Sunscreen composition

Abstract

The invention discloses a sunscreen composition, and belongs to the technical field of cosmetics. The sunscreen composition provided by the invention comprises the following components in parts by mass: 1-3 parts of homosalate; 1-3 parts of a purslane extract; 0.01 to 0.05 part of a pandanus tectorius fruit extract; 0.3 to 0.7 part of a winter-cold vegetable leaf extract; 1-3 parts of a kousa dogwood peel extract; the sunscreen composition provided by the invention has the effects of sunscreen and UV resistance. In addition, the composition provided by the invention is integrally mild and non-irritant; the sunscreen composition provided by the invention can effectively block sunshine and resist UV when being applied to cosmetics, and meanwhile, the composition provided by the invention is natural in component source, simple in preparation method and suitable for actual production.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a sunscreen composition. Background Art

[0002] As the largest organ in the human body, the skin is not only our first line of defense against external aggressions, but also plays an important role in protecting the body from ultraviolet (UV) radiation. The UVA and UVB bands in ultraviolet rays can penetrate the surface of the skin, causing DNA damage, collagen degradation, and the production of free radicals. These changes may lead to skin aging, spots, wrinkles, and even increase the risk of skin cancer. Therefore, sun protection has gone beyond the scope of beauty and has become a key measure for skin health and disease prevention. In view of the continued increase in the incidence of skin cancer worldwide and the public's increasing attention to a healthy lifestyle, sun protection has become an indispensable part of public health awareness.

[0003] However, while existing sunscreen products provide a certain degree of UV protection, they generally have some obvious defects. For example, some chemical sunscreens contain potentially controversial ingredients such as parabens, which may cause skin irritation or allergic reactions in some cases. In addition, the sunscreen effect of many products is not long-lasting, requiring users to reapply frequently, which not only increases the cost of use but also brings inconvenience to users. At the same time, some sunscreen products on the market are thick and greasy, which may affect the normal breathing of the skin and even cause pores to be clogged. These defects limit the widespread acceptance of sunscreen products and the possibility of long-term continuous use.

[0004] Therefore, it is necessary to provide a sunscreen product that is light in texture, refreshing when applied, and safe, mild, and non-irritating. Summary of the invention

[0005] The purpose of the present invention is to overcome the deficiencies of the above-mentioned prior art and provide a sunscreen that is effective and mild.

[0006] Non-irritating sunscreen composition.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a sunscreen composition, comprising the following components in parts by weight: 1-3 parts of homosalate; 1-3 parts of purslane extract; 0.01-0.05 parts of Pandanus fruit extract; 0.3-0.7 parts of Achyranthes bidentata leaf extract; and 1-3 parts of Tetrapanax odoratus peel extract.

[0009] The sunscreen composition provided by the present invention selectively adds appropriate amounts of homosalate, purslane extract, pandanus fruit extract, hollyhock leaf extract, and four-orange peel extract. The five components can coordinate with each other and synergistically enhance the effect, thereby providing a high-efficiency sunscreen effect.

[0010] The present invention has found that the purslane extract contains rich active ingredients such as flavonoids, alkaloids, terpenes, organic acids, etc. These active ingredients give purslane multiple pharmacological effects, such as anti-tumor, anti-oxidation, neuroprotection, hypoglycemic, and anti-virus; in particular, vitamin E, vitamin C, carotene, glutathione, etc. have significant antioxidant effects, which help protect the skin from ultraviolet damage and play a sunscreen role to a certain extent. The pandanus fruit extract contains rich triterpenes, sterols, fatty acids, etc., especially high polyphenol content, and has significant effects of scavenging DPPH free radicals, hydroxyl free radicals, ABST free radicals, etc., and the pandanus fruit contains a high concentration of inorganic metal ions, some of which can synergize with flavonoids to promote the sunscreen ability of flavonoids. The winter vegetable extract contains rich flavonoids, phenolic compounds, etc.; the above substances can make the winter vegetable extract effectively anti-oxidative, protect the skin from environmental stimulation, and also have significant anti-inflammatory and sedative skin effects. The extract of the four o'clock flower contains rich phenylpropanoid compounds such as ferulic acid and chlorogenic acid, which have significant biological activities such as anti-oxidation and UV absorption. At the same time, the peel of the four o'clock flower fruit also contains rich flavonoid compounds such as anthocyanins, proanthocyanidins, quercetin, rutin and other compounds, which have significant antioxidant effects. The above four components combined with homosalate can achieve excellent antioxidant and anti-UV effects, and are mild and non-irritating.

[0011] As a preferred embodiment of the sunscreen composition of the present invention, the sunscreen composition comprises the following components in parts by weight:

[0012] 1-2 parts of homosalate; 1-2 parts of purslane extract; 0.01-0.03 parts of pandanus fruit extract; 0.3-0.5 parts of winter melon leaf extract; 1-2 parts of four odonata peel extract.

