310 results about "N acylaminoacid" patented technology

Skin care compositions containing N-acyl amino acid, particularly N-acyl derivatives of Phenylalanine or Tyrosine, their isomers, or their salts; at least one other skin care active selected from sugar amines, vitamin B3, retinoids, peptides, dialkanoyl hydroxyproline, hexamidine, salicylic acid, and phytosterol; and a dermatologically acceptable carrier for the N-acyl amino acid and the skin care active. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the skin care composition of the invention.

An aqueous hair cleansing composition comprising (a) at least one alkyl poly glucoside; (b) at least one betaine compound; and (c) at least one acyl amino acid, wherein the composition is sulfate free.

Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and / or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

Method for regulating the condition of mammalian skin comprising the steps of applying a first personal care composition to an area of skin where regulation is desired, wherein the first personal care composition comprises at least one skin care active selected from the group consisting of niacinamide, salicylic acid, peptides, N-acetyl glucosamine, panthenol, butylated hydroxytoluene, N-acyl amino acid compounds, hexamidine, green tea, ascorbyl glucoside, hexanediol, pentanediol, a skin lightening agent, a heat shock protein potentiator, and mixtures thereof, and delivering energy to the area of skin by contacting the skin with an energy delivery device for a treatment period of at least 2½ minutes, wherein the energy delivery device comprises a skin-contacting surface that is controllably heatable to a temperature of from 37° C. to 50° C.

To provide a stable water-repellent inorganic powder which is substantially free from re-dissolution of a silicon compound used for surface treatment whether an organic solvent is polar or non-polar.A water-repellent inorganic powder which is surface-treated with a silicon compound, wherein the silicon compound is one having a group reactive with the inorganic powder, and when the inorganic powder is dispersed in any of polar organic solvents and non-polar organic solvents, the retention of the silicon compound is at least 90%. Preferably, the silicon compound is an aqueous emulsion of any of methylhydrogen silicone oil, alkoxy-modified silicone oil, amino-modified silicone oil, epoxy-modified silicone oil, polyether-modified silicone oil or carboxyl-modified silicone oil, and to the aqueous emulsion, at least one surfactant selected from the group consisting of a sorbitan fatty acid ester type, a polyoxyethylene sorbitan fatty acid ester type, a polyethylene glycol fatty acid ester type, a polyoxyethylene fatty acid ester type, an N-acylamino acid type, a polyoxyethylene alkyl ether type and a polyoxyethylene alkylphenyl ether type, is incorporated.

Personal care compositions containing at an alpha-glucan and / or beta-glucan; at least one additional skin and / or hair care active selected from the group consisting of sugar amine, vitamin B3, retinoids, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), menthyl anthranilate, cetyl pyridinium chloride, ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, tetrahydrocurcumin, their derivatives, their precursors, and combinations thereof; and a dermatologically acceptable carrier.

The invention discloses environment-friendly high-wear-resistance lubricating oil and a preparation method thereof. The lubricating oil comprises base oil, an antirust agent, an antioxidant and an anti-wear agent at extreme pressure, wherein the anti-wear agent at extreme pressure is a synthesized fullerene C60N-acyl amino acid derivative. The environment-friendly high-wear-resistance lubricating oil and the preparation method thereof have the advantages that the product has high biodegradation ratio, is applicable to any occasions and has extremely low friction coefficient; the product does not contain elements such as sulfur and phosphorus, so when the environment-friendly high-wear-resistance lubricating oil is used as internal combustion engine oil, pollutants discharged by an internal combustion engine are reduced and the discharge requirement above national IV can be met.

Skin care compositions containing dehydroacetic acid, its isomers, salts, and derivatives thereof; at least two skin care actives selected from sugar amines, vitamin B3 compounds, phytosterols, salicylic acid compounds, hexamidines, dialkanoyl hydroxyproline compounds, flavonoids, n-acyl amino acid compounds, and their derivatives, and combinations thereof; and a dermatologically acceptable carrier for the dehydroacetic acid and the skin care actives. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the skin care composition of the invention.

