113 results about "Homosalate" patented technology

The present invention relates to a process for the separation and purification of lactic acid from a fermentation medium wherein the lactic acid is totally or partially in the form of a salt or salts. The lactic acid producing microorganisms are separated from the other components of the fermentation medium. This solution is concentrated and then acidified to a pH below or equal to 3. The acidified solution is passed over a cation exchange resin to give a fraction that has maximum of 25% lactic acid salts relative to the dry weight of the solution. This fraction is subjected to bipolar fractionating electrodialysis. The resulting lactic acid is further purified, concentrated and then recovered.

Low cost sunscreening formulations having SPF values greater than 40 contain homosalate, octyl salicylate or mixtures thereof, in combination with oxybenzone, and optionally further contain octyl methoxycinnamate, avobenzone or mixtures thereof.

This invention provides a compound of formula (I):or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; processes for the synthesis or manufacture of the compound of formula (I), or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; and the use of said compound, or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof, for the treatment of patients suffering from or subject to diseases, disorders or conditions involving cell survival, proliferation, and migration, including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer, (e.g., AML and malignant glioma)glomerulosclerosis, fibrotic disease and inflammation.

Acid concentrates, and dialysate compositions prepared therefrom, contain citric acid and an effective amount of a buffering agent selected from acetate and / or lactate. The buffering agent allows a physiologically acceptable amount of citrate to maintain the desired pH of the dialysate.

The present invention relates to cells or plants that can produce polylactate or its copolymers and to a method for preparing polylactate or its copolymers using the same. More specifically, cells or plants with the ability to produce polylactate or hydroxyalkanoate-lactate copolymers comprise both a gene encoding an enzyme that converts lactate into lactyl-CoA and a gene encoding polyhydroxyalkanoate (PHA) synthase which uses lactyl-CoA as a substrate. Also described is a method for preparing polylactate or hydroxyalkanoate-lactate copolymers which comprises culturing the cells in a medium containing lactate or lactate and various hydroxyalkanoates or culturing the plants. Effective preparation of hydroxyalkanoate-lactate copolymer which comprises various hydroxyalkanoates as well as polylactate, using the cells or the plants, is disclosed.

The invention discloses a method for preparing L-lactic acid and / or L-lactate. The method sequentially comprises the following steps of: a) preparing an L-lactic acid fermentation solution by microbial fermentation; b) treating the L-lactic acid fermentation solution by adopting any one of flocculation, filtration, centrifuging and ultra-filtration to obtain a clear fermentation solution; c) performing acidolysis and filtration on the clear fermentation solution to obtain acidolysis filtrate; d) decolorizing the acidolysis filtrate to obtain a decolorized solution; and e) separating the decolorized solution by adopting anion adsorption exchange resin, and thus obtaining the L-lactic acid and / or the L-lactate. By adopting the technical scheme, the method only has five steps, and a nano membrane filtration step and a molecular distillation step are not used any more, so compared with the conventional method, the method has the advantages of a few steps, low equipment purchasing cost and using cost, low energy consumption and easily controlled production cost. By adopting the method, the manufacturing cost of the L-lactic acid and / or the L-lactate is low.

A basic facial and body treatment cosmetic formulation is a combination of a cationic emulsifying agent, an oil soluble liquid polymer and a naturally occurring lactate buffer system. The basic formulation is a starter system that can be specialized to skin moisturizers, skin lighteners, skin pigmenting agents, sunscreens, antioxidants, line reducing products, wrinkle reducing products, anti-cellulite products, pharmaceuticals and the like.

A composition for sunscreen or sunscreen enhancer is disclosed. The composition includes UV-blocking component comprising natural extracts, natural oils or nutrients or a combination of these. The composition is capable of protecting skin from the harmful effects of UV-light and it is capable of acting as an enhancer of sunscreen actives, such as zinc oxide, titanium dioxide or other sunscreen actives, such as Avobenzone, Dioxybenzone, Ecamsule, Meradimate, Oxybenzone, Sulisobenzone, Cinoxate, Ensulizole, Homosalate, Octinoxate, Octisalate, Octocrylene PABA, Padimate O or Trolamine salicylate.

