34 results about "DABCO" patented technology

The invention relates to a method for synthesizing tetrasubstituted ‑1,3‑enedicarboxylic acid, and discloses a method for synthesizing tetrasubstituted ‑1,3‑enedicarboxylic acid. The method comprises the following steps: using 1,3‑enyne and iodide as raw materials, potassium formate as a formate source, DABCO as a hydrogen transfer catalyst, Ir(bpy)2(dtbpy)PF6 as a photocatalyst, and cesium carbonate as a base, introducing CO2 under normal pressure, and obtaining an enedicarboxylic acid compound with an excellent to good yield under room temperature and visible light irradiation for 24 hours. The method has mild reaction conditions, good regioselectivity, and good functional group tolerance, and makes up for many deficiencies of the prior art.

Disclosed is a method of synthesizing a compound selected from the group consisting of C-alkyl glycosides, C-alkenyl glycosides, C-heteroaryl glycosides, Se-glycosides and S-glycosides, the method comprising: a. Reacting a natural unprotected sugar with a 2-chloro-1, 1, 1, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 The method comprises the following steps: reacting 1, 3-dimethylimidazoline chloride (DMC) and a mixture of heteroaryl mercaptan and trimethylamine (Et3N) in a mixture of water and dialkane to generate heteroaryl glycosyl thioether; b, under the irradiation of a blue light LED, in the presence of Hantzsch ester (HE), 1, 4-diazabicyclo [2.2. 2] octane (DABCO) and DMSO, heteroaryl glycosyl thioether and a reagent are subjected to light-induced cross coupling, and the compound is generated.

The invention relates to the technical field of organic synthesis, in particular to a method for preparing deuterated benzoxathiacyclohexadiene-4-ketone. At present, a method for preparing the deuterated benzoxathiacyclohexadiene-4 ketone is not reported yet. In order to solve the problems, the invention provides the method for preparing the deuterated benzoxathiinecyclo-hexadiene-4-ketone, and the deuterated benzoxathiinecyclo-hexadiene-4-ketone is successfully synthesized by taking thiosalicylic acid, DABCO.CD2Cl2, a solvent, water and HI as reaction raw materials through a one-pot method. The method provided by the invention provides a new thought for the preparation of the deuterated benzoxathiacyclo-hexadiene-4-ketone derivative, and has a relatively good application prospect.

The invention relates to a method for preparing oxcarbazepine impurities, which comprises the following steps of: reacting iminostilbene serving as a raw material with an oxidizing agent N-methylmorpholine-N-oxide under the catalysis of potassium osmate and DABCO to generate a diol intermediate; oxidizing the diol intermediate in the presence of an oxidizing agent 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone to obtain an alpha-hydroxy ketone intermediate; oxidizing the alpha-hydroxy ketone intermediate (III) in the presence of ammonium nitrate and copper acetate to obtain a diketone intermediate; and reacting the diketone intermediate (II) with isocyanate chlorosulfonate to obtain the oxcarbazepine impurity 11-ketone oxcarbazepine (I). The preparation method has the advantages of being convenient to operate, high in yield and good in product purity. # imgabs0 #

The present invention discloses a method for preparing 5-chloroindanone, and belongs to the technical field of chemical material preparation. The present invention uses 2-bromo-4-chlorobenzaldehyde as a raw material and acrylate under the action of DABCO to generate an intermediate; then, a cyclization reaction is performed under the action of a palladium catalyst and a base to generate 5-chloroindanone. The present invention adds an ionic liquid catalyst to cooperate with DABCO to perform a Baylis-Hillman reaction, thereby reducing the amount of DABCO used and improving the yield; through the bromine on the benzene ring and the olefin positional cyclization reaction, the generation of isomers is greatly reduced, while avoiding the isomers caused by the Friedel-Crafts cyclization reaction and a large amount of waste acid and wastewater, providing an effective new path for the preparation of 5-chloroindanone.