The invention relates to a synthetic method of lauric acyl amino acid sodium, particularly to a synthetic method which uses lauric acid and phosgene as raw materials. The synthetic method comprises the following steps: ensuring that the reaction lasts for 1 to 20 hours at a temperature of 60 to 100 DEG C with the effect of organic amide catalyst; obtaining acyl chloride through vacuum distillation after the reaction is finished; dripping lauric acyl chloride obtained according to the phosgene method into amino acids alkaline solution for reaction; controlling and ensuring the pH value to be within the range of 8 to 10, the reaction temperature to be 15 to 20 DEG C, and the reaction time to be 4 to 5 hours; carrying out cooling after the reaction is finished; acidizing the reaction solution to pH 1 to 2 with hydrochloric acid solution; filtering, washing and drying white sediment to obtain lauric acyl amino acid; dissolving the prepared lauric acyl amino acid with alcohol; adding alcohol solution with sodium hydroxide of equal molar amount; and crystallizing, sucking, filtering and drying after cooling to obtain the lauric acyl amino acid sodium. According to the invention, the synthetic method is reasonable in process, high in reaction efficiency and good in product quality; the three wastes are seldom generated; and no residual phosphorus and sulfur are contained in the product. Therefore, the synthetic method can be widely used in the production of high-end surface active agents, and has significant utility value and social and economic benefits.

The invention relates to a production process and special device of the condensation process of N-long-chain acyl amino acid salt. By adopting the process and special device, the hydrolysis of acyl chloride can be inhibited and the content of the by-product fatty acid salt can be reduced in the condensation process of acyl amino acid type surfactant. Therefore, the weight of the surfactant can be increased, the content of fatty acid salt can be reduced by 50%-75% compared with the single-pot reaction, the conversion rate can be increased to more than 99%, the feeding ratio can be reduced, the condensation time can be shortened and the production efficiency can be increased.

The present invention relates to formulations for corrosion-inhibiting, emulsifying, lubricating or as a surfactant in organic hydrocarbon and / or water based system containing an acyl amino acid derivative and a triazole derivative.

Clear solid suspension antiperspirant compositions comprise 0.5 to 50% by weight of a particulate antiperspirant active material of which less than 50% by weight of its particles are below 110pm diameter and a refractive index of from 1.49 to 1.57 at 22° C. is suspended in a water-immiscible carrier liquid of which at least 50% by weight is selected from liquid non-volatile silicone oils and liquid alkyl-aryl esters and not more than 25% by weight of the carrier liquid comprises a volatile silicone oil. The carrier liquid and the antiperspirant have refractive indexes which differ by no more than 0.02 at 22° C and the structurant which solidifies the carrier liquid comprises a fibre-forming non-polymeric structurant, and preferably an N-acyl aminoacid amide such as GPl and / or a cyclodipeptide such as a thymol derivative of (2S-cis)-(-)-5-benzyl-3,6-dioxo-2-piperazine acetic acid.

An acylamino acid compound is described which can be used in food preparations to generate a savory tingling sensation without burning effect.

The invention relates to novel oxazinones designed to bind to the penicillin receptor, methods of synthesizing the compounds, and the use of the compounds as antibacterial agents. The compounds have the general formula (I)Preferably the compounds have a carboxyethyl or a substituted carboxymethyl substituent at the 2-position and a hydroxyl group at the 5-position and have a molecular shape suitable for binding to and reacting with the active site of a pencillin-recognizing enzyme. The compounds are synthesized by condensing a carboxyl-protected N-hydroxy amino acid with a 3-hydroxyprotected-4-bromobutanoic acid to form a a doubly protected N-hydroxy N-acylamino acid, which is cyclized with an organic base to yield a doubly protected 1,2-oxazin-3-one. The protecting groups are then removed to provide an antibacterial agent.