[0013] The present invention has been found that the mass fraction of the components in the sunscreen composition will affect the performance of the product. When the mass fraction of the components is further selected to be within the above range (including the endpoint value), the obtained product has excellent antioxidant and anti-UV effects, and is mild, non-irritating and anti-inflammatory.

[0014] As the most preferred embodiment of the sunscreen composition of the present invention, the sunscreen composition comprises the following components by weight:

[0015] 1-2 parts of homosalate; 1-2 parts of purslane extract; 0.03 parts of pandanus fruit extract; 0.5 parts of winter melon leaf extract; 1-2 parts of four odonata peel extract.

[0016] The present invention has found that the mass parts of the components in the sunscreen composition will affect the performance of the product. When the mass parts of the components are further selected to be within the above range (including the endpoint values), the obtained product has better antioxidant and anti-UV effects, and is mild, non-irritating and anti-inflammatory.

[0017] As a preferred embodiment of the sunscreen composition of the present invention, the pandanus fruit extract is extracted from pandanus fruit, and the hollyhock extract is extracted from hollyhock leaves.

[0018] The preparation method of the pandanus fruit extract is to use ethyl acetate reflux extraction; the specific steps are:

[0019] (1) taking fresh pandanus fruit, removing the core and skin, placing it in 3-5wt% saline, soaking for 30-45min and then taking it out;

[0020] (2) adding 2-4 times the volume of water to the pandanus fruit pulp soaked in salt water, homogenizing, and then freeze-drying the homogenate to obtain powder A;

[0021] (3) Add 3-4 times the volume of water-saturated ethyl acetate to powder A at 30±2°C and reflux 4 times;

[0022] (4) After extraction, the extract solution was filtered, vacuum evaporated at 35±1°C to remove ethyl acetate, and then concentrated;

[0023] (5) Dry the concentrate to constant weight.

[0024] The present invention has found that, in the pandanus fruit extraction process, salt water immersion can effectively remove the allergenic components that may exist in the pandanus fruit, and the use of water-saturated ethyl acetate can preserve the original active substances in the pandanus fruit as much as possible, and then the use of a vacuum rotary evaporator can effectively and completely remove the ethyl acetate. After the above treatment, the obtained pandanus fruit extract has higher purity and better effect.

[0025] Preferably, the pandanus fruits are screened before being peeled and pitted to select the pandanus fruits that are free of pests and diseases and are complete and mature.

[0026] In the second aspect of the present invention, the present invention provides a method for preparing a Herba Lysimachiae leaf extract, the specific steps of which are:

[0027] (1) Drying and crushing the leaves of winter melon;

[0028] (2) Add 3-4 times the volume of water-saturated ethyl acetate at 30±2°C and reflux 4 times;

[0029] (3) After extraction, the extract solution was filtered, vacuum evaporated at 35±1°C to remove ethyl acetate, and then concentrated;

[0030] (4) Drying the concentrated solution to constant weight;

[0031] The present invention has found that in the process of extracting winter melon leaves, the use of water-saturated ethyl acetate can preserve the original active substances in the winter melon leaves as much as possible, and then the use of a vacuum rotary evaporator can effectively and completely remove the ethyl acetate. After the above treatment, the obtained winter melon leaf extract has higher purity and better effect.

[0032] As an implementation mode of the sunscreen spray of the present invention, the cosmetic comprises the following components in mass percentage: 1-3wt% of sunscreen composition; 3-6wt% of glycerin; 0.1-0.3wt% of allantoin; 0.3-0.5wt% of phenoxyethanol; 0.1-0.3wt% of chlorphenesin; 3-5wt% of C12-15 alcohol benzoate; and the balance is made up of water.

[0033] In a third aspect of the present invention, the present invention provides a method for preparing a cosmetic, the preparation method comprising the following steps:

[0034] (1) glycerin, allantoin, C12-15 alcohol benzoate, sunscreen composition and water are stirred and mixed, heated to 60±10° C., and homogenized until completely mixed to obtain component A;

[0035] (2) adding chlorphenesin to component A and stirring evenly to obtain component B;

[0036] (3) Add phenoxyethanol to component B and stir evenly, then stop stirring and discharge the material to obtain the cosmetics.

[0037] Compared with the prior art, the present invention has the following beneficial effects:

[0038] The present invention provides a sunscreen composition, in which five ingredients can cooperate with each other and synergize to achieve full-stage sunscreen and anti-UV effects within a given range, and the composition is refreshing to apply, light in texture, gentle and non-irritating. Specifically, the sunscreen composition can effectively protect against the sun, resist UV and absorb ultraviolet rays. The sunscreen spray containing the sunscreen composition provided by the present invention is overall gentle and non-irritating, has a wide range of applicable objects, and can effectively resist oxidation, resist UV and absorb ultraviolet rays. In addition, the components of the sunscreen composition provided by the present invention are naturally derived, and the preparation method is simple, which is suitable for actual production. DETAILED DESCRIPTION

[0039] In order to better understand the present invention, the present invention is further described below in conjunction with specific examples, wherein the terms used in the examples are for describing specific embodiments and do not constitute limitations on the scope of protection of the present invention.

