2results about "Cyano group formation/introduction" patented technology

The application relates to an industrialized preparation method and application of high-purity alpha-amino nitrile. The application belongs to the technical field of fine chemical synthesis. The purpose of the application is to solve the technical problems of low yield and purity, high cost and unsuitability for industrialized production of the existing alpha-amino nitrile synthesis method. The method of the application is as follows: taking imine as a substrate, alpha-amino nitrile is synthesized by reacting with acetone cyanohydrin under the action of an ionic liquid. The method of the application synthesizes a nucleophilic addition cyanyl product of a carbon-nitrogen double bond in one step at room temperature. By selecting the ionic liquid and reasonably controlling the proportioning of various substances, the reaction process is greatly accelerated, the high-efficiency synthesis of alpha-amino nitrile is realized, the purity of alpha-amino nitrile is remarkably improved, the substrate adaptability is good, and the method can be widely applied to the synthesis in the fields of medicines and the like in the industry and the academia.

This invention discloses an iron-catalyzed C-H bond cyanotylation method for aromatic compounds. The method includes the following steps: in a solvent, using trimethylcyanosilane as the cyano source, peroxide as the oxidant, iron as the catalyst, amino acids and their derivatives as ligands, and a base as an additive, the aromatic ring of an aromatic compound undergoes a C-H bond cyanotylation reaction to generate a cyano-substituted aromatic compound. This invention offers advantages such as a widely available, inexpensive, and environmentally friendly catalyst; a widely available and inexpensive oxidant; mild reaction conditions and high selectivity; a relatively inexpensive and low-toxicity cyano source; good reactivity with heterocyclic aromatic compounds; good compatibility with substrate functional groups and a wide range of substrate applications; compatibility with drug molecules and drug molecule derivatives, enabling effective cyanotylation of aromatic rings. Under optimized reaction conditions, the yield of the target product after separation can reach 90%.