87 results about "Alkalinizing agent" patented technology

The present invention relates to novel pharmaceutical composition comprising meloxicam for the treatment of acute pain, wherein the composition comprises at least a hydrophilic polymer and one or more alkalizing agents or combinations thereof.

The present invention relates to novel pharmaceutical composition comprising meloxicam for the treatment of acute pain, wherein the composition comprises at least a hydrophilic polymer and one or more alkalizing agents or combinations thereof.

The present invention relates to novel pharmaceutical composition comprising meloxicam for the treatment of acute pain, wherein the composition comprises at least a hydrophilic polymer and one or more alkalizing agents or combinations thereof.

The utility model belongs to the technical field of chemical industrial analytical instruments, and particularly relates to a sodium ion analyzer with an automatic alkalizer regulation function, which comprises a shell, a detection box, a mixing mechanism, a water inlet pipeline, a water drainage pipeline and a filling mechanism, the filling mechanism is arranged in the shell and is used for filling the alkalizer; the PH value measuring component is arranged on the water inlet pipeline and is used for detecting the PH value of the sample water in real time; the detection mechanism is arranged on the detection box and is used for detecting the concentration of sodium ions in the water sample; wherein the filling mechanism comprises a reagent bottle, an air pump and an adjustable flow meter, the reagent bottle and the air pump are both installed in the shell, an air conveying pipe is communicated between the reagent bottle and the air pump, the adjustable flow meter is arranged on the air conveying pipe, and the reagent bottle is further communicated with a liquid discharging pipe. According to the device, the air flow can be accurately controlled, so that the filling speed of an alkalizer in the reagent bottle can be accurately regulated and controlled.

The present invention is directed to a kit-of-parts for bleaching keratin fibers, having a bleaching composition A comprising a) one or more persalt(s) and / or peroxy salt(s), and b) one or more alkalizing agent(s), an aqueous oxidizing composition B, and a composition C comprising c) one or more non-acetylated sugar alcohol(s), and / or their mixtures, wherein the bleaching composition A comprises less than 5% by weight of water, calculated to the total weight of the bleaching composition A.

The invention provides a preparation method of high-stability cross-linked hydroxypropyl starch ether, and relates to the technical field of starch ether processing. The method comprises the following steps: adding water into a starch raw material to prepare starch milk, adding part of an alkalizer, and stirring for activation; raising the temperature to a first temperature, adding the residual alkalizer, and uniformly stirring and mixing; adding an etherifying agent, heating to a second temperature, carrying out first-stage etherification, adding a cross-linking agent after the hydroxypropyl substitution degree DS of the starch reaches 0.10, and carrying out second-stage etherification at the second temperature; and finally, carrying out post-treatment on the etherified product to prepare the cross-linked hydroxypropyl starch ether. According to the cross-linked hydroxypropyl starch ether produced by the method, the problems of local gelatinization and by-product residue of the existing cross-linked hydroxypropyl starch ether are solved, the industrial production of the high-stability food-grade safe hydroxypropyl cross-linked starch ether is realized, and the product better meets the market demand.

The invention discloses a tail water alkalization adjusting device and adjusting method based on a multistage reaction tank. The device comprises a tail water input pipe, an alkalization dissolving tank, an alkali liquor storage tank, a pH regulation reaction tank and a control system. The method comprises the following steps: firstly, respectively inputting tail water to be treated into an alkalization dissolving tank and a pH regulation reaction tank through a tail water input pipe; one part of tail water to be treated is used as a solvent of an alkalizer, and an alkalization dissolution control box is used for controlling the dissolution degree of the alkalizer in an alkalization dissolution tank to obtain alkali liquor; alkali liquor is stored in the alkali liquor storage tank, the alkali liquor is added into the pH adjusting reaction tank through the pH adjusting and alkali liquor storage control box, the alkali liquor is mixed with the remaining part of tail water again, the tail water is discharged after being treated to reach the standard, and therefore alkalization adjusting treatment of all the tail water is achieved. According to the present invention, the modular design is adopted, the structure is compact, the application range is wide, the maintenance cost is low, the automatic control can be integrated, and the real-time monitoring of the water quality change and the precise control of the adding amount adjustment can be achieved.