[0040] The experimental methods in the following examples without specifying specific conditions are usually carried out under conventional conditions or under conditions recommended by the manufacturer. Unless otherwise specified, percentages and parts are calculated by weight.

[0041] Some raw materials and their sources are as follows:

[0042] Homosalate: purchased from Xi'an Guohao Biotechnology Co., Ltd.;

[0043] Purslane extract: Xi'an Wei'ao Biotechnology Co., Ltd.;

[0044] Pandanus fruit extract: Guangzhou Hean Chemical Co., Ltd.;

[0045] Winter amaranth leaf extract: purchased from Shaanxi Zhoushi Digital Industry Development Group Co., Ltd.;

[0046] Four ochernia root peel extract: purchased from Shaanxi Zhoushi Digital Industry Development Group Co., Ltd.

[0047] Pandanus fruit: purchased from Sichuan Chengshiyuan Trading Co., Ltd.;

[0048] Winter melon leaves: purchased from Dongshankou Vegetable Market in Guangzhou.

[0049] Preparation, comprising the following steps:

[0050] Preparation of Pandanus Fruit Extract:

[0051] Embodiment 1:

[0052] (1) taking fresh pandanus fruit, removing the core and skin, placing it in 4 wt % salt water, soaking for 45 min and then taking it out;

[0053] (2) adding 3 times the volume of water to the pandanus fruit pulp soaked in salt water, homogenizing, and then freeze-drying the homogenate to obtain powder A;

[0054] (3) Powder A was added with 4 times the volume of water-saturated ethyl acetate at 30°C and refluxed 4 times;

[0055] (4) After extraction, the extraction solution was filtered, vacuum evaporated at 35° C. to remove ethyl acetate, and then enzymatically hydrolyzed with 5 wt % peptide enzyme for 3 h and concentrated;

[0056] (5) Dry the concentrate to constant weight.

[0057] Embodiment 2:

[0058] (1) taking fresh pandanus fruit, removing the core and skin, placing it in 3 wt % salt water, soaking for 45 min and then taking it out;

[0059] (2) adding 4 times the volume of water to the pandanus fruit pulp soaked in salt water, homogenizing, and then freeze-drying the homogenate to obtain powder A;

[0060] (3) Powder A was added with 3 volumes of water-saturated ethyl acetate at 28°C and refluxed 4 times;

[0061] (4) After extraction, the extraction solution was filtered, vacuum evaporated at 34° C. to remove ethyl acetate, and then enzymatically hydrolyzed with 4 wt % peptide enzyme for 4 h and concentrated;

[0062] (5) Dry the concentrate to constant weight.

[0063] Embodiment 3:

[0064] (1) taking fresh pandanus fruit, removing the core and skin, placing it in 5 wt% salt water, soaking for 30 min and then taking it out;

[0065] (2) adding 2 times the volume of water to the pandanus fruit pulp soaked in salt water, homogenizing, and then freeze-drying the homogenate to obtain powder A;

[0066] (3) Powder A was added with 3 volumes of water-saturated ethyl acetate at 32°C and refluxed 4 times;

[0067] (4) After extraction, the extraction solution was filtered, vacuum evaporated at 36° C. to remove ethyl acetate, and then enzymatically hydrolyzed with 6 wt % peptidase for 2 h and concentrated;

[0068] (5) Dry the concentrate to constant weight.

[0069] Comparative Example 1: The difference from Example 1 is that no salt water soaking is used.

[0070] Comparative Example 2: The difference from Example 1 is that no peptide enzyme is used for enzymolysis.

[0071] Comparative Example 3: The difference from Example 1 is that 60wt% ethanol is used instead of water-saturated ethyl acetate.

[0072] Preparation method of winter melon extract:

[0073] Embodiment 4:

[0074] (1) Drying and crushing the leaves of winter melon;

[0075] (2) Add 3 volumes of water-saturated ethyl acetate at 30°C and reflux 4 times;

[0076] (3) After extraction, the extract solution was filtered, vacuum evaporated at 35° C. to remove ethyl acetate, and then concentrated;

[0077] (4) Dry the concentrate to constant weight.

[0078] Example 5

[0079] (1) Drying and crushing the leaves of winter melon;

[0080] (2) Add 4 times the volume of water-saturated ethyl acetate at 28°C and reflux 4 times;

[0081] (3) After extraction, the extract solution was filtered, vacuum evaporated at 36°C to remove ethyl acetate, and then concentrated;

[0082] (4) Dry the concentrate to constant weight.