The application discloses a method for photocatalytically preparing 3-aminoquinoxalin-2(1 H )-ketone compounds, and belongs to the field of organic synthesis. The application comprises the following steps: quinoxalin-2(1 H )-ketone compounds, fatty amine compounds, a photocatalyst mpg-C3N4 (mesoporous graphite phase carbon nitride) and an alkali DABCO (1,4-diazabicyclo (2.2.2) octane) are added into an organic solvent and uniformly mixed; the reaction is carried out under the irradiation of light in an oxygen atmosphere; and after the reaction is completed, the 3-aminoquinoxalin-2(1 H )-ketone product is obtained through treatment and separation. The application uses DABCO as an alkali and an electron transfer agent, and adopts mpg-C3N4 to photocatalytically prepare 3-aminoquinoxalin-2(1 H )-ketone compounds under the auxiliary condition of DABCO, and it is concluded from DABCO quenching experiments and cyclic voltammetry experiments that there is a single electron transfer relationship between them; and the application has the advantages of mild reaction conditions, simple operation and the ability to synthesize 3-aminoquinoxalin-2(1 H )-ketone compounds in one step.

An oligomerization catalyst, oligomer products, methods for making and using same. The catalyst is synthesized MFI zeolite (ZSM-5) made from a combination of DABCO and methylamine (MEA) in the presence of Na cations.

The invention belongs to the technical field of organic synthesis methodology, and particularly relates to a photoinduced beta-cyano sulfone compound synthesis method based on a triarylamine electron donor acceptor compound and application of the photoinduced beta-cyano sulfone compound. According to the method, a substituted sulfonium salt serves as an electron acceptor, triarylamine serves as an electron donor to form an EDA compound, and under the action of visible light, the EDA compound is synthesized into a beta-cyano sulfone compound based on the triarylamine electron donor acceptor compound. The method comprises the following steps: by taking substituted cyanohydrin as a raw material and 4-diazabicyclo [2.2. 2] octane di (sulfur dioxide) adduct [(DABCO). (SO2) 2] as a sulfur source, adding an organic solvent, reacting in an inert gas at a certain temperature, and realizing a bifunctionalization process of olefin through far-end functional group migration, thereby obtaining the beta-cyano sulfone compound. The method does not need harsh reaction conditions, the reaction can be completed in one step, the reaction conditions are mild, and the method is green and environment-friendly. The beta-cyano sulfone compound and the derivative thereof prepared by the method are expected to be applied to the research and development fields of anti-cancer, antiviral and antibacterial medicines and the like.

The application belongs to the technical field of biological medicine, and relates to construction and application of a kind of nano oxygen delivery system based on internal peroxide. The application designs and synthesizes a kind of nano drug which can be used as a molecular oxygen delivery agent. In the nano drug, active molecules are composed of internal peroxide compound and 1,4-diazabicyclo[2.2.2]octane (DABCO), and the two molecules are constructed on gold nanorods to improve water solubility, biocompatibility and targeting of the active molecules. Finally, the active molecule modified gold nanorods obtained by the application can be used to relieve the damage of tissues and organs caused by hypoxia.

The invention relates to the field of polyester, and discloses low-humidity sensitive reactive foaming polyurethane resin and a preparation method thereof. The foaming polyurethane resin comprises the following raw materials, the component A comprises the following components in parts by weight: 40-50 parts of polyether polyol, 2-10 parts of a chain extender, 0.1-1 part of a tin amine compound catalyst and 0.05-1 part of water; the tin amine compound catalyst is prepared from DBTDL and DABCO according to the weight ratio of 1 to (0.8 to 1.2); and the component B comprises the following components in parts by weight: 25-35 parts of isocyanate, 10-20 parts of polyether polyol and 0.5-3 parts of a cross-linking agent. According to the invention, through active intervention of environment humidity and temperature, by utilizing a synergistic effect of compounding of specific types and specific proportions of tin amine catalysts, dynamic balance of a foaming reaction and a gel reaction is directly realized in a surface area, and generation of defects such as surface cell rupture and collapse is inhibited from the source; therefore, the foamed polyurethane which is narrow in cell size distribution and has a natural flat and smooth surface is obtained, and meanwhile, a foundation is provided for processing and production of the foamed polyurethane in a high-humidity environment and maintenance of relatively good comprehensive performance of the foamed polyurethane.

