Sleep-improving agent

A sleep-improving agent and sleep-improving technology, which is applied in the field of sleep-improving agents for improving sleep. It can solve the problems of no clear sleep-regulating active ingredients, etc., and achieve the effects of prolonging non-rapid eye movement sleep, improving sleep, and excellent sedation

Inactive Publication Date: 2010-05-19
财团法人大坂生物科学研究所 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the sleep-regulating active ingredients in this plant are not identified in these reports

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The manufacture method of oxojiangyao hydroxyalkenic acid

[0040]Cut the whole grass of fresh Hemerocallis finely, use methanol as solvent, and extract at room temperature for 1 week. Then, it was filtered and the filtrate was concentrated, combined ion exchange resin (Diaion HP-20), cis-phase silica gel, gel filtration (Sephadex, GS) in open column chromatography, combined gel filtration in split-recycle HPLC (Sephadex, GS), and the obtained solid (hereinafter referred to as "methanol extract") was separated to obtain oxojiangyao hydroxyalkenine.

[0041] The results obtained for the data obtained with respect to oxo-hydroxyalkenine are as follows.

[0042] ·Colorless needle crystals (H 2 O-MeOH): mp 152-153°C (decomp.); IR (KBr) v max 3350, 1660, 1615, 1504cm -1 .

[0043] · 1 H NMR (D 2 O, 400MHz) δ: 6.40 (1H, m, 2'), 6.19 (1H, d d d, J=4, 4, 2H z, 4'), 5.63 (1H, d d d d, J=14, 4, 4, 2H z, 5' ), 4.74 (1H, d d d d, J=14, 4, 4, 2Hz, 5'), 4.34 (1H, d...

preparation example 1

[0088] Preparation Example 1: Tablet

[0089] According to a conventional method, a tablet is prepared from the following composition.

[0090] Oxyroxyalkanine 200mg

[0091] Lactose 60mg

[0092] Potato Starch 30mg

[0093] Polyvinyl alcohol 2mg

[0094] Magnesium Stearate 1mg

[0095] Tar pigment trace

preparation example 2

[0096] Preparation example 2: powder

[0097] According to a conventional method, a powder is prepared from the following composition.

[0098] Oxyroxyalkanine 200mg

[0099] Lactose 275mg

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Abstract

An object of the present invention is to provide a novel sleep-improving agent and sedative agent. The above object is achieved by providing a sleep-improving agent and a sedative agent containing, as an active ingredient, oxypinnatanine or its derivative represented by the following chemical formula (I).

Description

technical field [0001] The invention relates to a novel sleep-improving agent, in particular to a sleep-improving agent for improving sleep. Background technique [0002] In modern society, there is an increasing tendency for people suffering from insomnia due to stress and 24-hour lifestyle habits. In the report of the "Healthy づくりのためのSleep Guideline Seminar" (Symposium for Creating Healthy Sleep Guidelines) started by the Ministry of Health, Labor and Welfare in 2003, the proportion of "people suffering from insomnia" rose to 21.4%, becoming Serious Problem. Therefore, the number of people who wish to sleep comfortably has increased more than ever, and accordingly, the need for drugs for improving insomnia will increase in the future. At present, various sleeping pills are used, but most of these sleeping pills have side effects such as headache, discomfort, and physical dependence after waking up, so it may not be possible to say that natural sleep can be obtained. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/30A61K31/341A61P25/20A23L29/00A23L33/00
CPCA23L1/3051C07D307/30A23L1/0325A23L33/175A61P25/20
Inventor 里出良博黄志力和田雅史内山奈穗子小西天二中村宪夫
Owner 财团法人大坂生物科学研究所
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