72 results about "2-Hydroxybenzoic acid" patented technology

The invention discloses a preparation method of 3,6-dichloro-2-hydroxybenzoic acid, which sequentially comprises the following steps: 1) salifying 2,5-dichlorophenol; 2) carboxylation: transferring the 2,5-dichlorophenate solution into a high-pressure reaction kettle, adding a cocatalyst, and introducing CO2 to carry out high-pressure carboxylation reaction to obtain the reaction product containing 3,6-dichloro-2-hydroxybenzoate, wherein the cocatalyst is composed of potassium carbonate and activated carbon; 3) refinement: after cooling the reaction product containing 3,6-dichloro-2-hydroxybenzoate obtained in the step 2) to room temperature, adding an alkali solution, regulating the pH value to 11-13, uniformly stirring, filtering to recover activated carbon, stratifying the filtrate, and taking the water phase; and adding an acid solution into the water phase, regulating the pH value to 1-3, carrying out vapor distillation to recover the 2,5-dichlorophenol, cooling to crystallize, carrying out vacuum filtration, and drying to obtain the 3,6-dichloro-2-hydroxybenzoic acid.

The invention relates to a preparation method of a self-assembly Ni-MOFs electrochromic QR code device. The method comprises the steps as follows: 1,4,5,8-naphthalenetetracarboxylic dianhydride and 5-amino-2-hydroxybenzoic acid are put in toluene, and an anhydride ligand is obtained; the ligand is dissolved in DMF and a solution A is obtained; nickel salt is dissolved in ethanol and a solution B is obtained; pretreated FTO glass is irradiated by ultraviolet ozone, the obtained FTO glass is sequentially placed in the solution A, ethanol, the solution B and ethanol for self-assembly, circulatingoperation is performed, and an FTO electrode with a Ni-MOFs film attached on the surface is obtained; a working electrode displaying QR code patterns is formed through laser etching, another FTO glass is used as a counter electrode, gel electrolyte is injected, and the device is obtained after packaging. Controllable preparation of the Ni-MOFs film is realized, the prepared QR code device can beswitched between display and hiding when positive and negative voltage is applied, and meanwhile, the device has good electrochromic performance and has wide application prospects in the fields of Internet of Things, intelligent wearable devices and the like.

The invention provides a Chinese medicinal compound preparation for treating skin diseases, which is prepared from the raw materials including safflower, clove, pricklyash peel, atractylodes rhizome, corktree bark, broom cypress fruit, Chinese dittany bark, roor of sessile stemona, Chinese mugwort leafmulberry leaf, cortex pseudolaricis, cnidium fruit, flavescent sophora root, centipede, camphor, 2-hydroxybenzoic acid, benzene carboxylic acid, dimethyl sulfoxide and 50-60% of ethanol.

Disclosed is a topical skin care composition, and method for its use, that includes 55 to 65% by weight of water, 15 to 20% by weight of a combination of 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate (homosalate), 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3 -dione (avobenzone), 2-ethylhexyl 2-hydroxybenzoate (octisalate), and 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate (octocrylene), 3 to 4% by weight of distearlydimonium chloride, and 1 to 3% by weight of a combination of euterpe oleracea fruit extract, punica granatum sterols, caprooyl tetrapeptide-3, tocopherol or tocopherol acetate, and niacinamide, wherein the composition has a sun protection factor of at least 15 or about 15 to 20.

The invention belongs to the technical field of fluorescence detection materials and discloses an enhanced fluorescent probe and a preparation method and application thereof. The fluorescent probe is 5-{4-[3-(2-{2-[2-(toluene-4-sulfamine)-ethyl]-1H-benzo(de)isoquinoline-1,3(2 H)-diketone-6-amino}-ethylamino)-propoxy]-phenylazo}-2-hydroxybenzoic acid and has a molecular structural formula shown in a formula (1). The probe compound is prepared from visible light excited and emitted fluorescent chromophore naphthalimides and an azo reductase recognition group 5-aminosalicylic acid azobenzene derivative. The probe compound not only has better water solubility, but also is high in accuracy when being used for azo reductase detection, is convenient to use and can simultaneously trace release of anti-inflammatory drugs such as 5-aminosalicylic acid and provide a supplementary means for diagnosis and treatment of colitis.

Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material. A method for producing a 2-bromo-4,5-dialkoxybenzoic acid represented by the following formula (2): (wherein each of R1 and R2 represents a lower alkyl group), the method including causing a 3,4-dialkoxybenzoic acid represented by the following formula (1): (wherein R1 and R2 have the same meanings as defined above) to react with bromine in concentrated hydrochloric acid.

