2 results about "Zopiclone" patented technology

This invention belongs to the field of clinical efficacy evaluation technology, specifically relating to a method and system for evaluating the efficacy of oral antisleep granules combined with acupoint application in treating insomnia of the heart-kidney disharmony type. The method includes the following steps: selecting subjects to form an observation group and a control group; the control group receiving oral zopiclone tablets; the observation group receiving the same treatment as the control group, combined with oral antisleep granules and acupoint application; observing and comparing indicators: comparing the indicators of the control group before and after treatment with those of the observation group before and after treatment to obtain the efficacy difference between the two groups. The indicators include: a Traditional Chinese Medicine (TCM) syndrome score, where a scale is used to score difficulty falling asleep, shallow sleep with easy awakening / difficulty falling back asleep after waking, early awakening, and lower back and knee weakness. The efficacy evaluation method and system of this application can evaluate the efficacy of oral antisleep granules combined with acupoint application in treating insomnia of the heart-kidney disharmony type.

This invention relates to a method for detecting zopiclone impurities, the method comprising the following steps: Step A: preparation of diluent; Step B: preparation of test solution: take zopiclone, add diluent, and dilute to prepare a test solution; Step C: preparation of reference solution: take impurity 6-(5-chloro-2-pyridinyl)-7-ethoxy-5,6-dihydropyrrolo[3,4-b]pyrazin-5-one reference standard and zopiclone reference standard, add diluent, sonicate to dissolve, and prepare a reference solution; Step D: determination method: take the test solution and reference solution respectively, inject them into a high-performance liquid chromatograph, record the chromatogram, and calculate the impurity content; wherein, the chromatographic conditions are: using octadecylsilane-bonded silica gel as the packing material; using acetonitrile-buffered saline solution as the mobile phase; flow rate of 0.5 mL to 2.5 mL per minute; detection wavelength of 280 nm to 320 nm; column temperature of 25 °C to 35 °C; sample chamber temperature of 0 °C to 15 °C; injection volume of 10 to 30 μl.