200 results about "Imidazolidinone" patented technology

The present invention discloses novel imidazolidinones which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazolidinones as well as methods of using them to treat disorders associated with the HCV protease.

A polishing composition which achieves surfaces with high planarity and the reduction of corrosions in the wiring metal surface at the same time is provided.Such compositions include(A) an oxidizing agent;(B) at least one acid selected from an amino acid, a carboxylic acid of no more than 8 carbon atoms, and an inorganic acid;(C) a sulfonic acid having a concentration of 0.01% by mass or more and having an alkyl group of 8 or more carbon atoms;(D) a fatty acid having a concentration of 0.001% by mass or more and having an alkyl group of 8 or more carbon atoms; and(E) at least one compound selected from a pyridine carbonyl compound, a nonionic water-soluble polymer, 2-pyrrolidone, N-methylpyrrolidone, 1,3-dimethyl-2-imidazolidinone, gramine, adenine, N,N′-diisopropylethylenediamine, N,N′-bis(2-hydroxyethyl)ethylenediamine, N,N′-dibenzylethylenediamine, and N,N′-diphenylethylenediamine.

An alkyl substituted triazazole type antifungal compound for preparing the antifungal medicines, and its various enantiomers, diaisomers, Nox and precursors are disclosed.

Nucleotide sequences are disclosed that may be used to impart herbicide resistance to green plants. The sources of novel resistance were originally isolated in mutant rice plants. The sequences impart pre-emergence resistance, post-emergence resistance, or both pre-emergence resistance and post-emergence resistance to multiple herbicides. To date, resistance has been demonstrated against at least the following herbicides: imazethapyr, imazapic, imazapyr, imazamox, sulfometuron methyl, imazaquin, chlorimuron ethyl, metsulfuron methyl, rimsulfuron, thifensulfuron methyl, pyrithiobac sodium, tribenuron methyl, and nicosulfuron. Green plants transformed with these sequences are resistant to these herbicides and to derivatives of these herbicides, and to at least some of the other herbicides that normally inhibit acetohydroxyacid synthase (AHAS), particularly imidazolinone and sulfonylurea herbicides.

The invention is concerned with novel imidazolidinone derivatives of formula (I):wherein R1 to R11 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR beta and can be used in pharmaceutical compositions.

Recording onto a non-ink-absorbing recording medium is performed using an aqueous ink composition containing a first solvent composed of at least one selected from 2-pyrrolidone, 1,3-dimethyl-imidazolidinone, and N,N′-dimethylpropylene urea, a second solvent composed of at least one selected from 1,2-hexanediol and 1,2-pentanediol, and a third solvent composed of at least one selected from glycol diethers and heating the non-ink-absorbing recording medium at 40 to 60° C.

Disclosed is a polishing composition which realizes both high planarity and reduction of corrosion in the surface of a wiring metal. Specifically disclosed is a polishing composition containing an oxidizing agent (A), at least one or more acids (B) selected from amino acids, carboxylic acids having 8 or less carbon atoms and inorganic acids, a sulfonic acid (C) having a concentration of not less than 0.01% by mass and an alkyl group having 8 or more carbon atoms, a fatty acid (D) having a concentration of not less than 0.001% by mass and an alkyl group having 8 or more carbon atoms, and at least one or more compounds (E) selected from pyridinecarbonyl compounds, nonionic water-soluble polymers, 2-pyrrolidone, N-methylpyrrolidone, 1,3-dimethyl-2-imidazolidinone, gramine, adenine, N,N'-diisopropylethylenediamine, N,N'-bis(2-hydroxyethyl)ethylenediamine, N,N'-dibenzylethylenediamine and N,N'-diphenylethylenediamine.

The invention relates to an aldehyde-removal paint and a preparation method thereof, particularly a multiplex aldehyde-removal internal wall latex paint and a preparation method thereof, belonging to the field of architectural decoration materials. The latex paint is prepared from the following raw materials in parts by weight: 22-26 parts of water, 0.4-0.5 part of hydroxyethyl cellulose, 0.1-0.3 part of water-based multifunctional assistant, 0.5-0.8 part of water-based dispersing agent, 0.1-0.2 part of water-based wetting agent, 0.4-0.7 part of water-based defoaming agent, 15-18 parts of titanium white, 8-10 parts of kaolin, 10-15 parts of calcium carbonate, 4-5 parts of kieselguhr, 2-3 parts of anionic slurry, 1-2 parts of imidazolidinone, 23-26 parts of vac-veova emulsion, 1.0-1.2 parts of antifreezing agent, 0.3-0.5 part of bactericidal mold preventive and 1.0-1.5 parts of thickener. The multiplex aldehyde-removal internal wall latex paint can implement multiplex aldehyde removal, has the advantages of high aldehyde-removal efficiency and high durability, and can release anions and enhance the indoor air quality.