A toxicological friendly antifreeze composition having improved thermal stability is provided. In one embodiment, the antifreeze composition comprises from 5 to 80 wt. % of an aqueous freezing point depressant selected from alkali metal salts of acetates, formates, proprionates, adipiates, and succinates, and mixtures thereof; 0.1 to 10 wt. % of at least one of a 2-ethylhexanoic acid, isononanoic acid and 3,5,5-trimethylhexanoic acid; and 0.1 to 10 wt. % of at least one of octanoic acid, nonanoic acid, decanoic acid, undecanoic acid, dodecanoic acid, neodecanoic acid, benzoic acid, 2-hydroxybenzoic acid, p-terbutylbenzoic acid, and mixtures thereof. In one embodiment, the composition is employed as a concentrate in admixture with 10 to 90 wt. % water.

The invention discloses a cobalt complex and a preparation method thereof, and the cobalt complex is characterized by having good electrocatalytic activity on hydrogen peroxide, the molecular formula of the cobalt complex is C26H26N4O10Co, the crystal system is orthorhombic, the space group is Pbcn, the cell parameters alpha, gamma and beta satisfy: a=15.928Angstrom, b=10.602Angstrom, c=15.596Angstrom, alpha is equal to gamma, is equal to beta and is equal to 90 degrees. The cobalt complex prepared in the invention is obtained by a mixing reaction of a cobalt salt and a derivative of 5-aminosalicylic acid, namely, 5-((2-pyridyl) methylene amino)-2-hydroxybenzoic acid according to a certain proportion, the cobalt complex has a specific spatial structure and an accurate molecular formula, the synthesis steps are simple, the yield can reach 45-70%, and the cobalt complex has good electrocatalytic activity, thereby being capable of being used as an electrocatalytic active material having a potential application prospect.

The invention discloses a synthetic method for 3,6-dichloro-2-hydroxybenzoic acid, which sequentially comprises the following steps: 1) salifying 2,5-dichlorophenol, 2) performing carboxylation, and 3) performing refinement, wherein according to Step 2), a 2,5-dichlorophenol saline solution is transferred into a high-pressure reactor, a catalyst is added, CO2 is supplied for high-pressure carboxylation reaction, a reaction product containing 3,6-dichloro-2-hydroxybenzoic acid salt is obtained, and the catalyst is potassium chloride; and according to Step 3), an alkaline solution is added after the reaction product is cooled to a room temperature, pH is adjusted to 11-13, an aqueous phase is obtained after layering, an acid solution is added to the aqueous phase, the pH is adjusted to 1-3, and after vapor distillation is performed and 2,5-dichlorophenol is recovered, suction filtration and drying are performed, and 3,6-dichloro-2-hydroxybenzoic acid is obtained. 3,6-dichloro-2-hydroxybenzoic acid synthesized with the method has the characteristics of low cost and higher yield.

The invention discloses a copper complex and a preparation method thereof, and the copper complex is characterized by having good electrocatalytic activity on hydrogen peroxide, the molecular formula of the copper complex is C46H34N6O14Cu2, the crystal system is clinorhomboidal, the space group is P-1, the cell parameters are as follows: alpha is equal to 99.90 degrees, beta is equal to 101.2 degrees and gamma is equal to 93.69 degrees. The copper complex is prepared from a mixing reaction of a copper salt, 5-(di(carboxymethyl) amino)-2-hydroxybenzoic acid and 1,10-phenanthroline according to a certain proportion, the copper complex has a specific spatial structure and an accurate molecular formula, the synthesis steps are simple, and the yield can reach 30-70%. The copper complex prepared in the invention has good electrocatalytic activity, thereby having a broad application prospect of being used as a potential electrocatalytic active material.

Disclosed is a Bacillus thuringiensis (Bt) biological pesticide effervescence tablet, which comprises Bt biological pesticide raw powder and findings including wetting agent, emulsifying agent, crumbling agent, and binding agent. The constituents include Bt biological pesticide raw powder, lignin sulfonic acidic sodium, stearic acid, 2-hydroxybenzoic acid, sodium hydrogen carbonate, and starch. The invention has the advantages of less contamination, easy transportation, long keeping time and easiness in application.

The invention provides an outer plugging resin. The outer plugging resin comprises, by weight, 30 to 60 parts of modified epoxy resin, 40 to 60 parts of a filler, 1 to 10 parts of a curing agent, 0.5to 2 parts of an accelerator, 0.05 to 0.2 parts of a defoaming agent, 0.05 to 0.2 parts of a coupling agent and 0.5 to 2 parts of an antioxidant. The modified epoxy resin is 4-benzamido-2-hydroxybenzoic acid-modified tetrabromobisphenol A type epoxy resin.

