Synthetic method of 2-(4-alkyl substituted benzoyl) phenylformic acid

Abstract

The invention discloses a synthetic method of 2-(4-alkyl substituted benzoyl) phenylformic acid with a structure represented by a formula (I). The 2-(4-alkyl substituted benzoyl) phenylformic acid is prepared by reacting phthalic anhydride with a structure represented by a formula (II) with alkylbenzene with a structure represented by a formula (III) in a reaction solvent, wherein the phthalic anhydride and the alkylbenzene are used as raw materials. The synthetic method is characterized in that trifluoromethanesulfonic salt is used as a catalyst; and a feeding mol ratio of the organic amine trifluoromethanesulfonic salt to the phthalic anhydride is 1-50% :1. The organic amine trifluoromethanesulfonic salt catalyst is used to replace the traditional alchlor catalyst, and the organic aminetrifluoromethanesulfonic salt has high water solubility, water stability and lower cost and is easy to obtain and prepare. The method has the advantages of greatly reduced consumption of the organic amine trifluoromethanesulfonic salt, no waste acid generation, high reaction yield, mild reaction condition, safe and simple operation, few three wastes and larger implementation value.

Description

(1) Technical field The invention relates to a method for synthesizing 2-(4-alkyl-substituted benzoyl)benzoic acid by using phthalic anhydride and alkyl-substituted benzenes as raw materials. (2) Background technology 2-(4-Alkyl-substituted benzoyl)benzoic acid is an important key intermediate in organic synthesis. For example, 2-(4-alkyl substituted benzoyl) benzoic acid is an important intermediate for the synthesis of substituted anthraquinones. 2-Ethylanthraquinone (2-pentylanthraquinone) is the main raw material and intermediate for the production of hydrogen peroxide, photosensitive materials, dyes and degradable resins by anthraquinone method. Before the present invention provides, the industrialized application method of existing literature report synthesis 2-(4-alkyl substituted benzoyl) benzoic acid is (EP 451714,1991, 90%; Journal of Jiangxi Normal University, 2000,24 (2) , 152-154, 85%): The target product is prepared by using phthalic anhydride and alkylben...

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Problems solved by technology

This method has problems such as a large amount of catalyst used, cannot be recycled, and a large amount of hydrogen chloride is generated after post-processing, which has great corrosion on equipment and is not environmentally friendly.

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