The invention discloses an etherified-esterified composite starch emulsifier and a preparation method thereof. The etherification-esterification composite starch emulsifier is prepared by the following steps: adding an alkalizer accounting for 10-30% of the mass of a starch dry basis into starch, uniformly mixing, and placing in a drying oven at 30-50 DEG C for 0.5-2 hours to obtain a mixture; adding sodium chloroacetate into the mixture, uniformly mixing, and standing for 0.5-3 hours; adding fatty acid, uniformly mixing, and standing for 12-48 hours to obtain a reaction material; loading the reaction material into a ball milling tank of a stirring ball mill, adding a ball milling medium with the diameter of 4-8mm, stirring and reacting at 35-65 DEG C for 10-120 minutes, and separating the ball milling medium after the reaction is finished to obtain a reaction product; and soaking the reaction product with 70-95% ethanol to obtain the product. The etherification substitution degree of the etherification-esterification composite starch emulsifier reaches 0.3495 or above, the substitution degree can reach 0.00865 or above, the reaction efficiency reaches 32%, the emulsifying property reaches 92% or above, the emulsifying stability reaches 85% or above, and the emulsifying property is excellent.

The present invention relates to a dry fermentation comprising, per kilogram of dry matter: 4.7 mol to 8.1 mol of a propionate salt; 1.2 mol to 3.0 mol of a calcium cation; 2.4 mol to 7.8 mol of an alkali metal cation selected from the group consisting of sodium, potassium, and combinations thereof; and. 1 g to 50 g of a glucose equivalent weight of hydrolyzed glucan; the calcium cation and the propionate are present in a molar ratio of 0.2 to 0.6 in the dry fermentation. The dried propionate leavening according to the present invention combines a very high propionate content with a light taste. The present invention also provides a method of preparing a dry ferment of the present invention, said method comprising an incubation step in which the pH is maintained in the range of 5.0 to 7.5 by adding an alkalizing agent comprising an alkaline water-soluble alkali metal salt and an alkaline water-soluble calcium salt.

The present invention relates to the technical field related to sodium ion analysis, and discloses an integrated sodium ion concentration analyzer, comprising an integrated cabinet, a detection barrel fixedly installed inside the integrated cabinet, a first pipe connected to the top of the detection barrel, a first control valve provided on the first pipe, a pH sensor fixedly installed inside the detection barrel, and an adjustment mechanism provided inside the detection barrel. The present invention can move a conical plug to different positions of an infusion tube port as needed, can change the flow rate of an alkalizing agent in the infusion tube port, and conveniently control and adjust the delivery rate of the alkalizing agent; in addition, the alkalizing agent inside a plurality of drainage pipes will be respectively delivered to different positions inside the adjustment barrel, and when the alkalizing agent contacts and mixes with the solution, the output end of the first motor will drive the agitator to rotate, and the plurality of drainage pipes outside the agitator will act as the stirring blades of the agitator and stir the mixed solution and the alkalizing agent, so that the solution and the alkalizing agent can quickly mix and react and adjust the pH value of the solution.

The present invention provides a pharmaceutical composition for treating or preventing peripheral nerve disorders induced by chemotherapeutic drugs, comprising an alkalizing agent. By administering this pharmaceutical composition, peripheral nerve disorders induced by chemotherapeutic drugs, particularly chemotherapeutic drugs for cancer, can be treated or prevented. Also provided is an anticancer pharmaceutical composition for inhibiting the expression of peripheral nerve disorders, the anticancer pharmaceutical composition comprising an alkalizing agent and a cancer chemotherapeutic agent. The administration of this pharmaceutical composition makes it possible to treat cancers in which the expression of peripheral nerve disorders can be suppressed.

The application belongs to the technical field of starch chemical modification, and particularly relates to a preparation method of acetylated distarch phosphate. The method comprises the following steps: mixing starch with a deep eutectic solvent composed of choline chloride, glycerol and a small amount of water, adding a phosphate crosslinking agent and a delayed-release alkalizing agent for crosslinking reaction after pH adjustment, performing acetylation reaction by adding acetic anhydride or vinyl acetate after cleaning by alcohol solvent replacement, and finally obtaining the product through neutralization, washing, dehydration and drying. The process utilizes the deep eutectic solvent to control water activity and particle structure, and combines the slow-release alkali source to maintain a stable reaction environment, so that the crosslinking and acetylation are uniformly carried out, and the side reactions and residual salt load are effectively reduced. The obtained acetylated distarch phosphate has stable substitution degree, uniform particle structure and excellent performance in freeze-thaw stability, and is suitable for multiple fields such as papermaking, textile and oil field additives.