New esters derived from (RR, SS)-3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl 2-hydroxybenzoate, analog to Tramadol, a process for obtaining them and the use of these compounds for the production of a medicament with analgesic properties.

These new products of general formula (I) exhibit an analgesic activity higher than that of tramadol.

The invention relates to a hyponitric chemical deburring liquid and a deburring method for an iron-based cylindrical coil spring. The deburring liquid is prepared by the following compositions according to per liter liquid 200 to 220 milliliters of hydrochloric acid, 20 to 30 milliliters of nitric acid, 15 to 20 micrograms of 2-hydroxybenzoic acid, 0.5 to 1.0 gram of gelatine, 1 to 2 grams of polyethyleneglycol, 2 to 3 grams of nonyl phenol polyethenoxy ether, the balance being water. The chemical deburring method comprises the following steps of: a). preparation of deburring liquid; b). deburring; c). cold-water washing; d). neutralizing treatment; e). cold-water washing; f). hot-water washing; g). drying; and h). immersion of rust-preventative oil. The deburring liquid has the advantages that: the content of the nitric acid in the deburring liquid is very low, thereby nitrogen oxide generated is very limited, consequently the deburring liquid has low pollution and is environment-friendly. Simultaneously, the deburring production process has simple operation, short working procedure time, and high burr removal rate, and is suitable for mass production of the cylindrical coil springs which have complex shapes and are difficult to perform mechanical deburring; and the surface finish quality of parts after deburring is high. Moreover, the raw materials of the deburring liquid are low in price and the energy consumption of the deburring treatment is low, thereby the method is favorable for saving the resources and reducing the production cost.

The invention provides a Cr (III) chelate, and a preparation method and application thereof. The preparation method for the chelate comprises the following steps: preparing 5,5-methylene di(2-hydroxybenzoic acid); putting Cr (III) Cl3.6H2O and the 5,5-methylene di(2-hydroxybenzoic acid) into a reactor, dissolving by using organic alcohol, adding zinc particles, dripping ethanediamine in a reflux state, and continuously reacting for 15 to 60 minutes, wherein 1.85g of 5,5-methylene di(2-hydroxybenzoic acid), 0.1 to 1g of zinc particles, 10 to 30ml of organic alcohol and 0.5 to 1g of ethanediamine are added into each 1g of Cr(III)Cl3.6H2O; and cooling and filtering a reaction liquid to obtain a target product. The chelate is high in water solubility, has a sustained release function, is easily absorbed and can be applied to preparing weight-reducing medicines.

The invention provides a recycling method of a 2-hydroxybenzoic acid-2-ethyl caprolactone production liquid waste. The method comprises: adjusting the pH of wastewater produced in an esterification synthesis procedure to 2 through hydrochloric acid with mass concentration of 30%, fully stirring for half an hour, separating out white crystals from the wastewater, and centrifugally dewatering to obtain salicylic acid crystals, wherein the purity of the crystals is not smaller than 98% and the water content is not larger than 18%; the obtained salicylic acid crystals can be used as production raw materials of 2-hydroxybenzoic acid-2-ethyl caprolactone, and the salicylic acid crystals are directly applied in the esterification synthesis of OS104 without being dried; and the consumption of the salicylic acid raw material is reduced, the production cost is lowered, and meanwhile, the wastewater treatment cost is reduced.

The invention provides a medical agent for preventing the information-recording material from rotting, used for preventing various disk and mag tape from rotting. The long-acting mildew-resistant medicinal agent is comprised with the following raw material with the weight proportion being: m-nitrobenzaldehyde: 10-70%, ª‡-benzalacet aldehyde bromide: 10-70%, 2-hydroxybenzoic acid: 5-40%, geoceric acid: 0.5-20%. The medicine can release the mildew-resistant medical agent of many times as much as that of lowest bacteria inhibitor, possesses high effective killing or inhibiting ability for the common fungus in air, and can preventing the information recording material such as various disk, mag tape and compact disk from rotting.

The invention discloses a method for chemically synthesizing 3,5-diio-2-hydroxybenzene formyl chloride. The method comprises the step of: with 3,5-diio-2-hydroxybenzoic acid and di(trichloromethyl) carbonic ester as raw materials, reacting for 1-10 hours at the temperature of 40-150 DEG C in an organic solvent under the action of an organic amine catalyst, and processing reaction liquid to obtain 3,5-diio-2-hydroxybenzene formyl chloride, wherein the charging mol ratio of the 3,5-diio-2-hydroxybenzoic acid to the di(trichloromethyl) carbonic ester is 1: (0.34-2.0), the charging mol ratio of the 3,5-diio-2-hydroxybenzoic acid to the organic amine is 1: (0.01-1.0), and the mass ratio of the organic solvent to the 3,5-diio-2-hydroxybenzene formyl chloride is (5-20): 1. The method disclosed by the invention has the advantages of available raw materials, low cost, simplicity and safety in operation, environmental friendliness and higher product yield and purity and has greater application value and good social and economical benefits.

