(Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative and preparation method therefor

A technology of trifluoromethyl and sulfanyl, applied in the field of -4-trifluoromethyl-5-sulfanyl-4-pentenone derivatives and its preparation, can solve the problem of not obtaining olefin addition products and other problems, to achieve the effect of wide application range of substrates, mild reaction conditions and good application prospects
CN110698313AActive Publication Date: 2020-01-17ZHEJIANG NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG NORMAL UNIVERSITY
Publication Date
2020-01-17

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Abstract

The invention discloses a (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative and a preparation method therefor. The method comprises the steps of adding and mixing alkyne thioether with a structure represented by a formula II, S-(trifluoromethyl)dibenzothiophene onium trifluoromethyl sulfonate with a structure represented by a formula III, ruthenium tri(2,2-bipyridyl)dichloride, alkali anda solvent, forming a reaction system under blue-light irradiation, and carrying out aftertreatment after a reaction is completed, thereby obtaining the (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative with a structure represented by a formula I. According to the method, the stereoselective synthesis of the (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative is achieved in one step.The reaction conditions are mild, the substrate applicable range is broad, the reaction yield is good, the operation is simple, and a new way is provided for synthesis of trifluoromethyl containing pentenone compounds.
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Description

technical field

[0001] The invention belongs to the field of organic synthesis, and specifically relates to a (Z)-4-trifluoromethyl-5-sulfanyl-4-pentenone derivative and a preparation method thereof. Background technique

[0002] The C-H bond is the simplest and most common functional group in organic compounds. The selective oxidation of hydrocarbons to synthesize oxygen-containing organic chemical products occupies an extremely important position in industrial synthesis, especially in petrochemicals. However, the selective oxidation of hydrocarbons faces many problems. First of all, due to the high activation energy of the C-H bond of saturated hydrocarbons, it is difficult to oxidize, and usually requires the addition of high temperature and high pressure or an equivalent strong oxidant. Secondly, target products such as alcohols, ketones, aldehydes, and acids are mostly thermodynamically unstable intermediate compounds, which are easily further deeply oxidized. These ...

Claims

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