[0083] Embodiment 6:

[0084] (1) Drying and crushing the leaves of winter melon;

[0085] (2) Add 3 volumes of water-saturated ethyl acetate at 32°C and reflux 4 times;

[0086] (3) After extraction, the extract solution was filtered, vacuum evaporated at 34°C to remove ethyl acetate, and then concentrated;

[0087] (4) Dry the concentrate to constant weight.

[0088] Comparative Example 4: The difference from Example 4 is that 60 wt% ethanol is used instead of water-saturated ethyl acetate;

[0089] Comparative Example 5: The difference from Example 4 is that hot air drying is used instead of vacuum rotary evaporation.

[0090] Preparation of sunscreen composition and components by weight:

[0091] Embodiment 7:

[0092] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 1); 0.5 parts of winter melon leaf extract (Example 4); 2 parts of four odonata peel extract.

[0093] Embodiment 8:

[0094] 1 part of homosalate; 3 parts of purslane extract; 0.05 parts of pandanus fruit extract (Example 1); 0.3 parts of winter melon leaf extract (Example 4); 1 part of four odonata peel extract.

[0095] Embodiment 9:

[0096] 3 parts of homosalate; 1 part of purslane extract; 0.01 parts of pandanus fruit extract (Example 1); 0.7 parts of winter melon leaf extract (Example 4); 3 parts of four odonata peel extract.

[0097] Example 10

[0098] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 2); 0.5 parts of winter melon leaf extract (Example 5); 2 parts of four odonata peel extract.

[0099] Embodiment 11

[0100] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 3); 0.5 parts of winter melon leaf extract (Example 6); 2 parts of four odonata peel extract.

[0101] Comparative Example 6:

[0102] 0 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 1); 0.5 parts of winter melon leaf extract (Example 4); 2 parts of four odonata peel extract.

[0103] Comparative Example 7:

[0104] 2 parts of homosalate; 0 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 1); 0.5 parts of winter melon leaf extract (Example 4); 2 parts of four odonata peel extract.

[0105] Comparative Example 8:

[0106] 2 parts of homosalate; 2 parts of purslane extract; 0 parts of pandanus fruit extract (Example 1); 0.5 parts of winter melon leaf extract (Example 4); 2 parts of four odonata peel extract.

[0107] Comparative Example 9:

[0108] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 1); 0 parts of winter melon leaf extract (Example 4); 2 parts of four o'clock rose peel extract.

[0109] Comparative Example 10:

[0110] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 1); 0.5 parts of winter melon leaf extract (Example 4); 0 parts of four o'clockwork peel extract.

[0111] Comparative Example 11:

[0112] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Comparative Example 1); 0.5 parts of winter melon leaf extract (Example 4); 2 parts of four odonata peel extract.

[0113] Comparative Example 12:

[0114] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Comparative Example 2); 0.5 parts of winter melon leaf extract (Example 4); 2 parts of four odonata peel extract.

[0115] Comparative Example 13:

[0116] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Comparative Example 3); 0.5 parts of winter melon leaf extract (Example 4); 2 parts of four odonata peel extract.

[0117] Comparative Example 14:

[0118] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 1); 0.5 parts of winter melon leaf extract (Comparative Example 4); 2 parts of four odonata peel extract.

[0119] Comparative Example 15:

[0120] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 1); 0.5 parts of winter melon leaf extract (Comparative Example 5); 2 parts of four odonata peel extract.

[0121] Comparative Example 16:

[0122] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 1); 0.5 parts of winter melon leaf extract (commercially available); 2 parts of four odonata peel extract.

[0123] Comparative Example 17:

[0124] 2 parts of homosalate; 2 parts of purslane extract; 0.03 parts of pandanus fruit extract (commercially available); 0.5 parts of winter melon leaf extract (Example 4); 2 parts of four odonata peel extract.

[0125] Comparative Example 18:

[0126] 2 parts of homosalate; 0 parts of purslane extract; 0 parts of pandanus fruit extract (Example 1); 0 parts of winter melon leaf extract (Example 4); 0 parts of four o'clock rose peel extract.

[0127] Comparative Example 19:

[0128] 0 parts of homosalate; 2 parts of purslane extract; 0 parts of pandanus fruit extract (Example 1); 0 parts of winter melon leaf extract (Example 4); 0 parts of four o'clock rose peel extract.

[0129] Comparative Example 20:

[0130] 0 parts of homosalate; 0 parts of purslane extract; 0.03 parts of pandanus fruit extract (Example 1); 0 parts of winter melon leaf extract (Example 4); 0 parts of four o'clockwork peel extract.

[0131] Comparative Example 21:

[0132] 0 parts of homosalate; 0 parts of purslane extract; 0 parts of pandanus fruit extract (Example 1); 0.5 parts of winter melon leaf extract (Example 4); 0 parts of four odonata peel extract.

