A kind of preparation method of halogenated alkanes synthesized with styrene and its derivatives and trichloroalkane

Abstract

The invention discloses a halogenated alkane synthesized by using styrene and its derivatives and trichloroalkane and a preparation method thereof. By using styrene and its derivatives and trichloroalkane as substrates, chloroalkyl is carried out under light conditions. and dimerization reaction, reacting 10-14h to prepare trifluorodichloroalkane; wherein the reaction temperature is 10-45°C, and the reaction is carried out under normal pressure simultaneously; As a catalyst, the reaction speed is accelerated; at the same time, alkali, iodine source, triphenylphosphine and deionized water are added to the whole reaction system; the whole reaction is carried out in a solvent; meanwhile, the whole reaction needs to be carried out under a nitrogen atmosphere. After the reaction is completed, the halogenated alkane can be obtained after purification treatment, and the halogenated alkane is a tail-to-tail dimerization product prepared by using styrene and its derivatives as reactants. At the same time, the invention has the advantages of simple and easy-to-obtain raw materials, novel and simple preparation process, less pollution, low energy consumption and high yield.

Description

technical field [0001] The invention relates to the field of organic chemical synthesis, more specifically to a method for preparing halogenated alkanes synthesized from styrene and its derivatives and trichloroalkane. Background technique [0002] The introduction of halogen groups such as fluorine and chlorine into organic molecules has become a widely used drug discovery method, and the dimerization reaction of styrene and its derivatives has become one of the important reactions for introducing halogen groups. Or Lewis acid catalysis and transition metal catalysis have been used for this transformation. As we all know, even if two substances have the same chemical formula but different structural formulas, the two substances often have great differences in chemistry, physics and pharmacology. At present, in the dimerization reaction of styrene and its derivatives, most of them are head-to-tail or head-to-head dimerization products. Even if there are tail-to-tail dimeriz...

AI Technical Summary

Problems solved by technology

At present, in the dimerization reaction of styrene and its derivatives, most of them are head-to-tail or head-to-head dimerization products. Even if there are tail-to-tail dimerization products in a few reactions, they are due to side reactions, and the content is very small. Difficult to extract and study, which is not conducive to drug discovery

However, there has not been a tail-to-tail dimerization product using styrene and its derivatives as reactants.

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