The invention discloses a preparation method of a 2-(2, 2, 6, 6-tetramethyl piperidine nitroxide radical-4-subunit) acetic acid derivative and an application thereof. According to the 2-(2, 2, 6, 6-tetramethylpiperidine nitroxide radical-4-subunit) acetic acid derivative, commercialized 2, 2, 6, 6-tetramethyl-4-piperidone is subjected to simple oxidation to obtain 4-carbonyl-2, 2, 6, 6-tetramethylpiperidine nitroxide radicals, then the 4-carbonyl-2, 2, 6, 6-tetramethylpiperidine nitroxide radicals react with corresponding phosphorylation reagents, hydrolysis is carried out, the raw materials used in the method are cheap and easy to obtain, compared with the 2, 2, 6, 6-tetramethylpiperidine nitroxide radicals in the production process, the production efficiency is high, and the production cost is low, the compound is stable in property, basically free of any smell, convenient to store and capable of being stored at the room temperature, meanwhile, the preparation method is simple and easy to obtain, and when the compound is used as a catalyst, due to the fact that the compound is high in activity, large in solubility in a water phase and extremely small in catalyst dosage.