The invention discloses a preparation method of 5-chloroindanone, and belongs to the technical field of chemical material preparation. The preparation method comprises the following steps: taking 2-bromo-4-chlorobenzaldehyde as a raw material and reacting with acrylate under the action of DABCO to generate an intermediate; and performing cyclization reaction under the action of a palladium catalyst and alkali to generate the 5-chloroindanone. According to the invention, the ionic liquid catalyst is added to cooperate with the DABCO to carry out Baylis-Hillman reaction, so that the dosage of the DABCO is reduced, and the yield is improved; through the positioning cyclization reaction of bromine on a benzene ring and olefin, the generation of isomers is greatly reduced, the isomers and a large amount of waste acid and wastewater caused by Friedel-Crafts cyclization reaction are avoided, and an effective new path is provided for the preparation of 5-chloroindanone.

The invention relates to the technical field of organic synthesis, in particular to a method for synthesizing N-(acetamidomethyl) benzothiazine-4-ketone. At present, N-chloromethylacetamide is used in a synthetic method of N-(acetamidomethyl) benzothiazine-4-ketone, the synthetic route of the N-chloromethylacetamide is complex, and toxic raw materials such as CO gas also need to be used in the synthetic process of the N-chloromethylacetamide. In order to solve the problems, the invention provides the method for synthesizing the N-(acetamidomethyl) benzothiazine-4-ketone, the N-(acetamidomethyl) benzothiazine-4-ketone is successfully prepared by taking benzothiazine-4-ketone, DABCO.DCM, hydroiodic acid, acetonitrile and the like as reaction raw materials through a one-pot method, the use of N-halogenated methylacetamide is avoided in the reaction, and the reaction yield is high. The reaction is more efficient, and the reaction process is more environment-friendly.

The invention discloses a fluorescence detection reagent, a method for doping labeled nucleotide by using the reagent, and a kit or a mixture system. The fluorescence detection reagent contains an enzymatic deoxygenation system and a plurality of reducing agents, and does not contain DABCO. The composition is suitable for application scenarios involving detection of fluorescence signals, in particular for application including detection of single-molecule fluorescence signals.

The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of an indole-substituted dihydrothiophene compound. According to the method, MBH ester derived from oxoindole and alpha-enol dithioester are taken as raw materials, reaction is realized through DABCO catalysis and a'two-step one-pot method 'under a mild room temperature condition, and an intermediate does not need to be separated. The method is simple and convenient in process operation, mild in condition, controllable in raw material cost and environment-friendly. The obtained product is novel in structure and good in yield, and has remarkable application potential in the fields of research and development of antibacterial, anti-inflammatory and anti-tumor drugs and the like.

The present application relates to the technical field of organic synthesis, in particular to a method for preparing deuterated benzoxathiie-4-ketone. At present, there is no report on the method for preparing deuterated benzoxathiie-4-ketone. In view of the above problems, the present application provides a method for preparing deuterated benzoxathiie-4-ketone. The method uses thiosalicylic acid, DABCO·CD2Cl2, a solvent, water and HI as reaction raw materials, and successfully synthesizes deuterated benzoxathiie-4-ketone by one-pot method. The method provides a new idea for the preparation of deuterated benzoxathiie-4-ketone derivatives, and has good application prospect.