The application discloses a kind of air cooling island flow accelerated corrosion simulation test system and method, main loop subsystem, including high-purity water tank, main loop outlet pipe, electrode flow cell and main loop return pipe;The water outlet of high-purity water tank is connected with the one end of main loop outlet pipe, the other end of main loop outlet pipe is connected with the water inlet of electrode flow cell, the one end of main loop return pipe is connected with the water outlet of electrode flow cell, the other end of main loop return pipe is connected with the backwater of high-purity water tank;Dosing subsystem is used to add alkali agent or oxidizing agent to main loop outlet pipe;Flow accelerated corrosion test subsystem includes test electrode and corrosion tester;Test electrode is placed in electrode flow cell, and test electrode is connected with the input end of corrosion tester by wire;The material of test electrode is the same as the material of the equipment to be simulated air cooling island;The application realizes the real simulation of air cooling island equipment, meets the simulation of high flow rate and anaerobic condition, and the error of simulation test result is small.

The invention discloses a dust suppression material based on calcium slow-release crosslinking. The dust suppression material comprises 2-6 parts of xylan, 9-85 parts of sodium chloroacetate, 0.12-0.85 part of calcium chloride, 0.6-1 part of citric acid, 1-2 parts of ethyl lactate, 24-56 parts of a basifier, 1-9 parts of a wetting agent and 1500-3000 parts of distilled water. Xylan is modified through carboxymethylation reaction, a calcium slow-release system is constructed to control the release rate of Ca < 2 + >, slowly released Ca < 2 + > is wrapped by carboxyl of adjacent xylan chains to form local crosslinking points, Ca < 2 + > serves as a molecular bridge, and linear molecular chains are connected into a stable three-dimensional network; the prepared dust suppression material has high wetting and permeability, high bonding strength, high water-retaining property, high environmental durability and a long-acting dust suppression effect.

Methods are disclosed herein for producing ester derivatives of alpha-glucan comprising alpha-1,6 linkages. Such methods can comprise esterifying an alkalized alpha-glucan in an esterification reaction composition that otherwise does not contain any added alkalizing agent. Further disclosed are alpha-glucan ester compositions produced by the disclosed processes, as well as various applications of using these compositions.

The present invention relates to an oral pharmaceutical composition comprises semaglutide, SNAC (Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate), one or more alkalizing agent and one or more pharmaceutically acceptable excipients.

The present invention provides a pharmaceutical composition for treating an acute-phase peripheral neuropathy induced by a chemotherapeutic agent, the pharmaceutical composition comprising an alkalizing agent. By administering this pharmaceutical composition, it is possible to treat an acute-phase peripheral neuropathy induced by a chemotherapeutic agent, in particular, a chemotherapeutic agent for cancer. The present invention also provides an anticancer pharmaceutical composition that contains an alkalizing agent and a chemotherapeutic agent for cancer and that is designed to suppress an acute-phase peripheral neuropathy induced by the chemotherapeutic agent or to suppress worsening of symptoms caused by the peripheral neuropathy. By administering this pharmaceutical composition, it is possible to provide a cancer treatment in which an acute-phase peripheral neuropathy or worsening of symptoms caused by the peripheral neuropathy is suppressed.

The invention relates to the technical field of concrete admixtures, and particularly discloses an anti-crack inorganic polymer silicon-aluminum polymer admixture as well as a preparation method and application thereof. The method comprises the following steps: (1) adding an alkalizer and a co-stabilizer into an aluminum sulfate solution, and carrying out continuous stirring treatment under heating and heat preservation conditions to obtain a precursor solution; and (2) adding diethanolisopropanolamine into the precursor liquid, continuously stirring under the conditions of heating and heat preservation, standing the obtained reaction liquid to naturally precipitate, and taking the supernate after the reaction is completed. And (3) heating the supernate, adding fluosilicic acid under a stirring condition, and then preserving heat to obtain the admixture. The inorganic high-molecular silicon-aluminum polymer admixture obtained by the invention can be subjected to in-situ reaction with a large amount of Ca < 2 + > generated by hydration reaction at the early hardening stage of concrete to form a high-strength gelling product, so that the tensile strength of the concrete is improved, and the crack resistance of the concrete is improved.

