309 results about "N acylaminoacid" patented technology

Skin care compositions containing N-acyl amino acid, particularly N-acyl derivatives of Phenylalanine or Tyrosine, their isomers, or their salts; at least one other skin care active selected from sugar amines, vitamin B₃, retinoids, peptides, dialkanoyl hydroxyproline, hexamidine, salicylic acid, and phytosterol; and a dermatologically acceptable carrier for the N-acyl amino acid and the skin care active. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the skin care composition of the invention.

An aqueous hair cleansing composition comprising (a) at least one alkyl poly glucoside; (b) at least one betaine compound; and (c) at least one acyl amino acid, wherein the composition is sulfate free.

Method for regulating the condition of mammalian skin comprising the steps of applying a first personal care composition to an area of skin where regulation is desired, wherein the first personal care composition comprises at least one skin care active selected from the group consisting of niacinamide, salicylic acid, peptides, N-acetyl glucosamine, panthenol, butylated hydroxytoluene, N-acyl amino acid compounds, hexamidine, green tea, ascorbyl glucoside, hexanediol, pentanediol, a skin lightening agent, a heat shock protein potentiator, and mixtures thereof, and delivering energy to the area of skin by contacting the skin with an energy delivery device for a treatment period of at least 2½ minutes, wherein the energy delivery device comprises a skin-contacting surface that is controllably heatable to a temperature of from 37° C. to 50° C.

The invention relates to a synthetic method of lauric acyl amino acid sodium, particularly to a synthetic method which uses lauric acid and phosgene as raw materials. The synthetic method comprises the following steps: ensuring that the reaction lasts for 1 to 20 hours at a temperature of 60 to 100 DEG C with the effect of organic amide catalyst; obtaining acyl chloride through vacuum distillation after the reaction is finished; dripping lauric acyl chloride obtained according to the phosgene method into amino acids alkaline solution for reaction; controlling and ensuring the pH value to be within the range of 8 to 10, the reaction temperature to be 15 to 20 DEG C, and the reaction time to be 4 to 5 hours; carrying out cooling after the reaction is finished; acidizing the reaction solution to pH 1 to 2 with hydrochloric acid solution; filtering, washing and drying white sediment to obtain lauric acyl amino acid; dissolving the prepared lauric acyl amino acid with alcohol; adding alcohol solution with sodium hydroxide of equal molar amount; and crystallizing, sucking, filtering and drying after cooling to obtain the lauric acyl amino acid sodium. According to the invention, the synthetic method is reasonable in process, high in reaction efficiency and good in product quality; the three wastes are seldom generated; and no residual phosphorus and sulfur are contained in the product. Therefore, the synthetic method can be widely used in the production of high-end surface active agents, and has significant utility value and social and economic benefits.

The invention relates to a production process and special device of the condensation process of N-long-chain acyl amino acid salt. By adopting the process and special device, the hydrolysis of acyl chloride can be inhibited and the content of the by-product fatty acid salt can be reduced in the condensation process of acyl amino acid type surfactant. Therefore, the weight of the surfactant can be increased, the content of fatty acid salt can be reduced by 50%-75% compared with the single-pot reaction, the conversion rate can be increased to more than 99%, the feeding ratio can be reduced, the condensation time can be shortened and the production efficiency can be increased.

The present invention relates to formulations for corrosion-inhibiting, emulsifying, lubricating or as a surfactant in organic hydrocarbon and/or water based system containing an acyl amino acid derivative and a triazole derivative.

The invention relates to novel oxazinones designed to bind to the penicillin receptor, methods of synthesizing the compounds, and the use of the compounds as antibacterial agents. The compounds have the general formula (I)Preferably the compounds have a carboxyethyl or a substituted carboxymethyl substituent at the 2-position and a hydroxyl group at the 5-position and have a molecular shape suitable for binding to and reacting with the active site of a pencillin-recognizing enzyme. The compounds are synthesized by condensing a carboxyl-protected N-hydroxy amino acid with a 3-hydroxyprotected-4-bromobutanoic acid to form a a doubly protected N-hydroxy N-acylamino acid, which is cyclized with an organic base to yield a doubly protected 1,2-oxazin-3-one. The protecting groups are then removed to provide an antibacterial agent.