The invention discloses a column layer ultra-microporous metal organic framework material and a preparation method and application thereof in gas separation, the chemical formula of the metal organic framework material is [Co3 (BDC-CH3) 3 (DABCO)] n, BDC-CH3 is a first organic ligand 2-methyl-1, 4-phthalic acid, and DABCO is a second organic ligand 1, 4-diazabicyclo [2.2. 2] octane. The pore structure of the column layer ultramicropore metal organic framework material is a triangular pore channel, the column layer ultramicropore metal organic framework material has high adsorption energy and high adsorption capacity for acetylene, regeneration can be achieved, acetylene can be preferentially adsorbed from acetylene / carbon dioxide mixed gas, the adsorption selectivity is relatively high, and therefore efficient separation of acetylene and carbon dioxide is achieved.

The present invention discloses a columnar ultramicroporous metal organic framework material, a preparation method thereof and an application in gas separation. The chemical formula of the metal organic framework material is [Co3(BDC-CH3)3(DABCO)] n The columnar ultramicroporous metal-organic framework material of the present invention has a triangular pore structure, exhibiting strong adsorption energy and high adsorption capacity for acetylene. It is also regenerative and can preferentially adsorb acetylene from an acetylene / carbon dioxide mixture with relatively high adsorption selectivity, thereby achieving efficient separation of acetylene and carbon dioxide.

This invention discloses a columnar metal-organic framework material, its preparation method, and its application in oxygen purification. The material has the general structural formula MNi-dabco, where M represents the divalent metal ion Fe. 2+ Co 2+ Ni 2+ Cu 2+ One of the components; Ni represents potassium tetracyanonitrile hydrate; dabco represents the columnar ligand triethylenediamine. The CoNi-dabco of this invention exhibits an Ar adsorption capacity of 7.69 cm³ / g under 298 K and 1 bar conditions, and an IAST selectivity of 1.71 for an Ar / O₂ (5 / 95, v / v) binary mixture. Using this material for dynamic breakthrough separation, high-purity oxygen with a purity exceeding 99.99% can be obtained in one step from an Ar / O₂ (5 / 95, v / v) mixture, with an oxygen yield exceeding 6.08 L / kg, demonstrating significant potential for industrial application.

The present invention discloses a visible light-mediated 3-alkylquinoxaline-2 (1 H ) A method for synthesizing ketone compounds, comprising reacting the raw material 3,4-dihydro-1 H The 2-quinoxaline ketone compound and the alkyl NHPI ester compound are placed in a reaction solvent, and reacted under the action of a catalyst 4CzIPN and a base DABCO, and under the conditions of blue light irradiation and air environment to obtain the target product 3-alkylquinoxaline-2 (1 H ) ketone compounds. The present invention uses greener and cleaner visible light as energy to induce the reaction, and uses green and environmentally friendly solvent dimethyl carbonate as a reaction solvent. The raw materials are simple and easy to obtain, and the yield of the target product is high.

The invention discloses a singlet oxygen-triplet oxygen synergistic delivery carrier and application thereof, and belongs to the technical field of biological medicines. The carrier is formed by taking an internal peroxide structure as a core and taking L-proline and 1, 4-diazabicyclo [2.2. 2] octane (DABCO) as singlet oxygen physical quenching groups. An internal peroxide structure is subjected to a reverse cyclization reaction at a certain temperature to release toxic singlet oxygen, and meanwhile, a quenching group quenches part of singlet oxygen to generate triplet oxygen, so that the molecule has the effects of relieving tumor hypoxia and killing tumors at the same time. An in-vitro test proves that the molecule provided by the invention releases triplet oxygen while releasing singlet oxygen, so that synergistic delivery of singlet oxygen-triplet oxygen is realized. According to the invention, establishment of the singlet oxygen-triplet oxygen synergistic delivery carrier is successfully realized, and the singlet oxygen-triplet oxygen synergistic delivery carrier can be used for relieving tumor hypoxia and improving the singlet oxygen killing effect, and has a wide application prospect.