[0133] Comparative Example 22:

[0134] 0 parts of homosalate; 0 parts of purslane extract; 0 parts of pandanus fruit extract (Example 1); 0 parts of winter melon leaf extract (Example 4); 2 parts of four o'clock rose peel extract.

[0135] Raw materials and mass percentage of leave-on skin care products:

[0136] Application Example 1: 2 wt% sunscreen composition (Example 7); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0137] Application Example 2: 1 wt% sunscreen composition (Example 7); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0138] Application Example 3: 3 wt% sunscreen composition (Example 7); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0139] Application Example 4: 2 wt% sunscreen composition (Example 8); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0140] Application Example 5: 2 wt% sunscreen composition (Example 9); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0141] Application Example 6: 2 wt% sunscreen composition (Example 10); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0142] Application Example 7: 2 wt% sunscreen composition (Example 11); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0143] Comparative Application Example 1: 2 wt% sunscreen composition (Comparative Example 6); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0144] Comparative Application Example 2: 2 wt% sunscreen composition (Comparative Example 7); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0145] Comparative Application Example 3: 2 wt% sunscreen composition (Comparative Example 8); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0146] Comparative Application Example 4: 2 wt% sunscreen composition (Comparative Example 9); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0147] Comparative Application Example 5: 2 wt% sunscreen composition (Comparative Example 10); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0148] Comparative Application Example 6: 2 wt% sunscreen composition (Comparative Example 11); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0149] Comparative Application Example 7: 2 wt% sunscreen composition (Comparative Example 12); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0150] Comparative Application Example 8: 2 wt% sunscreen composition (Comparative Example 13); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0151] Comparative Application Example 9: 2 wt% sunscreen composition (Comparative Example 14); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0152] Comparative Application Example 10: 2 wt% sunscreen composition (Comparative Example 15); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0153] Comparative Application Example 11: 2 wt% sunscreen composition (Comparative Example 16); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0154] Comparative Application Example 12: 2 wt% sunscreen composition (Comparative Example 17); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0155] Comparative Application Example 13: 2 wt% sunscreen composition (Comparative Example 18); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0156] Comparative Application Example 14: 2 wt% sunscreen composition (Comparative Example 19); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0157] Comparative Application Example 15: 2 wt% sunscreen composition (Comparative Example 20); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0158] Comparative Application Example 16: 2 wt% sunscreen composition (Comparative Example 21); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0159] Comparative Application Example 17: 2 wt% sunscreen composition (Comparative Example 22); 5 wt% glycerin; 0.2 wt% allantoin; 0.2 wt% phenoxyethanol; 0.2 wt% chlorphenesin; 4 wt% C12-15 alcohol benzoate; the balance is made up with water.

[0160] Blank application example: 5wt% glycerol; 0.2wt% allantoin; 0.2wt% phenoxyethanol; 0.2wt% chlorphenesin; 4wt% C12-15 alcohol benzoate; the balance is made up with water.

[0161] The water described in the application examples, comparative application examples and blank application examples is deionized water.

[0162] The preparation method of Application Example 1 is specifically as follows:

[0163] (1) Glycerin, allantoin, C12-15 alcohol benzoate, sunscreen composition and water are stirred and mixed, heated to 60±10° C., and homogenized until completely mixed to obtain component A.

[0164] (2) Add chlorphenesin to component A and stir evenly to obtain component B.

[0165] (3) Add phenoxyethanol to component B and stir evenly, then stop stirring and discharge the material to obtain the cosmetics.

[0166] The preparation methods of Application Examples 2-7, Comparative Application Examples 1-17, and Blank Application Examples are consistent with that of Application Example 1, except that no components are added.

[0167] Test 1

[0168] Skin patch testing

[0169] With the 2015 "Technical Specifications for Safety of Cosmetics" as the reference standard, the cosmetic irritation evaluation was conducted on the products of corresponding application examples 1-7 and comparative application examples 1-17. The test method was skin patch test, and the test was conducted on 240 randomly distributed people aged 16-65 years old.

[0170] Test method: Put the test substance into the patch tester, the dosage is 0.020-0.025g, cover the patch tester with the test substance on the back or forearm of the subject with non-irritating cloth-based tape, and gently press it with the palm to make it evenly adhere to the skin surface for 24 hours. After removing the test patch tester, observe the skin reaction after the indentation disappears 30 minutes later. If the result is negative, observe again 24 hours and 48 hours after the patch test.

[0171] Evaluation criteria:

[0172] Grade 0: negative reaction;

[0173] Grade 1: Suspicious reaction, only slight erythema;

[0174] Grade 2: weak positive reaction, erythema, infiltration, edema, and papules may be present;

[0175] Grade 3: Strong positive reaction, erythema, infiltration, edema, papules, and the reaction may extend beyond the test area;

[0176] Grade 4: Very strong positive reaction, obvious erythema, severe infiltration, edema, confluent herpes, and the reaction exceeds the test area.