The invention discloses a method for preparing lactic acid with bipolar membrane electrodialysis technology. Lactic acid fermentation liquid passes through an electrodialyzer, which transforms contained lactates into lactic acid. The membrane tank configuration of the adopted electrodialyzer can be of two-cell type including an acid cell and a salt cell divided by an anion membrane or of three-chamber type including an acid cell, a salt cell and a base cell divided by a cation membrane and an anion membrane. For preparation, lactic acid fermentation liquid is transmitted into the salt cell and water is transmitted into the acid cell or the base cell. Under the effect of a circulating pump, the materials flow circularly with a current density of 80-160mA / cm2 at an operation temperature of 25-60 DEG C. The invention can completely supersede the prior calcium lactate acidifying technology without addition of acids for H+ supply and without production of waste acid, salt or base liquid. The transformation efficiency of lactic acid is higher than 98 percent, the recovery of lactic acid is higher than 90 percent and the current efficiency is higher than 70 percent, so the method can reduce environment pollution and lower consumption of chemical raw materials and energy and has remarkable industrial application value and environmental benefit.

A beverage composition includes water, milk solids, a tea material, and a pH buffer that itself includes a lactate salt and a carbonate salt. The pH buffer reduces or eliminates precipitation of milk protein when dissolved milk solids are mixed with acidic tea components. Methods of preparing the composition, and packaged beverages are also described.

Formulations for animal feed include granules comprising a mixed butyrate lactate salt; in which the mixed butyrate lactate salt is an at least bivalent metal, such as calcium, and the butyrate and lactate are present in a molar ratio between 3:1 and 1:3. The granules may be coated. The optionally coated granules have a particle size of 0.1 mm or more, preferably 0.2 mm or more, and about 2 mm or less, preferably about 1 mm or less. In addition, the butyrate lactate salt may be combined with another active ingredient that may be chosen from the group consisting of plant extracts, prebiotic compounds, probiotics, yeast extracts, medium chain fatty acids, unsaturated long chain fatty acids, fat-soluble vitamins, and toxin absorbing compounds.

The invention discloses an imitated sebum matrix, an external preparation including the imitated sebum matrix and application thereof, and belongs to the technical field of cosmetics and medicines. The imitated sebum matrix is prepared from the following raw materials in percentage by weight: 1-60% of lipid, 0.5-20% of natural moisturizing factor and 20-80% of water, wherein the lipid is one or more of triglyceride, animal oil or / and vegetable oil, squalene and wax; the natural moisturizing factor is a mixture of sodium pyrrolidone carboxylate and lactate. The invention further discloses an external preparation including the imitated sebum matrix and application thereof. The imitated sebum matrix does not contain petrochemical materials, has the effects of supplementing sebum, promoting osmosis of active ingredients and the like, and can be used for external preparations such as cosmetics and medicines.

One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.

The invention discloses sunscreen aerosol and a preparing method thereof. The sunscreen aerosol is composed of sunscreen components, polydimethylsiloxane, emulsifying components and other additives like propylene glycol and magnesium aluminum silicate, wherein the sunscreen components include homosalate, ethylhexyl methoxycinnamate, ethylhexyl salicylate, 4-methylbenzyl camphor, titanium dioxide, and the emulsifying components include sodium acrylate / acrolyl-dimethyl sodium taurine, isohexadecane, polysorbate-80, coconut-based glucoside, oleyl alcohol, glyceryl stearate, and PEG-100 stearate. The sunscreen aerosol is low in viscosity, the product system is stable, the SPF value is constant and enduring, the breathability is good after the sunscreen aerosol is sprayed, the formed film is compact, excellent water resistance is achieved, and thus a long sunscreen effect is achieved.