A two-part hair dye which is composed of a first part containing an alkali agent, a second part containing hydrogen peroxide, and a non-aerosol foamer container for discharging a liquid mixture of the first part and the second part in the form of a foam, the liquid mixture containing the following components (A) and (B):(A) a polymer or copolymer containing 70% or more mole fraction of diallyldimethyl quaternary ammonium salt monomer, and(B) an N-acylamino acid salt, an N-acyl-N-alkylamino acid salt, or an ether carboxylic acid salt,wherein, an equivalent ratio of the anion site of the component (B) to the cation site of the component (A) (anion / cation) is more than 1, and a viscosity of the liquid mixture at 25° C. is 1 to 300 mPa·s.

Many cosmetic stick compositions containing a continuous phase of a water-immiscible cosmetic oil structured by a fibre-forming amido structurant and an active cosmetic ingredient either exhibit poor physical stability when formed, or cannot be made readily using conventional processes for making stick compositions. The problem can be ameliorated or overcome by the use of a combination of amido structurants comprising in class (i) an N-acylaminoacid amide in which the N-acyl substituent has the formula —CO—RX in which RX represents a branched C6 to C11 alkyl group in combination with a further amido structurant, (class (ii), including a polyamido-substituted cyclohexane, an amido derivative of di or tricarboxylic acids or an hydroxystearamide and particularly employing an N-acylaminoacid amide in which the N-acyl substituent contains a linear alkyl group, or a cyclodipeptide.

A chiral inorganic mesoporous material characterized by having a chiral twisted structure and being mesoporous; a process for producing the material; and a method of using the material. The process for inorganic mesoporous material production is a method in which one or more polymerizable inorganic monomers selected from the group consisting of polymerizable inorganic monomers and polymerizable inorganic monomers having a functional group capable of having a charge are polymerized in the presence of a solvent using as a template a self-assembly of a chiral surfactant such as an N-(higher alkanoyl)amino acid salt. Examples of the use of the inorganic mesoporous material include the separation of racemates and reaction fields for asymmetric syntheses.

A cosmetic composition comprises a) an N-acyl amino acid compound selected from the group consisting of N-acyl amino acid, its isomers, its salts, derivatives thereof, and mixtures thereof, and b) hexyldecanol.

A process of producing N-acyl amino acid based surfactants of Formula I,wherein, R is selected from C6 to C22 alkyl group, R1 is selected from H, C1 to C4 alkyl, R2 is selected from all groups on α carbon of natural amino acids, R3 is selected from COOX, CH2—SO3X, X is selected from Li+, Na+ or K+. The process comprising steps of:A) preparing fatty acid chlorides by halogenating fatty acids with either phosgene or thionyl chloride in the presence of catalytic amount of same or other N-acyl amino acid surfactant of Formula I or anhydrides of same surfactant; andB) reacting fatty acid chloride of step (A) with an amino acid in the presence of a base.

The invention discloses a natural-formulation multi-effect cleaning composition which comprises, by weight, 1-10 parts of surfactant, 0-5 parts of essence, 0.01-2 parts of preservative and 10-100 parts of water. The surfactant is at least one of N-acyl amino acid salt surfactant, lecithin, alkyl glycoside, lauryl alcohol ether sulfate, lauryl alcohol ether phosphate, coconut oil acyl diethanolamine, tallow fatty acid and heterogeneous alcohol ether. Natural products are adopted or used as natural product derivatives for chemical modification of a reaction product, so that the composition is wide in applicable cleaning range, high in detergency and little in damage to skin. The composition can remove dirt of hard-surface floor tiles and heavy oil stain of a kitchen range hood, can serve as tableware cleaning essence and fruit-vegetable cleaner, can serve as a laundry detergent and has a function of killing glucose coccus and Escherichia coli.

The invention relates to compounds of formula (I):or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and / or methods of the present invention comprises cocoyl glutamate.

To provide a wash composition comprising an N-long-chain-acyl amino acid and / or its salt, especially an N-long-chain-acyl neutral amino acid and / or its salt and hydroxypropyl starch phosphate and excellent in foam properties, washing power and feeling upon use, and to provide cosmetics containing the same. A wash composition comprises (A) an N-long-chain-acyl amino acid and / or its salt, especially an N-long-chain-acyl neutral amino acid and / or its salt and (B) hydroxypropyl starch phosphate. Further, it comprises (C) a fatty acid to improve foaming speed, and (D) an acyl acidic amino acid ester to improve moist feeling after drying.

