Traditional Chinese medicine instant powder with anti-stress effects on fishes and preparation method thereof

An instant powder and anti-stress technology, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of long drug withdrawal period, fish damage, low safety performance, etc. problems, to increase the dissolution rate, regulate the body's metabolism, and improve the survival rate

Active Publication Date: 2020-04-21
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, chemical anti-stress and sedative drugs for fish mainly include 30 kinds of ether, MS-222, phenobarbital, procaine hydrochloride and eugenol, etc., but these drugs all have the following shortcomings: (1) For some fish The sedative effect is unsatisfactory; (2) the residual amount of the drug in the fish is large; (3) the safety performance is low; (4) the drug withdrawal period is long; (5) the price is expensive, etc. Environmental pollution and harm
Non-toxic and non-chemical sedation methods such as freezing fish or supplementing carbon dioxide gas are expensive and may cause irreversible damage to fish, which is difficult to be accepted by the market

Method used

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  • Traditional Chinese medicine instant powder with anti-stress effects on fishes and preparation method thereof
  • Traditional Chinese medicine instant powder with anti-stress effects on fishes and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] 1. Drug composition: 7 parts of genkwa, 7 parts of kaempferia, 5 parts of clove, 5 parts of myrrh, and 5 parts of ferulicum.

[0034] 2. Preparation method

[0035] S1, pulverization; according to the above mass parts, take each component Chinese medicine respectively: 7 parts of genkwa, 7 parts of kaempferia, 5 parts of clove, 5 parts of myrrh, and 5 parts of ferulicum, and pulverize them into coarse powder with a particle size of 10 mesh respectively, well mixed;

[0036] S2. Extraction of volatile oil: place the above-mentioned mixed Chinese medicine coarse powder in a volatile oil extractor, add water with a total mass ratio of 10 to the mixed Chinese medicine coarse powder, and control the heating steam pressure to 0.13MPa to ensure relatively violent boiling in the extractor to ensure oil-water The temperature in the separator is 85°C, the extraction time is 20h, the volatile oil of traditional Chinese medicine is obtained and the dregs are collected;

[0037] S...

Embodiment 2

[0043] 1. Drug composition: 4 parts of genkwa, 3 parts of kaempferum, 3 parts of clove, 3 parts of myrrh, 3 parts of ferulicum, 3 parts of mugwort leaves, 2 parts of bletilla striata, and 2 parts of borneol.

[0044] 2. Preparation method

[0045] S1, pulverize; weigh each component Chinese medicine according to the following parts by mass: genkwa 4 parts, kaempferum 3 parts, cloves 3 parts, myrrh 3 parts, ferulicum 3 parts, Artemisia argyi 3 parts, bletilla striata 2 parts, borneol 2 parts , crushing other traditional Chinese medicines except borneol into a coarse powder with a particle size of 10 mesh and mixing them evenly, and separately crushing the borneol into a coarse powder of borneol with a particle size of 10 mesh;

[0046] S2, volatile oil extraction; the above-mentioned mixed Chinese medicine coarse powder is placed in the volatile oil extractor, add and mix the water of 1:8 with the total mass ratio of the mixed Chinese medicine coarse powder, control the heating...

Embodiment 3

[0054] 1. Drug composition: 5 parts of genkwa, 5 parts of kaempferum, 4 parts of clove, 4 parts of myrrh, 4 parts of ferulicum, 3 parts of mugwort leaves, 4 parts of cinnamon bark, 3 parts of borneol, and 3 parts of papaya.

[0055] 2. Preparation method

[0056] S1, pulverize; weigh each component of traditional Chinese medicine according to the following parts by mass: 5 parts of genkwa, 5 parts of kaempferia, 4 parts of clove, 4 parts of myrrh, 4 parts of ferulicum, 3 parts of wormwood, 4 parts of cinnamon, and 3 parts of borneol 1. 3 parts of herb discharge, other traditional Chinese medicines except borneol are pulverized into coarse powder with a particle diameter of 20 mesh and mixed evenly; the borneol is separately crushed into coarse powder with a particle diameter of borneol with a particle diameter of 20 mesh;

[0057] S2, volatile oil extraction; the above-mentioned mixed Chinese medicine coarse powder is placed in the volatile oil extractor, add and mix the water...

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Abstract

The invention discloses composition of traditional Chinese medicine instant powder with anti-stress and sedative effects on fishes and a preparation method of the traditional Chinese medicine instantpowder. The traditional Chinese medicine instant powder is composed of lilac daphne flower bud, rhizoma kaempferiae, clove, myrrh, ferula asafetida and other traditional Chinese medicines, and is prepared by the following steps: carrying out weighing and crushing, extracting volatile oil, performing water extraction on decoction dregs, weighing auxiliary materials, preparing acid source particles,preparing alkali source main medicine particles, preparing instant powder and the like, and specifically comprises grinding the materials, putting powder into a volatile oil extractor, continuously extracting with water to obtain light yellow volatile oil, extracting decoction dregs by using an ultrasonic extractor, performing spray drying on the obtained extracting solution to obtain medicine powder, mixing the volatile oil and the medicine powder, adding a proper amount of auxiliary materials into the mixure, and uniformly mixing them to obtain the traditional Chinese medicine instant powder. The traditional Chinese medicine instant powder can reduce harm caused by fish body stress struggling, improves water leaving survival keeping time and survival rate of fishes, has the advantages of being good in calming effect, free of residues, large in safety range and low in price, and has important significance in use of the anti-stress sedative for fish.

Description

technical field [0001] The invention relates to an antistress drug, in particular to a traditional Chinese medicine instant powder with antistress and sedative effects on fish and a preparation method thereof. Background technique [0002] During the long-distance transportation of fish, the stress or excessive struggle of fish often causes fish to get sick or die, thus causing great economic losses. The application of drugs with anti-stress and sedative effects can reduce the harm caused by the stress and struggle of the fish body, and at the same time increase the time and survival rate of the fish out of water. [0003] Antistress agents for fish are a class of drugs that can reduce metabolic activity in fish. After the anti-stress agent acts on the fish body, it first inhibits the cortex of the fish brain and enters the period of loss of touch, then acts on the basal ganglia and cerebellum to enter the excitatory period, and finally acts on the spinal cord to enter the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61K9/14A61K47/12A61K47/02A61K47/26A61K47/32A61P43/00A61P25/20A61K31/045
CPCA61K36/83A61K36/906A61K36/61A61K36/328A61K36/23A61K36/282A61K36/898A61K36/54A61K31/045A61K36/235A61K36/185A61K9/145A61K9/143A61K9/146A61P43/00A61P25/20A61K2236/331A61K2300/00
Inventor 刘翠艳范广太韩春杨
Owner ANHUI AGRICULTURAL UNIVERSITY
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