The present application provides a programmed
drug release composite microneedle, which is composed of a
drug-loaded needle tip layer and a base layer, can realize rapid release of
analgesic drugs and slow release of
sedative drugs, and the two drugs synergistically play the roles of analgesia,
sedation and improvement of
mood; through a plurality of experiments, it is verified that the microneedle has good
biocompatibility, no
skin irritation, no long-term
toxicity to main organs, and non-invasive and convenient operation, solves many defects of traditional
analgesic and
sedative dosage forms, and provides a new effective path for long-term home intervention of
chronic pain patients.