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A trityl-based luminescent free radical material and its preparation method and application

A technology based on trityl groups and free radicals, which is applied in the direction of luminescent materials, preparation of nitro compounds, generation of organic free radicals, etc. It can solve problems such as single fluorescent signal and background fluorescence interference cannot be ruled out

Active Publication Date: 2022-06-03
JILIN UNIV
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Problems solved by technology

However, most of these fluorophores can only provide a single fluorescent signal, and the interference of background fluorescence cannot be ruled out.

Method used

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  • A trityl-based luminescent free radical material and its preparation method and application
  • A trityl-based luminescent free radical material and its preparation method and application
  • A trityl-based luminescent free radical material and its preparation method and application

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preparation example Construction

[0045] The nitration product is subjected to a dehydrogenation reaction to obtain the trityl-based light-emitting free radical material.

[0049] In the present invention, the temperature of the nitration reaction is preferably 75 to 135 ° C, and the time is preferably 12 to 72 h. this invention

[0055] In the present invention, the dehydrogenation reaction is preferably carried out in a protective atmosphere, and the protective atmosphere is preferably nitrogen.

[0059] In the present invention, the detection of biological thiol preferably includes the detection of cysteine ​​in solution. the present invention to the

[0070] In the present invention, the linear range of the linear curve is preferably 0-400 μmol / L.

Embodiment 1

[0077]

[0080]

[0083]

[0086]

[0089]

[0092]

[0095]

[0098] performance test

[0100] The preparation concentration is 1 × 10

[0112] Simulated Clinical Assays

[0113] Normal intracellular levels of Cys (30-200 μM) are essential for maintaining levels of various proteins and the antioxidant GSH to

[0115] The nematodes were incubated at 20°C for 24 hours, and the fluorescence in the nematodes was basically not observed under a fluorescence confocal microscope.

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Abstract

The invention provides a trityl-based light-emitting free radical material and a preparation method and application thereof, belonging to the technical field of organic light-emitting materials. In the trityl radical luminescent material provided by the present invention, the common feature is the trityl radical connected to the nitro group with a strong electron-withdrawing effect; the central trityl radical not only acts as a The luminescent construction group also serves as an activation group to make trityl radicals more likely to be nucleophilicly substituted by biothiols. The synergistic effect of the two units (trityl radical and nitro group) enables the material to realize the detection purpose of multiple responses to biological thiols; to realize the detection of cysteine ​​three channels (fluorescence, ultraviolet and EPR signals). According to the above strategies, the purpose of identifying biothiols in RGB patterning, simulated clinical assays and fluorescence imaging was achieved.

Description

A kind of trityl type light-emitting radical material and its preparation method and application technical field The present invention relates to the technical field of organic light-emitting materials, in particular to a kind of trityl-based light-emitting free radical material and Its preparation method and application. Background technique [0002] Biothiols mainly include cysteine ​​(Cys), glutathione (GSH) and homocysteine ​​(Hcy). organism Biothiols in signal transmission, conversion, monitoring of cell death, protein synthesis, immune system regulation, maintenance It plays a huge role in the physiological balance, redox balance and detoxification of the organism in the organism. Abnormalities are important signals of many diseases. Therefore, the development of fluorescent probes for rapid and accurate detection of biological thiols is of great scientific importance. value and biological significance. [0003] Stable free radicals are a special class of org...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C205/12C07C201/08C07C17/263C07C25/18C07B60/00C09K11/06G01N21/33G01N21/64G01N21/78G01N24/10
CPCC07C205/12C07C201/08C07C17/263C07B61/02C09K11/06G01N21/6428G01N21/6486G01N21/33G01N21/78G01N24/10C09K2211/1007C07B2200/03G01N2021/6432C07C25/18Y02P20/55
Inventor 李峰张明李卓
Owner JILIN UNIV
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