The new method for preparing high crystallinity monodisperse water-soluble magnetic nano microparticles is characterized by that it selects the inorganic iron salts of anhydrous iron trichloride and iron chloride, etc. or metal organic iron compounds (such as iron pentacarbonyl, iron triacetylacetonate, iron biacetylacetonate, complex of cupferron and iron salt, iron octoate and ferric oxalate, etc.) as iron raw material, and utilizes high-temp. decomposition of them in high boiling point polar solvent (for example alpha-pyrrolidone and its derivatives (N-methyl-2-pyrrolidone and N-ethyl-2-pyrrolidone, etc.), N,N-dimethyl-2-imidazolone, hexametapol, gamma-butyrolactone and its derivative and low molecular weight (molecular weight M is less than or equal to 5000) polyglycol and its derivatives) to prepare magnetic nano microparticles. Said invention can adopts different iron raw materials and high boiling point polar solvents so as to obtain different types of magnetic nano microparticles (Fe, Fe2O3 and Fe3O4) with different sizes and crystallinities and different crystal structures.

The invention provides methods and oligonucleotide primers for assaying Brassica napus plants for the presence or absence of mutations that confer resistance to imidazolinone herbicides. Specifically, the methods and primers of the invention are useful for detecting the PM1 mutation of the B. napus AHAS1 gene and the PM2 mutation of the B. napus AHAS3 gene.

Nucleotide sequences are disclosed that may be used to impart herbicide resistance to green plants. The sources of novel herbicide resistance were originally isolated in mutant Coreopsis plants. Green plants transformed with these sequences are resistant to herbicides that normally inhibit acetolactate synthase (ALS), particularly imidazolinone and sulfonylurea herbicides.

Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and / or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.

The invention discloses a paddy rice ALS (Acetolactate Synthase) mutant protein for endowing plants with resistance to herbicides. The invention further discloses a nucleic acid for coding the protein. The protein comes from a paddy rice mutant plant resisting ALS inhibitor type herbicides, and in comparison with the ALS sequence in the genome of wild paddy rice, the protein sequence of the protein is simultaneously mutated at sites Ser 627 and Gly 628 or only mutated at the site Gly 628. Plants which express the protein sequence can resist (tolerate) acetolactate synthase inhibitor type herbicides, particularly imidazolinone herbicides. The herbicide-resistant effect of the mutant mutated simultaneously at the sides Ser 627 and Gly 628 disclosed by the invention is about 30 percent higher than the herbicide-resistant capability of the mutant plant only contains mutation at the site Ser 627 or Gly 628.

This invention relates to synthetic method of 1, 3 - dimethyl - 2-imidazolidinone. The invention solves the problem in exsiting method that the reaction need 85% concentration methanoic acid as reaction medium, and the generated methanoic acid has no means of reusing. The invention takes paraformaldehyde and 2-imidazolidinone as raw material, 30% to 45%methanoic acid as reaction medium. Firstly proceed paraformaldehyde depolymerization, then add 85%or 94% methanoic acid, warm-up till circumfluence reaction for 12 hours, then gain 1, 3 - dimethyl - 2-imidazolidinone. The invention could cyclic utilize sparse methanoic acid generated from 1, 3 - dimethyl - 2-imidazolidinone synthetic reaction, thereby advance capacity utilization rate, depress manufacturing cost.

The invention provides a method for increasing hybrid rape planting purity by applying a herbicide resistant mutant character, which belongs to a plant breeding method. A conventional breeding technique is applied to transfer and breed imidazoline ketone herbicide resistance to a cytoplasmic male sterility restorer; a resistance restorer is utilized to selectively breed new combination of hybrid rape; and when the new combination F1 is planted, an imidazoline ketone herbicide is sprayed once at the seedling stage, so that all false hybrids without resistance such as trace pollen selfing plants, foreign pollen pollution plants and all mechanical mixing plants in a sterile line can be killed and removed, thereby greatly increasing the hybrid rape planting purity and maximizing the potential yield increase and the yield level of hybrids.

The invention discloses ALS mutant type genes. The 75th nucleotide of the ALS mutant type genes in an ALS gene sequence of rice mutates from G to nucleotide C, the 339th nucleotide of the ALS mutant type genes in the ALS gene sequence of the rice mutates from A to nucleotide C, and the 710th nucleotide of the ALS mutant type genes in the ALS gene sequence mutates from C to nucleotide T. The invention further discloses application of ALS protein coded by the ALS mutant type genes in the aspect of herbicide resistance. The protein comes from a rice mutant plant resisting ALS inhibitor herbicide. Compared with the rice wild type ALS sequence, the protein sequence of the ALS mutant type genes mutates at Gln25, Gln113 and Ala237 sites. Green plants express the protein sequence, and acetolactate synthetase resistant inhibitor herbicide, particularly imidazolone and sulfonylurea herbicide, can be resisted.

