78results about How to "Reduce the feed ratio" patented technology

The invention relates to a production process and special device of the condensation process of N-long-chain acyl amino acid salt. By adopting the process and special device, the hydrolysis of acyl chloride can be inhibited and the content of the by-product fatty acid salt can be reduced in the condensation process of acyl amino acid type surfactant. Therefore, the weight of the surfactant can be increased, the content of fatty acid salt can be reduced by 50%-75% compared with the single-pot reaction, the conversion rate can be increased to more than 99%, the feeding ratio can be reduced, the condensation time can be shortened and the production efficiency can be increased.

The invention belongs to the technical field of organic compounds and in particular relates to a method for preparing dicyclohexyl methane diisocyanate by a non-phosgene method. In the method, 4,4'-diamino dicyclohexyl methane or an isomer mixture thereof or salt thereof or a mixture of amine and salt thereof, serving as a raw material, reacts with di(trichloromethyl)carbonic ester or trichloromethyl chloroformate or a mixture of the di(trichloromethyl)carbonic ester and the trichloromethyl chloroformate in an inert solvent. By the method, defects of long process route, complex technology, low safety and the like in the preparation of the 4,4'-dicyclohexyl methane diisocyanate by the traditional phosgene method are overcome. The method has the advantages of convenience of operation, high safety and environmental friendliness. In the method, reactants are charged and metered accurately and rate of charge is reduced, so production safety coefficient is improved. Tail gas is simple in treatment; hydrogen chloride gas generated by the reaction is absorbed by water; high-purity hydrochloric acid can be prepared; chloride ions can be utilized completely; and environmental friendliness is contributed.

The invention belongs to the technical field of organic compounds and in particular relates to a method for preparing methylcyclohexyl diisocyanate by non-phosgene. The method comprises the following step of: reacting methylcyclohexyl diamine or an isomer mixture thereof or salt thereof or a mixture of amine and salt thereof as a raw material with bis(trichloromethyl)carbonate or trichloromethyl chloroformate or a mixture of the bis(trichloromethyl)carbonate and the trichloromethyl chloroformate in an inert solvent. In the method, the phosgene is replaced by the bis(trichloromethyl)carbonate or the trichloromethyl chloroformate or the mixture of the bis(trichloromethyl)carbonate and the trichloromethyl chloroformate; and the bis(trichloromethyl)carbonate or the trichloromethyl chloroformate or the mixture of the bis(trichloromethyl)carbonate and the trichloromethyl chloroformate reacts with methylcyclohexyl diamine or salt thereof to prepare the methylcyclohexyl diisocyanate. Compared with the traditional phosgene method, the method provided by the invention has convenience for operation, high safety, environment friendliness and mild reaction condition; and because the charging and the reaction are performed in normal pressure, the requirements on production equipment are reduced, and the process is simplified.

The invention discloses preparation of a modified hydrodechlorination catalyst and a method for producing high-purity chloroacetic acid. The modified hydrodechlorination catalyst comprises the following ingredients by mass percent: 0.5-2.0% of a metal active component elementary substance, 1.0-4.0% of a metal additive elementary substance and the balance of a carrier, wherein the metal active component elementary substance is selected from one or more of palladium, platinum and nickel; the metal additive elementary substance is selected from one or more of rhenium, zirconium, ruthenium, cadmium, barium and vanadium; and the carrier is selected from one or more of activated carbon, aluminium oxide, titanium dioxide and aluminum fluoride. The catalyst has the characteristics of high hydrogenation reduction performance, good selectivity, stable performance, small charge rate during use, reusability, easy recycling and the like. According to the prepared catalyst, hydrodechlorination can be performed on dichloroacetic acid and trichloroacetic acid or a mixed liquid of the two to obtain high-purity chloroacetic acid, and zero mother liquor discharge is realized.

The present invention discloses a method for producing isopropanolamine by using a fixed bed tubular reactor. The method comprises: by using water as a catalyst, putting ammonia and epoxy propane with a molar ratio of (3.5-15):1 into a fixed bed reactor to perform a reaction, wherein the operation pressure of the reactor is 8-25 MPa, and the operation temperature is 160-220 DEG C; pumping a reaction product sequentially into a first flash evaporation tank and a second flash evaporation tank, performing two-stage flash evaporation and ammonia removal on the reaction product, and then introducing the processed reaction product into a dehydration tower for primary dehydration; introducing dehydration materials at the bottom of the dehydration tower into a monoisopropanolamine rectification tower, introducing discharged materials at the top of the monoisopropanolamine rectification tower into a monoisopropanolamine conversion reactor, and returning the materials to the bottom of the monoisopropanolamine rectification tower after reaction; introducing discharged materials at the top of the monoisopropanolamine rectification tower into a diisopropanolamine rectification tower, and after low pressure rectification, obtaining diisopropanolamine at the top of the diisopropanolamine rectification tower, and obtaining triisopropanolamine at the bottom of the diisopropanolamine rectification tower. The method provided by the present invention is capable of reducing the energy consumption of the whole process, effectively avoids reaction and side product generation, and improves the product purity.