The present invention refers to a composition for water-based foamed fluid with high thermal stability for drilling depressed areas in oil and gas wells, comprising: i) a base fluid or drilling water consisting of fresh water; ii) a stabilizing agent; ii) a viscosifying agent; iv) a filtering reducing agent; v) a clay inhibiting agent; vi) an alkalizing agent and acid gas sequestering agent; vii) a thermal stabilizing agent; and viii) a foaming agent. Also, the present invention refers to a system that uses said composition for fluid and water-based foamed fluid with high thermal stability, the method of preparing the composition for fluid, the method of preparing the fluid and application of the composition and fluid in a water-based foamed fluid system with high thermal stability for drilling depressed or low-pressure areas in oil and gas wells.

A composition for treating dentin hypersensitivity, comprising: a first component comprising: (i) a first rheology modifying polymer; (ii) a calcium ion source; (iii) a positively charged basic amino acid; and (iv) an acidifying agent, wherein the first component has a pH in the range of about 2.0 to about 7.0; a second component comprising: (i) a second rheology modifying polymer; (ii) a phosphate ion source; and (iii) an alkalizing agent, wherein the second component has a pH in the range of about 7.0 to about 14.0; wherein the first component and the second component are combined into a mixture such that a cationic amorphous calcium phosphate gel composition is created instantly when the pH of the mixture reaches a pH range of about 7.0 to about 9.5.

A hydraulic binder including (in % by dry weight); A. at least 50 of at least one ground and granulated blast-furnace slag; B. more than 5 of at least one calcium aluminate cement and / or of at least one calcium sulfoaluminate cement; C. more than 5 of at least one source of sulfate ions; D. between 1 and 5 of Ca(OH)2 and / or Portland cement; E. between 0.01 and 1 of at least one alkali metal carbonate; F. and at least one alkalifying reagent consisting of at least one alkali metal carbonate and / or bicarbonate, different from E; under the following conditions: (i) amount of C allows sulfate ions of C to react with B and A; (ii) the amount of F sufficiently causes a reaction with D in water resulting in a wet formulation with a pH not less than 12, for a water-to-mortar mixing rate between 10 and 35% by weight.

The present disclosure provides methods for treating or managing fibromyalgia and its associated symptoms in a subject in need hereof characterized by an early onset of one or more of: (1) a reduction in widespread pain characterized by about 0.3 or more difference in the LS mean change in the NRS Pain Score; (2) a reduction in sleep disturbance characterized by about 2.9 or more difference in the LS Mean change in PROMIS Sleep Disturbance T-score; (3) a reduction in fatigue characterized by about 2.0 or more difference in the LS Mean change in PROMIS Fatigue T-score; or (4) an improved sleep quality characterized by about 0.5 or more difference in the LS Mean change in NRS Sleep Quality Score, each as compared to placebo, comprising administering to a subject in need thereof 2.8 mg or 5.6 mg cyclobenzaprine HCl once daily in one or more dosage units by transmucosal administration. The present disclosure also provides methods for preventing or avoiding one or more of a clinically meaningful change in mean weight, a clinically meaningful change in mean systolic blood pressure or mean diastolic blood pressure, or a decline in sexual functioning in conjunction with treating or managing fibromyalgia or its associated symptoms in a subject in need thereof, the treatment or management being characterized by the transmucosal administration of cyclobenzaprine HCl in one or more dosage units (e.g., a first dosage unit or a second dosage unit). The cyclobenzaprine HCl of these methods is in the form of a mannitol eutectic (e.g., a 75%±2% by weight cyclobenzaprine HCl and 25%±2% by weight β-mannitol eutectic) and the one or more dosage units further comprise a basifying agent.

The present invention relates to a water-soluble deodorizing and sanitizing composition comprising a peroxydisulphate, a surfactant and optionally an acidifying agent or an alkalizing agent. The peroxydisulphate can be a sodium, potassium or ammonium peroxydisulphate. The surfactant can be a non-ionic, anionic or cationic surfactant. The acidifying agent can be citric acid, and the alkalizing agent can be sodium bicarbonate. The composition can be dry mixed or sprayed or nebulized on the material to be treated in the form of a solution, it is able to deodorize and sanitize solid and liquid malodorous matrices of any origin and can also be used in environments and for household surfaces and furnishings. The deodorizing and sanitizing composition is able to selectively reduce only the anaerobic bacterial load. The deodorizing and sanitizing composition can be made in the form of a kit, comprising: sodium, potassium or ammonium peroxydisulphate, a non-ionic, anionic or cationic surfactant, and optionally an acidifying agent or an alkalizing agent.