The invention discloses a method for identifying aromatic isomers 2-hydroxybenzoic acid and 3-hydroxybenzoic acid. The method is characterized by comprising the following steps: taking a 'H2SO4-KIO3-[NiL](ClO4)2-propanedioic acid-H2O2' nonlinear oscillating chemical system as an identification solution, and further distinguishing and identifying the aromatic isomers 2-hydroxybenzoic acid and 3-hydroxybenzoic acid according to oscillation response of the aromatic isomers on the system, wherein L in [NiL](ClO4)2 refers to 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazamacrocyclo-4,11-diene. An oscillation spectrum provided by the identification method is intuitive, and the method is capable of conveniently and rapidly identifying the aromatic isomers 2-hydroxybenzoic acid and 3-hydroxybenzoic acid, can be widely applied to other isomers and is simple in equipment, high in accuracy and easy in operation and observation.

The invention discloses a preparation method of a micromolecule cathepsin D inhibitor. The preparation method comprises the following steps that 2-mercaptobenzothiazole or its derivatives and 4-iodoaniline as starting materials undergo a reaction in a water phase by catalytic C-S coupling to produce 4-(2-benzothiazolylthio)aniline or its corresponding derivatives (A); and the 4-(2-benzothiazolylthio)aniline or its corresponding derivatives (A), and 3,5-dichloro-2-hydroxybenzoic acid undergo an amidation reaction to produce the micromolecule cathepsin D inhibitor (B). The preparation method has the advantages of easily available raw materials, simple reaction conditions, simple and convenient operation, low toxicity and pollution, simple post-treatment processes, high yield and high purity.

The invention provides an ointment for treating sabies, wherein the main constituents include sublimed sulfur, 2-hydroxybenzoic acid, cetyl alcohol, propylene glycol, methyl hydroxybenzoate, sodium dodecylsulfate, white Vaseline, white oil and distilled water.

The invention relates to a direct electro-reduction method for preparing ortho-hydroxybenzaldehyde with 2-hydroxybenzoic acid in H type electrolyser, which is characterized in that quaternary ammonium salt addictive is added in cat electrode room. It takes lead plate as cathode and anode, takes ortho-hydroxybenzaldehyde and hydric sulphate as electrolytic solution for cathode and anode, the current efficiency reach over 35% at 10- 40 Deg. C and current density of 500- 2000 A/ m2, which is 10% more than that without addictive.

A compound medicinal tinctura for treating extremity tinea prepared by charging 2-hydroxybenzoic acid, benzene carboxylic acid, boneol, wormseed tincture into the alcoholic solution proportionally and mixing. The preparation is a fusco-rufous liquid that can be directly daubed onto the affected parts.

The invention provides an imidazopyridine compound shown in the formula (1) and a preparation method and application thereof. The imidazopyridine compound shown in the formula (1) is obtained by taking 2-amidogen-4-hydroxypyridine, 4-bromine-2-methyl glyoxalidine hydroxybenzoate, dimethylethanolamine and 2-(trifluoromethyl)phenylethanol as the raw materials, taking alkali and metal catalysts as the catalysts and taking organic solvents as the solvents through multi-step reactions. The invention further provides the application of the imidazopyridine compound shown in the formula (1) which serves as an NEK2 inhibitor in regulating tumor cell growth.

The invention relates to light-resistant water-based environment-friendly stone-like paint and a preparation method thereof. A prepared modification filling material is added, and in the modificationfilling material, 2-hydroxybenzoic acid octyl ester can improve light resistance, and carboxymethyl cellulose can improve adhesion strength and stability of the internal structure; a water-based cosolvent and deionized water are added for dissolution and dispersion; a glacial acetic acid water solution can remove impurities in quartz sand, and fine holes formed by impurity removal impurities are to be filled, wherein the effect of the 2-hydroxybenzoic acid octyl ester and the carboxymethyl cellulose can be fully exerted by the fine pore structure, and the internal adhesion strength and stability can be improved. According to the technical scheme, a water-based acrylic resin emulsion is used, and the characteristics of weather resistance, light resistance, heat resistance, corrosion resistance, film coating fullness and the like of the water-based acrylic resin emulsion are fully exerted; and then a coalescing agent and a defoaming agent with a certain ratio are added to obtain the light-resistant water-based environment-friendly real stone-like paint which has the characteristics of good light resistance, strong adhesion, stable structure, no powder falling and the like.