Ascorbic acid derivatives of the general formula 1: wherein R<1> is a C2-C22 acyl group, an amino acid group, or a C1-C17 alkyl group; R<2> is ammonium or a metal cation; and each of R<3> or R<4>, independently, is hydrogen, a C2-C22 acyl group, an amino acid residue, or a C1-C17 alkyl group, are more stable than ascorbic acid and can be used as a source of vitamin C in pharmaceutical, nutraceutical and cosmetic compositions.

There is provided a process for producing an N-acyl amino acid amide, comprising a condensation reaction of an N-acyl amino acid with an amine and / or an ammonia, preferably a primary amine, a secondary amine and / or an ammonia under dehydration in the presence of a boron compound as the catalyst under coexistence of an alcohol as the auxiliary solvent, at a high yield for a short time. A medium for hylotropic dehydration such as hydrocarbon compounds may be used in the reaction.

The invention discloses a preparation method of N-acylamino acid or salt thereof. The preparation method comprises the following step of: carrying out amidation reaction on fatty acyl chloride and amino acid under an alkaline condition. The preparation method is characterized in that reactants, namely the fatty acyl chloride, the amino acid and alkali, are subjected to mixed reaction in a static mixer in the amidation reaction. According to the preparation method of the N-acylamino acid or the salt thereof, an intermittent reaction process can be adopted, and a continuous reaction process can also be adopted; all mixing and reaction processes are carried out in the static mixer, so that the defects of poor reaction uniformity and difficulty in heat exchange of the traditional reaction mode are overcome, the problem of mixing of high-viscosity system materials is solved especially, and the reaction transformation ratio is obviously improved. The preparation method disclosed by the invention can carry out the continuous production of the N-acylamino acid or the salt thereof and is an optimized industrial preparation method of N-fatty acylamino acid or the salt thereof.

The invention discloses shaving foam composition applicable to sensitive skin. The composition is prepared from components in parts by weight as follows: 30-80 parts of water, 0.1-15 parts of an N-acyl amino acid surfactant, 0.1-30 parts of a polyglycerol fatty acid ester surfactant, 0.1-15 parts of a glycoside surfactant, 0.2-30 parts of a betaine surfactant, 0.1-1 part of hydroxypropyl methyl cellulose, 0.1-2 parts of fucose, 0.1-30 parts of witch hazel water, 0.1-10 parts of panthenol, 0.1-5 parts of glucoside, 0.1-10 parts of erythritol and 0.1-1 part of an aloe extract. The composition brings soft, smooth and comfortable shaving feeling and good skin care to consumers with sensitive skin, no liquefied gas is used, and environmental disruption is reduced. The invention further provides cosmetics containing the composition and applications of the composition.

Improved processes for making an N-acyl amino acid salt from a fatty alkyl ester or a polyol ester are disclosed. Each process uses a polyol selected from glycerin or propylene glycol in an amount effective to keep the reaction mixture fluid until conversion to the N-acyl amino acid salt reaches the desired level of completion. In one process, a fatty alkyl ester reacts with an amino acid salt in the presence of glycerin or propylene glycol to produce an N-acyl amino acid salt. In another process, a polyol ester reacts with the amino acid salt in the presence of added glycerin or propylene glycol to produce the N-acyl amino acid salt. We surprisingly found that an effective amount of glycerin or propylene glycol minimizes or eliminates reaction mixture solidification or foaming, reduces color, and minimizes the level of di- and tripeptide by-products. In a related process, water is added when conversion of the amino acid salt to the N-acyl amino acid salt is in the range of 50 to 90 mole %. Water addition improves processability, advances conversion without producing excessive soap, and helps to ensure that the N-acyl amino acid salt will have low color and a small proportion of by-products.

A cosmetic composition comprises a) an N-acyl amino acid compound selected from the group consisting of N-acyl amino acid, its isomers, its salts, derivatives thereof, and mixtures thereof, and b) hexyldecanol.