The invention discloses anti-infective, safe and efficient hemostatic aerogel which is prepared by supercritical drying after hydrogel is prepared from 8-O-acetyl saponin methyl ester-grafted chitosan, sodium alginate, gellan gum and water; the 8-O-acetyl saponin methyl ester-grafted chitosan is prepared by grinding for 20-30 minutes under infrared light after chitosan salt is mixed with 8-O-acetyl shanzhiside methyl ester according to the mass ratio of (5-8):l; the molecular weight of the chitosan salt is 50-100 kDa, and the degree of deacetylation is 90-100 percent; the chitosan salt is at least one of hydrochloride, acetate and lactate. The 8-O-acetyl saponin methyl ester is grafted to the chitosan, the hydrogel is prepared by the coordination of the sodium alginate, the water and the gellan gum, and the aerogel is obtained by supercritical drying; the prepared hemostatic aerogel is good in swelling property, strong in adhesiveness and quick in hemostasis, difficultly enters blood to cause the thrombosis risk, has an anti-infective effect and is particularly suitable for quick hemostasis of severe bleeding such as deep acute trauma and arterial rupture.

The present invention relates to sodium lactate extracting and concentrating method and apparatus, and aims at eliminating membrane contamination in sodium lactate extracting and concentrating electroosmosis process. The frequently pole-reversing electroosmosis process for extracting and concentrating sodium lactate from garbage fermenting liquid includes the following steps: 1. adding solution essential for extracting sodium lactate; 2. installing additional apparatus; 3. starting electroosmosis and reversing the polarity of the first electrode and the second electrode once every 10-30 min with the pole-reversing circuit; and 4. regulating the 4 two-position-three-way direction controlling valves to alter the work positions after each polarity reversing operation. The present invention has lowered membrane contamination, long service life of membrane, saving in cost, high lactate recovering rate up to 90 %, and concentrated lactate concentration up to 18 %.

The present invention provides for a crystalline form of trimetrexate either as a glucuronate, acetate, hydrochloride, methanosulfonate or lactate salt, which can be processed galenically as a stable, well-defined solid substance and processes for producing the crystalline forms. Such crystalline forms allow for prolonged stability in storage and for oral and intravenous administration of the drug.

The present invention relates to a catalyst for the cross-linking of silicone rubber materials with a cross-linker on the basis of lactate. In particular, the present invention provides a composition for the production of a silicone rubber material with a cross-linker on the basis of lactate, wherein the composition comprises a catalyst, which comprises at least two compounds, which are different from each other and which are selected independently of each other from metal salts of carboxylic acids. In addition, the present invention provides a method for the production of such a composition, as well as a use of the catalyst for the cross-linking of a silicone rubber material, in particular for cross-linking a silicone rubber material with a cross-linker on the basis of lactate, as well as a use of the composition of the present invention for the production of a silicone rubber material, in particular for use as a sealant, an adhesive, or a coating agent.

The invention provides a method for synthesizing homosalate through an ester exchange reaction of methyl salicylate or ethyl salicylate and 3,3,5-trimethylcyclohexanol under the catalysis of an alkali. The method has the advantages of simple operation, high conversion rate, economy, environmental protection, and suitableness for industrial production.

The present invention relates to a lactate powder, more particularly a lactate powder having a lactate content of at least 20 wt. % and a water content of less than 3.5 wt. %, said powder comprising calcium cations as well as sodium cations. According to the invention, a calcium lactate powder combining high stability with excellent water dissolution properties can be obtained even though anhydrous calcium lactate represents the bulk of the powder if the powder additionally contains a certain amount of sodium lactate. The inventors have found that the presence of sodium lactate greatly improves the dissolution behavior of the anhydrous calcium lactate while maintaining the storage stability of the powder. The present inventors also established that the dissolution behavior of the powder can be further improved by the addition of a fast-dissolving carbohydrate material.

Cementitious compositions in which the cementitious properties of fly ash are carefully controlled are described. The cementitious compositions may be substantially free harsh acids and bases such as citric acids (≈pH 2.2) and alkali metal activators including alkali hydroxides (≈pH 12-14) and metal carbonates (≈pH 11.6). The use of these harsh chemicals creates acid base reactions during use of the products. Instead of these harsh chemicals, a lactic acid salt based activator is be used as a reaction accelerator. Boric compounds may be used as a retarder in the compositions.

