79results about How to "Great implementation value" patented technology

The invention relates to a multi-dimensional transformation system of a direct-shear test instrument of large-sized rock mass structure faces, which comprises n bottom shim plates and n side shim plates, wherein the n bottom shim plates are sequentially superposed from top to bottom according the area size to form a bottom shim plate assembly. The bottom surfaces of samples at the upper part and the lower part of the bottom shim plate assembly contact in a stress way, the lower part of the bottom shim plate assembly contacts with a frame in a stress way, and the centroids of each bottom shim plate, the sample at the upper part and the sample at the lower part are positioned on the same upright straight line; the side shim plates are positioned at the side face of the sample at the lower part and are arranged on steps between the adjacent bottom shim plates and steps between the bottom shim plate at the lowest part and the frame, the top surface of each side shim plate is positioned on the same plane, and the same plane is lower than a connection face between the sample at the upper part and the sample at the lower part; and the side shim plate which is farthest away from the side face of the sample at the lower part contacts with the frame in a stress way. The invention can carry out direct-shear test on the shearing strength of structure faces with different dimensions so as to obtain the change rule and the stable threshold value of the size effect of the shearing strength of the structure faces.

The invention provides a robot smart arm joint driver and a decelerating device thereof, consisting of a flange, a motor fixed frame, an end cover, a deep ditch ball bearing, a permanent magnetic DC moment motor, a hexagon thin nut, a spring washer, a sleeve 1, a bearing retaining cover, a second sleeve, a harmonic reducer, a through shaft, a rolling needle bearing, a thrust rolling needle bearing and a connecting flange. The permanent magnetic DC moment motor is fixed on the motor fixed frame; the rotor of the motor is connected with the connecting flange which is connected with the harmonic generator of the harmonic reducer; the steel wheel of the harmonic reducer is fixed on the motor fixed frame by a screw; the flexible wheel of the harmonic reducer is connected with the through shaft and the flange; the rolling needle bearing is arranged between the rotor of the motor and the harmonic generator and the through shaft; the deep ditch ball bearing is arranged between the flange and the motor fixed frame. The joint driver and the decelerating device have the advantages of compact structure, smart motion, simple control, good application effect and great implementation value.

The invention discloses a method for preparing a supported nanometer gold catalyst by laser deposition, which comprises the following steps: hanging and fixing metal Au on the middle part of a laser deposition pond; putting a carrier in the laser deposition pond at a position closer to the bottom than the metal Au; heating the carrier to 25-600 DEG C and stirring the carrier so as to ensure that the carrier is in a moving state; under a vacuum condition and the protection of inert gas, focusing pulsed laser onto the surface of the metal Au by a laser so as to excite Au atoms into an atomic beam which is directionally and uniformly deposited on the surface of the carrier; and obtaining the supported nanometer gold catalyst. The preparation method has simple operation and no environmental pollution, and the prepared supported nanometer gold catalyst has higher catalytic activity, selectivity and stability. The supported nanometer gold catalyst can be applied to the fields of fuel-cell catalysts, carbon monoxide oxidation catalysts, catalytic hydrogenation catalysts, catalytic reforming catalysts, and the like and has greater implementation values and important social and economic benefits.

The invention belongs to the technical field of antibiotic drug synthesis, in particular to a synthesis methodof cefcapene pivoxil hydrochloride. The invention is mainly used for process improvement and optimization of cefcapene pivoxil, and the advantage of the synthesis process of cefcapene pivoxil are obvious; new catalytic agents are used, such as phenol, boric acid and other reagents, thereby improving the product quality, increasing the yield, simplifying the operating steps and realizing greater productivity effect and social effect.

The invention provides a preparation method of fosaprepitant dimeglumine. The preparation method comprises the following steps: by taking aprepitant as a raw material, carrying out phosphorylation on the raw material under an alkaline condition to obtain a dibenzyl ester intermediate; further hydrolyzing the intermediate to obtain fosaprepitant; and further reacting with N-methyl-D-glucosamine to obtain the fosaprepitant dimeglumine. The method provided by the invention is simple to operate and mild in reaction condition, and avoids pressurization and v, so that the method is safe and effective and suitable for industrial production on a large scale.