[0177] Test results: The skin reactions of all subjects except comparative application example 6 (level 1) were negative.

[0178] A second test was conducted on Comparative Application Example 6, which still had a Grade 1 suspicious reaction. This may be because the pandanus fruit contains certain allergenic components, which are removed after being soaked in saline. However, the pandanus fruit extract in Comparative Application Example 6 was not soaked in saline, resulting in it containing certain allergenic components. Therefore, the saline soaking step is indispensable.

[0179] Test 2:

[0180] SPF value determination

[0181] The objects to be tested are application examples, comparative application examples, and blank application examples of sunscreen spray.

[0182] Standard reference product: high SPF standard product (P2), SPF value 16.1±2.4.

[0183] Subjects: A total of 260 subjects, 10 subjects in each group, 5 males and 5 females in each group, aged 29-59 years old, meeting the voluntary inclusion criteria.

[0184] Light source: Daylight simulator xenon arc lamp, all performances meet the requirements of measurement specifications.

[0185] Test method: Test in accordance with the specific requirements of the "Cosmetic Safety Technical Specifications 2015 Edition". Take the subject's back prone position for irradiation. 24 hours before the test, pre-test the subject's skin's minimum erythema dose (MED value) for ultraviolet radiation, and adjust the ultraviolet radiation dose according to the predicted results for the test sample. On the day of the test, first select a spot no less than 30cm on the subject's back. 2 Normal skin area, (2.00±0.05)mg / cm 2 The sample dosage was used to evenly apply the sample to be tested or the standard reference substance to the above-mentioned area, and then the UV irradiation dose of the sample was selected and irradiated in three conditions: no sample was applied to the skin, the standard sample was applied; and the sample to be tested was applied. The experimental results were observed for 24 hours, and the MED values ​​were recorded and the SPF values ​​were calculated. At the same time, the subjects were invited to evaluate the use experience, which was divided into five evaluation levels from refreshing to sticky, 1-refreshing; 2-relaxed; 3-general, slightly sticky; 4-relaxed; 5-sticky. The results are shown in Table 1.

[0186] SPF = MED value for protected skin / MED value for unprotected skin

[0187] Table 1

[0188]

[0189]

[0190] From the data of application examples 1-7, it can be seen that application example 1 has the best sun protection effect.

[0191] It can be seen from the results of Application Example 1 and Comparative Application Examples 1-5 that the sunscreen effect described in this application cannot be achieved without any one of the raw materials.

[0192] Comparative Application Example 6 is not evaluated because it is suspected of causing allergies and has no actual use function.

[0193] It can be seen from the results of Application Example 1 and Comparative Application Examples 7-8 and 12 that the pandanus fruit extract extracted using the pandanus fruit extraction process defined in the present invention can achieve a better sunscreen effect when combined with other raw materials.

[0194] It can be seen from the results of Application Example 1 and Comparative Application Examples 9-10 and 11 that the Achyranthes bidentata leaf extract extracted using the Achyranthes bidentata leaf extraction process defined in the present invention, combined with other raw materials, can achieve a better sunscreen effect.

[0195] It can be seen from the results of Application Example 1 and Comparative Application Examples 13-17 that the raw materials used in the present invention have a synergistic effect and can achieve a better sunscreen effect when used together.

[0196] It can be seen from the results of Application Example 1 and the blank application example that the raw materials used in the present invention have a sunscreen effect.

[0197] According to the evaluation of the subjects, the application examples, comparative application examples (except comparative application example 6), and blank application examples all felt refreshing and non-sticky.

[0198] Test 3:

[0199] PFA determination value

[0200] The object to be measured is an application example, a comparative application example, or a blank application example.

[0201] The PFA value of the reference standard is 4.4±0.6, and it is prepared according to the S1 formula in the ISO24442 method.

[0202] Subjects: A total of 260 subjects, 10 subjects in each group, 5 males and 5 females in each group, aged 29-59 years old, meeting the voluntary inclusion criteria.

[0203] Light source: Daylight simulator xenon arc lamp, all performances meet the requirements of measurement specifications.