The invention discloses a method for efficiently synthesizing an indanone compound, which comprises the following steps: sequentially adding benzamide and norbornene into a reaction container according to a molar ratio of 1: 2, then adding a solvent, then adding 10.0% of a catalyst Pd (PPh3) 2Cl2, 20.0% of a ligand PCy3, 300% of an oxidant Cu (OAc) 2, 200% of alkali K2CO3 and 100% of the molar weight of benzamide, reacting for 24 hours in 5 mL of toluene in an air atmosphere under the condition of 130 DEG C oil bath, cooling to room temperature, adding water, and reacting for 2 hours at the temperature of 120 DEG C to obtain the indanone compound. And extracting with ethyl acetate for three times, combining organic layers, concentrating under reduced pressure, and purifying the product by column chromatography to obtain the indanone compound. The reaction substrate is wide in source, commercially available, good in yield, good in selectivity, easy to separate and purify, less in pollution and simple in operation step, a coupling reaction among molecules of raw materials can be avoided, and the generated indanone compound is widely applicable to organic synthesis design of organic chemical reaction, bioactive intermediates, advanced materials and pesticides.

The invention discloses a method for synthesizing a methylated aza-uracil derivative, which comprises the following steps: adding an aza-uracil derivative into a glass reaction container, and stirring to react under the irradiation of a 10W blue lamp with the wavelength of 455 nm by taking DMSO as a methyl source and a solvent, taking fluorescein as a photocatalyst and taking DABCO as alkali. And separating and purifying the crude product by column chromatography to obtain the 6-methyl aza-uracil derivative. According to the invention, fluorescein which is cheap and easy to obtain is used as a photocatalyst, and a metal catalyst and a strong oxidant are not needed. In addition, the reaction conditions are mild, and excellent functional group tolerance is achieved.

The application relates to the technical field of pharmaceutical chemistry, and discloses a benzazepine bridged ring derivative and a preparation method thereof. The preparation method comprises the following steps: adding a substrate (1.0 eq), a sulfur-substituted benzylpropyl aldehyde (1.5 eq), a base DABCO (0.2 eq) and dry acetonitrile (2.0 mL) into a reaction test tube, mixing the mixture at normal temperature for 24 hours, concentrating and purifying after the reaction is completed to obtain a hemiacetal product 3. Then the hemiacetal product, chloroform (0.5 mL) and H2O (100 muL) are added into the reaction test tube, and stirring is carried out at 60 DEG C for 72 hours. The reaction is monitored to be completed through thin layer chromatography, then the reaction mixture is directly purified through column chromatography to obtain a corresponding target product. The preparation method has the advantages of simple operation, mild reaction and high yield. The derivative provided by the application has good antibacterial activity, and has a wide market application prospect.

The present invention belongs to the field of detection and analysis technology, and discloses a mercury fluorescent probe based on carbazole boronic acid and a preparation method thereof. 9H-carbazole-3-boronic acid pinacol ester and compound Y (any one of KOH, K2CO3, Cs2CO3, NaH, triethylamine, DBU, DMAP, and DABCO) are dissolved in a polar aprotic solvent, and then alkylene oxide is added. After heating and stirring for a period of time, material A is obtained; the organic phase in material A is extracted with EA, and then compound B is obtained by column chromatography purification; compound B is dissolved with a solution of acetone / water or THF / water, and then a mixture of NaIO4 and CH3COONH4 or a mixture of NaIO4 and hydrochloric acid is added. After reacting for a period of time, the organic phase is extracted with EA, and then the fluorescent probe is obtained by column chromatography purification. The fluorescent probe provided by the present invention can be used for quantitative detection of mercury ions and methylmercury in water samples, and has good sensitivity and selectivity. The present invention further provides the application of two other compounds as fluorescent probes in mercury detection.