The invention discloses a calcined anionic clay visible-light catalyst and a preparation method and purposes thereof. The catalyst is prepared by the following steps of preparing mixed solution of metal salts and urea; heating the mixed solution to the temperature of between 100 and 120 DEG, reacting for 36 to 54 h, and obtaining acidic turbid liquid of which the pH value is between 6.0 and 6.5; centrifuging the acidic turbid liquid, taking precipitation out, washing the precipitation by deionized water until the pH value is neutral, and dewatering and drying; and grinding the dried precipitation, calcining the precipitation at the temperature of between 400 and 900 DEG C for 4 to 6 h, and thus obtaining the calcined anionic clay visible light catalyst, wherein the metal salts comprise divalent metal salts and trivalent metal salts. The prepared calcined anionic clay visible light catalyst can catalytically degrade organic wastewater in visible light, ultraviolet light equipment is not required, a feeding ratio is low, the degradation time is short, and the calcined anionic clay visible-light catalyst has low energy consumption and high efficiency and is suitable for the treatment of medium and low-concentration industrial wastewater.

The invention discloses a cycleanine production and purification method which includes the steps: cooling cycleanine production reaction liquid for the first time; filtering the cycleanine productionreaction liquid; cooling filtrate for the second time and then performing standing, crystallization, filtering and drying to obtain a cycleanine product. According to the cycleanine production and purification method, cycleanine product post-treatment purification operation steps are simplified, hot filtration is omitted, the potential safety hazards of operators are reduced, production operationsafety level is reduced, and the method is green and environmentally friendly. The obtained cycleanine product is high in purity and good in quality, medication safety is improved, and industrialization is facilitated.

The invention discloses a high-purity metformin hydrochloride preparation method. N-methyl pyrrolidone is used as a solvent, dicyandiamide and dimethylamine hydrochloride are taken as a solute, the solvent and the solute are added into a synthesis kettle for reaction, and metformin hydrochloride is prepared through steps of stirring, cooling, spin-drying, washing, crystallizing and drying. The metformin hydrochloride prepared through the preparation method provided by the invention has the advantages that the yield is higher than 96.4 percent, and the product purity is higher than 99.93 percent.

The invention relates to the field of animal feeds for livestock and poultry, and especially relates to a feed added with a protein-mulberry leaf additive for reducing cholesterol contents of livestock meat, poultry meat and eggs as well as a preparation method thereof. The feed added with the protein-mulberry leaf additive for reducing the cholesterol contents of the livestock meat, the poultry meat and the eggs comprises the following raw-material ingredients in parts by weight: 35-60 parts of protein-mulberry leaves, 15-20 parts of pine needle powder, 1.2-2.0 parts of dendranthema indicum, 2.0-2.7 parts of wormwood, 1.0-1.5 parts of eucommia ulmoides leaves, 1.0-1.5 parts of lotus leaves, 10-20 parts of rice bran, 10-20 parts of corn powder and 10-30 parts of fermentation broth of live bacteria. The protein-mulberry leaves, the dendranthema indicum, the wormwood, the pine needle powder, the eucommia ulmoides leaves, the lotus leaves and so on are mixed according to a certain ratio in the preparation method, and the mixture is then fermented; thus, the fermented materials are enabled to exert synergistic effects, and the feed is capable of improving qualities of the livestock meat, the poultry meat and the eggs. Moreover, the feed is capable of enhancing antioxidant capabilities of living bodies and slaughtered muscle tissues of the livestock and the poultry, so as to reduce oxidation products and prevent fatty acid formation in the meat; thus, the feed greatly reduces the low-density cholesterol contents in the livestock bodies and the poultry bodies.

The invention relates to an austenitic stainless steel for passenger cars, which comprises chemical compositions in mass percent: not more than 0.03% of C, 0.3-0.9% of Si, 0.6-1.5% of Mn, 16.0-18.0% of Cr, 5.5-7.5% of Ni, 0.1-0.22% of N, 0.1-0.6% of Cu, not more than 0.040% of P, no more than 0.03% of S, and the balance of Fe and unavoidable impurity elements; and moreover, Md is between 20-45 DEG C. A method for producing the stainless steel comprises the steps that a steel ingot or a slab is produced; then, the steel ingot or the slab is heated by a heating furnace to 1210-1270 DEG C, and the heating time is between 1-2 minute/mm; the steel ingot or the slab is rolled into a strip steel or a plate after being thermally deformed within the scope of 900-1200 DEG C; solid solution treatment and acid washing are carried out within the temperature scope of 1050-1150 DEG C, and the thermal treatment time is determined every 3-5 minutes according to the thickness of each millimeter; and next, cold rolling is carried out, 80% of austenite is enabled to be converted into deformed martensite after the cold rolling, the total rolling reduction of cold rolling is generally 60-80%, and the temperature of a material is controlled not to be higher than 45 DEG C during the cold rolling process.

