19 results about "DABCO" patented technology

Disclosed is a method of synthesizing a compound selected from the group consisting of C-alkyl glycosides, C-alkenyl glycosides, C-heteroaryl glycosides, Se-glycosides and S-glycosides, the method comprising: a. Reacting a natural unprotected sugar with a 2-chloro-1, 1, 1, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 The method comprises the following steps: reacting 1, 3-dimethylimidazoline chloride (DMC) and a mixture of heteroaryl mercaptan and trimethylamine (Et3N) in a mixture of water and dialkane to generate heteroaryl glycosyl thioether; b, under the irradiation of a blue light LED, in the presence of Hantzsch ester (HE), 1, 4-diazabicyclo [2.2. 2] octane (DABCO) and DMSO, heteroaryl glycosyl thioether and a reagent are subjected to light-induced cross coupling, and the compound is generated.

The present invention discloses a method for preparing 5-chloroindanone, and belongs to the technical field of chemical material preparation. The present invention uses 2-bromo-4-chlorobenzaldehyde as a raw material and acrylate under the action of DABCO to generate an intermediate; then, a cyclization reaction is performed under the action of a palladium catalyst and a base to generate 5-chloroindanone. The present invention adds an ionic liquid catalyst to cooperate with DABCO to perform a Baylis-Hillman reaction, thereby reducing the amount of DABCO used and improving the yield; through the bromine on the benzene ring and the olefin positional cyclization reaction, the generation of isomers is greatly reduced, while avoiding the isomers caused by the Friedel-Crafts cyclization reaction and a large amount of waste acid and wastewater, providing an effective new path for the preparation of 5-chloroindanone.

The application discloses a method for photocatalytically preparing 3-aminoquinoxalin-2(1 H )-ketone compounds, and belongs to the field of organic synthesis. The application comprises the following steps: quinoxalin-2(1 H )-ketone compounds, fatty amine compounds, a photocatalyst mpg-C3N4 (mesoporous graphite phase carbon nitride) and an alkali DABCO (1,4-diazabicyclo (2.2.2) octane) are added into an organic solvent and uniformly mixed; the reaction is carried out under the irradiation of light in an oxygen atmosphere; and after the reaction is completed, the 3-aminoquinoxalin-2(1 H )-ketone product is obtained through treatment and separation. The application uses DABCO as an alkali and an electron transfer agent, and adopts mpg-C3N4 to photocatalytically prepare 3-aminoquinoxalin-2(1 H )-ketone compounds under the auxiliary condition of DABCO, and it is concluded from DABCO quenching experiments and cyclic voltammetry experiments that there is a single electron transfer relationship between them; and the application has the advantages of mild reaction conditions, simple operation and the ability to synthesize 3-aminoquinoxalin-2(1 H )-ketone compounds in one step.

An oligomerization catalyst, oligomer products, methods for making and using same. The catalyst is synthesized MFI zeolite (ZSM-5) made from a combination of DABCO and methylamine (MEA) in the presence of Na cations.

The application belongs to the technical field of biological medicine, and relates to construction and application of a kind of nano oxygen delivery system based on internal peroxide. The application designs and synthesizes a kind of nano drug which can be used as a molecular oxygen delivery agent. In the nano drug, active molecules are composed of internal peroxide compound and 1,4-diazabicyclo[2.2.2]octane (DABCO), and the two molecules are constructed on gold nanorods to improve water solubility, biocompatibility and targeting of the active molecules. Finally, the active molecule modified gold nanorods obtained by the application can be used to relieve the damage of tissues and organs caused by hypoxia.

The invention relates to the field of polyester, and discloses low-humidity sensitive reactive foaming polyurethane resin and a preparation method thereof. The foaming polyurethane resin comprises the following raw materials, the component A comprises the following components in parts by weight: 40-50 parts of polyether polyol, 2-10 parts of a chain extender, 0.1-1 part of a tin amine compound catalyst and 0.05-1 part of water; the tin amine compound catalyst is prepared from DBTDL and DABCO according to the weight ratio of 1 to (0.8 to 1.2); and the component B comprises the following components in parts by weight: 25-35 parts of isocyanate, 10-20 parts of polyether polyol and 0.5-3 parts of a cross-linking agent. According to the invention, through active intervention of environment humidity and temperature, by utilizing a synergistic effect of compounding of specific types and specific proportions of tin amine catalysts, dynamic balance of a foaming reaction and a gel reaction is directly realized in a surface area, and generation of defects such as surface cell rupture and collapse is inhibited from the source; therefore, the foamed polyurethane which is narrow in cell size distribution and has a natural flat and smooth surface is obtained, and meanwhile, a foundation is provided for processing and production of the foamed polyurethane in a high-humidity environment and maintenance of relatively good comprehensive performance of the foamed polyurethane.

