Preparation method of N-acylamino acid or salt thereof

An acyl amino acid and amino acid technology are applied in the field of preparation of N-acyl amino acid surfactants, which can solve the problems of uneven mixing of the reaction system, poor reaction uniformity, and difficulty in continuous production, and achieve compact structure, small footprint, Simple maintenance effect

Active Publication Date: 2013-11-27
NANJING HUASHI NEW MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the poor reaction uniformity, uneven mixing of the reaction system and difficulty in heat exchange in the existing production process of N-acyl amino acid or its salt, especially in the case of high viscosity of the late reaction system, the conversion rate is not high and it is difficult to Continuous production and other defects provide a method for preparing an acyl amino acid or a salt thereof

Method used

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  • Preparation method of N-acylamino acid or salt thereof
  • Preparation method of N-acylamino acid or salt thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Batch preparation method of sodium cocoyl glycinate

[0041] The 2500Kg sodium glycinate aqueous solution from the storage tank (sodium glycinate content of 10wt%, pH value of 9.0, temperature of 20℃) and 30% sodium hydroxide solution with gear pump (applicable viscosity of 30Pa.s) were respectively 15M 3 / h and 0-0.5M 3 The / h flow rate is pumped into Sulzer's SMX-type first-stage static mixer, and the cocoyl chloride 500Kg, with 0.50M 3 The / h flow is pumped into the secondary static mixer with an acid-resistant pump, the shells of the primary and secondary static mixers are cooled with refrigerant, the temperature of the material at the outlet of the secondary static mixer is maintained at 20-30 °C, and the pH value is maintained at 9-10. The pH value is adjusted by adjusting the flow rate of sodium hydroxide solution, the material flows through the cooler to cool down to 20°C, returns to the glycine storage tank, and performs a cyclic reaction. The dropwise additio...

Embodiment 2

[0049] Continuous preparation of sodium cocoyl glycinate

[0050] 8% sodium glycinate aqueous solution, 25% sodium hydroxide solution, and cocoyl chloride respectively enter the first mixing reaction unit composed of two-stage SMX static mixer and cooler according to the flow ratio of 5:0.35:0.4 (weight), and the static mixing The device is cooled by refrigerant. Mixed material and 25% sodium hydroxide solution, cocoyl chloride respectively according to flow ratio 5.7:0.3:0.4 (weight) then enter the second mixing reaction unit, this unit is also made up of two-stage SMX static mixer and cooler. The temperature of the material entering the first mixing reaction unit is 15-20°C. As the reaction proceeds gradually, the heat released is taken away by the cooling medium. The outlet temperature of the cooler of the second mixing reaction unit is controlled at 25-35°C, and the pH is adjusted by adjusting The sodium hydroxide flow is controlled at 8-10. After the material is fully m...

Embodiment 3

[0052] Batch preparation method of sodium C12 acyl glycinate

[0053] Using the same conditions as in Example 1, C12 acid chloride was used to replace cocoyl chloride and the molar ratio of glycine was kept at 1:1, and KOH was used to replace sodium hydroxide. The detection result of the reactant was 0.7% potassium glycinate, the conversion rate was 90%, and the material viscosity was 3600 mPa·s.

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Abstract

The invention discloses a preparation method of N-acylamino acid or salt thereof. The preparation method comprises the following step of: carrying out amidation reaction on fatty acyl chloride and amino acid under an alkaline condition. The preparation method is characterized in that reactants, namely the fatty acyl chloride, the amino acid and alkali, are subjected to mixed reaction in a static mixer in the amidation reaction. According to the preparation method of the N-acylamino acid or the salt thereof, an intermittent reaction process can be adopted, and a continuous reaction process can also be adopted; all mixing and reaction processes are carried out in the static mixer, so that the defects of poor reaction uniformity and difficulty in heat exchange of the traditional reaction mode are overcome, the problem of mixing of high-viscosity system materials is solved especially, and the reaction transformation ratio is obviously improved. The preparation method disclosed by the invention can carry out the continuous production of the N-acylamino acid or the salt thereof and is an optimized industrial preparation method of N-fatty acylamino acid or the salt thereof.

Description

technical field [0001] The present invention relates to a preparation method of N-acyl amino acid surfactant, in particular to an optimized industrial preparation method of N-fatty acyl amino acid or its salt. Background technique [0002] N-acyl amino acids and salts are a class of compounds obtained by acylation of amino acids, usually formed by condensation of fatty acid chlorides and amino acids. These compounds have good surface activity, foaming performance, cleaning performance and mildness, and are widely used in cosmetics. , personal cleaning and care products, and also have broad applications in other fields such as food additives, metal processing, ore flotation, oil extraction, and agriculture, biological products and pharmaceutical preparation. [0003] The production process of N-acyl amino acids and salts is usually prepared by dropping fatty acid chlorides into amino acid solutions under alkaline conditions for condensation reaction. The solvent is water or a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/47C07C231/02
Inventor 汪昌国
Owner NANJING HUASHI NEW MATERIAL
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