280 results about "Diphosphines" patented technology

This invention relates to a method to selectively oligomerize olefins comprising contacting olefins with: 1) at least one diaryl-substituted diphosphine ligand; 2) a chromium metal precursor; and 3) optionally, one or more activators. In a particular embodiment, the method for selectively oligomerizing olefins includes trimerizing ethylene to selectively form 1-hexene.

The invention relates to a method for preparing aldehyde through linear chain olefin hydroformylation. According to the method, a continuous reaction mode is used for performing olefin hydroformylation reaction in a homogeneous catalyst system; a catalyst is a composite catalysis system composed of a rhodium complex, a biphenyl backbone or biphenyl backbone diphosphine ligands and triphenylphosphine or triphenyl phosphate monophosphorous ligands; a reaction solvent comprises butyraldehyde, valeraldehyde, toluene or isodecanol; when the catalyst system uses propylene or butene-1 as raw materials under the condition of a low molar ratio of the diphosphine ligands to the rhodium complex, contents of the aldehyde generated by hydroformylation of the propylene and the butene-1 is larger than 97% and 95% respectively; and when the catalyst system uses a mixture of the butene-1 and butene-2 as raw materials, and the content of n-valeraldehyde in hydroformylation reaction products can reach above 85%.

The invention relates to a kind of chiral diphosphite ligands, an iridium composite catalyst thereof, a preparation method and application thereof. The ligands are obtained through using chiral (R)-(S)-1-dimethylamino ethyiferroene as raw materials to react with diphenyl phosphonium chloride under the effect of butyl lithium and then to carry out displacement reaction with diaryl phosphine alkane. The chiral diphosphite ligands respectively act with homotropilidene compositions of iridous chloride, tetrabutyl ammonium iodide and glacial acetic acid, and imine asymmetrical hydrogenization catalysts can be obtained. When the iridium-diphosphine catalysts are used for catalyzing 2-methyl-6-ethyl-N-methylene aniline (EMA-imine) hydrogenization reaction, (S)-N-(1-anisyl-2-propyl)-2-methyl-6- ethylaniline ((S)-NNA) can be obtained, and the antimer excessive value (ee) can reach 86.5 percent. The (S)-NNA and chloracetyl chloride carry out acylation reaction to obtain (S)-metolachlor with the ee value of 86 percent. Thereby, the ligands provided by the invneiton can be used for synthesizing chiral herbicidal chemicals of (S)-metolachlor.

The oligomerization of ethylene using a chromium catalyst having a bridged diphosphine ligand can produce a selective product distribution (to predominantly hexene or predominantly octene/hexene) when activated with an aluminoxane. The oligomerization reaction also produces polymer by product—particularly when the aluminoxane is provided in a non-aromatic solvent. The present invention mitigates this problem.

A process for the carbonylation of a conjugated diene, which involves reacting the conjugated diene with carbon monoxide and a co-reactant having a mobile hydrogen atom in the presence of a catalyst system including: (a) a source of palladium; and (b) a bidentate diphosphine ligand of formula II,

R¹R²>P¹—R³_m—R—R⁴_n—P²<R⁵R⁶   (II)

wherein P¹ and P² represent phosphorus atoms;

R¹, R², R⁵ and R⁶ independently represent the same or different optionally substituted organic radical containing a tertiary carbon atom through which each radical is linked to the phosphorus atom;

R³ and R⁴ independently represent the same or different optionally substituted methylene groups;

R represents an organic group having the bivalent bridging group C¹—C² through

which R is connected to R³ and R⁴;

m and n independently represent a natural number in the range of from 0 to 4, wherein the rotation about the bond between the carbon atoms C¹ and C² of the bridging group is restricted a temperature in the range of from 0° C. to 250° C., and wherein the dihedral angle between the plane occupied by the three atom sequence composed of C¹, C² and the atom directly bonded to C¹ in the direction of P¹, and the plane occupied by the three atom sequence C¹, C² and the atom directly bonded to C² in the direction of P², is in the range of from 0 to 120°; and

(c) a source of an anion.

This invention enables the “bulk” oligomerization of ethylene (i.e. the oligomerization of ethylene in the presence of the oligomer product) using a catalyst system comprising 1) a very low concentration of a chromium catalyst and 2) a three part activator. The chromium catalyst contains a diphosphine ligand, preferably a so called P—N—P ligand. The activator includes an aluminoxane, trimethyl aluminum, and triethyl aluminum.

The present invention discloses an ethylene tetrapolymerization catalyst composition, which comprises a diphosphine ligand represented by a formula I, a transition metal compound, an aluminum-containing co-catalyst, water and an organic solvent, wherein R1, R2, R3 and R4 are respectively and independently selected from alkyl, cycloalkyl and aryl, and R5 is selected from alkyl, cycloalkyl and aryl. The invention further discloses a method for carrying out an ethylene tetrapolymerization reaction by using the catalyst composition. The formula I is defined in the specification.