The present disclosure relates to combinations, dosage forms, and pharmaceutical formulations that comprise an active pharmaceutical ingredient, such as pitolisant, and an alkalinizing agent for improving absorption of the active pharmaceutical ingredient.

The present invention relates to a proprietary encapsulation technology where in a composition comprising mangiferin will maintain in-situ alkaline environment and minimizes the precipitation issues of mangiferin in the acidic environment. A composition of mangiferin has been disclosed. A natural hydrophilic plant-based carrier along with a selected alkalizer is being embedded in the encapsulation matrix which subsequently acts as a platform to ensure the alkaline environment with better solubility of bioactive across the physiological pH range.

The invention provides a rapid evaluation method for the chain segment characteristics of ethyl cellulose, which comprises the following steps: preparing an EC emulsion from an ethyl cellulose sample to be detected, and determining the chain segment characteristics of ethyl cellulose by measuring the parameters of the EC emulsion. The detection parameters of the EC emulsion product comprise the ethyoxyl content, the emulsion peak number, the average particle size and the particle size distribution. The preparation method of the EC emulsion comprises the following steps: S1, crushing and sieving an ethyl cellulose sample for later use; s2, placing the ethyl cellulose undersize product in a reactor, sequentially adding a plasticizer and a solvent into the reactor while stirring, and dispersing to obtain an oil-phase intermediate; and S3, adding an emulsifier and an alkalizer into the oil-phase intermediate, and adding the oil-phase intermediate into distilled water for multiple times under high-shear dispersion to obtain the EC emulsion to be detected. According to the method, the emulsification technology is applied to determination of EC chain segment distribution characteristics for the first time, the method has good applicability and universality, the whole detection process is efficient and rapid, data reliability is enhanced, and application predictability is accurate.

Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and / or keratinocyte cells. In addition, compositions and methods for increasing or decreasing the growth rate of hair follicles is disclosed by altering the intracellular pH. Additionally, methods for preparing a stable liposomal containing solution are described.

Provided are water for treating seafood, a method for producing the same, and a method for producing seafood whose freshness is maintained. [Solution] Seafood processing water contains electrolyzed water and an alkalizing agent, and has a pH greater than 7.0 and not greater than 10.5. The alkalizing agent is added to acidic electrolyzed water to produce seafood processing water with a pH greater than 7.0 and not greater than 10.5. By applying this seafood processing water to seafood, seafood that has been kept fresh can be produced.

The present invention is to provide an amorphous solid dispersion comprising elacestrant dihydrochloride of formula (I), in combination with one or more pharmaceutically acceptable excipients such as a stabilizing agent including a polymer and / or an alkalizing agent. Additionally, the invention provides a process for the preparation of such amorphous solid dispersions and an amorphous form of elacestrant dihydrochloride. The resulting amorphous form or amorphous solid dispersions are advantageous for the formulation of pharmaceutical dosage forms and compositions, enhancing the bioavailability and stability of elacestrant dihydrochloride.

Compositions and methods are disclosed herein for inducing (up-regulating) the expression and / or activity of sulfotransferases in the hair follicles, e.g., the scalp. The compositions include (i) an agent configured to increase the sulfonating ability of hair bearing skin, hair follicles, and / or keratinocyte cells in a person; (ii) an alkalinizing agent; (iii) liposomes encapsulating at least some of the alkalinizing agent; (iv) an antioxidant configured to prevent oxidative degradation of the liposomes; and (v) a buffer system configured to increase dermal penetration of the liposomes, and / or stabilize the liposome solution; and (vi) a solvent; and (vii) minoxidil or a salt thereof. Additional methods and compositions include the use of the topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and / or keratinocyte cells. In addition, compositions and methods for increasing or decreasing the growth rate of hair follicles is disclosed by altering the intracellular pH. Additionally, methods for preparing a stable liposomal containing solution are described.