The invention discloses a fluorescence detection reagent, a method for doping labeled nucleotide by using the reagent, and a kit or a mixture system. The fluorescence detection reagent contains an enzymatic deoxygenation system and a plurality of reducing agents, and does not contain DABCO. The composition is suitable for application scenarios involving detection of fluorescence signals, in particular for application including detection of single-molecule fluorescence signals.

The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of an indole-substituted dihydrothiophene compound. According to the method, MBH ester derived from oxoindole and alpha-enol dithioester are taken as raw materials, reaction is realized through DABCO catalysis and a'two-step one-pot method 'under a mild room temperature condition, and an intermediate does not need to be separated. The method is simple and convenient in process operation, mild in condition, controllable in raw material cost and environment-friendly. The obtained product is novel in structure and good in yield, and has remarkable application potential in the fields of research and development of antibacterial, anti-inflammatory and anti-tumor drugs and the like.

The present application relates to the technical field of organic synthesis, in particular to a method for preparing deuterated benzoxathiie-4-ketone. At present, there is no report on the method for preparing deuterated benzoxathiie-4-ketone. In view of the above problems, the present application provides a method for preparing deuterated benzoxathiie-4-ketone. The method uses thiosalicylic acid, DABCO·CD2Cl2, a solvent, water and HI as reaction raw materials, and successfully synthesizes deuterated benzoxathiie-4-ketone by one-pot method. The method provides a new idea for the preparation of deuterated benzoxathiie-4-ketone derivatives, and has good application prospect.

The present invention discloses a columnar ultramicroporous metal organic framework material, a preparation method thereof and an application in gas separation. The chemical formula of the metal organic framework material is [Co3(BDC-CH3)3(DABCO)] n The columnar ultramicroporous metal-organic framework material of the present invention has a triangular pore structure, exhibiting strong adsorption energy and high adsorption capacity for acetylene. It is also regenerative and can preferentially adsorb acetylene from an acetylene / carbon dioxide mixture with relatively high adsorption selectivity, thereby achieving efficient separation of acetylene and carbon dioxide.

This invention discloses a columnar metal-organic framework material, its preparation method, and its application in oxygen purification. The material has the general structural formula MNi-dabco, where M represents the divalent metal ion Fe. 2+ Co 2+ Ni 2+ Cu 2+ One of the components; Ni represents potassium tetracyanonitrile hydrate; dabco represents the columnar ligand triethylenediamine. The CoNi-dabco of this invention exhibits an Ar adsorption capacity of 7.69 cm³ / g under 298 K and 1 bar conditions, and an IAST selectivity of 1.71 for an Ar / O₂ (5 / 95, v / v) binary mixture. Using this material for dynamic breakthrough separation, high-purity oxygen with a purity exceeding 99.99% can be obtained in one step from an Ar / O₂ (5 / 95, v / v) mixture, with an oxygen yield exceeding 6.08 L / kg, demonstrating significant potential for industrial application.

The application relates to the technical field of pharmaceutical chemistry, and discloses a benzazepine bridged ring derivative and a preparation method thereof. The preparation method comprises the following steps: adding a substrate (1.0 eq), a sulfur-substituted benzylpropyl aldehyde (1.5 eq), a base DABCO (0.2 eq) and dry acetonitrile (2.0 mL) into a reaction test tube, mixing the mixture at normal temperature for 24 hours, concentrating and purifying after the reaction is completed to obtain a hemiacetal product 3. Then the hemiacetal product, chloroform (0.5 mL) and H2O (100 muL) are added into the reaction test tube, and stirring is carried out at 60 DEG C for 72 hours. The reaction is monitored to be completed through thin layer chromatography, then the reaction mixture is directly purified through column chromatography to obtain a corresponding target product. The preparation method has the advantages of simple operation, mild reaction and high yield. The derivative provided by the application has good antibacterial activity, and has a wide market application prospect.

This invention relates to the field of fine chemical technology and discloses a method for preparing N-methyl-2,3-dihydrobenzothiazin-4-one. Specifically, the method involves using 2-mercapto-N-methylbenzamide and 1-(chloromethyl)-1,4-diazabicyclo[2.2.2]octane-1-ammonium chloride (DABCO•DCM) as raw materials, with hydroiodic acid (HI) as an important additive. A one-step reaction is carried out in acetonitrile at 100-120°C. After purification, the target product, N-methyl-2,3-dihydrobenzothiazin-4-one, is obtained. This method is simple to operate, has a high yield, and does not require the use of formaldehyde, a carcinogen, as a reactant, making it potentially applicable.