The invention discloses a method for recycling triphenyl phosphine oxide and 2-mercaptobenzothiazole from the production waste liquid of cephalosporin active ester, which includes the following steps: 1 to 10 percent sodium hydroxide solution is added drop by drop into the production waste liquid of the cephalosporin active ester under 0 to 80 DEG C; the pH value of the system is adjusted to be 10 to 12, and then the waste liquid is mixed fully for 0.5 to 6 hours, standing still and layering; an organic layer is decompressed to recycle an organic solvent; the solid waste slag is recrystallized directly to obtain the triphenyl phosphine oxide; the 2-mercaptobenzothiazole is extracted and obtained from water layer by a using acid neutralization method. The recycling method of the invention has the advantages of the simple operation, the high recycling rate, the good product purity, the good atom economy, etc., which effectively solves the problems existing in the prior art, such as the complicated operation, the high energy consumption, the low yield rate, the serious environment pollution, etc., thus having a wide implementary value and potential social economic benefits.

The pneumatic flexible torsional knuckle includes one fixed disc, one middle axle and one circular rotating disc. The middle axle is mounted onto the fixed disc and has its upper end connected to the circular rotating disc. On two sides of the fixed disc, there are two flexible pneumatic cylinders with one first end cap and one second end cap each. The first end caps are connected to the fixed disc and have through hole to atmosphere; and the second end caps are connected to the circular rotating disc. Each of the flexible pneumatic cylinders includes an arc rubber tube, one spring steel wire wound closely in the inner wall of the rubber tube. The pneumatic flexible torsional knuckle of the present invention has simple reasonable structure and small size.

The present invention provides a pneumatically flexible climbing robot, including a pneumatically flexible driver, a pneumatically flexible fetlock, a vacuum grip device and a osculum linker, the pneumatically flexible driver includes a front lid, a middle lid and a thick rubber hose, two ends of the thick rubber hose are jointed with the front lid and the middle lid, a pylome connected to atmosphere is set on the front lid, a helix steel wire is embedded in the wall of the thick rubber hose; the pneumatically flexible fetlock includes a back lid and three thin rubber hoses, one side of the middle lid is jointed with the thick rubber hose, the other end of the middle lid is set with three steps jointed with one side of three thin rubber hoses at 120 degrees, the other ends of three thin rubber hoses are jointed with the back lid, a helix steel wire is embedded in the wall of the thin rubber hose; two ends of the front lid, middle lid and back lid are fixedly connected with the osculum linker respectively, the osculum linker is fixedly connected with the vacuum grip. The pneumatically flexible climbing robot has a simple structure, small volume and strong flexibility.

The invention discloses a synthesis device and a synthesis method of 1,3-butanediol. An acetaldehyde aqueous solution is subjected to condensation reaction in a reaction rectification tower loaded with alkaline anion resin, acetaldehyde fractionated from the top of the tower is returned to a raw material tank for recycling, and 3-hydroxybutyraldehyde fractionated from a tower kettle directly enters a tower reactor for hydrogenation reaction; hydrogenation reaction of the 3-hydroxybutyraldehyde and hydrogen is carried out in the tower reactor, hydrogen at the top of the tower is recycled, and crude 1,3-butanediol obtained in the tower kettle enters a vacuum refining system; the crude product of 1,3-butanediol enters a light removal tower to remove light components, then enters a heavy removal tower, and the top of the tower obtains a 1,3-butanediol product with purity greater than 99.6% and no peculiar smell, and the method has the characteristics of short flow, low energy consumption,less pollution and continuous production.

The invention relates to a method for synthesizing meta-OH / MeO-PBDEs, which comprises the following steps: the meta-OH / MeO-PBDEs are obtained by taking 2, 4-dibromophenol or aminophenol and 5-fluoro-2-nitroanisole as a raw material through a series of reactions such as a coupling reaction, nitro group reduction, deamination, demethoxylation, bromo-substitution or through a series of reactions such as the coupling reaction, the bromo-substitution, a Sandmeyer reaction, the nitro group reduction, the deamination, the demethoxylation, the bromo-substitution. The method has reasonable reaction conditions and high product purity, and the product purity is usually more than 80 percent. The method has larger practical value to the synthesis of meta-OH / MeO-PBDEs containing more than five bromines (containing five bromines), and provides more standard sample support to the detection of high-bromine PBDE derivatives in the environment. The meta-OH / MeO-PBDEs are generated.