The invention discloses an ALS mutant gene. The nucleotide at the 75th locus of the ALS mutant gene in an ALS gene sequence of rice is changed from G to C, the nucleotide at the 339th locus is changed from A to C, the basic group at the 1099th locus is changed from C to T, and the basic group at the 1880th locus is changed from G to A. The invention further discloses ALS protein coded by the ALS mutant gene and application of the ALS protein. The protein comes from a rice mutant plant resistant to ALS inhibitor herbicide. Compared with a wild ALS sequence of rice, the sequence of the protein is subjected to mutation at the loci of Gln25, Gln113, His367 and Ser627. It is expressed by green plants that the sequence of the protein can resist acetolactate synthetase inhibitor herbicide and particularly imidazolone and sulfonylurea herbicide.

Enantiomeric bicyclic lactone compounds as can be prepared via an N-heterocyclic carbene-catalyzed annulation reaction.

Recording onto a non-ink-absorbing recording medium is performed using an aqueous ink composition containing a first solvent composed of at least one selected from 2-pyrrolidone, 1,3-dimethyl-imidazolidinone, and N,N′-dimethylpropylene urea, a second solvent composed of at least one selected from 1,2-hexanediol and 1,2-pentanediol, and a third solvent composed of at least one selected from glycol diethers and heating the non-ink-absorbing recording medium at 40 to 60° C.

An object of the present invention is to prevent, in blending an inorganic filler for the purpose of improving rigidity of a thermoplastic resin, deterioration in impact resistance and surface smoothness caused by the inorganic filler. The invention relates to a polyphenylene ether based resin composition containing (a) from 10 to 93% by weight of a polyphenylene ether based resin and optionally a styrene based resin, (b) from 2 to 20% by weight of a styrene based thermoplastic elastomer modified with an imidazolidinone compound, and (c) from 5 to 60% by weight of an inorganic filler that has been surface treated with a silane compound.

The production process of 1, 3-dimethyl-2-imidazolinone includes the following technological steps: synthesizing 2-imidazolinone with ethylene diamine and urea as material and water as solvent; and synthesizing 1, 3-dimethyl-2-imidazolinone with 2-imidazolinone, formaldehyde and formic acid as material. The present invention has the advantages of high yield, including the yield of 2-imidazolinone of 95 % and the yield of 1, 3-dimethyl-2-imidazolinone of 90 %, wide material source, low material cost, reuse of the solvent, and less waste.

The invention discloses a herbicide-resistance-based rape hybrid seed producing method and applications thereof, and relates to the field of plant seed production. The method includes (1) introducing a wide-spectrum type herbicide-resistant gene into a rape male parent line to obtain a herbicide-resistant rape male parent line that is an imidazolidinone-resistant line 12WH381 or a glufosinate-resistant line Z7B10, (2) pollinating a female parent that is sterile after a chemical androcidal action by utilizing pollen of the herbicide-resistant rape male parent line, and harvesting hybrid seeds from male parent plants, and (3) coating the hybrid seeds with a herbicide, or spraying a corresponding herbicide to the hybrid seeds when the hybrid seeds are planted to remove false hybrid seeds at the same time of removing weeds so as to obtain high-purity rape hybrid seeds or group. The applications include (1) hybrid seed production for rape, (2) improvement on rape three-line seed production methods at present, (3) improvement on rape nucleus-sterility two-line seed production methods at present and (4) improvement on rape chemical androcidal seed production systems at present.

The invention provides a three-primer molecular marking method for detecting an imidazolone herbicide resisting gene of cabbage type rape and belongs to the field of plant molecular breeding. Primer pairs of AP15F / AP18R and AP15F / AP19R are added into two polymerase chain reaction (PCR) reaction systems respectively to subject cabbage type rape deoxyribonucleic acid (DNA) to amplification, and homozygote free of resistance gene BnALS1R, homozygote containing resistance gene BnALS1R and heterozygote containing resistance gene BnALS1R are distinguished. By means of the method, whether rapeseed germplasm resources or breeding population of the rape contain the imidazolone herbicide resisting gene BnALS1R or not can be rapidly and accurately detected, whether the contained herbicide gene is the homozygote or the heterozygote can be accurately distinguished, the selection efficiency of the resistance gene BnALS1R can be improved, and the breeding process of imidazolone herbicide resisting rape breeds can be accelerated.

Enantiomeric bicyclic lactone compounds as can be prepared via an N-heterocyclic carbene-catalyzed annulation reaction.

The invention discloses a wheat ALS mutation gene. The 331th nucleotide of an ALS gene sequence of 6BL chromosome of a wheat B genome is changed into nucleotide A from G. The invention further discloses wheat ALS mutation protein encoded by the wheat ALS mutation gene and application of the wheat ALS mutation protein. The protein is from a wheat mutant plant of an anti-ALS inhibitor herbicide. Compared with a wheat mild ALS sequence, the protein sequence mutates at a Val111 site. A green plant expresses that the mutation protein sequence can be resistant and tolerant to an acetolactate synthase inhibitor herbicide, especially an imidazolone herbicide. After 3mL of imazameth / L water (9-fold recommended concentration) is applied to a wheat seedling with one leaf and one core of the wheat ALS mutation protein, the plant can still normally grow, develop and fruit.