The application discloses a 7-amino coumarin derivative and a synthesis method and application thereof, and the synthesis method comprises the following steps: placing substituted 3-cyano-4-methyl coumarin and 20% Dabco of the volume of the substituted 3-cyano-4-methyl coumarin in a thick-wall pressure-resistant pipe containing a stirrer, adding tetrahydrofuran solvent, then slowly adding dimethyl butyne diacid in a stoichiometric ratio under stirring, and monitoring the reaction by TLC at normal temperature, removing the solvent under reduced pressure after the reaction is completed, and performing column chromatography separation to obtain the 7-amino coumarin derivative; the application has the advantages of flexible reaction time, cheap and easily-obtained solvent, simple operation, wide application range and the like, and is suitable for industrialized production; the synthesized 7-amino coumarin derivative has certain inhibiting effects on potato dry rot fungus, brassica nigra, tomato botrytis cinerea and apple rot fungus, and can be used as an antibacterial agent.

The present disclosure provides for a silver buffer composition for the staining of biological samples, where the disclosed silver buffer compositions are free from borax. In some embodiments, the silver buffer compositions include water, isopropyl alcohol, triethanolamine, and DABCO, wherein the composition has a pH ranging from about 9.3 to about 9.9. Also disclosed are methods of staining a biological sample using the disclosed silver buffer compositions.

The application relates to a preparation method of an oxidized indole compound and belongs to the technical field of catalytic synthesis. The application aims at solving the problems of high energy consumption, high cost and harsh reaction conditions in the existing synthesis method. The method comprises the following steps: adding heteroaryl formic acid compounds, N-aryl acrylamide compounds, DABCO, K2S2O8 and Fe(acac)3 into a solvent in sequence to obtain a mixed solution, irradiating the mixed solution with a light source under room temperature and in an inert gas atmosphere, and obtaining the oxidized indole compound. The method has the advantages of simple operation, preparation of the oxidized indole compound at room temperature, mild reaction conditions, use of cheap iron salt as a metal catalyst, cheap and easily-obtained raw materials, simple, convenient and efficient reaction, efficient realization of the reaction of the kilogram scale synthesis through the one-pot method with a catalytic amount of iron salt, and great potential large-scale application value. The application can be applied to the field of organic synthesis.

The invention discloses a metal organic framework material with a methoxy functional group and a preparation method and application thereof, and the preparation method of the metal organic framework material comprises the following steps: mixing and dispersing Zn (NO3) 2, 2-methoxyterephthalic acid and 1, 4-diazabicyclo [2.2. 2] octane DABCO in a solvent, dropwise adding an HNO3 solution to adjust the pH value of the solution to be acidic, and adding the mixed solution into a reaction kettle; stirring for 20-40 minutes, sealing, and carrying out heating reaction at 110-130 DEG C for 40-60 hours; and after the reaction is finished, carrying out post-treatment to finish the preparation. The metal organic framework material disclosed by the invention has relatively high separation selectivity on C2H2 / C2H4 / C2H6 at normal temperature and normal pressure.

This invention discloses a green, efficient, and selective method for synthesizing arylsulfonated tetrahydropyrido[1,2-a]indole, relating to the fields of organic synthesis technology and antitumor activity evaluation. Using DABCO·(SO2)2 as the SO2 source and acetone or 1,2-dichloroethane as the solvent, this invention achieves a tandem cyclization reaction of N-alkenyl-substituted indole initiated by aryl sulfone radicals under visible light conditions, selectively yielding arylsulfonated tetrahydropyrido[1,2-a]indole products with different reaction sites. Preliminary antitumor activity evaluation of the obtained arylsulfonated tetrahydropyrido[1,2-a]indole products was then conducted, revealing that product 3wd exhibited significant inhibitory activity against mouse skin melanoma cells B16F10. The synthetic method of this invention is green, efficient, and selective, and product 3wd exhibits significant inhibitory activity against B16F10 cells.

The invention provides a continuous synthesis method of p-acetoxyacetophenone. The continuous synthesis method comprises the following steps: (1) feeding a solution A containing p-acetophenone, a composite catalyst and a first organic solvent and a solution B containing acetic anhydride and a second organic solvent into a reactor for reaction; and step (2), carrying out post-treatment. Wherein the composite catalyst is prepared from 4-dimethylaminopyridine (DMAP) and triethylene diamine (DABCO), and the molecular weight of the composite catalyst is 8000-9000; in the step (1), the reactor is a micro-channel reactor; and in the step (1), the operation pressure of the reaction is negative pressure. The method disclosed by the invention realizes atom economy, efficient catalyst utilization and material closed-loop circulation, has the outstanding advantages of high yield (greater than or equal to 99%), good purity (greater than or equal to 99.8%), extremely few three wastes, low energy consumption, safety and easiness in amplification, and is suitable for green industrial production.