Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Cr (III) chelate, and preparation method and application thereof

A chelate and product technology, applied in chemical instruments and methods, active ingredients of heavy metal compounds, compounds containing elements of Group 6/16 of the periodic table, etc., can solve the problems of low water solubility, poor bioavailability, etc. Good water solubility, reducing positive charge and increasing utilization

Inactive Publication Date: 2012-09-12
SHANXI UNIV
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its water solubility is low and its bioavailability is poor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cr (III) chelate, and preparation method and application thereof
  • Cr (III) chelate, and preparation method and application thereof
  • Cr (III) chelate, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Preparation of Cr(III) Chelate

[0020] Step 1: Mix 13.8g of 2-hydroxybenzoic acid with 25ml of hydrochloric acid and stir, raise the temperature to 70°C, add 10g of 30% formaldehyde solution, keep the temperature not exceeding 80°C during the feeding process, and heat up to 90°C for 8h after feeding. After cooling, the reaction solution was poured into 100 mL of water, the precipitated crystals were filtered, washed repeatedly with water to remove the acid, and dried at 100°C to obtain 5,5'-methylenebis(2-hydroxybenzoic acid) with a yield of 75%. Elemental analysis press C 15 H 12 O 6 , Theoretical value: C, 62.50; H, 4.20; Experimental value: C, 62.01, H, 4.28.

[0021] Step 2: Add 2.67g (10.0mmol) CrCl 3 ·6H 2 O and 1.44g (5.0mmol) of 5,5'-methylenebis(2-hydroxybenzoic acid) were placed in a 50mL round bottom flask, dissolved with 10mL of organic alcohol, added 0.3g of arsenic-free zinc particles, and slowly dripped under reflux Add 1mL of anhydrous ethylenedi...

Embodiment 2

[0025] Example 2: Preparation of Cr(III) Chelate:

[0026] Weigh 2.67g (10.0mmol) CrCl 3 ·6H 2 O and 1.44g (5.0mmol) of 5,5'-methylenebis(2-hydroxybenzoic acid) were placed in a 100mL round-bottomed flask, dissolved with 30mL of organic alcohol, added 1g of arsenic-free zinc particles, and dropped under reflux 2mL of anhydrous ethylenediamine, the color of the solution changed from green to red, continue to react for 30 minutes, a large amount of pink powder precipitated, suction filtered, washed with anhydrous organic alcohol and ether for three to five times, dried at room temperature to constant weight, yield Is 78%.

Embodiment 3

[0027] Example 3: Weight loss activity of Cr(III) chelate

[0028] The weight loss activity was verified by feeding mice experiments. Thirty Kunming mice, half male, weight (10-12g), provided by the Experimental Animal Center of Shanxi Provincial Academy of Traditional Chinese Medicine. Ordinary feed is provided by Guangzhou Cybino Biological Technology Co., Ltd. High-fat feed formula: ordinary feed 66.5%, sucrose 20%, lard 10%, cholesterol 2.5%, sodium cholate 1%. According to body weight, they were randomly divided into 3 groups (half males), 10 normal group, 10 model group, and 10 administration group. Since the beginning of the experiment, the mice in the normal group were given normal diet, and the other groups were given high-fat diet. The drug was started after 11 weeks of feeding. The dose was 50g / kg per day, and the rats were gavage once a day in the morning. The experiment lasted for 19 weeks. Weigh the animals regularly. After the experiment, the rats were fasted...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a Cr (III) chelate, and a preparation method and application thereof. The preparation method for the chelate comprises the following steps: preparing 5,5-methylene di(2-hydroxybenzoic acid); putting Cr (III) Cl3.6H2O and the 5,5-methylene di(2-hydroxybenzoic acid) into a reactor, dissolving by using organic alcohol, adding zinc particles, dripping ethanediamine in a reflux state, and continuously reacting for 15 to 60 minutes, wherein 1.85g of 5,5-methylene di(2-hydroxybenzoic acid), 0.1 to 1g of zinc particles, 10 to 30ml of organic alcohol and 0.5 to 1g of ethanediamine are added into each 1g of Cr(III)Cl3.6H2O; and cooling and filtering a reaction liquid to obtain a target product. The chelate is high in water solubility, has a sustained release function, is easily absorbed and can be applied to preparing weight-reducing medicines.

Description

Technical field [0001] The invention relates to a metal chelate, specifically a Cr(III) chelate and a preparation method, and the application of the chelate in the preparation of weight-loss drugs. Background technique [0002] Cr(III) ion (trivalent chromium ion) has the effect of enhancing the function of insulin and promoting the metabolism of sugar, protein and lipids. The content of Cr(III) in the human body gradually decreases with age. The lack of Cr(III) can reduce the sensitivity of tissues to insulin. Chromium (III) complexes as Cr(III) supplements have shown an important role in the treatment of type II diabetes. Supplementing an appropriate amount of Cr(III) complexes to diabetic patients can enhance the effect of insulin, release the impaired glucose tolerance of the human body, and reduce blood sugar levels and serum cholesterol levels. The chromium supplements currently on the market include chromium nicotinate, various amino acid chromium and chromium picolinate...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07F11/00A61K31/28A61P3/04A61P3/06
Inventor 刘斌赵亚琴杨斌盛
Owner SHANXI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com