The invention discloses a method for synthesizing methylated products of nitrogen heterocyclic and oxygen heterocyclic compounds, which comprises the following synthesis processes: firstly, placing a target heterocyclic compound in a glass reaction container, then adding dimethyl sulfoxide (DMSO) as a methyl donor and a solvent, adopting fluorescein as a photocatalyst, adding 1, 2, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4 2, 4-diazabicyclo [2.2. 2] octane (DABCO) is used as an alkaline additive. Under the condition of room temperature, a blue light source with the power being 10 watts and the wavelength being 455 nanometers is used for carrying out illumination stirring reaction. And after the reaction is completed, purifying through a column chromatography separation technology to finally obtain the methyl-substituted nitrogen heterocyclic or oxygen heterocyclic compound. The unique photocatalytic system disclosed by the invention can efficiently realize methylation reaction of nitrogen heterocyclic ring and oxygen heterocyclic ring without depending on a metal catalyst or a strong oxidant, and excellent yield and good functional group compatibility are obtained.

This invention relates to the field of fine chemical technology and discloses a method for preparing N-methyl-2,3-dihydrobenzothiazin-4-one. Specifically, the method involves using 2-mercapto-N-methylbenzamide and 1-(chloromethyl)-1,4-diazabicyclo[2.2.2]octane-1-ammonium chloride (DABCO•DCM) as raw materials, with hydroiodic acid (HI) as an important additive. A one-step reaction is carried out in acetonitrile at 100-120°C. After purification, the target product, N-methyl-2,3-dihydrobenzothiazin-4-one, is obtained. This method is simple to operate, has a high yield, and does not require the use of formaldehyde, a carcinogen, as a reactant, making it potentially applicable.

Synthesizing an ionene polymer includes combining a soft segment, a hard segment, and a solvent to yield a mixture, and heating the mixture to yield the ionene polymer. The soft segment includes bromine end-capped poly(tetramethylene oxide (Br-PTMOn-Br), and the hard segment comprises a linear aliphatic compound or 1,4-diazabicyclo[2.2.2]octane (DABCO).

The application discloses a 7-amino coumarin derivative and a synthesis method and application thereof, and the synthesis method comprises the following steps: placing substituted 3-cyano-4-methyl coumarin and 20% Dabco of the volume of the substituted 3-cyano-4-methyl coumarin in a thick-wall pressure-resistant pipe containing a stirrer, adding tetrahydrofuran solvent, then slowly adding dimethyl butyne diacid in a stoichiometric ratio under stirring, and monitoring the reaction by TLC at normal temperature, removing the solvent under reduced pressure after the reaction is completed, and performing column chromatography separation to obtain the 7-amino coumarin derivative; the application has the advantages of flexible reaction time, cheap and easily-obtained solvent, simple operation, wide application range and the like, and is suitable for industrialized production; the synthesized 7-amino coumarin derivative has certain inhibiting effects on potato dry rot fungus, brassica nigra, tomato botrytis cinerea and apple rot fungus, and can be used as an antibacterial agent.

The present disclosure provides for a silver buffer composition for the staining of biological samples, where the disclosed silver buffer compositions are free from borax. In some embodiments, the silver buffer compositions include water, isopropyl alcohol, triethanolamine, and DABCO, wherein the composition has a pH ranging from about 9.3 to about 9.9. Also disclosed are methods of staining a biological sample using the disclosed silver buffer compositions.

The application relates to a preparation method of an oxidized indole compound and belongs to the technical field of catalytic synthesis. The application aims at solving the problems of high energy consumption, high cost and harsh reaction conditions in the existing synthesis method. The method comprises the following steps: adding heteroaryl formic acid compounds, N-aryl acrylamide compounds, DABCO, K2S2O8 and Fe(acac)3 into a solvent in sequence to obtain a mixed solution, irradiating the mixed solution with a light source under room temperature and in an inert gas atmosphere, and obtaining the oxidized indole compound. The method has the advantages of simple operation, preparation of the oxidized indole compound at room temperature, mild reaction conditions, use of cheap iron salt as a metal catalyst, cheap and easily-obtained raw materials, simple, convenient and efficient reaction, efficient realization of the reaction of the kilogram scale synthesis through the one-pot method with a catalytic amount of iron salt, and great potential large-scale application value. The application can be applied to the field of organic synthesis.