The present invention relates to a kind of high-performance photoelectric function rare earth complex material and its preparation method. Said invention uses substituted diphosphine dioxide containing aromatic group as ligand, and utilizes complexation reaction to synthesize a series of high-effective rare earth photoelectric function complexes, and prepares doped red electroluminescent device containing above-mentioned rare earth photoelectric function material, said electroluminescent device can obtan satisfactory result in the luminance, current density and efficiency under the high current density.

A direct hydrocarbonylation process for the production of 1,4-butanediol is described. The process comprises reacting allyl alcohol with carbon monoxide and hydrogen in an alcohol solvent in the presence of a catalyst system comprising a rhodium complex, a trialkyl phosphine, and a diphosphine. The process gives a high yield of 1,4-butanediol in a one-step reaction.

The invention relates to luminescent novel material synthesis technologies and particularly relates to blue-green materials with novel tri/tetra-coordination dual-core copper [I] coordination compounds and a preparation method thereof. According to the preparation method, the novel dual-core copper [I] coordination compound blue-green materials, namely [Cu2[bmptzH][[mu]-dppm]2][ClO4]2 and [Cu2[fptz][[mu]-dppm]2][ClO4], which simultaneously have two coordination bonding manners, namely tri-coordination and tetra-coordination, and have special structures, are synthesized from functionalized pyridine triazole bidentate chelating ligands (5-tert-butyl-3-[6-methyl-pyridine-2-yl]-1,2,4-triazole and 5-trifluoromethyl-3-[pyridine-2-yl]-1,2,4-triazole) and an organic diphosphine auxiliary ligand (bis[diphenylphosphino]methane). The blue-green materials show very good photoluminescence properties in a solid state, and the photoinduced quantum efficiency is 66% and 77% respectively.

A process for the hydrogenation, using molecular hydrogen (H2), of a catalytic system, wherein the catalytic system comprises a base and a complex of formula; (II) wherein Y represents simultaneously or independently a hydrogen or halogen atom, a hydroxy group, or an alkoxy, carboxyl or other anionic radical, and N2P2 is a tetradentate diimine-diphosphino ligand.

A catalysis system used by a method for synthesizing chiral cyclic amine through catalyzing asymmetric hydrogenation of quinolin-3-amine by iridium is a chiral diphosphine complex of iridium. A reaction is carried out under the following conditions: the temperature is 25-70DEG C; a solvent is a toluene/tetrahydrofuran mixed solvent (V/V=3:1); the pressure is 2-14atm; a ratio of a substrate to a catalyst is 25:1; and the catalyst is a (1,5-cyclooctadiene)iridium chloride dimer and chiral diphosphine ligand complex. A corresponding chiral cyclic amine derivative is prepared from quinolin-3-amine, and the enantiomeric excess value can reach 94%. The method has the advantages of simple and practical operation, easily available raw material, high enantioselectivity, good yield, and green, atom-economic and environmentally-friendly reaction.

The iridium catalyzed enantiotropic hydrosubstituting process of aromatic pyridine ring and pyrazine ring uses catalyst system comprising chiral coordination compound of iridium and additive compound. The reaction conditions includes temperature of 0-80 deg.c; solvent of dichloromethane, toluene, tetrahydrofuaran, 1, 2-dichloro ethane, isopropanol, etc.; additive compound of tetrabutyl ammonium iodide, iodine, amine, etc.; pressure of 1-100 atm; substrate/catalyst ratio up to 5000; and chiral coordination compound of diphosphine, N-P compound, S-P compound, etc. The catalyst system is prepared through reaction of iridium precursor and chiral compound in the said solvent and the addition of the additive compound while stirring; and can produce asymmetrical induction up to 96 %. The process of the present invention is environment friendly.

The invention relates to a chiral diphosphine ligand and a chiral catalyst, and a preparation and application method thereof. The preparation method of a BINAP (2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) chiral diphosphine ligand based on novel imidazole and imidazole cation modification. Imidazole and imidazole cation are introduced to the 5,5'- position of the BINAP molecule framework to synthesize the chiral diphosphine ligand. The assembly of the imidazole and imidazole cation into the chiral diphosphine ligand molecule can effectively enhance the stability of the chiral catalyst in an ionic liquid and the affinity with the imidazole ionic liquid, and avoids loss of the catalyst in the cyclic process. The imidazole-modified chiral diphosphine ligand has the following chemical structural formula, wherein the spatial configuration of the imidazole-modified chiral diphosphine ligand is S type or R type.

The invention discloses a preparation method of an ezetimibe intermediate compound as shown in formula II. The method includes the step of: in an organic solvent, in the absence of water and oxygen, and under the effects of an asymmetric hydrogenation catalyst and an organic alkali, subjecting compound I and hydrogen to an asymmetric catalytic hydrogenation reaction as shown in the following. Specifically, R is a conventional protecting group in the field, can protect a phenolic hydroxyl group and is stable under alkaline conditions. The asymmetric hydrogenation catalyst is a ruthenium-diphosphine-diamine catalyst invented by Ryoji Noyori, a Japanese scientist and a Nobel Prize winner. The preparation method provided in the invention has mild reaction conditions, can prepare products with high optical purity, yield and purity, and has after-treatment that is convenient to operate, thus being easy to realize industrialized production.

