Method for chemically synthesizing 3,5-diio-2-hydroxybenzene formyl chloride

A technology for hydroxybenzoyl chloride and chemical synthesis, which is applied in 3 fields, can solve the problems of high energy consumption in the concentration process, difficult treatment of acidic wastewater, and large hidden dangers in production safety, and achieves low cost, high product yield and purity, and reasonable conditions. Effect
CN102206152AInactive Publication Date: 2011-10-05ZHEJIANG RONGYAO CHEM +2
6 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG RONGYAO CHEM
Publication Date
2011-10-05
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
Patent Text Reader

Abstract

The invention discloses a method for chemically synthesizing 3,5-diio-2-hydroxybenzene formyl chloride. The method comprises the step of: with 3,5-diio-2-hydroxybenzoic acid and di(trichloromethyl) carbonic ester as raw materials, reacting for 1-10 hours at the temperature of 40-150 DEG C in an organic solvent under the action of an organic amine catalyst, and processing reaction liquid to obtain 3,5-diio-2-hydroxybenzene formyl chloride, wherein the charging mol ratio of the 3,5-diio-2-hydroxybenzoic acid to the di(trichloromethyl) carbonic ester is 1: (0.34-2.0), the charging mol ratio of the 3,5-diio-2-hydroxybenzoic acid to the organic amine is 1: (0.01-1.0), and the mass ratio of the organic solvent to the 3,5-diio-2-hydroxybenzene formyl chloride is (5-20): 1. The method disclosed by the invention has the advantages of available raw materials, low cost, simplicity and safety in operation, environmental friendliness and higher product yield and purity and has greater application value and good social and economical benefits.
Need to check novelty before this filing date? Find Prior Art

Description

(1) Technical field

[0001] The invention relates to a method for synthesizing an intermediate of iodosamide sodium, in particular to a method for chemically synthesizing 3,5-diiodo-2-hydroxybenzoyl chloride. (2) Background technology

[0002] Closantel Sodium (Closantel Sodium) is a broad-spectrum, high-efficiency, low-toxic anthelmintic, which can be used to treat and prevent parasitic infections in cattle and sheep, and can be administered in various forms such as oral or intramuscular injection. The drug is effective against some nematodes and arthropod insects that are in close contact with the blood circulation or blood-sucking parasites, such as adults and larvae of Fasciola hepatica, Fasciola large and Fasciola gigantea, Haemonchus, Sinostomum, Avian mouth nematode, Geiger Nematodes, Chabert's nematodes, etc. have high-efficiency killing effects. Combining with plasma protein in animals, the drug has the effect of prolonging the drug effect, and can prevent cattle an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More