The present application relates to a kind of preparation cycloxapridone method.The method of the present application is prepared by cyclization reaction with
amide compound or cyclic
urea compound as catalyst, the
amide compound or cyclic
urea compound is preferably N',N-
dimethylformamide or N',N-dimethylimidazolinone.Cycloxapridone can be greatly reduced by using the method of the present application The generation of ethoxy impurities improves the purity of the product, and the price of catalyst is cheap, easy to synthesize, and the reaction condition is mild, can significantly reduce production cost, has good industrial application value.