The invention relates to a novel nitrogen heterocycle ligand/phosphine ligand transition metal complex, and preparation and application thereof in asymmetric catalytic hydrogenation and hydrogen transfer. The complex has the following structural formula: [MLnL' XY], wherein the transition metal M is Ru, Rh, Ir, Pd, Pt, Co, Ni or Os. The complex also contains a nitrogen heterocycle ligand, two monophosphine ligands or one diphosphine ligand, and the like. The transition metal compound, dinitrogen or mononitrogen ligand and diphosphine or monophosphine ligand react at 0-120 DEG C in an organic solvent for 0.5-20 hours to obtain the complex. The complex is used for asymmetric catalytic transfer hydrogenation or asymmetric hydrogenation reaction, and especially for asymmetric catalytic hydrogenation reaction of ketones, esters, hypnones and derivatives thereof, diphenyl ketones and derivatives thereof, beta-N,N-dimethylamino-alpha hypnones and derivatives thereof and other ketone compounds of which the alpha site is a large steric hindrance alkyl group.

The catalysts of formula (II): [Ru(L)m(L')wXY], wherein X and Y represent simultaneously or independently a hydrogen or halogen atom, a hydroxy group, or an alkoxy, carboxyl or other anionic radical, m is 1 or 2, w is 1 when m is 1 and w is 0 when m is 2, L is a phosphino-amine or phosphino-imine bidentate ligand and L' a diphosphine, are useful for the hydrogenation of substrates having a carbon-hetero atom double bond.

The invention discloses a new method for preparing a biphenyl diphosphine ligand 2,2'-diphenylphosphinomethyl-1,1'-biphenyl (BISBI) and derivatives thereof. The method is characterized by comprising the following steps: (1) under the protection of inert gases, adding 40-60 parts of triphenylphosphine and 250-360 parts of ether solvents to a reaction flask, stirring the mixture to dissolve the mixture and adding 3-20 parts of alkali metals and 0-5 parts of electron-rich aromatics to the reaction flask to react for 2-24 hours at 20-120 DEG C to prepare a diphenulphosphine metal compound and a phenyl metal compound; (2) dropwise adding 15-20 parts of tertiary butyl chloride to the reaction solution to remove the generated phenyl metal compound; and (3) dropwise adding the solution formed by 15-40 parts of 2,2'-disubstituted methyl-1,1'-biaryl compound and 20-40 parts of ether solvent to the reaction solution with phenyl metal compound removed to react for 6-24 hours at 0-40 DEG C and carrying out extraction, drying, concentration and recrystallization to obtain the diphosphine ligand 2,2'-diphenylphosphinomethyl-1,1'-biphenyl (BISBI) and the derivatives thereof. The method has the characteristics of cheap and easily obtained raw materials and mild reaction conditions, is simple and convenient for operation, and is easy to realize industrial production.

The invention discloses chiral ferrocene diphosphine ligands. The ligands take chiral ferrocene amine as the raw material, after ortho-lithiation, the lithiated raw material reacts with a phosphine chloride to obtain a monophosphine intermediate, and the intermediate reacts with different secondary phosphines, thus obtaining chiral ferrocene diphosphine ligands with different chiral centers. The diphosphine ligands provided by the invention have the characteristics of novel structure, stability in air and simple synthesis, the complex catalysts formed by the diphosphine ligands and metals havestrong substrate universality, and show high catalytic activity and stereoselectivity in asymmetric hydrogenation reaction of latent chiral olefins, latent chiral ketones, latent chiral imines and the like.

The invention discloses an ethylene trimerization catalyst composition which comprises diphosphine ligand shown in formula I, a transition metal compound, an aluminum-containing promoter and peroxide, and in formula I shown in the specification, R1 and R4 are identical or different and are independently selected from alkyl, a naphthenic base and an aromatic group; R' and R'' are hydrogen or are independently selected from alkyl, cycloalkane and aromatic groups. Meanwhile, the invention further provides a method for ethylene trimerization reaction with the catalyst composition. The ethylene trimerization catalyst composition is high in catalysis activity on the contrary and good in catalysis activity and selectivity of 1-octylene.

The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of an ammonium salt and a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.

A process for the tetramerisation of ethylene under solution phase conditions is carried out in the presence of an activated catalyst at a temperature above 80° C. and up to a temperature of about 115° C. The activated catalyst is provided by combining a source of chromium, a diphosphine ligating compound and optionally a catalyst activator or combination of catalyst activators. The process forms at least 30% 1-octene and a polyethylene co-product that, together with any other reaction products, remains substantially dissolved in the liquid phase. The polyethylene co-product has a weight average molecular weight (Mw) of less than 200 000 g/mol, a number average molecular weight (Mn) of less than 3 000 g/mol, and a melt flow index of more than 20 g/10 minutes.