A pneumatic flexible joint based on a curved pneumatic cylinder comprises at least there curved pneumatic flexible cylinders, a upper turntable, a lower fractionating tray, a spherical shell and a hemisphere shell, wherein the curved pneumatic flexible cylinder consists of a curved rubber tubing and a spring steel wire. The spring steel wire is tightly wound to the inner tube of the rubber tubing along the radial spiral of the curved rubber tubing, and the density of spring turns outside the curved rubber tubing is lower than the density spring turns inside the curved rubber tubing; the hemisphere shell can installed on the spherical shell by rotating, and the hemisphere shell is fixed and connected with the upper turntable; the spherical shell is fixed and connected with the lower fractionating tray; and at least three curved flexible pneumatic cylinders are provided between the lower fractionating tray and the upper turntable, and the three cylinders are distributed uniformly; the first cover and the second cover are provided to both ends of each curved flexible pneumatic cylinder respectively, and the covers is fixed and connected with the lower fractionating tray. The first cover is provided with through holes connecting to the outside and the second cover is fixed and connected with the upper turntable. The invention has the advantages of good rigidness, simple and reasonable structure, small scale and good flexibility.

The invention discloses a synthetic method for adenine. Malononitrile and thiourea are employed as raw materials. The raw materials are subjected to a cyclization reaction under action of sodium alkoxide, and 4,6-diamino-2-sulfydryl pyrimidine. Then through three reaction routes, adenine is obtained. Though the method has many reaction steps, no refining or drying are needed for the product of each reaction step, the product can be used in the next reaction step, and the operation is simple. The raw materials are easily available, the prices are relatively low, the reaction conditions are mild, the operation is simple, the reaction steps are decreased, the reaction time is shortened, the overall reaction yield is high, and the synthetic method is suitable for industrial production.

A drilling tool combining a long spiral drill rod with a down-hole hammer comprises the drill rod and a spiral blade surrounding the drill rod in a spiral mode. A down-hole hammer drill bit is arranged on the lower portion in the drill rod, and a propelling mechanism of the down-hole hammer is arranged on the upper portion in the drill rod. The propelling mechanism comprises an air cylinder, a ventilation pipe penetrates through the air cylinder and a piston longitudinally, a first air outlet used for supplying air to an air cylinder cavity between an air cylinder end cover and the piston is formed in the side wall of the ventilation pipe, a longitudinal movement track of the piston is constituted by the cylinder body inner wall of the air cylinder and the outer wall of the ventilation pipe, the bottom end of the piston is connected with an ejection rod used for ejecting the down-hole hammer, the ejection rod is connected with the upper end of a guide rod through a spring, and the guide rod is fixedly connected with the down-hole hammer after penetrating through a bottom cover of the air cylinder. The outlet end of the ventilation pipe is in airtight connection with the air inlet end of a hose, and the air outlet end of the hose is in airtight connection with an air inlet port of the down-hole hammer. Different hole forming processes can be adopted according to soil layers and rock layers different in hardness, and the drilling tool has high implementation value.

The invention discloses heterojunction solar cell coating equipment, method and system, a solar cell, an assembly and a power generation system, and belongs to the field of solar cell processing. Theheterojunction solar cell coating equipment is used for depositing a heterojunction solar cell amorphous silicon-based thin film, and comprises a process cavity, wherein the process cavity comprises at least two intrinsic process cavities used for deposition of an intrinsic layer silicon thin film process, and at least one doping process cavity used for deposition of an N-type silicon film or P-type silicon film process, and the cavities in the intrinsic process cavities and the doping process cavity are isolated by isolation valves. By combining the control of gas proportion and pressure, theequipment can process a plurality of solar cells at the same time, so that the overall processing efficiency is greatly improved, and the equipment is suitable for commercial use.

The invention discloses a method for preparing bisbenzothiazole disulfide (DM) and triphenylphosphine (TPP) by a pot method, comprising the following processes: an organic solvent A, bis (trichloromethyl) carbonate shown in formula (II) and triphenyl phosphine oxide are sequentially added to a reaction bottle, and the insulating reaction is carried out for 0.5 to 10 hours at the temperature of minus 30 DEG C to 90 DEG C; the reaction solution is added with mixed solution of 2-sulfhydryl benzothiazole and organic base which are dissolved by an organic solvent B shown in formula (III), and the mixture reaction is carried out for 0.5 to 10 hours at the temperature of -30 DEG C to 90 DEG C; after the reaction is completed, drawing and filtering are carried out, the filter cake is dried and then the bisbenzothiazole disulfide is obtained, the organic solvent in the filter solution is recycled to obtain crude products, the crude products are re-crystallized to obtain the triphenylphosphine. The method has the advantages of simple operation, high reaction yield, high product purity and good atom economy, thus solving the problem that by-products can cause environment pollution, and the like, owning to difficult recovery and utilization in the process of producing cephalothin active ester, and the method has great implement value and potential social and economic benefits.