[0204] Test method: Test in accordance with the specific requirements of "Determination Method of Long Wave Ultraviolet Protection Index (PFA Value) of Sunscreen Cosmetics" in Chapter 8 of "Cosmetic Safety Technical Specifications". Take the subject's back in a prone position for irradiation. 24 hours before the test, pre-test the subject's skin's minimum blackening amount (MPPD value) to ultraviolet irradiation. According to the predicted results, adjust the ultraviolet irradiation amount for the test sample. On the day of the test, first select a spot no less than 30cm on the subject's back. 2 Normal skin area, (2.00±0.05)mg / cm 2 The sample dosage is used to evenly apply the sample to be tested or the standard reference substance to the above area, and then the UV irradiation measurement of the sample is selected, and irradiation is carried out in three cases: the subject's skin is not coated with the sample, the standard substance is coated, and the sample to be tested is coated. After 22 hours, the experimental results are observed, the MPPD value is recorded, and the PFA value is calculated. At the same time, the subjects are invited to evaluate the use experience, which can be divided into five evaluation levels from refreshing to sticky, 1-refreshing; 2-relaxed; 3-general, slightly sticky; 4-relaxed; 5-sticky. The results are shown in Table 2.

[0205] PFA = MPPD value of protected skin / MPPD value of unprotected skin

[0206] Table 2

[0207]

[0208]

[0209] Experiments show that the sunscreen spray provided by the present invention has a PFA value of 3.7±0.24-4.2±0.09, and has a good sunscreen effect.

[0210] From the data of application examples 1-7, it can be seen that application example 1 has the best sun protection effect.

[0211] It can be seen from the results of Application Example 1 and Comparative Application Examples 1-5 that the sunscreen effect described in this application cannot be achieved without any one of the raw materials.

[0212] Comparative Application Example 6 is not evaluated because it is suspected of causing allergies and has no actual use function.

[0213] It can be seen from the results of Application Example 1 and Comparative Application Examples 7-8 and 12 that the pandanus fruit extract extracted using the pandanus fruit extraction process defined in the present invention can achieve a better sunscreen effect when combined with other raw materials.

[0214] It can be seen from the results of Application Example 1 and Comparative Application Examples 9-10 and 11 that the Achyranthes bidentata leaf extract extracted using the Achyranthes bidentata leaf extraction process defined in the present invention, combined with other raw materials, can achieve a better sunscreen effect.

[0215] It can be seen from the results of Application Example 1 and Comparative Application Examples 13-17 that the raw materials used in the present invention have a synergistic effect and can achieve a better sunscreen effect when used together.

[0216] It can be seen from the results of Application Example 1 and the blank application example that the raw materials used in the present invention have a sunscreen effect.

[0217] According to the evaluation of the subjects, the application examples, comparative application examples (except comparative application example 6), and blank application examples all felt refreshing and non-sticky.

[0218] Test 4

[0219] Toxicology Testing

[0220] According to the "Technical Specifications for Safety of Cosmetics 2015 Edition", the test item is a 30s rinse acute eye irritation test.

[0221] Test substance: the sunscreen spray obtained in Application Example 1.

[0222] Test animals and breeding environment: 3 adult rabbits of ordinary grade, provided by Suibei Experimental Animal Breeding Farm, Baiyun District, Guangzhou, Laboratory Animal Production License: SCXK (Guangdong) 2020-0050. The temperature of the experimental animal breeding room is 19-26℃, the relative humidity is 40-70%, and the experimental animal use license is SYXK (Guangdong) 2024-0365.

[0223] Experimental method: Gently separate the left eyelid of the animal, drop 0.1 mL of the test substance into the conjunctival sac, and make the upper and lower eyelids passively closed for 1 second. The right eye is not treated and serves as a self-control. 30 seconds after eye drops, wash with sufficient pure water with a fast flow rate that will not cause damage to the animal's eyes for 30 seconds. Use a handheld slit lamp and sodium fluorescein (24 hours) to examine the eyes at 1 hour, 24 hours, 72 hours, 4 days, and 7 days after eye drops. If no irritation reaction occurs within 72 hours, the observation can be terminated. If there is still an irritation reaction within 7 days, it will be observed until 21 days.

[0224] Experimental results: Under the test condition of 30s flushing, the highest irritation scores of the test substance to the test animals were: 0 for cornea, 0 for iris, and 0 for conjunctiva, indicating that it was non-irritating.

[0225] Test 5:

[0226] Multiple skin irritation tests

[0227] According to the "Technical Specifications for Safety of Cosmetics" (2015 edition), the testing items are multiple skin irritation tests.

[0228] Test substance: Sunscreen spray obtained in Application Example 1

[0229] Test animals and breeding environment: 3 adult rabbits of ordinary grade, provided by Suibei Experimental Animal Breeding Farm, Baiyun District, Guangzhou, Laboratory Animal Production License: SCXK (Guangdong) 2020-0050. The temperature of the experimental animal breeding room is 19-26℃, the relative humidity is 40-70%, and the experimental animal use license is SYXK (Guangdong) 2024-0365.