A two-part hair dye which is composed of a first part containing an alkali agent, a second part containing hydrogen peroxide, and a non-aerosol foamer container for discharging a liquid mixture of the first part and the second part in the form of a foam, the liquid mixture containing the following components (A) and (B):

(A) a polymer or copolymer containing 70% or more mole fraction of diallyldimethyl quaternary ammonium salt monomer, and

(B) an N-acylamino acid salt, an N-acyl-N-alkylamino acid salt, or an ether carboxylic acid salt,

wherein, an equivalent ratio of the anion site of the component (B) to the cation site of the component (A) (anion/cation) is more than 1, and a viscosity of the liquid mixture at 25° C. is 1 to 300 mPa·s.

A cosmetic composition comprises a) an N-acyl amino acid compound selected from the group consisting of N-acyl amino acid, its isomers, its salts, derivatives thereof, and mixtures thereof, and b) hexyldecanol.

The invention discloses a natural-formulation multi-effect cleaning composition which comprises, by weight, 1-10 parts of surfactant, 0-5 parts of essence, 0.01-2 parts of preservative and 10-100 parts of water. The surfactant is at least one of N-acyl amino acid salt surfactant, lecithin, alkyl glycoside, lauryl alcohol ether sulfate, lauryl alcohol ether phosphate, coconut oil acyl diethanolamine, tallow fatty acid and heterogeneous alcohol ether. Natural products are adopted or used as natural product derivatives for chemical modification of a reaction product, so that the composition is wide in applicable cleaning range, high in detergency and little in damage to skin. The composition can remove dirt of hard-surface floor tiles and heavy oil stain of a kitchen range hood, can serve as tableware cleaning essence and fruit-vegetable cleaner, can serve as a laundry detergent and has a function of killing glucose coccus and Escherichia coli.

The invention relates to compounds of formula (I):

or a salt thereof, wherein R¹, A, L, and R² and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

Ascorbic acid derivatives of the general formula 1: wherein R<1> is a C2-C22 acyl group, an amino acid group, or a C1-C17 alkyl group; R<2> is ammonium or a metal cation; and each of R<3> or R<4>, independently, is hydrogen, a C2-C22 acyl group, an amino acid residue, or a C1-C17 alkyl group, are more stable than ascorbic acid and can be used as a source of vitamin C in pharmaceutical, nutraceutical and cosmetic compositions.

There is provided a process for producing an N-acyl amino acid amide, comprising a condensation reaction of an N-acyl amino acid with an amine and/or an ammonia, preferably a primary amine, a secondary amine and/or an ammonia under dehydration in the presence of a boron compound as the catalyst under coexistence of an alcohol as the auxiliary solvent, at a high yield for a short time. A medium for hylotropic dehydration such as hydrocarbon compounds may be used in the reaction.

Improved processes for making an N-acyl amino acid salt from a fatty alkyl ester or a polyol ester are disclosed. Each process uses a polyol selected from glycerin or propylene glycol in an amount effective to keep the reaction mixture fluid until conversion to the N-acyl amino acid salt reaches the desired level of completion. In one process, a fatty alkyl ester reacts with an amino acid salt in the presence of glycerin or propylene glycol to produce an N-acyl amino acid salt. In another process, a polyol ester reacts with the amino acid salt in the presence of added glycerin or propylene glycol to produce the N-acyl amino acid salt. We surprisingly found that an effective amount of glycerin or propylene glycol minimizes or eliminates reaction mixture solidification or foaming, reduces color, and minimizes the level of di- and tripeptide by-products. In a related process, water is added when conversion of the amino acid salt to the N-acyl amino acid salt is in the range of 50 to 90 mole %. Water addition improves processability, advances conversion without producing excessive soap, and helps to ensure that the N-acyl amino acid salt will have low color and a small proportion of by-products.