The air operated flexibility universal spheric joint, its characteristic is by seals covers (1), seals the attachment (2), the rubber pipe (3), the tight circle (4), seals the attachment (5), seals covers (6) to compose, in seals covers (2) on to be separated 120 to be equipped with three threaded hole, in seals covers (6) on to be separated 120 to be equipped with three stairs holes, also stair hole pocket for threaded hole, three same rubber pipes (3) the about beginnings and ends separately with seal the attachment (2) and seal the connection (5) to connect, Seals the attachment (2) to seal through the thread covers (1) to connect, the tight circle (4) the tight wrap in the rubber pipe (3) outside, seals the attachment (5) to cover (6) through spiral Wen Yufeng to connect, is sealing the attachment (5) the center to suppose to pass the hole, causes the rubber pipe (3) the cavity and the atmosphere is interlinked. Its structure simple reasonable, movement nimble, control simple, the use effect is good, has the bigger implementation value.

A flatting agent for a polyester hydroxyalkylamide type powder coating and a preparation method thereof. The flatting agent comprises the components of acrylic resin synthesized from (methyl) glycidyl acrylate and other monomers, C10-C18 long-chain diacid, wax or wax analog, and a metal salt or organic metal complex. The flatting agent provided by the invention is obtained by grinding and mixing acrylic resin, C10-C18 long-chain diacid, wax or wax analog, and metal salt or organic metal complex according to the proportion at room temperature. The flatting agent provided by the invention can be used in a polyester-hydroxyalkylamide type powder coating to form a good flatting film after curing, and does not generate unfavorable influences on other performances of the film.

The invention belongs to the field of medicine and particularly relates to a method for preparing a solifenacin intermediate. After 2-halogenated diphenyl ketone is used for carbonyl protection, n-butyllithium is used for removing bromine, then the formyl group is added; a condensation reaction with nitromethane and catalytic hydrogenation for reduction are carried out, and then acidification is conducted; later, cyclization is carried out, and a solifenacin intermediate compound I is obtained through alkaline hydrolysis after reduction and chiral resolution. The structural formula of the solifenacin intermediate is shown in the description. According to the method for preparing the solifenacin intermediate, the initial raw materials easy to obtain are utilized, and the production cost is reduced. The process route is advanced, the reaction conditions are mild, the reaction yield is high, less three wastes are caused, expensive and toxic reagents do not exist, reaction solvents can be used repeatedly after distillation, industrial production is facilitated, and implementation value and social, economic and environmental protection benefits are high.

The invention relates to a 2-amino-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide synthesis method, wherein the compound 2-amino-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide is a key intermediate for synthesizing dasatinib. The synthesis method comprises that: 1) trichloroacetyl chloride and ethyl vinyl ether are subjected to a nucleophilic substitution and hydrolysis reaction one-pot method to synthesize 3-ethoxyacrylic acid; 2) 3-ethoxyacrylic acid is subjected to an acyl chlorination and amidation reaction one-pot method to synthesize N-(2-chloro-6-methyl phenyl)-3-ethoxy acrylamide; and 3) N-(2-chloro-6-methyl phenyl)-3-ethoxy acrylamide, NBS and thiourea are subjected to a reaction to obtain 2-amino-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide. The synthesis method has characteristics of yield increase, cost reduction, operation simplifying, and high implementation value.

The invention relates to a pneumatic flexible swinging joint which comprises a base and an end cover, wherein a first rubber hose and a second rubber hose, which are parallel from front to back, are hermetically connected between the base and the end cover; spaces in the first rubber hose and the second rubber hose are respectively a first internal joint cavity and a second internal joint cavity; a first threaded hole and a second threaded hole which are communicated with atmosphere are formed on the base; the first threaded hole is communicated with the first internal joint cavity; the second threaded hole is communicated with the second internal joint cavity; metal wires are embedded in both of the first rubber hose and second rubber hose; a left baffle and a right baffle are fixedly connected to the base; and the left baffle and the right baffle are hinged with the end cover. The pneumatic flexible swinging joint has the advantages that the structure is simple, the pneumatic flexible swinging joint can be easily miniaturized and can be conveniently assembled, disassembled and maintained, the operation is flexible, and the application value is higher.