The invention disclose a 4,4-dimethyl 3,5,8-trioxabic [5,1,0]ycloctane and particularly relates to a preparation process method of a gadobutrol epoxy side chain intermediate. According to the preparation process method disclosed by the invention, by adjusting the weight ratio of feeding materials, optimizing reaction conditions and improving post treatment and purification methods, the impurity content of an obtained gadobutrol epoxy side chain intermediate product is low; the quality of the intermediate product is greatly improved while the yield is increased, so that the difficulty of process control of the gadobutrol crude drugs during the production process is reduced, and the quality and the qualification rate of the gadobutrol crude drugs are improved. The preparation process method disclosed by the invention has the advantages of simple operation methods in all process steps, safe and feasible solvent and technological conditions, realization of green and environmental-friendly production and wide application prospect.

The invention discloses a method for producing gamma-chloropropyl trichlorosilane. The method comprises the following process steps of: forming mixed solution by using chloropropene and trichlorosilane; adding part of platinum catalyst solution into part of the mixed solution; reacting for a period of time, and uniformly adding the residual mixed solution dropwise; reacting the mixed solution with the residual platinum catalyst solution continuously; adding part of chloroplatinic acid catalyst solution and all n-butylamine; reacting for a period of time, and adding the residual chloroplatinicacid catalyst solution; and under the conditions of vacuum degree of more than or equal to 0.096 MPa and gaseous phase temperature on the top of more than or equal to 95 DEG C after the dropping of the residual mixed solution and the reaction are finished, distilling materials to obtain the product gamma-chloropropyl trichlorosilane. In the method, the mixed solution of the raw materials are added into a reaction system uniformly; the reaction catalyst at the early stage and the reaction catalyst at the later stage are added segmentally; initiation and the reaction are performed by stages; the reaction is performed completely; a small number of reaction byproducts are obtained; a reaction conversion rate is high; the purity of the product is improved; and reaction time is shortened.

The invention discloses a preparation method of an asymmetric organic persulfide compound. The preparation method comprises the following step: under the promotion of alkali, carrying out one-pot reaction on a compound shown in a formula (I), a compound shown in a formula (II) and thiourea to obtain the asymmetric organic persulfide compound shown in a formula (III). The preparation method is mild in reaction condition, easy to operate and high in yield. The preparation method can be used for preparing organic persulfide compounds and realizing the overvulcanization modification of pharmaceutical molecules such as acetaminophen and estrone and natural product molecules such as zingiberone and amino acid.

The invention discloses a narrow molecular weight distribution chloroether resin and a preparation method thereof. The narrow molecular weight distribution chloroether resin comprises, by mass, 1.5-3parts of a dodecyl sodium salt, 2.5-7 pats of isobutyl vinyl ether, 0.4-0.9 parts of a persulfate, 2.5 parts of sodium dodecyl sulfate, 1.25-2.15 parts of a buffer agent, 65-80 parts of vinyl chlorideand 17.5-35 parts of isobutyl vinyl ether. The preparation method comprises: adding a part of isobutyl vinyl ether into a polymerization reactor, reducing a use amount of a buffer agent in the polymerization reactor to 0-1/3 the total use amount of the buffer agent and carrying out a reaction process under constant temperature and constant pressure control to obtain chloroether resin. The chloroether resin has narrow molecular weight distribution, contains regular particles and has a loose structure and good processing properties. The preparation method has the advantages of stable reaction,easy control, large polymerization rate, short reaction time and low raw material cost.

The invention relates to a synthesis method of a rosuvastatin calcium intermediate. The rosuvastatin calcium intermediate is [4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamide)-5-pyrimidyl] triphenylphosphonium bromide.[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamide)-5-pyrimidyl] triphenylphosphonium bromide is successfully prepared by a one-pot method by using a mixed organic solvent of tetrahydrofuran and methylbenzene to unify a reaction medium for a three-step reaction. Any separation and purification operation is not required in a reaction process; the synthesis steps are simplified; a feed ratio in the reaction process is reduced; raw materials are saved; a better reaction yield and purity are achieved; the total yield reaches above 80%; the purity is above 99.6%; the operating cost is saved; the production cost is lowered.