[0230] Test method: 24 hours before the test, the hair on both sides of the animal's back spine was kicked off, and the shaved area was 3cm*3cm on each side. During the test, 0.5mL of the test substance was evenly applied to the skin of the left test area, and the right side was controlled with distilled water. The application was done once a day for 14 consecutive days. Starting from the second day, the hair was removed before application every day, and refined oil was used first, then washed with warm water, and then applied. After 1 hour, the skin reaction was observed and the skin irritation reaction was scored according to the relevant provisions of the "Cosmetic Safety Technical Specifications 2015 Edition" (Chapter VI). After the test, the total score for 14 days, the average score of each animal for 14 days, and the average score of each animal every day were calculated, and the skin irritation intensity was graded.

[0231] Test results: In multiple skin irritation tests on test animals, the average score of skin irritation response of each animal per day was 0.27, which is non-irritating.

[0232] The embodiments described above are part of the embodiments of the present application, rather than all of the embodiments. The detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents the selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present application.

Claims

1. A sunscreen composition, characterized in that: The sunscreen composition comprises the following components in parts by weight: Homosalate 1-3 parts; 1-3 parts of purslane extract; 0.01-0.05 parts of Pandanus fruit extract; 0.3-0.7 parts of wintergreen leaf extract; 1-3 parts of ophiopogon japonicus peel extract; The pandanus fruit extract is extracted from pandanus fruit, and the hollyhock leaf extract is extracted from hollyhock leaves; The preparation method of the winter melon leaf extract is as follows: (1) Drying and crushing the leaves of winter melon; (2) Add 3-4 times the volume of water-saturated ethyl acetate at 30±2°C and reflux 4 times; (3) After extraction, the extract solution was filtered, vacuum evaporated at 35±1°C to remove ethyl acetate, and then concentrated; (4) Drying the concentrated solution to constant weight; The preparation method of the pandanus fruit extract is as follows: (1) taking fresh pandanus fruit, removing the core and skin, placing it in 3-5wt% saline, soaking for 30-45min and then taking it out; (2) Add 2-4 times the volume of water to the pandanus fruit pulp soaked in salt water, homogenize, and then freeze-dry the homogenate to obtain powder A (3) Add 3-4 times the volume of water-saturated ethyl acetate to powder A at 30±2°C and reflux 4 times; (4) After extraction, the extraction solution is filtered, vacuum evaporated at 35±1° C. to remove ethyl acetate, and then enzymatically hydrolyzed with 4-6 wt % peptide enzyme for 2-4 h, and the enzymatic hydrolyzate is concentrated; (5) Dry the concentrate to constant weight.

2. The sunscreen composition according to claim 1, characterized in that: The sunscreen composition comprises the following components in parts by weight: Homosalate 1-2 parts; 1-2 parts of purslane extract; 0.01-0.03 parts of Pandanus fruit extract; 0.3-0.5 parts of wintergreen leaf extract; 1-2 parts of four o'clock peel extract.

3. The sunscreen composition according to claim 2, characterized in that: The sunscreen composition comprises the following components in parts by weight: Homosalate 1-2 parts; 1-2 parts of purslane extract; 0.03 parts of Pandanus fruit extract; 0.5 parts of wintergreen leaf extract; 1-2 parts of four o'clock peel extract.

4. A leave-on cosmetic, characterized in that: The invention comprises the sunscreen composition according to any one of claims 1 to 3.

5. A sunscreen spray, characterized in that: The invention comprises the sunscreen composition according to any one of claims 1 to 3.

6. The sunscreen spray according to claim 5, characterized in that: Including the following raw materials in mass percentage: Sunscreen composition 1-3 wt%; Glycerol 3-6wt%; Allantoin 0.1-0.3wt%; Phenoxyethanol 0.3-0.5wt%; Chlorphenesin 0.1-0.3wt%; C12-15 alcohol benzoate 3-5wt%; The balance was made up with deionized water.

7. The sunscreen spray according to claim 6, characterized in that: Including the following raw materials in mass percentage: Sunscreen composition 1-3 wt%; Glycerol 5wt%; Allantoin 0.2wt%; Phenoxyethanol 0.3-0.5wt%; Chlorphenesin 0.2wt%; C12-15 alcohol benzoate 3-5wt%; The balance was made up with deionized water.

8. The sunscreen spray according to claim 7, characterized in that: Including the following raw materials in mass percentage: Sunscreen composition 1-3 wt%; Glycerol 3-6wt%; Allantoin 0.1-0.3wt%; Phenoxyethanol 0.4wt%; Chlorphenesin 0.1-0.3wt%; C12-15 alcohol benzoate 4wt%; The balance was made up with deionized water.

9. A method for preparing the sunscreen spray according to claims 6-8, characterized in that: The specific steps are: (1) glycerin, allantoin, C12-15 alcohol benzoate, sunscreen composition and deionized water are stirred and mixed, heated to 60±10° C., and homogenized until completely mixed to obtain component A; (2) adding chlorphenesin to component A and stirring evenly to obtain component B; (3) Add phenoxyethanol to component B and stir evenly, then stop stirring and discharge the material to obtain the cosmetics.

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