The invention relates to an automatic ecological parking garage, comprising a motor, a grid winding shaft, a grid unwinding shaft, another motor, a braking shaft for active turnover plate, an equipment control tank, a support, a support bar, a parking grid, a grid linking hinge, a linking hinge of turnover plate, a sign post, a turnover plate, a grid linking shaft and a pulley of linking shaft. There is a green lawn under the parking grid, which is adaptable for the occasion that the parking is convenience in living region. As the motor 1 (clockwise rotation) and the motor 4 (clockwise rotation) are started, the parking grid is unwound; the turnover plate is dropped to make cars drive in the parking garage placidly, and as the motor 4 (anticlockwise rotation) is started again, the turnover plate is lifted. As the motor 4 (clockwise rotation) is started, the turnover plate is dropped to make cars drive out of the parking garage placidly; as the motor 1 (anticlockwise rotation) is started, the parking grid is winded; and as the motor 4 (anticlockwise rotation) is started, the turnover plate is lifted. The invention is provided with novel structure, convenient installation and usage. It can avoid the road jam and decrease the car to be stolen. At the same time the greening area in living region can be increased and the ecological circumstance is improved. It has bigger economical and social benefit and implementary value.

The invention provides a method for refining trimethylamine through extractive distillation and purification. The method comprises an extractive distillation tower and an extracting agent recovery tower which are connected front and back, wherein a raw material containing trimethylamine enters the extractive distillation tower from the middle of the extractive distillation tower, an extracting agent enters the extractive distillation tower from the middle-upper part of the extractive distillation tower, a high-purity trimethylamine product is extracted from the top of the extracting agent recovery tower, an extracting agent and water enter the extracting agent recovery tower after being extracted from the bottom of the extractive distillation tower, water is extracted from the top of the extracting agent recovery tower, and the extracting agent is recycled after being extracted from the bottom of the extracting agent recovery tower. Trimethylamine containing water is purified and refined with the extractive distillation method adopting dimethyl sulfoxide as an extracting agent, the purity of trimethylamine can be 99% or above, the recovery rate of the product can be 99% or above, the purification refining operation of trimethylamine can be effectively completed, and the method has higher implement value and economic benefits.

A wavelet analysis-based method for determining contribution degree of surface topography of each level to the shear strength comprises the following steps: performing three-level division on the surface morphology of the structural plane based on wavelet analysis, determining a macroscopic geometric profile, a surface undulating form and microcosmic roughness of the surface of the structural plane, and analyzing contribution of all levels of surface morphologies to the shear strength of the structural plane; through the shear strength contribution ratio Q of the macroscopic geometric profile,the surface fluctuation form and the microcosmic roughness of the surface of the structural surface, determining the contribution of all levels of surface morphologies to the shear strength of the structural plane of rock mass , wherein the larger the Q is, the larger the contribution of the surface geometrical characteristics to the shear strength of the structural surface is, and otherwise, thesmaller the contribution of the surface geometrical characteristics to the shear strength is. According to the method, the accuracy of structural plane surface form description is remarkably improved, and the molding time and economy are saved.

The invention discloses a method for chemically synthesizing 3,5-diio-2-hydroxybenzene formyl chloride. The method comprises the step of: with 3,5-diio-2-hydroxybenzoic acid and di(trichloromethyl) carbonic ester as raw materials, reacting for 1-10 hours at the temperature of 40-150 DEG C in an organic solvent under the action of an organic amine catalyst, and processing reaction liquid to obtain 3,5-diio-2-hydroxybenzene formyl chloride, wherein the charging mol ratio of the 3,5-diio-2-hydroxybenzoic acid to the di(trichloromethyl) carbonic ester is 1: (0.34-2.0), the charging mol ratio of the 3,5-diio-2-hydroxybenzoic acid to the organic amine is 1: (0.01-1.0), and the mass ratio of the organic solvent to the 3,5-diio-2-hydroxybenzene formyl chloride is (5-20): 1. The method disclosed by the invention has the advantages of available raw materials, low cost, simplicity and safety in operation, environmental friendliness and higher product yield and purity and has greater application value and good social and economical benefits.