The invention discloses a method for continuously producing lactate by utilizing heavy phase lactic acid. The method comprises the steps as follows: (a) dilution is carried out; (b) carbon column decolorization is carried out; (c) in the extraction step, an organic extraction phase comprises extracting agents, a solvent and phase conditioning agents, the extracting agents are amide compounds or a mixture of the amide compounds, the solvent adopts liquid paraffin, the phase conditioning agents adopt alcohol compounds or the mixture of the alcohol compounds, and the mass ratio of the extracting agents, the solvent and the phase conditioning agents is (5.5 to 6.5):(2.5 to 3.5):(0.5 to 1); and the mass ratio of the organic extraction phase and heavy phase lactic acid to be extracted is (1.1 to 1.5):1, and the operating temperature for extraction ranges from 20 to 70 DEG C; (d) back extraction is carried out; (e) fine filtration is performed; and (f) concentration is performed. Lactic acid is selectively transferred to the organic extraction phase to form a loaded organic phase, and lactate aqueous solution is obtained after back extraction so as to prepare lactate, so that impurities and lactic acid in the heavy phase lactic acid can be separated effectively, the process route is simple, and the manufacturing cost is low.

A process for the production of hemicellulose derived monosaccharides comprising: (a) contacting an aqueous hemicellulosic stream with a C3-8 alkyl alcohol at elevated temperature and acidic pH to produce a reaction mixture comprising at C3-8 alkyl ester and a hemicellulose-derived monosaccharide; and (b) separating the reaction mixture obtained from step (a) into an aqueous phase comprising said hemicellulose-derived monosaccharide and an organic phase comprising said C3-08 alkyl ester. The product of step (b) may be further processed using an optional step: (c) reacting said hemicellulose-derived monosaccharide obtained from step (b) with a metal hydroxide or a quaternary ammonium hydroxide to produce a metal lactate or quaternary ammonium lactate.

Disclosed herein are liquid personal care cleansing compositions comprising a carrier (e.g., aqueous), a detergent surfactant for personal cleansing (i.e., hair, skin, or nails), and a thickening system that may include components that are naturally-derived and naturally-processed. The thickening system includes a gum, a lactate, and a lactylate, and is substantially free of synthetic amides such as ethanolamines. The lactate and lactylate have surprisingly been found to break the gelatinous, gooey blob characteristics that result when thickening with a natural gum alone, resulting in a homogenous smooth consistency to the personal care composition thickened with the thickener system.

The invention provides a sunscreen transparent lipstick which is prepared from the following components in percentage by weight: 90.1wt% of first component and 0.9wt% of second component, wherein the first component is a mixture of the following components: a mixture of dibutyl lauroyl glutamine, polyamide-3 and a bis-stearyl ethidene diamine / neopentyl glycol / stearyl alcohol hydrodimerized linoleate copolymer, C12-15 cholesteryl benzoate, heptyl undecylenate, benzophenone-3, ethylhexyl salicylate, homosalate, C10-30 acid cholesterol / lanosterol mixed ester, hydrogenated C6-20 polyolefin and dextrin isostearate; the second component is an auxiliary additive. The lipstick provided by the invention can pass through a three-month stability test, and is clear and transparent in appearance, good in sunscreen effect, high in melting point, good in moistening degree and difficult to break off.

We propose a procedure for the determination of lactic acid or lactate in biological fluids, which is simple and low cost with respect to the known methodologies. This procedure can be used by unskilled personnel and it can be implemented in disposable test strips and portable measure devices. The procedure is based on the photochemical reaction of lactic acid with Fe(III), which is reduced to Fe(II) when irradiated with UV light. The Fe(II), produced proportionally to the amount of lactate in the sample, is determined electrochemically or using its reaction with a colored complexing agent, such as 1,10-phenanthroline, and determined by spectrophotometry. This method is advantageous both for the low cost of the reagents employed, and for their short and long term stability.

A composition comprises surface-modified nanoparticles of at least one amphoteric metal oxide or oxyhydroxide. The nanoparticles bear, on at least a portion of their surfaces, a surface modification comprising (i) at least one surface modifier selected from lactate, thiolactate, and mixtures thereof, and (ii) at least one surface modifier selected from halide, nitrate, acetate, carbonate, formate, propionate, sulfate, bromate, perchlorate, tribromoacetate, trichloroacetate, trifluoroacetate, carboxylate comprising from one to about four alkyleneoxy moieties, chlorate, and mixtures thereof.