the technical field of organic synthesis, and more particularly to a method for preparing phenol by hydroxylation of boronic acid derivatives in air without light catalyst and base. The method comprises the following steps: under room temperature conditions, oxygen in air is used as an oxidant, and oxidation hydroxylation reaction of aryl boronic acid and ether solvent occurs under light, and after the reaction is completed, phenolic compounds are obtained by post-processing. In the preparation process, no transition metal is added as a catalyst, no light catalyst is added, no oxidant is added, no base is added, no heating is added, and phenolic compounds are prepared in high yield under light catalytic conditions.

The invention discloses a biphenyl type tridentate ligand iridium complex and application of the biphenyl type tridentate ligand iridium complex in asymmetric hydrogenation of alpha, beta-unsaturated aldehyde compounds. The preparation method of the biphenyl type tridentate ligand iridium complex comprises the following steps: S1, reacting a metal iridium precursor and a biphenyl type tridentate ligand for 0.3-0.7 h in absolute ethyl alcohol in a glove box environment of an argon atmosphere, and replacing the argon atmosphere with hydrogen for 3-5 times; s2, the reaction mixture is subjected to a reaction for 0.3-0.7 h under the normal-pressure hydrogen condition; s3, concentrating the reaction mixture under high vacuum to obtain a product. The preparation method is simple and good in stability, and when the biphenyl type tridentate ligand iridium complex is used as a catalyst for non-hydrogenation reaction of alpha, beta-unsaturated aldehyde compounds, the biphenyl type tridentate ligand iridium complex shows very high catalytic activity and chemical selectivity.