The present invention provides a pneumatically flexible climbing robot, including a pneumatically flexible driver, a pneumatically flexible fetlock, a vacuum grip device and a osculum linker, the pneumatically flexible driver includes a front lid, a middle lid and a thick rubber hose, two ends of the thick rubber hose are jointed with the front lid and the middle lid, a pylome connected to atmosphere is set on the front lid, a helix steel wire is embedded in the wall of the thick rubber hose; the pneumatically flexible fetlock includes a back lid and three thin rubber hoses, one side of the middle lid is jointed with the thick rubber hose, the other end of the middle lid is set with three steps jointed with one side of three thin rubber hoses at 120 degrees, the other ends of three thin rubber hoses are jointed with the back lid, a helix steel wire is embedded in the wall of the thin rubber hose; two ends of the front lid, middle lid and back lid are fixedly connected with the osculumlinker respectively, the osculum linker is fixedly connected with the vacuum grip. The pneumatically flexible climbing robot has a simple structure, small volume and strong flexibility.

The invention provides a light-weight reinforced mixing light-weight soil and preparation method thereof. The raw material component and weight proportion of the light-weight reinforced mixing light-weight soil as follows: 52-93% natural light material, 0.1-4% fiber material, 4-24% water, 3-20% firming agent; the advantages of the light-weight reinforced mixing light-weight soil are: (1) light weight: density is between 0.5-1.3 g / cm<3>; (2) density can be adjusted at will: changing different natural light material and proportion of every component to adjust density; (3) strength adjustability; (4) strong tensile strength and can be adjusted; (5) convenient operation, well effect: natural light material has stable mechanical property, so prepared light-weight soil has well effect; (6) widely application.

The invention discloses a synthetic method of 2-(4-alkyl substituted benzoyl) phenylformic acid with a structure represented by a formula (I). The 2-(4-alkyl substituted benzoyl) phenylformic acid is prepared by reacting phthalic anhydride with a structure represented by a formula (II) with alkylbenzene with a structure represented by a formula (III) in a reaction solvent, wherein the phthalic anhydride and the alkylbenzene are used as raw materials. The synthetic method is characterized in that trifluoromethanesulfonic salt is used as a catalyst; and a feeding mol ratio of the organic amine trifluoromethanesulfonic salt to the phthalic anhydride is 1-50% :1. The organic amine trifluoromethanesulfonic salt catalyst is used to replace the traditional alchlor catalyst, and the organic aminetrifluoromethanesulfonic salt has high water solubility, water stability and lower cost and is easy to obtain and prepare. The method has the advantages of greatly reduced consumption of the organic amine trifluoromethanesulfonic salt, no waste acid generation, high reaction yield, mild reaction condition, safe and simple operation, few three wastes and larger implementation value.

The invention pertains to the technical field of drug combination preparation, more particularly relates to a preparation technique for mezlocillin. The preparation technique for mezlocillin comprises the following steps: ampicillin trihydrate and 1-chloroformyl-3-methylsulfonyl-2-imidazolidinone carry out acylation reaction under alkaline condition and then extraction, acidification and crystallization are conducted to obtain the mezlocillin. The invention is characterized in that when acylation reaction is conducted, reaction menstruum is water and acetone; after acylation reaction is finished, an ether extractant is added for carrying out extraction; and menthyl acetate is added before acidification so as to carry out acidified crystallization. The synthetic technique has obvious advantages, provides powerful guarantee for synthesizing the mezlocillin with high quality and has relatively great implementation value and long-term social and economic benefit.

The invention relates to a method for converting crystal form of zopiclone. The invention uses zopiclone of crystal form C as material, to process crystal form conversion in dimethyl carbinol, while the reaction temperature is from 20DEG C to the boiling point of solvent system, and cools temperature to 0DEG C after the reaction, filters and dries to obtain zopiclone of crystal form A. The inventive method is characterized in safe and reliable production, high yield and high product quality.

The invention belongs to the field of medicines, and concretely relates to a preparation method of an acotiamide intermediate. The method comprises the following steps: preparing acyl chloride from 2,4,5-trimethoxybenzoic acid, condensing acyl chloride and thiourea, and carrying out ring closure on the obtained material and haloalkyl pyruvate to prepare the acotiamide intermediate compound I. The structural formula of the acotiamide intermediate is shown in the description. A simple and easily available initial raw material is used in the invention, so the production cost is reduced. The method has the advantages of advanced process route, mild reaction conditions, high reaction yield, few three wastes, no expensive or toxic reagents, easy separation and reuse of a reaction solvent, indiscriminate application of the reaction solvent after distillation, easy industrial production, large enforcement values, and large social, economic and environmentally-friendly benefits.